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PT90727A - Processo para a preparacao de uma proteina possuindo um ou mais determinantes imuno-reactivos e/ou antigenicos de um antigenio de superficie eimeria e de vacinas contra a coccidiose que a contem - Google Patents

Processo para a preparacao de uma proteina possuindo um ou mais determinantes imuno-reactivos e/ou antigenicos de um antigenio de superficie eimeria e de vacinas contra a coccidiose que a contem

Info

Publication number
PT90727A
PT90727A PT90727A PT9072789A PT90727A PT 90727 A PT90727 A PT 90727A PT 90727 A PT90727 A PT 90727A PT 9072789 A PT9072789 A PT 9072789A PT 90727 A PT90727 A PT 90727A
Authority
PT
Portugal
Prior art keywords
immunomoreactive
coccidiosis
efficacy
protein
preparation
Prior art date
Application number
PT90727A
Other languages
English (en)
Other versions
PT90727B (pt
Inventor
Mary-Helen Binger
Werner Altenburger
Richard Anthony Chizzonite
Richard Allen Kramer
Peter Thomas Lomedico
Stephen J Mcandrew
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PT90727A publication Critical patent/PT90727A/pt
Publication of PT90727B publication Critical patent/PT90727B/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
    • C07K14/455—Eimeria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/20—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans from protozoa
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PT90727A 1988-06-03 1989-06-02 Processo para a preparacao de uma proteina possuindo um ou mais determinantes imuno-reactivos e/ou antigenicos de um antigenio de superficie eimeria e de vacinas contra a coccidiose que a contem PT90727B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20272188A 1988-06-03 1988-06-03

Publications (2)

Publication Number Publication Date
PT90727A true PT90727A (pt) 1989-12-29
PT90727B PT90727B (pt) 1994-11-30

Family

ID=22750986

Family Applications (1)

Application Number Title Priority Date Filing Date
PT90727A PT90727B (pt) 1988-06-03 1989-06-02 Processo para a preparacao de uma proteina possuindo um ou mais determinantes imuno-reactivos e/ou antigenicos de um antigenio de superficie eimeria e de vacinas contra a coccidiose que a contem

Country Status (22)

Country Link
US (2) US5661015A (pt)
EP (1) EP0344808B1 (pt)
JP (1) JP3051130B2 (pt)
KR (1) KR0156545B1 (pt)
CN (3) CN1040126C (pt)
AR (1) AR241942A1 (pt)
AT (1) ATE120489T1 (pt)
AU (1) AU635704B2 (pt)
CA (1) CA1340538C (pt)
DE (1) DE68921923T2 (pt)
DK (1) DK272889A (pt)
ES (1) ES2070866T3 (pt)
FI (1) FI101453B1 (pt)
HU (1) HU212505B (pt)
IE (1) IE67544B1 (pt)
IL (1) IL90489A0 (pt)
MC (1) MC2039A1 (pt)
NO (1) NO303876B1 (pt)
NZ (1) NZ229377A (pt)
PT (1) PT90727B (pt)
YU (1) YU47880B (pt)
ZA (1) ZA893740B (pt)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5174993A (en) * 1981-12-24 1992-12-29 Health Research Inc. Recombinant avipox virus and immunological use thereof
US5273901A (en) * 1984-07-05 1993-12-28 Enzon Corp. Genetically engineered coccidiosis sporozoite 21.5 Kb antigen, ac-6b
US5279960A (en) * 1984-07-05 1994-01-18 Enzon Corp. 25 KD coccidial antigen of eimeria tenella
US5824656A (en) * 1988-01-15 1998-10-20 Merck & Co., Inc. Recombinant and native group B eimeria tenella immunogens useful as coccidiosis vaccines
DE68927350T2 (de) * 1988-07-05 1997-04-24 British Tech Group Usa Gentechnologisch hergestellter coccidiose-impfstoff
ZA902147B (en) * 1989-03-28 1990-12-28 Akzo Nv Coccidiosis vaccine
DE68909041T2 (de) * 1989-06-21 1994-01-13 Akzo Nv Eimeria tenella-Vakzin.
ZA9010461B (en) * 1990-01-26 1991-10-30 Hoffmann La Roche Recombinant coccidiosis vaccines-5-7 eimeria surface antigen
JPH07500483A (ja) * 1991-03-14 1995-01-19 ブリティッシュ・テクノロジー・グループ・ユーエスエイ・インコーポレーテッド 組換え体抗コクシジアワクチン
US6008342A (en) * 1991-07-12 1999-12-28 Roche Vitamins Inc. DNA encoding eimeria antigen
US5403581A (en) * 1991-07-12 1995-04-04 Hoffmann-La Roche Inc. Coccidiosis vaccines
EP0831897B1 (en) 1995-06-07 2001-03-28 Pfizer Inc. In ovo vaccination against coccidiosis
JP3534774B2 (ja) 1995-06-07 2004-06-07 ファイザー・インク コクシジウム症に対する卵内予防接種
ZA965586B (en) 1995-07-03 1997-01-31 Akzo Nobel Nv Coccidiosis poultry vaccine
US5891692A (en) * 1996-03-29 1999-04-06 Life Technologies, Inc. Method for increasing the viability and transformation ability of bacteria during or after storage at low temperatures
US6632923B1 (en) 1996-11-27 2003-10-14 Boston Heart Foundation, Inc. Low density lipoprotein binding proteins and their use in diagnosing and treating atherosclerosis
US6627205B2 (en) 1997-12-01 2003-09-30 Pfizer Incorporated Ovo vaccination against coccidiosis
NZ500033A (en) * 1998-10-07 2001-06-29 Akzo Nobel Nv Hydrophilic eimeria polypeptides for use as coccidiosis vaccines
US6984378B1 (en) 1999-02-26 2006-01-10 Pfizer, Inc. Method for the purification, recovery, and sporulation of cysts and oocysts
ZA200400479B (en) * 2001-07-06 2006-05-31 Abic Biolog Lab Teva Nucleic acids encoding recombinant 56 a 82 KDA antigens from gametocytes of Eimeria maxima and their use
KR100490669B1 (ko) * 2001-08-30 2005-05-19 (주)아비코아생명공학연구소 조류 콕시듐증을 유발하는 에이메리아 종의 포자소체 표면항원에 대한 ｓｃＦｖ 재조합 항체
CN103316371A (zh) 2001-08-30 2013-09-25 恩布里克斯公司 制备卵囊的改进方法
JP3995541B2 (ja) * 2002-06-28 2007-10-24 株式会社ゲン・コーポレーション 抗鶏コクシジウム症組成物
DE10330235A1 (de) * 2003-07-04 2005-01-20 Bayer Healthcare Ag Neues Eimeria Gen und Protein sowie deren Verwendung
EP1667702A2 (en) * 2003-09-10 2006-06-14 Baxter International Inc., Baxter Healthcare Corp. Peptides that inhibit complement activation
WO2005089262A2 (en) * 2004-03-12 2005-09-29 University Of Georgia Research Foundation, Inc. Novel peanut skin extract as a vaccine adjuvant
US7087425B2 (en) * 2004-03-31 2006-08-08 Embrex, Inc. Method of purifying oocysts using enzymatic digestion of fecal debris
US20110078828A1 (en) * 2004-09-10 2011-03-31 Guardian Biotechnologies Inc. Multi epitope vaccine for poultry
EP1666489B1 (en) * 2004-12-01 2007-11-21 Zeon Corporation DNA encoding an antigenic protein of eimeria apical membrane antigen 1 and use thereof
CN100398156C (zh) * 2005-11-23 2008-07-02 南京农业大学 用于预防鸡球虫病的免疫调节型dna疫苗
US20080194006A1 (en) * 2007-02-08 2008-08-14 Embrex, Inc. Methods of releasing sporocysts from oocysts using controlled shear forces
US11701683B2 (en) 2010-12-22 2023-07-18 The Procter & Gamble Company Methods for foil stamping parts having asymmetrical edges
JP2020502204A (ja) 2016-12-22 2020-01-23 インターベット インターナショナル ベー． フェー． 改善された有効性を有するエイメリアワクチン
JP2022535747A (ja) * 2019-05-28 2022-08-10 ケース ウエスタン リザーブ ユニバーシティ Ｄｎａのメチル化を保存するための組成物および方法
JP2023529314A (ja) 2020-05-27 2023-07-10 ケース ウエスタン リザーブ ユニバーシティ Ｄｎａのメチル化を保存するための組成物および方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4237224A (en) 1974-11-04 1980-12-02 Board Of Trustees Of The Leland Stanford Jr. University Process for producing biologically functional molecular chimeras
DE2814039C3 (de) 1978-03-31 1981-02-19 Gesellschaft Fuer Biotechnologische Forschung Mbh (Gbf), 3300 Braunschweig Verfahren zur Herstellung von Hybrid-Bakterien
EP0135073A3 (en) * 1983-08-19 1987-05-27 American Cyanamid Company Antigens and monoclonal antibodies reactive against merozites of eimeria spp.
EP0135712A3 (en) * 1983-08-19 1987-05-27 American Cyanamid Company Antigens and monoclonal antibodies reactive against sporozoites of eimeria spp.
US4710377A (en) * 1983-08-19 1987-12-01 American Cyanamid Company Antigens and monoclonal antibodies reactive against sporozoites of Eimeria spp.
US4650676A (en) 1983-08-19 1987-03-17 American Cyanamid Company Antigens and monoclonal antibodies reactive against merozoites of Eimeria spp.
CA1340520C (en) * 1984-06-05 1999-05-04 Karel Z. Newman Jr. Antigenic proteins and vaccines containing them and protective antibodies directed to them for prevention of coccidiosis caused by eimeria tenella and eimeria necatrix
US4874705A (en) * 1985-05-16 1989-10-17 Solvay & Cie, S.A. DNA encoding an antigenic protein derived from Eimeria tenella and vaccines for prevention of coccidiosis caused by Eimeria tenella
US5187080A (en) * 1984-06-05 1993-02-16 Solvay & Cie S.A. DNA encoding an antigenic protein derived from Eimeria tenella and vaccines for prevention of coccidiosis caused by Eimeria tenella
US4639372A (en) * 1984-06-29 1987-01-27 Merck & Co., Inc. Coccidiosis vaccine
EP0190254A4 (en) * 1984-07-05 1987-03-09 Genex Corp GENE CLONE AND PROCESS FOR THE PREPARATION AND USE THEREOF.
US5273901A (en) * 1984-07-05 1993-12-28 Enzon Corp. Genetically engineered coccidiosis sporozoite 21.5 Kb antigen, ac-6b
DE3684295D1 (de) * 1985-12-03 1992-04-16 Solvay Antigene proteine und diese enthaltende impfstoffe zur verhuetung von kokzidiose.
EP0241139A3 (en) * 1986-03-13 1989-04-19 Merck & Co. Inc. Anti-idiotypic vaccine for coccidiosis
US5496550A (en) * 1986-08-14 1996-03-05 Chilwalner Method of reducing the output of Eimeria oocysts from a newborn chick
EP0614973A1 (en) * 1987-03-06 1994-09-14 Amgen Boulder Inc. Polypeptide useful in diagnosis of coccidia infection and recombinant-DNA methods for manufacturing same
EP0315073A2 (en) * 1987-11-02 1989-05-10 Matsushita Electric Industrial Co., Ltd. A composition for pattern forming materials
NZ227595A (en) * 1988-01-15 1991-11-26 Merck & Co Inc Recombinant production of eimeria tenella antigens and their use
NZ227597A (en) * 1988-01-15 1991-11-26 Merck & Co Inc Eimeria tenella group b immunogens and their production
AU620366B2 (en) * 1988-02-12 1992-02-20 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Cloned genes coding for avian coccidiosis antigens which induce a cell-mediated response and method of producing the same
DE3926461A1 (de) * 1989-07-15 1991-01-24 Suttner Gmbh & Co Kg Ventilpistole, insbesondere fuer ein hochdruckreinigungsgeraet

Also Published As

Publication number Publication date
NZ229377A (en) 1992-06-25
HUT52963A (en) 1990-09-28
IE891812L (en) 1989-12-03
KR0156545B1 (ko) 1998-11-16
US5661015A (en) 1997-08-26
DK272889A (da) 1989-12-04
FI101453B (fi) 1998-06-30
NO303876B1 (no) 1998-09-14
JPH037594A (ja) 1991-01-14
CN1038837A (zh) 1990-01-17
MC2039A1 (fr) 1990-05-30
AR241942A1 (es) 1993-01-29
FI101453B1 (fi) 1998-06-30
CN1187368A (zh) 1998-07-15
CA1340538C (en) 1999-05-11
ES2070866T3 (es) 1995-06-16
PT90727B (pt) 1994-11-30
HU212505B (en) 1996-07-29
DK272889D0 (da) 1989-06-02
DE68921923T2 (de) 1995-08-10
US20030175311A1 (en) 2003-09-18
JP3051130B2 (ja) 2000-06-12
YU47880B (sh) 1996-05-20
IE67544B1 (en) 1996-04-17
ZA893740B (en) 1990-02-28
CN1040126C (zh) 1998-10-07
DE68921923D1 (de) 1995-05-04
FI892714A0 (fi) 1989-06-02
FI892714L (fi) 1989-12-04
ATE120489T1 (de) 1995-04-15
EP0344808B1 (en) 1995-03-29
KR910000183A (ko) 1991-01-29
CN1076204C (zh) 2001-12-19
IL90489A0 (en) 1990-01-18
CN1186695A (zh) 1998-07-08
AU3601689A (en) 1989-12-07
NO892251L (no) 1989-12-04
EP0344808A1 (en) 1989-12-06
YU113889A (en) 1991-10-31
AU635704B2 (en) 1993-04-01
NO892251D0 (no) 1989-06-02
CN1077438C (zh) 2002-01-09

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