PT87118A - Process for the preparation of n-aryl-piperazine-alcanamide by products and of pharmaceutical compounds containing them - Google Patents
Process for the preparation of n-aryl-piperazine-alcanamide by products and of pharmaceutical compounds containing themInfo
- Publication number
- PT87118A PT87118A PT87118A PT8711888A PT87118A PT 87118 A PT87118 A PT 87118A PT 87118 A PT87118 A PT 87118A PT 8711888 A PT8711888 A PT 8711888A PT 87118 A PT87118 A PT 87118A
- Authority
- PT
- Portugal
- Prior art keywords
- 6alkyl
- aminocarbonyl
- optionally substituted
- alcanamide
- piperazine
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000006227 byproduct Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000003226 pyrazolyl group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Photolithography (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3412987A | 1987-04-01 | 1987-04-01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT87118A true PT87118A (pt) | 1988-04-01 |
| PT87118B PT87118B (pt) | 1992-07-31 |
Family
ID=21874492
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT87118A PT87118B (pt) | 1987-04-01 | 1988-03-30 | Processo para a preparacao de derivados de n-aril-piperazina-alcanamida e de composicoes farmaceuticas que os contem |
Country Status (20)
| Country | Link |
|---|---|
| EP (2) | EP0285219B1 (pt) |
| JP (1) | JP2574377B2 (pt) |
| KR (1) | KR960016539B1 (pt) |
| AT (2) | ATE207474T1 (pt) |
| AU (1) | AU609790B2 (pt) |
| CA (1) | CA1315790C (pt) |
| DE (2) | DE3856501T2 (pt) |
| DK (1) | DK174878B1 (pt) |
| ES (2) | ES2091183T3 (pt) |
| FI (1) | FI97617C (pt) |
| GR (1) | GR3020983T3 (pt) |
| HU (2) | HUT57740A (pt) |
| IE (1) | IE81057B1 (pt) |
| IL (1) | IL85919A (pt) |
| NO (1) | NO178660C (pt) |
| NZ (1) | NZ223847A (pt) |
| PH (1) | PH25507A (pt) |
| PT (1) | PT87118B (pt) |
| RU (1) | RU2014328C1 (pt) |
| ZA (1) | ZA882352B (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0455789B1 (en) * | 1989-11-22 | 1994-03-16 | Janssen Pharmaceutica N.V. | Method of preventing or limiting reperfusion damage |
| US5840896A (en) * | 1989-11-22 | 1998-11-24 | Janssen Pharmaceutica, N.V. | Method of preventing or limiting reperfusion damage |
| JP2660086B2 (ja) * | 1990-07-03 | 1997-10-08 | 明治製菓株式会社 | 脳及び心機能障害改善剤 |
| US5276035A (en) * | 1990-07-26 | 1994-01-04 | Novo Nordisk A/S | 1,4-disubstituted piperazines |
| IE914218A1 (en) * | 1991-09-11 | 1993-03-24 | Mcneilab Inc | Novel 4-arylpiperazines and 4-arylpiperidines |
| SE9202266D0 (sv) * | 1992-07-31 | 1992-07-31 | Kabi Pharmacia Ab | Novel piperazine carboxamides |
| ES2125285T3 (es) * | 1992-07-31 | 1999-03-01 | Bristol Myers Squibb Co | Derivados inhibidores de la reabsorcion de adenosina de difenil-oxazoles, tiazoles e imidazoles. |
| CA2186023C (en) * | 1994-04-20 | 2006-11-07 | Walter Brieden | Process for preparing 2-piperazine carboxylic acid derivatives |
| EP0870502A3 (en) * | 1997-04-10 | 2001-04-04 | Kyowa Hakko Kogyo Co., Ltd. | Use of adenosine uptake inhibitors for the manufacture of a medicament for the treatment of pancreatitis |
| AU8438798A (en) | 1997-06-16 | 1999-01-04 | Janssen Pharmaceutica N.V. | Use of draflazine-analogues for treating pain |
| UA89503C2 (uk) | 2004-09-13 | 2010-02-10 | Х. Луннбек А/С | Заміщені похідні аніліну |
| EP2937341B1 (en) | 2004-12-30 | 2017-07-05 | Janssen Pharmaceutica N.V. | 4-(benzyl)-piperazine-1-carboxylic acid phenylamide derivatives and related compounds as modulators of fatty acid amide hydrolase (faah) for the treatment of anxiety, pain and other conditions |
| UA108233C2 (uk) | 2010-05-03 | 2015-04-10 | Модулятори активності гідролази амідів жирних кислот | |
| CN110511220B (zh) * | 2018-05-22 | 2022-04-01 | 上海挚盟医药科技有限公司 | 作为钾通道调节剂的对二氨基苯衍生物、其制备方法及其在医药上的应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1795375A1 (de) * | 1968-09-21 | 1972-01-05 | Boehringer Mannheim Gmbh | Basische AEther und Verfahren zur Herstellung derselben |
| US4766125A (en) * | 1981-06-23 | 1988-08-23 | Janssen Pharmaceutica N.V. | N-aryl-piperazinealkanamides useful for protecting hearts from myocardial injury caused by ischaemia, anoxia or hypoxia |
-
1988
- 1988-03-10 NZ NZ223847A patent/NZ223847A/xx unknown
- 1988-03-16 CA CA000561610A patent/CA1315790C/en not_active Expired - Lifetime
- 1988-03-29 AT AT96200236T patent/ATE207474T1/de not_active IP Right Cessation
- 1988-03-29 DE DE3856501T patent/DE3856501T2/de not_active Expired - Lifetime
- 1988-03-29 DE DE3855520T patent/DE3855520T2/de not_active Expired - Lifetime
- 1988-03-29 ES ES88200587T patent/ES2091183T3/es not_active Expired - Lifetime
- 1988-03-29 ES ES96200236T patent/ES2167510T3/es not_active Expired - Lifetime
- 1988-03-29 EP EP88200587A patent/EP0285219B1/en not_active Expired - Lifetime
- 1988-03-29 AT AT88200587T patent/ATE142627T1/de not_active IP Right Cessation
- 1988-03-29 AU AU13847/88A patent/AU609790B2/en not_active Expired
- 1988-03-29 EP EP96200236A patent/EP0727421B1/en not_active Expired - Lifetime
- 1988-03-29 NO NO881407A patent/NO178660C/no not_active IP Right Cessation
- 1988-03-30 DK DK198801797A patent/DK174878B1/da not_active IP Right Cessation
- 1988-03-30 PT PT87118A patent/PT87118B/pt not_active IP Right Cessation
- 1988-03-30 KR KR1019880003493A patent/KR960016539B1/ko not_active Expired - Fee Related
- 1988-03-30 PH PH36714A patent/PH25507A/en unknown
- 1988-03-30 IL IL85919A patent/IL85919A/xx not_active IP Right Cessation
- 1988-03-31 RU SU884355523A patent/RU2014328C1/ru active
- 1988-03-31 JP JP63076629A patent/JP2574377B2/ja not_active Expired - Lifetime
- 1988-03-31 FI FI881525A patent/FI97617C/fi not_active IP Right Cessation
- 1988-03-31 HU HU881601A patent/HUT57740A/hu unknown
- 1988-03-31 ZA ZA882352A patent/ZA882352B/xx unknown
- 1988-03-31 IE IE98988A patent/IE81057B1/en not_active IP Right Cessation
-
1995
- 1995-06-20 HU HU95P/P00287P patent/HU211129A9/hu unknown
-
1996
- 1996-09-12 GR GR960402273T patent/GR3020983T3/el unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG3A | Patent granted, date of granting |
Effective date: 19920123 |
|
| MM4A | Annulment/lapse due to non-payment of fees, searched and examined patent |
Free format text: MAXIMUM VALIDITY LIMIT REACHED Effective date: 20080330 |