PT969873E - Hidrato de carbono glicopeptido antigene multiplo, vacina abrangendo o mesmo e seu uso - Google Patents

Hidrato de carbono glicopeptido antigene multiplo, vacina abrangendo o mesmo e seu uso

Info

Publication number: PT969873E
Authority: PT; Portugal
Prior art keywords: same; multiple antigen; carbon hydrate; vaccine coating; antigen glycopeptide
Prior art date: 1997-03-27

Application number

PT98913748T

Other languages

English (en)

Inventor

Bay Sylvie

Cantacuzene Daniele

Leclerc Claude

Lo-Man Richard

Original Assignee

Pasteur Institut

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-03-27

Filing date

1998-03-27

Publication date

2006-09-29

1998-03-27 Application filed by Pasteur Institut filed Critical Pasteur Institut

2006-09-29 Publication of PT969873E publication Critical patent/PT969873E/pt

Links

DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical compound NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 title 1
102000002068 Glycopeptides Human genes 0.000 title 1
108010015899 Glycopeptides Proteins 0.000 title 1
FRYDSOYOHWGSMD-UHFFFAOYSA-N [C].O Chemical compound [C].O FRYDSOYOHWGSMD-UHFFFAOYSA-N 0.000 title 1
239000000427 antigen Substances 0.000 title 1
102000036639 antigens Human genes 0.000 title 1
108091007433 antigens Proteins 0.000 title 1
239000011248 coating agent Substances 0.000 title 1
238000000576 coating method Methods 0.000 title 1
229960005486 vaccine Drugs 0.000 title 1
150000001720 carbohydrates Chemical group 0.000 abstract 4
239000000863 peptide conjugate Substances 0.000 abstract 2
210000002966 serum Anatomy 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/285—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
- A61K2039/645—Dendrimers; Multiple antigen peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Microbiology (AREA)
Mycology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)
Carbon And Carbon Compounds (AREA)

PT98913748T 1997-03-27 1998-03-27 Hidrato de carbono glicopeptido antigene multiplo, vacina abrangendo o mesmo e seu uso PT969873E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US4172697P	1997-03-27	1997-03-27

Publications (1)

Publication Number	Publication Date
PT969873E true PT969873E (pt)	2006-09-29

Family

ID=21918009

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT98913748T PT969873E (pt)	1997-03-27	1998-03-27	Hidrato de carbono glicopeptido antigene multiplo, vacina abrangendo o mesmo e seu uso

Country Status (10)

Country	Link
US (1)	US7696326B2 (pt)
EP (1)	EP0969873B1 (pt)
AT (1)	ATE328611T1 (pt)
AU (1)	AU6832398A (pt)
CA (1)	CA2285018C (pt)
DE (1)	DE69834808T2 (pt)
DK (1)	DK0969873T3 (pt)
ES (1)	ES2265162T3 (pt)
PT (1)	PT969873E (pt)
WO (1)	WO1998043677A1 (pt)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
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US6660842B1 (en)	1994-04-28	2003-12-09	Tripep Ab	Ligand/receptor specificity exchangers that redirect antibodies to receptors on a pathogen
US6933366B2 (en)	1996-12-27	2005-08-23	Tripep Ab	Specificity exchangers that redirect antibodies to bacterial adhesion receptors
US7018637B2 (en) *	1998-02-23	2006-03-28	Aventis Pasteur, Inc	Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines
GB9808932D0 (en)	1998-04-27	1998-06-24	Chiron Spa	Polyepitope carrier protein
EP1150708A2 (en) *	1999-02-11	2001-11-07	Genzyme Corporation	Polynucleotide encoding multimers of antigenic peptides in order to enhance presentation of the antigenic peptide by mhc molecules
EP1417965A1 (en) *	2002-11-07	2004-05-12	Vereniging Voor Christelijk Wetenschappelijk Onderwijs	C-type lectin binding molecules, identification and uses thereof
US8133881B2 (en)	2003-01-13	2012-03-13	Shire Llc	Carbohydrate conjugates to prevent abuse of controlled substances
KR20050099536A (ko) *	2003-02-06	2005-10-13	트리펩 아베	글리코실화된 특이성 교환체
US7335359B2 (en)	2003-02-06	2008-02-26	Tripep Ab	Glycosylated specificity exchangers
JP5097400B2 (ja) *	2003-09-03	2012-12-12	デンドリセラピューティクス、インク．	複合ワクチン
US9079765B2 (en)	2004-10-01	2015-07-14	Midatech Ltd.	Nanoparticles comprising antigens and adjuvants, and immunogenic structures
GB0428394D0 (en) *	2004-12-24	2005-02-02	Chiron Srl	Saccharide conjugate vaccines
CA2674269C (en)	2006-01-03	2018-06-12	University Of Georgia Research Foundation, Inc.	Three component glycolipopeptides
ES2366552T3 (es)	2006-01-13	2011-10-21	Institut Pasteur	Síntesis enzimática a gran escala de glicoconjugados de mucina y sus aplicaciones en inmunología.
CN101631818B (zh)	2006-08-11	2013-02-06	星药股份有限公司	聚赖氨酸树状聚体造影剂成像大分子
EP2076557A4 (en)	2006-08-11	2012-08-29	Starpharma Pty Ltd	POLYLYSINE DENDRIMER CONTRAST AGENT
US20120039984A1 (en)	2008-07-03	2012-02-16	University Of Georgia Research Foundation, Inc.	Glycopeptide and uses thereof
CN102448491A (zh) *	2009-04-01	2012-05-09	迈阿密大学	疫苗组合物和其使用方法
EP2500033A1 (en) *	2011-03-17	2012-09-19	Institut Pasteur	Method for preparing muliple antigen glycopeptide carbohydrate conjugates
CN105307684A (zh) *	2012-10-02	2016-02-03	葛兰素史密丝克莱恩生物有限公司	非直链糖缀合物
US9815886B2 (en)	2014-10-28	2017-11-14	Adma Biologics, Inc.	Compositions and methods for the treatment of immunodeficiency
WO2017101786A1 (zh) *	2015-12-14	2017-06-22	韩苏	一种多肽化合物及其制备方法与应用
US10259865B2 (en)	2017-03-15	2019-04-16	Adma Biologics, Inc.	Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection

Family Cites Families (6)

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US4386026A (en)	1981-04-20	1983-05-31	Merck & Co., Inc.	Cell-specific glycopeptide ligands
US5229490A (en)	1987-05-06	1993-07-20	The Rockefeller University	Multiple antigen peptide system
ES2078521T3 (es) *	1990-05-18	1995-12-16	Boehringer Ingelheim Int	Nuevos conjugados de proteina-polication.
GB9202219D0 (en) *	1992-02-03	1992-03-18	Connaught Lab	A synthetic heamophilus influenzae conjugate vaccine
IL105503A (en) *	1992-04-28	1999-05-09	Astra Ab	Carbon peptide couplets capable of eliciting an immune response of T cells
WO1993022343A1 (en)	1992-05-01	1993-11-11	The Rockfeller University	Multiple antigen peptide system having adjuvant properties and vaccines prepared therefrom

1998
- 1998-03-27 CA CA2285018A patent/CA2285018C/en not_active Expired - Lifetime
- 1998-03-27 PT PT98913748T patent/PT969873E/pt unknown
- 1998-03-27 DE DE69834808T patent/DE69834808T2/de not_active Expired - Lifetime
- 1998-03-27 AT AT98913748T patent/ATE328611T1/de active
- 1998-03-27 AU AU68323/98A patent/AU6832398A/en not_active Abandoned
- 1998-03-27 ES ES98913748T patent/ES2265162T3/es not_active Expired - Lifetime
- 1998-03-27 DK DK98913748T patent/DK0969873T3/da active
- 1998-03-27 WO PCT/EP1998/001922 patent/WO1998043677A1/en not_active Ceased
- 1998-03-27 EP EP98913748A patent/EP0969873B1/en not_active Expired - Lifetime
2007
- 2007-01-03 US US11/619,457 patent/US7696326B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0969873A1 (en)	2000-01-12
US20070098730A1 (en)	2007-05-03
EP0969873B1 (en)	2006-06-07
CA2285018C (en)	2011-01-04
DE69834808D1 (de)	2006-07-20
AU6832398A (en)	1998-10-22
ES2265162T3 (es)	2007-02-01
WO1998043677A1 (en)	1998-10-08
CA2285018A1 (en)	1998-10-08
DE69834808T2 (de)	2007-06-06
ATE328611T1 (de)	2006-06-15
US7696326B2 (en)	2010-04-13
DK0969873T3 (da)	2006-10-09

Publication	Publication Date	Title
PT969873E (pt)	2006-09-29	Hidrato de carbono glicopeptido antigene multiplo, vacina abrangendo o mesmo e seu uso
NZ503763A (en)	2003-01-31	Antigenic compositions and vaccines comprising a high molecular weight (HMW) protein of Clamydia for therapeutic and prophylactic use
ATE384792T1 (de)	2008-02-15	Antikörpervarianten mit höheren bindungsaffinitäten im vergleich zu parentalen antikörpern
DK0536275T3 (da)	1999-02-22	Tumorvækstinhibitorer udledt fra væv, fremgangsmåde til deres fremstilling samt anvendelse heraf
NZ512083A (en)	2003-02-28	Methods of increasing lean tissue mass using OB protein compositions
DE69222956D1 (de)	1997-12-04	Kleinste erkennungseinheit eines pem-mucin-"tandem repeat"-spezifischen monoklonalen antikoerpers
ES2293973T3 (es)	2008-04-01	Anticuerpos anti-ccr2 humanizados y metodos de uso de los mismos.
EP1378525A3 (en)	2004-01-14	Humanized antibodies that bind to the antigen bound by antibody NR-LU-13 and their use in pretargeting methods
BR9810907A (pt)	2000-08-01	Anticorpos monoclonais e policlonais, peptìdeo suscetìvel de gerar um anticorpo, agente imunogênico, sequência de nucleotìdeos, composição farmacêutica, uso de pelo menos um anticorpo, kit de diagnóstico, e, processo para preparar um agente imunogênico
NZ506553A (en)	2002-11-26	Epitopes in viral envelope proteins and specific antibodies directed against these epitopes: use for detection of hcv viral antigen in host tissue
DE69638024D1 (de)	2009-10-22	Melanoma antigene p15 und deren anwendung in diagnostischen und therapeutischen verfahren
NZ305083A (en)	1999-06-29	Use of cd40 binding proteins (a cd40 ligand or monoclonal antibody that specifically binds to cd40) for stimulating a immune response
ATE230418T1 (de)	2003-01-15	Monoklonaler antikörper gegen das humane mx- protein mxa
ES2082132T3 (es)	1996-03-16	Composicion que contiene al menos dos anticuerpos distintos o fragmentos de ellos.
NO972522L (no)	1997-08-06	Monoklonale antistoffer med immunoundertrykkende aktivitet
ATE444081T1 (de)	2009-10-15	Proteine-abgabe durch polare epithelzellen schichte
DE59608073D1 (de)	2001-12-06	Antikörper gegen ein, einen histidin-anteil aufweisendes fusionspolypeptid
ES2122921A1 (es)	1998-12-16	Proteinas recombinantes de fusion del virus del sindrome reproductivo y respiratorio porcino (prsv) y su empleo en diagnostico.
GB2299994A (en)	1996-10-23	Equine arteritis virus peptides antibodies and their use in a diagnostic test
FR2718849B1 (fr)	1996-06-14	Procédé d'immunodosage de l'antithrombine III activée par un glycosaminoglycane, anticorps monoclonaux correspondants et leur procédé d'obtention.
EP1388543A3 (en)	2004-03-03	Antibodies against phosphorylated VASP (vasodilator-stimulated phosphoprotein), hybridoma cells for their preparation, and their use
WO1990014844A3 (en)	1991-03-07	Sugars as cleavable linkers for the delivery and release of agents in native form
ES2092960A1 (es)	1996-12-01	Gen de la proteina 1 de union a transferrina (tbp1) de actinobacillus pleuropneumoniae, utilizacion de esta en la preparacion de productos para la vacunacion contra la pleuroneumonia y en reactivos de diagnostico.
DK0889907T3 (da)	2004-10-18	Monoklonale antistoffer, som binder humant væksthormon (hGH)
RU95104325A (ru)	1996-12-27	Коньюгаты антител с улучшенными свойствами