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PT739212E - Utilizacao de interleucina-12 para a prevencao de doenca causada pela reaccao do enxerto contra o hospedeiro - Google Patents

Utilizacao de interleucina-12 para a prevencao de doenca causada pela reaccao do enxerto contra o hospedeiro

Info

Publication number
PT739212E
PT739212E PT95908628T PT95908628T PT739212E PT 739212 E PT739212 E PT 739212E PT 95908628 T PT95908628 T PT 95908628T PT 95908628 T PT95908628 T PT 95908628T PT 739212 E PT739212 E PT 739212E
Authority
PT
Portugal
Prior art keywords
interleukin
hospedeiro
enexerto
utilization
prevention
Prior art date
Application number
PT95908628T
Other languages
English (en)
Inventor
Megan Sykes
Stanley F Wolf
Original Assignee
Gen Hospital Corp
Genetics Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Hospital Corp, Genetics Inst filed Critical Gen Hospital Corp
Publication of PT739212E publication Critical patent/PT739212E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5434—IL-12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/208—IL-12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Transplantation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT95908628T 1994-01-21 1995-01-20 Utilizacao de interleucina-12 para a prevencao de doenca causada pela reaccao do enxerto contra o hospedeiro PT739212E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/186,529 US5573764A (en) 1994-01-21 1994-01-21 Use of interleukin-12 to prevent graft versus host disease

Publications (1)

Publication Number Publication Date
PT739212E true PT739212E (pt) 2002-08-30

Family

ID=22685309

Family Applications (1)

Application Number Title Priority Date Filing Date
PT95908628T PT739212E (pt) 1994-01-21 1995-01-20 Utilizacao de interleucina-12 para a prevencao de doenca causada pela reaccao do enxerto contra o hospedeiro

Country Status (14)

Country Link
US (2) US5573764A (pt)
EP (1) EP0739212B1 (pt)
JP (1) JP3825043B2 (pt)
AT (1) ATE215380T1 (pt)
AU (1) AU698410B2 (pt)
CA (1) CA2181568C (pt)
DE (1) DE69526206T2 (pt)
DK (1) DK0739212T3 (pt)
ES (1) ES2179096T3 (pt)
IL (1) IL112373A (pt)
PT (1) PT739212E (pt)
TW (1) TW349021B (pt)
WO (1) WO1995019786A1 (pt)
ZA (1) ZA95463B (pt)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5573764A (en) * 1994-01-21 1996-11-12 Genetics Institute, Inc. Use of interleukin-12 to prevent graft versus host disease
US5674483A (en) * 1995-01-31 1997-10-07 National Jewish Medical And Research Center Treatment for diseases involving inflammation
DE69620877T2 (de) * 1995-02-06 2002-12-12 Genetics Institute, Inc. Arzneimittelformulierungen für il-12
WO1997016203A1 (en) * 1995-11-01 1997-05-09 Genetics Institute, Inc. Methods for administration of il-12
AU4908197A (en) * 1996-10-18 1998-05-15 Valentis, Inc. Gene expression and delivery systems and uses
AU726207B2 (en) * 1996-10-18 2000-11-02 Syntex (U.S.A.) Inc. IL-12 gene expression and delivery systems and uses
US6086876A (en) * 1997-02-07 2000-07-11 The Wistar Insitute Methods and compositions for the inhibition of interleukin-12 production
WO1998051327A1 (en) * 1997-05-16 1998-11-19 Toray Industries, Inc. Therapeutic agent, treatment method, prophylactic agent, and prophylactic method for canine and feline immunological diseases
EP1516630A3 (en) * 1997-10-31 2006-05-03 Wyeth Use of anti-il-12 antibodies in transplantation rejection
US6080399A (en) 1998-04-23 2000-06-27 Arch Development Corporation Vaccine adjuvants for immunotherapy of melanoma
US7115712B1 (en) 1999-12-02 2006-10-03 Maxygen, Inc. Cytokine polypeptides
US7638496B2 (en) 2000-02-15 2009-12-29 Valeant Pharmaceuticals North America Nucleoside analogs with carboxamidine modified monocyclic base
US20040175827A1 (en) * 2001-07-02 2004-09-09 Fowler Daniel H. Methods of generating human cd4+ th2 cells and uses thereof
US20040258661A1 (en) * 2001-10-31 2004-12-23 Daniel Fowler Generation of use of tc1 and tc2 cells
US7718196B2 (en) * 2001-07-02 2010-05-18 The United States Of America, As Represented By The Department Of Health And Human Services Rapamycin-resistant T cells and therapeutic uses thereof
WO2003020904A2 (en) * 2001-08-31 2003-03-13 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Methods of generating human cd4+ th1 cells
DE10248141B4 (de) * 2002-10-11 2007-04-19 Universitätsklinikum Hamburg-Eppendorf Nukleinsäuren und deren Verwendung für die Gentherapie
US7939058B2 (en) 2003-07-03 2011-05-10 University Of Southern California Uses of IL-12 in hematopoiesis
MX2010003720A (es) * 2007-10-08 2010-10-20 Intrexon Corp Celulas dendriticas creadas por ingenieria genetica y usos para el tratamiento de cancer.
US20100272863A1 (en) * 2009-04-24 2010-10-28 Griebel Jonathan M Soft shaped tortillas
EP2571516B1 (en) 2010-05-18 2017-11-15 Neumedicines, Inc Il-12 formulations for enhancing hematopoiesis
EP2718456B1 (en) 2011-06-13 2019-04-24 Neumedicines, Inc. Mitigation of cutaneous injury with il-12
WO2013016634A1 (en) 2011-07-27 2013-01-31 Neumedicines, Inc. Use of il-12 to generate endogenous erythropoietin
US11951157B2 (en) 2011-10-11 2024-04-09 Universitat Zurich Methods of treating malignant tumour with IL-12 and anti-PD-1 antibody
EP3925615A1 (en) * 2011-10-11 2021-12-22 Universität Zürich Combination medicament comprising il-12 and an agent for blockade of t-cell inhibitory molecules for tumour therapy
CA2862290A1 (en) 2012-01-18 2013-10-17 Neumedicines, Inc. Il-12 for radiation protection and radiation-induced toxicity mitigation
WO2013158959A1 (en) * 2012-04-19 2013-10-24 Tarix Pharmaceuticals Ltd. Compositions and methods for treatment of graft-versus-host disease
MX2022012823A (es) * 2020-04-17 2023-01-04 Univ Leland Stanford Junior Polipéptidos modificados de il-12 e il-23 y usos de los mismos.
US12071633B2 (en) * 2020-10-13 2024-08-27 Kriya Therapeutics, Inc. Viral vector constructs for delivery of nucleic acids encoding cytokines and uses thereof for treating cancer
JP2024539139A (ja) 2021-10-20 2024-10-28 シンセカイン インコーポレイテッド ヘテロ二量体ｆｃサイトカインおよびその使用
AU2022411048A1 (en) * 2021-12-17 2024-08-01 William Marsh Rice University Encapsulated cells expressing il-12 and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ249754A (en) * 1992-03-04 1997-06-24 Schering Corp Interleukin-10 and its use in inhibiting graft vs host disease or tissue rejection
DE4315127A1 (de) * 1993-05-07 1994-11-10 Behringwerke Ag Arzneimittel enthaltend die Untereinheit p40 von Interleukin-12
US5573764A (en) * 1994-01-21 1996-11-12 Genetics Institute, Inc. Use of interleukin-12 to prevent graft versus host disease

Also Published As

Publication number Publication date
AU698410B2 (en) 1998-10-29
DE69526206T2 (de) 2002-11-21
DK0739212T3 (da) 2002-06-03
EP0739212A1 (en) 1996-10-30
TW349021B (en) 1999-01-01
ZA95463B (en) 1995-09-27
CA2181568C (en) 2007-09-18
IL112373A (en) 2006-08-01
US5756085A (en) 1998-05-26
DE69526206D1 (de) 2002-05-08
ES2179096T3 (es) 2003-01-16
WO1995019786A1 (en) 1995-07-27
ATE215380T1 (de) 2002-04-15
JP3825043B2 (ja) 2006-09-20
EP0739212B1 (en) 2002-04-03
US5573764A (en) 1996-11-12
IL112373A0 (en) 1995-03-30
CA2181568A1 (en) 1995-07-27
AU1687595A (en) 1995-08-08
JPH09508371A (ja) 1997-08-26

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