PT937074E - Benzonaftiridinas como terapeutica bronquica - Google Patents

Benzonaftiridinas como terapeutica bronquica

Info

Publication number: PT937074E
Authority: PT; Portugal
Prior art keywords: pct; therapeutics; benzonaftiridines; bronchic; date
Prior art date: 1996-11-11

Application number

PT97950093T

Other languages

English (en)

Inventor

Rolf Beume

Dietrich Haefner

Hans-Peter Kley

Thomas Baer

Thomas Martin

Wolf-Ruediger Ulrich

Hildegard Boss

Dieter Flockerzi

Beate Schmidt

Armin Hatzelmann

Hermann Amschler

Karl-Josef Goebel

Karl Sanders

Original Assignee

Altana Pharma Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-11-11

Filing date

1997-11-05

Publication date

2003-07-31

1997-11-05 Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag

2003-07-31 Publication of PT937074E publication Critical patent/PT937074E/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Pulmonology (AREA)
Physical Education & Sports Medicine (AREA)
Cardiology (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Neurosurgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Heart & Thoracic Surgery (AREA)
Dermatology (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyrane Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

PT97950093T 1996-11-11 1997-11-05 Benzonaftiridinas como terapeutica bronquica PT937074E (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE19646298		1996-11-11
EP96118188		1996-11-13
DE19739056		1997-09-05

Publications (1)

Publication Number	Publication Date
PT937074E true PT937074E (pt)	2003-07-31

Family

ID=27216810

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT97950093T PT937074E (pt)	1996-11-11	1997-11-05	Benzonaftiridinas como terapeutica bronquica

Country Status (30)

Country	Link
US (1)	US6008215A (pt)
EP (1)	EP0937074B1 (pt)
JP (1)	JP4223075B2 (pt)
KR (1)	KR100484045B1 (pt)
CN (1)	CN1090188C (pt)
AT (1)	ATE234300T1 (pt)
AU (1)	AU733129B2 (pt)
BG (1)	BG63695B1 (pt)
BR (1)	BR9713338B1 (pt)
CA (1)	CA2270964C (pt)
CY (1)	CY2476B1 (pt)
CZ (1)	CZ288752B6 (pt)
DE (1)	DE69719778T2 (pt)
DK (1)	DK0937074T3 (pt)
EA (1)	EA001551B1 (pt)
EE (1)	EE03829B1 (pt)
ES (1)	ES2195189T3 (pt)
GE (1)	GEP20012390B (pt)
HU (1)	HU226981B1 (pt)
ID (1)	ID22042A (pt)
IL (1)	IL129054A (pt)
NO (1)	NO312764B1 (pt)
NZ (1)	NZ334976A (pt)
PL (1)	PL189641B1 (pt)
PT (1)	PT937074E (pt)
RS (1)	RS49607B (pt)
SI (1)	SI0937074T1 (pt)
SK (1)	SK283269B6 (pt)
TR (1)	TR199900856T2 (pt)
WO (1)	WO1998021208A1 (pt)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6306869B1 (en)	1998-05-05	2001-10-23	Byk Gulden Lomberg Chemische Febrik Gmbh	N-oxides
ES2224745T3 (es)	1998-08-31	2005-03-01	Altana Pharma Ag	N-oxidos de benzonaftiridina con actividad inhibidora de pde3 y pde4.
IT1303272B1 (it)	1998-10-29	2000-11-06	Zambon Spa	Derivati triciclici inibitori della fosfodiesterasi 4
DK1147089T3 (da) *	1999-01-15	2006-04-10	Altana Pharma Ag	Phenylphenanthridiner med PDE-IV-inhiberende virkning
CA2359449A1 (en)	1999-01-15	2000-07-20	Beate Gutterer	Phenanthridine-n-oxides with pde-iv inhibiting activity
WO2000042017A1 (en) *	1999-01-15	2000-07-20	Byk Gulden Lomberg Chemische Fabrik Gmbh	Phenanthridine-n-oxides with pde-iv inhibiting activity
AU2904300A (en) *	1999-01-15	2000-08-01	Byk Gulden Lomberg Chemische Fabrik Gmbh	Polysubstituted 6-phenylphenanthridines with pde-iv inhibiting activity
AU777012B2 (en) *	1999-08-21	2004-09-30	Takeda Gmbh	Synergistic combination of PDE inhibitors and beta 2 adrenoceptor agonist
NL1017973C2 (nl) *	2000-05-10	2002-11-08	Tristem Trading Cyprus Ltd	Inrichting.
DK1377574T3 (da)	2001-02-21	2005-04-25	Altana Pharma Ag	6-phenylbenzonaphtyridiner
US6479493B1 (en)	2001-08-23	2002-11-12	Cell Pathways, Inc.	Methods for treatment of type I diabetes
WO2004018465A2 (en) *	2002-08-17	2004-03-04	Altana Pharma Ag	Benzonaphthyridines with pde 3/4 inhibiting activity
US7470704B2 (en)	2002-09-04	2008-12-30	Nycomed Gmbh	Benzonaphthyridines
PL373989A1 (en) *	2002-09-04	2005-09-19	Altana Pharma Ag	Novel benzonaphthyridines
JP2006522151A (ja)	2003-04-01	2006-09-28	アプライドリサーチシステムズエーアールエスホールディングナームロゼフェンノートシャップ	不妊症におけるホスホジエステラーゼ阻害剤
AR049419A1 (es) *	2004-03-03	2006-08-02	Altana Pharma Ag	Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo
CN104761545A (zh)	2004-03-03	2015-07-08	塔科达有限责任公司	新的羟基-6-杂芳基菲啶及其作为pde4抑制剂的用途
BRPI0508481A (pt) *	2004-03-10	2007-07-31	Altana Pharma Ag	hidróxi-6-fenilenantridinas amido-substituìdas e seu uso como inibidores de pde4
CA2559200A1 (en)	2004-03-17	2005-09-29	Altana Pharma Ag	Novel n- (alkoxyalkyl) carbamoyl - substituted 6-phenyl-benzonaphthyridine derivatives and their use as pde3/4 inhibitors
JP4960870B2 (ja) *	2004-09-08	2012-06-27	ニコメッドゲゼルシャフトミットベシュレンクテルハフツング	新規の３−チア−１０−アザ−フェナントレン誘導体
WO2006027344A2 (en) *	2004-09-08	2006-03-16	Altana Pharma Ag	3-oxa-10-aza-phenanthrenes as pde4 or pde3/4 inhibitors
NZ589278A (en)	2005-03-02	2012-04-27	Nycomed Gmbh	Selected salts of 6-heterocyclyl substituted hexahydrophenanthridine derivatives
WO2007045979A1 (en)	2005-10-19	2007-04-26	Ranbaxy Laboratories Limited	Pharmaceutical compositions of muscarinic receptor antagonists
TW200808695A (en) *	2006-06-08	2008-02-16	Amgen Inc	Benzamide derivatives and uses related thereto
ES2528316T3 (es) *	2006-09-01	2015-02-06	Senhwa Biosciences, Inc.	Moduladores de la serina-treonina proteína quinasa y de PARP
CN112079769A (zh)	2008-04-23	2020-12-15	里格尔药品股份有限公司	用于治疗代谢障碍的甲酰胺化合物
AR079451A1 (es)	2009-12-18	2012-01-25	Nycomed Gmbh	Compuestos 3,4,4a,10b-tetrahidro-1h-tiopirano[4,3-c]isoquinolina
CN108299429B (zh) *	2018-04-09	2021-10-08	中南大学	一类八氢苯并萘啶化合物及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3899494A (en) *	1970-05-13	1975-08-12	Sandoz Ltd	Substituted 6-phenyl benzo-naphthyridines
EP0247971A3 (en) *	1986-05-29	1990-01-17	Sandoz Ag	Novel pharmaceutical compositions comprising and use of cis-6-(4-acetanilido)-8,9-dimethoxy-2-methyl-1,2,3,4,4a,10b-hexahydrobenzo[c][1,6]naphthyridin
MY105344A (en) *	1990-05-16	1994-09-30	Byk Gulden Lomberg Chemische Fabrik	New sulphonyl compounds

1997
- 1997-11-05 CZ CZ19991675A patent/CZ288752B6/cs not_active IP Right Cessation
- 1997-11-05 BR BRPI9713338-8A patent/BR9713338B1/pt not_active IP Right Cessation
- 1997-11-05 AU AU53170/98A patent/AU733129B2/en not_active Ceased
- 1997-11-05 IL IL12905497A patent/IL129054A/en not_active IP Right Cessation
- 1997-11-05 CN CN97199529A patent/CN1090188C/zh not_active Expired - Fee Related
- 1997-11-05 HU HU0000426A patent/HU226981B1/hu not_active IP Right Cessation
- 1997-11-05 WO PCT/EP1997/006096 patent/WO1998021208A1/en not_active Ceased
- 1997-11-05 PL PL97333429A patent/PL189641B1/pl unknown
- 1997-11-05 PT PT97950093T patent/PT937074E/pt unknown
- 1997-11-05 RS YUP-194/99A patent/RS49607B/sr unknown
- 1997-11-05 CA CA002270964A patent/CA2270964C/en not_active Expired - Fee Related
- 1997-11-05 SK SK623-99A patent/SK283269B6/sk not_active IP Right Cessation
- 1997-11-05 TR TR1999/00856T patent/TR199900856T2/xx unknown
- 1997-11-05 DE DE69719778T patent/DE69719778T2/de not_active Expired - Lifetime
- 1997-11-05 SI SI9730535T patent/SI0937074T1/xx unknown
- 1997-11-05 JP JP52212098A patent/JP4223075B2/ja not_active Expired - Fee Related
- 1997-11-05 EA EA199900421A patent/EA001551B1/ru not_active IP Right Cessation
- 1997-11-05 NZ NZ334976A patent/NZ334976A/xx not_active IP Right Cessation
- 1997-11-05 ES ES97950093T patent/ES2195189T3/es not_active Expired - Lifetime
- 1997-11-05 GE GEAP19974710A patent/GEP20012390B/en unknown
- 1997-11-05 EE EEP199900105A patent/EE03829B1/xx not_active IP Right Cessation
- 1997-11-05 KR KR10-1999-7004024A patent/KR100484045B1/ko not_active Expired - Fee Related
- 1997-11-05 DK DK97950093T patent/DK0937074T3/da active
- 1997-11-05 US US09/284,458 patent/US6008215A/en not_active Expired - Lifetime
- 1997-11-05 AT AT97950093T patent/ATE234300T1/de active
- 1997-11-05 EP EP97950093A patent/EP0937074B1/en not_active Expired - Lifetime
- 1997-11-05 ID IDW990180A patent/ID22042A/id unknown
1999
- 1999-04-05 BG BG103310A patent/BG63695B1/bg unknown
- 1999-05-11 NO NO19992282A patent/NO312764B1/no not_active IP Right Cessation
2004
- 2004-09-03 CY CY0400068A patent/CY2476B1/xx unknown

Also Published As

Publication number	Publication date
EE03829B1 (et)	2002-08-15
WO1998021208A1 (en)	1998-05-22
AU733129B2 (en)	2001-05-10
CA2270964A1 (en)	1998-05-22
ATE234300T1 (de)	2003-03-15
HUP0000426A2 (hu)	2001-02-28
YU19499A (sh)	2001-09-28
DE69719778T2 (de)	2004-02-05
BG63695B1 (bg)	2002-09-30
IL129054A (en)	2002-07-25
NO992282D0 (no)	1999-05-11
GEP20012390B (en)	2001-03-25
EA001551B1 (ru)	2001-04-23
NO312764B1 (no)	2002-07-01
TR199900856T2 (xx)	1999-07-21
EE9900105A (et)	1999-10-15
SK283269B6 (sk)	2003-04-01
RS49607B (sr)	2007-06-04
BR9713338A (pt)	2000-05-09
KR100484045B1 (ko)	2005-04-20
HK1022151A1 (en)	2000-07-28
HU226981B1 (hu)	2010-04-28
US6008215A (en)	1999-12-28
DK0937074T3 (da)	2003-06-23
PL333429A1 (en)	1999-12-06
PL189641B1 (pl)	2005-09-30
KR20000053100A (ko)	2000-08-25
EP0937074A1 (en)	1999-08-25
IL129054A0 (en)	2000-02-17
HUP0000426A3 (en)	2001-04-28
SK62399A3 (en)	1999-10-08
ES2195189T3 (es)	2003-12-01
CA2270964C (en)	2007-07-31
JP4223075B2 (ja)	2009-02-12
CY2476B1 (en)	2005-05-03
AU5317098A (en)	1998-06-03
NO992282L (no)	1999-05-11
JP2001503442A (ja)	2001-03-13
DE69719778D1 (de)	2003-04-17
EP0937074B1 (en)	2003-03-12
CN1090188C (zh)	2002-09-04
BR9713338B1 (pt)	2009-12-01
EA199900421A1 (ru)	1999-10-28
NZ334976A (en)	2000-10-27
CZ167599A3 (cs)	1999-11-17
CN1236367A (zh)	1999-11-24
ID22042A (id)	1999-08-26
CZ288752B6 (cs)	2001-08-15
SI0937074T1 (en)	2003-08-31
BG103310A (en)	2000-05-31

Publication	Publication Date	Title
PT937074E (pt)	2003-07-31	Benzonaftiridinas como terapeutica bronquica
DK0882021T3 (da)	2003-06-23	Nye phenanthridiner
DK0998460T3 (da)	2004-07-05	Hidtil ukendte tetrazolderivater
DK0889886T3 (da)	2003-01-20	Hidtil ukendte, i 6-stilling substituerede phenanthridiner
TR200100672T2 (tr)	2001-07-23	Yeni izoksazolinon antibakteriyel ajanları
PT941221E (pt)	2003-07-31	Dihidrobenzofuranos substituidos como inibidores de fosfodiesterase (pde)
PT920426E (pt)	2004-02-27	Novos derivados de tiazole com efeito inibidor de fosfodiesterase
DE59909760D1 (de)	2004-07-22	Benzonaphthyridin-n-oxide mit pde3 und pde4 inhibierender aktivität
ATE258930T1 (de)	2004-02-15	Dihydrobenzifurane
PT1086096E (pt)	2003-12-31	Benzamidas com substituintes etra-hidrofuraniloxi como inibidores da fosfodiesterase 4
ATE356810T1 (de)	2007-04-15	Polysubstituted 6-phenylphenanthridines mit pde- iv hemmender wirkung
ATE294793T1 (de)	2005-05-15	Phenantrhridin-n-oxides mit pde-iv hemmender wirkung
DE60025327D1 (de)	2006-03-30	6-arylphenanthridine mit pde-iv hemmender wirkung
DK1204659T3 (da)	2004-04-05	Serotonerge benzofuraner
AU758194C (en)	2004-04-08	Novel benzimidazoles and benzoxazoles
PT937075E (pt)	2004-05-31	Novas imidazo- e oxazolo-piridinas como inibidores da fosfodiesterese