RU2066194C1 - Biologically active composition (its variants) and a method of its preparing - Google Patents

Abstract

FIELD: medicine. SUBSTANCE: balsamic bioactive agent has oily extract of the following plants: peppermint, motherwort, sage leaves, pine buds, rose, caraway, pepper black, coriander fruits, pot-marigold flowers, milfoil, Saint-John's-wort, celandine, cudweed, thyme, marjoram herb, and also essential oils - mint, fir, coriander, anise, camphor, dill, pink, fennel as aromatic component. Aromatic component contains tonic additions (0.1% by the base weight, not above). Agent can be prepared at different combination of its components and content. Method of agent preparing is proposed also. EFFECT: high effectiveness of agent proposed.

Description

 The invention relates to therapeutic and prophylactic agents, and more particularly to balsamic agents based on oil extracts of plants and to the manufacturing technology of these agents.

 A number of balsamic products containing plant extracts in the extractant are known.

 A balsamic product suitable for application to the skin and containing a cosmetically effective amount of an extract soluble in the extractant obtained from plant tissue is proposed. The preparation may contain plant extract: Spinacia, Trifolium, Medicago, Nicatiana, Zea, Penicillaria and Allium. Water was used as an extractant.

 Known drug that regenerates the skin, containing as active ingredients plant extracts. The preparation contains (1-8)% Rumax plant extract and / or Urtica Loica extract and / or Juniperus Communis extract, as well as solid carriers and / or liquid diluents and, possibly, other additives. The drug can be used to treat lesions of human skin.

 A mixture of medicinal plants for the treatment and prevention of various human diseases is proposed. The mixture-based preparation contains 34-35 g of Icelandic moss, 25-30 g of Flores Calendule, 50-70 g of Radix Bardanae, 80-120 g of Herba Origani, 40-60 g of licorice root, 25-50 g of Radix Symhuti, 20-40 g Radix Cotini, 30-55 g Herba Chelidani and 20-50 g Herba Centauri.

 Known balsamic ointment "KARAGAY" [1] containing, in certain proportions, oil extract of capsicum, alcoholic extract of Tien Shan spruce resin, camphor, menthol, petroleum jelly, lanolin, paraffin.

 To obtain medicines from plants, including balms, currently developed industrial technologies are available.

Known, for example, is a method for the production of medicinal substances from plants of balsamic biologically active agents, which includes selecting the starting plants, loading them in a certain sequence and proportions into the extractant, co-processing, isolating the plant extract and adding a predetermined amount of flavoring component to the resulting product [2]
All the known technical solutions listed above determine to some extent the level of technology in the field under consideration, have their own specifics in application, advantages and limitations.

 The authors set the task of developing new biologically active balsamic drugs that expand the arsenal of existing therapeutic and prophylactic drugs and have an improved range of medical applications.

 To obtain promising balsamic remedies, the authors studied a large class of medicinal plants, their oil, water extracts, aromatizing and tonic components of the final product with numerous combinations of them according to existing recommendations, according to the recommendations given in the literature, and their own approaches.

 It was found that in the framework of the declared balsamic remedy - FITAON-1, which has a wide and effective range of medical applications, it is promising to extract the initial plants from the following: peppermint leaves, motherwort (five-lobed), pharmacy sage, ordinary pine buds, rosehips, caraway seeds ordinary, black pepper, coriander, calendula officinalis flowers, yarrow grass, St. John's wort, celandine, thyme ordinary, dried marshmallow, oregano.

 The listed series is offered as a base. Depending on the primary purpose, FITAON-1 may contain extracts of m plants (m 1,2,) from their base series of n (n 1,2,3,), provided n≥m.

 It is proposed to use K varieties of essential oils as a flavoring component: peppermint, fir, coriander, anise, camphor, dill, clove and fennel. Their number l is also selected from the condition of possible combinations l≥k using one of them, two, three, etc. in combination to obtain a flavoring component (l, k 1, 2, 3,).

 It has been found that it is preferable to use a flavoring component with tonic additives in an amount of not more than 0.1% with respect to the weight of the base of the flavoring component.

 As tonic additives, you can use various substances of this series. As a special case, a number can be offered: vanillin, hazelnut, chestnut, pine nut, walnut, sea buckthorn and rosehip oil. These additives can also be combined. Most preferred is the use of hazelnut and / or chestnut oil.

 It is proposed to use vegetable oils as an extractant: sunflower, olive, rapeseed or soybean oil. The authors found that the base series they offer for medicinal plants, extractant, flavoring component and tonic as a whole form the basis of the declared balsamic remedy with its own spectrum of medical purposes. As noted, possible combinations of specific ingredients from these series give the proposed balsamic remedy specific properties that enhance a particular effect from the main spectrum of prescriptions and block possible side effects.

 For example, the following formulations of the claimed balsamic agent may be proposed (as preferred options): extracts of plants of common pine buds, black pepper fruits, herbs of dried cinnamon and oregano in sunflower oil, fir and coriander essential oils, tonic additives of vanillin, hazelnut and chestnut oil . Or another group of oil extracts of plants of ordinary pine buds, coriander fruits, black pepper, grass, dried cinnamon, marjoram, yarrow, celandine, thyme, peppermint leaf in sunflower oil in combination with the above aromatic and tonic ingredients. In specific situations, it is possible to use other combinations of the above ingredients, including when plant extracts (without extractant, i.e., in terms of the plant feed) and essential oils are included in equal proportions.

а ΔC_i значение задаваемого отклонения содержания данного ингредиента, устанавливаемое предварительно исходя из преимущественного назначения предлагаемого средства.It is known that in order to obtain plant extracts in the required amount, it is necessary to use an extractant in an amount exceeding the mass of the initial medicinal plants and aromatizing component by several times (almost an order of magnitude). Therefore, it is advisable to set the quantitative content of ingredients without extractants and separately the ratio between them. Moreover, the content of each ingredient from among the plants and flavoring component is set as

and ΔC _{i is the} value of the set deviation of the content of this ingredient, which is established previously on the basis of the primary purpose of the proposed funds.

In the particular case, ΔC _i can be equal to zero. In the general case, ΔC _i may differ from C _o several times (3-5 times, for example). The authors believe that the boundaries of the intervals of the ingredients in the general case are not, strictly speaking, critical, since this or that effect from the spectrum of medical prescribes retains its significance and far from the conditional boundaries.

 The contents of the ingredients related to plant extracts are set for convenience of preparation based on the amount of feedstock (dried and chopped herbs, fruits, etc.). It can be assumed that the net amount of extract transferred to the extractant is to some extent proportional to the amount of feedstock. Based on this and the above information, the authors propose to choose the ratio between the plant extract and flavoring component, on the one hand, and the extractant, on the other, as 1: (5-12).

 It was found that the selected amount of tonic additives (approximately 0.1% by weight of the base of the flavoring component) is sufficient to fulfill their purpose in the claimed agent - to minimize the possible negative reaction of the patient to side effects and to enhance the effect of the biologically active agent.

It is established that the claimed balsamic remedy FITAON-1 has indications for use in various fields of medicine:
wound surgery, osteomyelitis, burns;
urology prostatitis, urethritis;
otolaryngology pharyngitis, laryngitis, otitis media, sinusitis, rhinitis, sinusitis, tonsillitis;
dermatology neurodermatitis, eczema, dermatitis, erythrasma, diaper rash, psoriasis, skin itching;
dentistry stomatitis, periodontal disease, prosthetics, gingivitis;
gynecology vaginitis, colpitis, cervical erosion, leukoplaxia;
proctology proctitis, hemorrhoids, paraproctitis;
physiotherapy, balneological ultraviolet irradiation (UV), massage, Bernard currents, electrophoresis.

 The tool has an analgesic, anti-inflammatory, antimicrobial and regenerative effect. The tool has antiexudative activity, helps to maintain the concentration of electrolytes, restore acid-base balance in case of damage to the skin and mucous membrane.

 FITAON-1 is a yellow oily liquid with a brownish or greenish tint with a specific odor. It contains sesquiterpene derivatives, glycosides, carotenoids, menthol, cineole, alpha-pinene, anethole, various micro and macro elements.

 The beneficial effect of the claimed agent in case of damage to the skin and mucous membrane is due to the analgesic, anti-inflammatory, antimicrobial and regenerating effects of the balsamic agent. The tool also has antiexudative activity, helps to maintain the concentration of electrolytes and, as a result, the restoration of acid-base balance.

 Depending on the severity and localization of the wound surface, treatment can be carried out in an open way by daily treatment of wounds with FITAON-1.

 No pronounced side effects were noted.

Contraindications may be with individual intolerance. In this case, it is possible to select an individual composition from among the above components and by varying the content of ingredients (in the range ± ΔC _i ).

 The authors also worked out the production technology of the claimed balsamic remedy, including selection of the source plants, their loading in a certain sequence and proportions into the extractant, joint processing, isolation of the plant extract and adding to the obtained product a given amount of flavoring component with tonic additives.

где m количество выбранных растений, а К количество выбранных ароматизирующих компонент. Соотношение экстракта растений без экстрагента (в пересчете на исходное сырье) и эфирного масла, с одной стороны, и экстрагента, с другой 1:(5-12).More specifically, the method for producing the balsamic biologically active agent FITAON-1 is given below. An extractant is placed in a pre-prepared container. As an extract, pre-refined sunflower, olive, rapeseed or soybean vegetable oil is used. Then the extraction tank is sequentially loaded with a partial amount of crushed plant raw materials from the selected row. The loading process is carried out at a temperature of t (85-95) ^o With and stirring. At the end of the load, the extraction of the plant extract is carried out by self-cooling the product to a temperature of (33-43) ^o C and maintained at this temperature for 47-49 hours with 15-20-minute mixing cycles at equal 3-hour time intervals. After this period, the oil extract is purified from the precipitate, sedimented for 22-24 hours and re-purified. Then the purified oil extract is again heated (heated) to a temperature of 33-43 ^o C and mixed with essential oil (oils) with tonic additives for at least 10 minutes After that, it is packaged in portions. In this case, the amount of the initial extractant, the partial amounts of the initial raw materials of the plants selected in the sequence of common yarrow, celandine, St. John's wort, marjoram, calendula officinalis, common caraway seeds, common thyme, dried mint, peppermint leaf, motherwort and sage pharmacy, kidneys of common pine, rosehips, black pepper and coriander, as well as the amount of aromatic component of essential oil (s) with tonic additives ivayut previously based on the fact that they correspond to the contents without extracting the condition:

where m is the number of selected plants, and K is the number of selected flavoring components. The ratio of plant extract without extractant (in terms of feedstock) and essential oil, on the one hand, and extractant, on the other 1: (5-12).

 The quantitative content of the components is chosen by analogy with the claimed compositions. For example, a balsamic remedy was obtained. For this, the extraction capacity was loaded with 550 kg of purified vegetable oil (540 ± 10), herbs of the yarrow, celandine, St. John's wort, oregano, fruits of caraway seeds, common thyme herbs 3.0 kg each were used as plant blanks; as well as peppermint leaves, ordinary pine buds and rosehips of 8.2 kg each. Camphor, peppermint and fennel essential oils of 2.75 kg each and tonic additives - hazelnut and chestnut oils of 0.003 kg each. Moreover, the oil extract was purified from the sediment on a suction filter or centrifuge, then on a Druk filter, and finally clean-up filtration was performed. The above technology allows you to get the claimed balsamic product with different contents of the ingredients and their combinations from the proposed basic series of plants, extractants, aromatizing and tonic components. As a basis, the modifications thus obtained FITAON-1 have a wide range of medical applications. The specific purpose is set separately for each modification.

Claims (1)

1. A biologically active composition containing medicinal plants, a flavoring component and vegetable oil, characterized in that it contains oil: sunflower, olive, rapeseed or soybean, as the medicinal plants use ordinary pine buds, fruits of black pepper, herbs, dried cinnamon and oregano and as a flavoring component, an essential oil selected from the range: peppermint, fir, coriander, anise, camphor, dill, clove and fennel, while the flavoring component contains a tonic is used in an amount of not more than 0.1% selected from the group: vanillin, and / or hazelnut oil, and / or chestnut, and / or pine nut, and / or walnut, and / or sea buckthorn, and / or rosehip in the following ratio of ingredients, g / l:
Medicinal plants 20-250
Flavoring component 5-200
Vegetable oil Up to 1000
2. A biologically active composition containing medicinal plants, a flavoring component and oil, characterized in that it contains vegetable oil: sunflower, olive, rapeseed or soybean, ordinary pine buds, fruits of black pepper, caraway, rosehip and coriander are used as medicinal plants , herbs, dried marshmallow, oregano, yarrow, celandine and thyme, peppermint leaf and calendula officinalis flowers, and as an aromatic component, essential oil is selected one of the series: mint, fir, coriander, anise, camphor, dill, cloves and fennel, while the flavoring component includes a tonic in an amount of not more than 0.1% selected from the group: vanillin, and / or walnut oil, and / or chestnut, and / or pine nut, and / or walnut, and / or sea buckthorn, and / or rose hip in the following ratio of ingredients, g / l:
Medicinal plants 20-250
Aromatic component 5-200
Vegetable oil Up to 1000
3. A method of obtaining a biologically active composition by extraction of plant materials with oil, followed by separation of the extract and adding a flavoring component to it, characterized in that medicinal plants are introduced into the purified vegetable oil at 85-95 ° C and the product is extracted by self-cooling to 33-43 ° C, then the product is maintained at this temperature for 47-49 hours with periodic stirring for 15-20 minutes, then after separation the oil extract is purified and defended for 22-24 hours, again ayut and before adding the flavor component is heated to 33-34 ° C.