PT95781A - Novo processo para a preparacao e isolamento directo de captopril - Google Patents

Novo processo para a preparacao e isolamento directo de captopril

Info

Publication number: PT95781A
Authority: PT; Portugal
Prior art keywords: substrate; captopril; direct isolation; alkali metal; metal hydroxide
Prior art date: 1989-11-06

Application number

PT95781A

Other languages

English (en)

Other versions

PT95781B (pt

Inventor

Neal G Anderson

David A Lust

Barbara J Bennett

Alan F Feldman

Robert E Polomski

Original Assignee

Squibb & Sons Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-11-06

Filing date

1990-11-05

Publication date

1991-09-13

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23714462&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT95781(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1990-11-05 Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc

1991-09-13 Publication of PT95781A publication Critical patent/PT95781A/pt

1997-11-28 Publication of PT95781B publication Critical patent/PT95781B/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Heart & Thoracic Surgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Compounds Of Unknown Constitution (AREA)
Pyrrole Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Semiconductor Lasers (AREA)

PT95781A 1989-11-06 1990-11-05 Novo processo para a preparacao e isolamento directo de captopril PT95781B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/432,028 US5026873A (en)	1989-11-06	1989-11-06	Process for direct isolation of captopril

Publications (2)

Publication Number	Publication Date
PT95781A true PT95781A (pt)	1991-09-13
PT95781B PT95781B (pt)	1997-11-28

Family

ID=23714462

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT95781A PT95781B (pt)	1989-11-06	1990-11-05	Novo processo para a preparacao e isolamento directo de captopril

Country Status (29)

Country	Link
US (1)	US5026873A (pt)
EP (1)	EP0427435B1 (pt)
JP (1)	JPH03169856A (pt)
KR (1)	KR0163956B1 (pt)
CN (1)	CN1028169C (pt)
AT (1)	ATE119148T1 (pt)
AU (1)	AU635341B2 (pt)
CA (1)	CA2027377A1 (pt)
CY (1)	CY1852A (pt)
CZ (1)	CZ277714B6 (pt)
DE (1)	DE69017355T2 (pt)
DK (1)	DK0427435T3 (pt)
EG (1)	EG18964A (pt)
ES (1)	ES2068349T3 (pt)
FI (1)	FI98814C (pt)
HK (1)	HK109895A (pt)
HU (1)	HU208525B (pt)
IE (1)	IE67284B1 (pt)
IL (1)	IL96018A (pt)
MX (1)	MX166721B (pt)
MY (1)	MY106445A (pt)
NO (1)	NO904796L (pt)
NZ (1)	NZ235958A (pt)
PH (1)	PH26962A (pt)
PL (1)	PL287642A1 (pt)
PT (1)	PT95781B (pt)
RU (1)	RU2001909C1 (pt)
SK (1)	SK278604B6 (pt)
ZA (1)	ZA908523B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU208954B (en) *	1990-09-21	1994-02-28	Egyt Gyogyszervegyeszeti Gyar	Process for producing 1-(3-mercapto-(2s)-methyl-1-oxo-propyl)-l-prolyn
US5387697A (en) *	1994-06-13	1995-02-07	Merck & Co., Inc.	Process for the preparation of 1-[3-acetylthio-2(s)-methylpropanoyl]-l-proline
JP3980684B2 (ja) *	1996-10-11	2007-09-26	株式会社カネカ	高品質カプトプリルの簡便な製造方法
CN107652215A (zh) *	2017-09-19	2018-02-02	重庆西南制药二厂有限责任公司	一种卡托普利的制备方法
CN110146624B (zh) *	2019-06-14	2022-02-22	湖南汉森制药股份有限公司	一种卡托普利有关物质的检测方法
CN110950792A (zh) *	2019-12-11	2020-04-03	华中药业股份有限公司	一种卡托普利的改进制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4105776A (en) *	1976-06-21	1978-08-08	E. R. Squibb & Sons, Inc.	Proline derivatives and related compounds
AU509899B2 (en) *	1976-02-13	1980-05-29	E.R. Squibb & Sons, Inc.	Proline derivatives and related compounds
US4241076A (en) *	1978-02-21	1980-12-23	E. R. Squibb & Sons, Inc.	Halogenated substituted mercaptoacylamino acids
NL7809120A (nl) *	1978-09-07	1980-03-11	Oce Andeno B V Grubbenvorsterw	Werkwijze voor de bereiding van proline-derivaten.
US4297282A (en) *	1979-03-02	1981-10-27	Sumitomo Chemical Company, Limited	Resolution of mercaptopropionic acids
HU184082B (en) *	1979-12-29	1984-06-28	Egyt Gyogyszervegyeszeti Gyar	Process for preparing 1-3-/3mercapto-/2s/-methyl-propinyl/-pyrrolidine-/2s/-carboxylic acid
US4332726A (en) *	1980-08-25	1982-06-01	E. R. Squibb & Sons, Inc.	Purification of mercaptoacyl amino acids
JPS58124764A (ja) *	1982-01-20	1983-07-25	Kanegafuchi Chem Ind Co Ltd	光学活性チオ−ル化合物の製造法
KR870001570B1 (ko) *	1984-12-19	1987-09-04	보령제약 주식회사	피롤리딘 유도체의 제조방법
IL91581A (en) *	1988-09-13	1993-07-08	Sepracor Inc	Methods for preparing optically active captopril and its analogues

1989
- 1989-11-06 US US07/432,028 patent/US5026873A/en not_active Expired - Lifetime
1990
- 1990-10-10 AU AU63977/90A patent/AU635341B2/en not_active Ceased
- 1990-10-11 CA CA002027377A patent/CA2027377A1/en not_active Abandoned
- 1990-10-11 MY MYPI90001775A patent/MY106445A/en unknown
- 1990-10-16 PH PH41385A patent/PH26962A/en unknown
- 1990-10-16 IL IL9601890A patent/IL96018A/en not_active IP Right Cessation
- 1990-10-19 IE IE375990A patent/IE67284B1/en not_active IP Right Cessation
- 1990-10-24 ZA ZA908523A patent/ZA908523B/xx unknown
- 1990-10-29 DK DK90311824.8T patent/DK0427435T3/da active
- 1990-10-29 ES ES90311824T patent/ES2068349T3/es not_active Expired - Lifetime
- 1990-10-29 AT AT90311824T patent/ATE119148T1/de not_active IP Right Cessation
- 1990-10-29 DE DE69017355T patent/DE69017355T2/de not_active Expired - Fee Related
- 1990-10-29 EP EP90311824A patent/EP0427435B1/en not_active Expired - Lifetime
- 1990-10-31 MX MX023131A patent/MX166721B/es unknown
- 1990-11-02 CZ CS905405A patent/CZ277714B6/cs not_active IP Right Cessation
- 1990-11-02 SK SK5405-90A patent/SK278604B6/sk not_active IP Right Cessation
- 1990-11-04 EG EG600690A patent/EG18964A/xx active
- 1990-11-05 NZ NZ235958A patent/NZ235958A/xx unknown
- 1990-11-05 RU SU904831477A patent/RU2001909C1/ru not_active IP Right Cessation
- 1990-11-05 NO NO90904796A patent/NO904796L/no unknown
- 1990-11-05 PT PT95781A patent/PT95781B/pt not_active IP Right Cessation
- 1990-11-05 HU HU907031A patent/HU208525B/hu not_active IP Right Cessation
- 1990-11-05 FI FI905467A patent/FI98814C/fi active IP Right Grant
- 1990-11-05 KR KR1019900017821A patent/KR0163956B1/ko not_active Expired - Fee Related
- 1990-11-06 PL PL28764290A patent/PL287642A1/xx unknown
- 1990-11-06 CN CN90108901A patent/CN1028169C/zh not_active Expired - Fee Related
- 1990-11-06 JP JP2302311A patent/JPH03169856A/ja active Pending
1995
- 1995-07-06 HK HK109895A patent/HK109895A/en not_active IP Right Cessation
1996
- 1996-03-08 CY CY185296A patent/CY1852A/xx unknown

Also Published As

Publication number	Publication date
ATE119148T1 (de)	1995-03-15
FI98814C (fi)	1997-08-25
DE69017355D1 (de)	1995-04-06
NO904796D0 (no)	1990-11-05
ES2068349T3 (es)	1995-04-16
IE67284B1 (en)	1996-03-20
FI98814B (fi)	1997-05-15
HUT55754A (en)	1991-06-28
IL96018A (en)	1996-05-14
IL96018A0 (en)	1991-07-18
HK109895A (en)	1995-07-14
RU2001909C1 (ru)	1993-10-30
CA2027377A1 (en)	1991-05-07
IE903759A1 (en)	1991-05-08
CS540590A3 (en)	1992-11-18
EG18964A (en)	1994-09-29
CN1051908A (zh)	1991-06-05
CN1028169C (zh)	1995-04-12
AU6397790A (en)	1991-05-09
PL287642A1 (en)	1991-05-20
HU208525B (en)	1993-11-29
SK278604B6 (en)	1997-11-05
AU635341B2 (en)	1993-03-18
PH26962A (en)	1992-12-28
MX166721B (es)	1993-01-29
NZ235958A (en)	1993-01-27
MY106445A (en)	1995-05-30
EP0427435A1 (en)	1991-05-15
ZA908523B (en)	1991-08-28
JPH03169856A (ja)	1991-07-23
EP0427435B1 (en)	1995-03-01
NO904796L (no)	1991-05-07
DK0427435T3 (da)	1995-03-27
HU907031D0 (en)	1991-05-28
CY1852A (en)	1996-03-08
FI905467A0 (fi)	1990-11-05
CZ277714B6 (en)	1993-03-17
KR910009657A (ko)	1991-06-28
KR0163956B1 (ko)	1998-12-01
US5026873A (en)	1991-06-25
DE69017355T2 (de)	1995-06-29
PT95781B (pt)	1997-11-28

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Legal Events

Date	Code	Title	Description
1991-09-13	BB1A	Laying open of patent application	Effective date: 19910403
1997-11-28	FG3A	Patent granted, date of granting	Effective date: 19970804
2010-02-11	MM4A	Annulment/lapse due to non-payment of fees, searched and examined patent	Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20100204

Date

Code

Title

Description

1991-09-13

BB1A

Laying open of patent application

Effective date: 19910403

1997-11-28

FG3A

Patent granted, date of granting

Effective date: 19970804

2010-02-11

MM4A

Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20100204