PT86821A - Process for the preparation of novel tetrazole intermediates useful for the preparation of antihypercholesterolemic compounds - Google Patents

Process for the preparation of novel tetrazole intermediates useful for the preparation of antihypercholesterolemic compounds

Info

Publication number: PT86821A
Authority: PT; Portugal
Prior art keywords: preparation; intermediates useful; novel tetrazole; tetrazole intermediates; antihypercholesterolemic compounds
Prior art date: 1987-02-25

Application number

PT86821A

Other languages

English (en)

Other versions

PT86821B (pt

Inventor

John J Wright

Sing-Yuen Sit

Neelakantan Balasubramanian

Peter J Brown

Original Assignee

Bristol Myers Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-02-25

Filing date

1988-02-24

Publication date

1988-03-01

1988-02-24 Application filed by Bristol Myers Co filed Critical Bristol Myers Co

1988-03-01 Publication of PT86821A publication Critical patent/PT86821A/pt

1992-05-29 Publication of PT86821B publication Critical patent/PT86821B/pt

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hematology (AREA)
Pharmacology & Pharmacy (AREA)
Diabetes (AREA)
Obesity (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

PT86821A 1987-02-25 1988-02-24 Processo para a preparacao de novos compostos derivados de tetrazol utilizados como compostos intermedios na preparacao de compostos antihipercolesterolemicos PT86821B (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US1855887A	1987-02-25	1987-02-25
US07/151,512 US4898949A (en)	1987-02-25	1988-02-18	Intermediates for the preparation of antihypercholesterolemic tetrazole compounds

Publications (2)

Publication Number	Publication Date
PT86821A true PT86821A (pt)	1988-03-01
PT86821B PT86821B (pt)	1992-05-29

Family

ID=26691250

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT86821A PT86821B (pt)	1987-02-25	1988-02-24	Processo para a preparacao de novos compostos derivados de tetrazol utilizados como compostos intermedios na preparacao de compostos antihipercolesterolemicos

Country Status (27)

Country	Link
US (1)	US4898949A (pt)
JP (1)	JP2603284B2 (pt)
KR (1)	KR960007167B1 (pt)
CN (1)	CN1030077C (pt)
AT (1)	AT395588B (pt)
AU (1)	AU610562B2 (pt)
BE (1)	BE1002115A3 (pt)
CA (1)	CA1328269C (pt)
CH (1)	CH678182A5 (pt)
DE (1)	DE3805789C2 (pt)
DK (2)	DK97388A (pt)
ES (1)	ES2009547A6 (pt)
FI (1)	FI96600C (pt)
FR (1)	FR2611201B1 (pt)
GB (1)	GB2202845B (pt)
GR (1)	GR1000473B (pt)
HU (3)	HU201534B (pt)
IE (1)	IE61608B1 (pt)
IT (1)	IT1216752B (pt)
LU (1)	LU87143A1 (pt)
MY (1)	MY102290A (pt)
NL (1)	NL8800468A (pt)
NO (1)	NO178432C (pt)
NZ (1)	NZ223621A (pt)
PT (1)	PT86821B (pt)
SE (3)	SE504553C2 (pt)
YU (1)	YU46781B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4870187A (en) *	1988-08-23	1989-09-26	Bristol-Myers Company	Antihypercholesterolemic tetrazol-1-yl compounds
FI94339C (fi)	1989-07-21	1995-08-25	Warner Lambert Co	Menetelmä farmaseuttisesti käyttökelpoisen /R-(R,R)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
US5260325A (en) *	1991-08-19	1993-11-09	E. I. Du Pont De Nemours And Company	Angiotensin II receptor blocking tertiary amides
CA2137049A1 (en) *	1993-12-15	1995-06-16	John K. Thottathil	Amino acid salts of and methods for preparing antihypercholesterolemic tetrazole compounds
KR100668575B1 (ko) *	1997-12-19	2007-01-17	워너-램버트 익스포트 리미티드	1,3-디올의 합성방법

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4160100A (en) *	1973-03-23	1979-07-03	American Home Products Corporation	Oxamic acid derivatives
US4013647A (en) *	1976-03-23	1977-03-22	American Home Products Corporation	Morpholine containing tetrazole-5-carboxamide derivatives
JPS53147073A (en) *	1977-05-24	1978-12-21	Sankyo Co Ltd	Mevalonolactone derivatives
NZ194557A (en) *	1979-08-17	1984-09-28	Merck & Co Inc	Substituted pyranone derivatives;dihydroxy acids therefrom;pharmaceutical compositions
US4375475A (en) *	1979-08-17	1983-03-01	Merck & Co., Inc.	Substituted pyranone inhibitors of cholesterol synthesis
US4567289A (en) *	1979-08-17	1986-01-28	Merck & Co., Inc.	Substituted pyranone inhibitors of cholesterol synthesis
EP0068038B1 (en) *	1981-06-29	1985-09-25	Merck & Co. Inc.	(+)-(4r,6s)-(e)-6-(2-(4'-fluoro-3,3',5-trimethyl-(1,1'-biphenyl)-2-yl)ethenyl)-3,4,5,6-tetrahydro-4-hydroxy-2h-pyran-2-one, a process for preparing and a pharmaceutical composition containing the same
US4739073A (en) *	1983-11-04	1988-04-19	Sandoz Pharmaceuticals Corp.	Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof
WO1984002131A1 (fr) *	1982-11-22	1984-06-07	Sandoz Ag	Produits analogues de mevalolactone et leurs derives, leurs procedes de production, compositions pharmaceutiques les contenant ainsi que leur utilisation en tant que produits pharmaceutiques
CA1268473A (en) *	1983-01-24	1990-05-01	Paul L. Anderson	Analogs of mevalonolactone and derivatives thereof, processes for their production, pharmaceutical compositions containing them and their use as pharmaceuticals
US5105017A (en) *	1983-07-18	1992-04-14	Eli Lilly And Company	Leukotriene antagonist intermediates
CA1327360C (en) *	1983-11-14	1994-03-01	William F. Hoffman	Oxo-analogs of mevinolin-like antihypercholesterolemic agents
US4613610A (en) *	1984-06-22	1986-09-23	Sandoz Pharmaceuticals Corp.	Cholesterol biosynthesis inhibiting pyrazole analogs of mevalonolactone and its derivatives
WO1986000307A2 (en) *	1984-06-22	1986-01-16	Sandoz Ag	Pyrazole analogs of mevalonolactone and derivatives thereof, processes for their production and their use
US4668794A (en) *	1985-05-22	1987-05-26	Sandoz Pharm. Corp.	Intermediate imidazole acrolein analogs
US4621099A (en) *	1985-09-23	1986-11-04	Usv Pharmaceutical Corporation	Polyene compounds useful in the treatment of allergic responses
US4681893A (en) *	1986-05-30	1987-07-21	Warner-Lambert Company	Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
US4678806A (en) *	1986-09-02	1987-07-07	Merck & Co., Inc.	Prodrugs of antihypercholesterolemic compounds
AU601264B2 (en) *	1987-02-25	1990-09-06	Bristol-Myers Squibb Company	Antihypercholesterolemic tetrazole compounds

1988
- 1988-02-18 US US07/151,512 patent/US4898949A/en not_active Expired - Lifetime
- 1988-02-24 DE DE3805789A patent/DE3805789C2/de not_active Expired - Fee Related
- 1988-02-24 CA CA000559671A patent/CA1328269C/en not_active Expired - Fee Related
- 1988-02-24 DK DK097388A patent/DK97388A/da not_active Application Discontinuation
- 1988-02-24 AU AU12132/88A patent/AU610562B2/en not_active Ceased
- 1988-02-24 PT PT86821A patent/PT86821B/pt not_active IP Right Cessation
- 1988-02-24 ES ES8800533A patent/ES2009547A6/es not_active Expired
- 1988-02-24 HU HU895133A patent/HU201534B/hu not_active IP Right Cessation
- 1988-02-24 NZ NZ223621A patent/NZ223621A/en unknown
- 1988-02-24 NO NO880802A patent/NO178432C/no not_active IP Right Cessation
- 1988-02-24 FI FI880868A patent/FI96600C/fi not_active IP Right Cessation
- 1988-02-24 NL NL8800468A patent/NL8800468A/nl not_active Application Discontinuation
- 1988-02-24 AT AT0046088A patent/AT395588B/de not_active IP Right Cessation
- 1988-02-24 HU HU895124A patent/HU201533B/hu not_active IP Right Cessation
- 1988-02-24 GB GB8804281A patent/GB2202845B/en not_active Expired - Fee Related
- 1988-02-24 GR GR880100100A patent/GR1000473B/el not_active IP Right Cessation
- 1988-02-24 IE IE50288A patent/IE61608B1/en not_active IP Right Cessation
- 1988-02-24 CH CH691/88A patent/CH678182A5/de not_active IP Right Cessation
- 1988-02-24 KR KR1019880001915A patent/KR960007167B1/ko not_active Expired - Fee Related
- 1988-02-24 FR FR888802212A patent/FR2611201B1/fr not_active Expired - Fee Related
- 1988-02-24 SE SE8800637A patent/SE504553C2/sv not_active IP Right Cessation
- 1988-02-24 IT IT8819526A patent/IT1216752B/it active
- 1988-02-24 MY MYPI88000180A patent/MY102290A/en unknown
- 1988-02-24 HU HU88885A patent/HU201532B/hu not_active IP Right Cessation
- 1988-02-24 JP JP63041828A patent/JP2603284B2/ja not_active Expired - Fee Related
- 1988-02-25 LU LU87143A patent/LU87143A1/fr unknown
- 1988-02-25 YU YU36488A patent/YU46781B/sh unknown
- 1988-02-25 BE BE8800219A patent/BE1002115A3/fr not_active IP Right Cessation
1992
- 1992-10-20 CN CN92111551A patent/CN1030077C/zh not_active Expired - Fee Related
1993
- 1993-03-24 SE SE9300977A patent/SE512485C2/sv not_active IP Right Cessation
- 1993-03-24 SE SE9300976A patent/SE503201C2/sv not_active IP Right Cessation
1997
- 1997-10-06 DK DK113897A patent/DK113897A/da not_active Application Discontinuation

Also Published As

Publication number	Publication date
DE3805789C2 (de)	2001-05-31
SE9300976D0 (sv)	1993-03-24
SE9300977L (pt)
AT395588B (de)	1993-01-25
DK97388D0 (da)	1988-02-24
CN1070642A (zh)	1993-04-07
YU46781B (sh)	1994-05-10
SE8800637L (sv)	1988-08-26
HUT47258A (en)	1989-02-28
US4898949A (en)	1990-02-06
GR1000473B (el)	1992-07-30
FI880868A7 (fi)	1988-08-26
NO880802L (no)	1988-08-26
HU895124D0 (pt)	1990-01-28
SE504553C2 (sv)	1997-03-03
IT1216752B (it)	1990-03-08
NZ223621A (en)	1991-06-25
NO178432C (no)	1996-03-27
NO880802D0 (no)	1988-02-24
FR2611201A1 (fr)	1988-08-26
KR880009946A (ko)	1988-10-06
IT8819526A0 (it)	1988-02-24
SE512485C2 (sv)	2000-03-20
NL8800468A (nl)	1988-09-16
GB8804281D0 (en)	1988-03-23
JPS63290872A (ja)	1988-11-28
DE3805789A1 (de)	1988-09-15
SE8800637D0 (sv)	1988-02-24
IE61608B1 (en)	1994-11-16
GB2202845A (en)	1988-10-05
IE880502L (en)	1988-08-18
BE1002115A3 (fr)	1990-07-10
ES2009547A6 (es)	1989-10-01
MY102290A (en)	1992-05-15
FR2611201B1 (fr)	1991-01-11
DK97388A (da)	1988-08-26
JP2603284B2 (ja)	1997-04-23
DK113897A (da)	1997-10-06
GB2202845B (en)	1991-05-22
SE503201C2 (sv)	1996-04-15
AU610562B2 (en)	1991-05-23
HU201532B (en)	1990-11-28
FI880868A0 (fi)	1988-02-24
HU201534B (en)	1990-11-28
PT86821B (pt)	1992-05-29
LU87143A1 (fr)	1988-09-20
CH678182A5 (pt)	1991-08-15
AU1213288A (en)	1988-09-01
SE9300977D0 (sv)	1993-03-24
FI96600C (fi)	1996-07-25
FI96600B (fi)	1996-04-15
YU36488A (en)	1990-02-28
CA1328269C (en)	1994-04-05
SE9300976L (pt)	1993-03-24
ATA46088A (de)	1992-06-15
NO178432B (no)	1995-12-18
HU201533B (en)	1990-11-28
CN1030077C (zh)	1995-10-18
GR880100100A (en)	1988-12-16
KR960007167B1 (ko)	1996-05-29

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DE3856515D1 (de)	2002-03-21	Zwischenprodukte zur Herstellung von benzoheterocyclischen Verbindungen
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PT88481A (pt)	1988-10-01	Process for the preparation of a new cephem compound
GR880100101A (en)	1988-12-16	Process for the preparation of antihypercholesterolemic tetrazol compounds
FI892012A7 (fi)	1989-10-29	Menetelmä uusien terapeuttisesti käyttökelpoisten 4-fenyyli-piperidiiniyhdisteiden valmistamiseksi
FI883997A0 (fi)	1988-08-30	Menetelmä terapeuttisesti käyttökelpoisten substituoitujen 2-fenyyli-4-kinoliinikarboksyylihappojen valmistamiseksi
FI893936A0 (fi)	1989-08-22	Menetelmä terapeuttisesti aktiivisten yhdisteiden valmistamiseksi sekä välituotteita
FI881064A7 (fi)	1988-09-10	Menetelmä tulehduksenvastaisten tai analgeettisten -aminoetyylisubstituoitujen fenyyliyhdisteiden valmistamiseksi
FI880467A0 (fi)	1988-02-02	Menetelmä terapeuttisesti käyttökelpoisten substituoitujen 3,4-dihydro-2H-bentsopyraanien valmistamiseksi
PT87503A (pt)	1989-05-31	Process for the preparation of new cathecolamine by products
FI891144A0 (fi)	1989-03-09	Menetelmä uusien terapeuttisesti käyttökelpoisten suolayhdisteiden valmistamiseksi
PT88545A (pt)	1988-10-01	Process for the manufacture of benzimidazoline-2-oxo-1-carboxylic acid derivative compounds
IT1197330B (it)	1988-11-30	Procedimento per la sintesi di acido tauroursodesossicolico biidrato
PT86821A (pt)	1988-03-01	Process for the preparation of novel tetrazole intermediates useful for the preparation of antihypercholesterolemic compounds
GR3003256T3 (en)	1993-02-17	Process for the preparation of intermediates for the synthesis of fosfomycin
PT87643A (pt)	1988-07-01	Process for the preparation of pyran compounds
FI883589A0 (fi)	1988-08-01	Menetelmä tyydyttämättömien aminohappoyhdisteiden valmistamiseksi
PT88432A (pt)	1989-07-31	Process for the preparation of 4-oxo-3-quinolinecarboxylic acids useful as antibacterial agents
PT88431A (pt)	1989-07-31	Process for the preparation of 4-oxo-3-quinolinecarboxylic acids useful as antibacterial agents
FR2603580B1 (fr)	1990-05-25	Procede de preparation d'un compose organique polyfluorure
NO951094D0 (no)	1995-03-22	Fremgangsmåte for syntese av anvendelige mellomprodukter av substituerte imidazolforbindelser
FI922268L (fi)	1992-05-19	Menetelmä uusien terapeuttisesti käyttökelpoisten N-difenyylialkyylialkoksisubstituoitujen 3-piperidiinikarboksyylihappojohdannaisten valmistamiseksi

Legal Events

Date	Code	Title	Description
1992-05-29	FG3A	Patent granted, date of granting	Effective date: 19911128
2005-07-29	MM3A	Annulment or lapse	Effective date: 20050530