PT89992A - Processo para a preparacao de derivados e isomeros da 4,5,6,7-tetrahidroisotiazolo{4,5--c}piridina - Google Patents
Processo para a preparacao de derivados e isomeros da 4,5,6,7-tetrahidroisotiazolo{4,5--c}piridinaInfo
- Publication number
- PT89992A PT89992A PT89992A PT8999289A PT89992A PT 89992 A PT89992 A PT 89992A PT 89992 A PT89992 A PT 89992A PT 8999289 A PT8999289 A PT 8999289A PT 89992 A PT89992 A PT 89992A
- Authority
- PT
- Portugal
- Prior art keywords
- preparation
- isomers
- tetrahydroisotiazole
- pyridine
- derivatives
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 title 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 abstract 1
- 229960004373 acetylcholine Drugs 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000001270 agonistic effect Effects 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Psychiatry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB888806013A GB8806013D0 (en) | 1988-03-14 | 1988-03-14 | Heterocyclic compounds |
| GB888822564A GB8822564D0 (en) | 1988-09-26 | 1988-09-26 | Heterocyclic compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT89992A true PT89992A (pt) | 1989-11-10 |
| PT89992B PT89992B (pt) | 1994-05-31 |
Family
ID=26293631
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT89992A PT89992B (pt) | 1988-03-14 | 1989-03-13 | Processo para a preparacao de derivados e isomeros da 4,5,6,7-tetrahidroisotiazolo{4,5--c}piridina |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4923880A (pt) |
| EP (1) | EP0336555B1 (pt) |
| JP (1) | JPH01275585A (pt) |
| AT (1) | ATE81130T1 (pt) |
| AU (1) | AU630085B2 (pt) |
| CA (1) | CA1337201C (pt) |
| DE (1) | DE68903019T2 (pt) |
| DK (1) | DK169676B1 (pt) |
| ES (1) | ES2052901T3 (pt) |
| FI (1) | FI91411C (pt) |
| GR (1) | GR3006606T3 (pt) |
| IE (1) | IE62782B1 (pt) |
| IL (1) | IL89351A0 (pt) |
| NO (1) | NO177145C (pt) |
| NZ (1) | NZ228182A (pt) |
| PT (1) | PT89992B (pt) |
| ZA (1) | ZA891769B (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2645862B1 (fr) * | 1989-04-18 | 1991-07-12 | Esteve Labor Dr | Derives d'isothiazolo-pyrydone azetidinyl substitues, leur preparation et leur application en tant que medicaments |
| US5574028A (en) * | 1994-10-31 | 1996-11-12 | Eli Lilly And Company | Method for treating anxiety |
| IL124419A0 (en) * | 1995-12-07 | 1998-12-06 | Lilly Co Eli | Composition for treating pain |
| US20050137222A1 (en) * | 2003-12-18 | 2005-06-23 | H. Lundbeck A/S | Treatment of insomnia in human patients |
| US20110098777A1 (en) * | 2009-10-23 | 2011-04-28 | Silverstone Leon M | Method and apparatus for treatment of neurodegenerative diseases including depression, mild cognitive impairment, and dementia |
| PT3274331T (pt) | 2015-03-24 | 2020-04-02 | H Lundbeck As | Fabrico de 4,5,6,7-tetra-hidroisoxazolo[5,4-c]- piridin-3-ol |
| CN121002031A (zh) * | 2023-04-18 | 2025-11-21 | 范德比尔特大学 | 作为毒蕈碱型乙酰胆碱受体m4的正向别构调节剂的吡咯并吡啶衍生物 |
| WO2024220635A1 (en) * | 2023-04-18 | 2024-10-24 | Vanderbilt University | Thiazolopyridine derivatives as positive allosteric modulators of the muscarinic acetylcholine receptor m4 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8314391D0 (en) * | 1983-05-24 | 1983-06-29 | Kefalas As | Heterocyclic compounds |
| IL87709A (en) * | 1987-09-16 | 1992-11-15 | Pfizer | Process for preparing haloalkyl thiazoles and some such novel haloalkyl thiazoles |
| DE3820775A1 (de) * | 1988-06-20 | 1989-12-21 | Thomae Gmbh Dr K | Neue 4,5,7,8-tetrahydro-6h-thiazolo(5,4,-d)azepine, ihre herstellung und ihre verwendung als arzneimittel |
| JP3054738B2 (ja) * | 1988-07-22 | 2000-06-19 | 武田薬品工業株式会社 | チアゾロ［５，４―ｂ］アゼピン誘導体 |
-
1989
- 1989-02-21 IL IL89351A patent/IL89351A0/xx not_active IP Right Cessation
- 1989-02-28 DE DE8989301996T patent/DE68903019T2/de not_active Expired - Fee Related
- 1989-02-28 EP EP89301996A patent/EP0336555B1/en not_active Expired - Lifetime
- 1989-02-28 IE IE64889A patent/IE62782B1/en not_active IP Right Cessation
- 1989-02-28 ES ES89301996T patent/ES2052901T3/es not_active Expired - Lifetime
- 1989-02-28 AT AT89301996T patent/ATE81130T1/de not_active IP Right Cessation
- 1989-03-01 NZ NZ228182A patent/NZ228182A/xx unknown
- 1989-03-08 ZA ZA891769A patent/ZA891769B/xx unknown
- 1989-03-10 FI FI891155A patent/FI91411C/fi not_active IP Right Cessation
- 1989-03-13 CA CA000593449A patent/CA1337201C/en not_active Expired - Fee Related
- 1989-03-13 US US07/322,632 patent/US4923880A/en not_active Expired - Fee Related
- 1989-03-13 PT PT89992A patent/PT89992B/pt not_active IP Right Cessation
- 1989-03-13 NO NO891071A patent/NO177145C/no unknown
- 1989-03-14 DK DK121789A patent/DK169676B1/da active
- 1989-03-14 AU AU31262/89A patent/AU630085B2/en not_active Ceased
- 1989-03-14 JP JP1059860A patent/JPH01275585A/ja active Pending
-
1992
- 1992-12-21 GR GR920403014T patent/GR3006606T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI91411C (fi) | 1994-06-27 |
| FI891155A7 (fi) | 1989-09-15 |
| DK121789A (da) | 1989-09-15 |
| IE890648L (en) | 1989-09-14 |
| NO177145C (no) | 1995-07-26 |
| EP0336555A1 (en) | 1989-10-11 |
| US4923880A (en) | 1990-05-08 |
| EP0336555B1 (en) | 1992-09-30 |
| NO891071D0 (no) | 1989-03-13 |
| IE62782B1 (en) | 1995-02-22 |
| DK169676B1 (da) | 1995-01-09 |
| GR3006606T3 (pt) | 1993-06-30 |
| DE68903019T2 (de) | 1993-07-08 |
| ATE81130T1 (de) | 1992-10-15 |
| AU3126289A (en) | 1989-09-14 |
| NO177145B (no) | 1995-04-18 |
| FI891155A0 (fi) | 1989-03-10 |
| AU630085B2 (en) | 1992-10-22 |
| NZ228182A (en) | 1990-08-28 |
| PT89992B (pt) | 1994-05-31 |
| JPH01275585A (ja) | 1989-11-06 |
| ES2052901T3 (es) | 1994-07-16 |
| ZA891769B (en) | 1989-12-27 |
| DK121789D0 (da) | 1989-03-14 |
| CA1337201C (en) | 1995-10-03 |
| FI91411B (fi) | 1994-03-15 |
| NO891071L (no) | 1989-09-15 |
| IL89351A0 (en) | 1989-09-10 |
| DE68903019D1 (de) | 1992-11-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG3A | Patent granted, date of granting |
Effective date: 19931118 |
|
| MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 19990531 |