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PT3652178T - Compostos bicíclicos de cetona e métodos de utilização dos mesmos - Google Patents

Compostos bicíclicos de cetona e métodos de utilização dos mesmos

Info

Publication number
PT3652178T
PT3652178T PT187408158T PT18740815T PT3652178T PT 3652178 T PT3652178 T PT 3652178T PT 187408158 T PT187408158 T PT 187408158T PT 18740815 T PT18740815 T PT 18740815T PT 3652178 T PT3652178 T PT 3652178T
Authority
PT
Portugal
Prior art keywords
methods
ketone compounds
bicyclic ketone
bicyclic
compounds
Prior art date
Application number
PT187408158T
Other languages
English (en)
Original Assignee
H Hoffnabb La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Hoffnabb La Roche Ag filed Critical H Hoffnabb La Roche Ag
Publication of PT3652178T publication Critical patent/PT3652178T/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41961,2,4-Triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/12Radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05Isotopically modified compounds, e.g. labelled
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
PT187408158T 2017-07-14 2018-07-12 Compostos bicíclicos de cetona e métodos de utilização dos mesmos PT3652178T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762532767P 2017-07-14 2017-07-14

Publications (1)

Publication Number Publication Date
PT3652178T true PT3652178T (pt) 2024-03-18

Family

ID=62916677

Family Applications (1)

Application Number Title Priority Date Filing Date
PT187408158T PT3652178T (pt) 2017-07-14 2018-07-12 Compostos bicíclicos de cetona e métodos de utilização dos mesmos

Country Status (30)

Country Link
US (3) US11098058B2 (pt)
EP (2) EP4397309A3 (pt)
JP (2) JP7258843B2 (pt)
KR (2) KR102664604B1 (pt)
CN (2) CN119613408A (pt)
AR (1) AR112274A1 (pt)
AU (3) AU2018300043B2 (pt)
BR (1) BR112020000771A2 (pt)
CA (2) CA3067944C (pt)
CL (1) CL2020000101A1 (pt)
CO (1) CO2020000134A2 (pt)
CR (1) CR20200002A (pt)
DK (1) DK3652178T3 (pt)
ES (1) ES2973661T3 (pt)
FI (1) FI3652178T3 (pt)
HR (1) HRP20240354T1 (pt)
HU (1) HUE065793T2 (pt)
IL (2) IL294961A (pt)
LT (1) LT3652178T (pt)
MA (1) MA49560B1 (pt)
PE (1) PE20200793A1 (pt)
PH (1) PH12020500105A1 (pt)
PL (1) PL3652178T3 (pt)
PT (1) PT3652178T (pt)
RS (1) RS65308B1 (pt)
SG (1) SG11202000333UA (pt)
SI (1) SI3652178T1 (pt)
TW (1) TWI805595B (pt)
UA (1) UA125448C2 (pt)
WO (1) WO2019012063A1 (pt)

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PT3652178T (pt) 2017-07-14 2024-03-18 H Hoffnabb La Roche Ag Compostos bicíclicos de cetona e métodos de utilização dos mesmos
WO2019086494A1 (en) 2017-10-31 2019-05-09 F. Hoffmann-La Roche Ag Bicyclic sulfones and sulfoxides and methods of use thereof
AR119673A1 (es) * 2019-01-11 2022-01-05 Hoffmann La Roche Compuestos bicíclicos de cetona y métodos para utilizarlos
WO2021198981A1 (en) 2020-04-01 2021-10-07 Janssen Biopharma, Inc. Antiviral compounds and uses thereof
WO2021221444A1 (ko) 2020-04-27 2021-11-04 주식회사 오토텍바이오 Ubr 박스 도메인 리간드로의 화합물
TW202304921A (zh) 2021-04-02 2023-02-01 美商建南德克公司 製造雙環酮化合物之方法
WO2023039795A1 (zh) * 2021-09-16 2023-03-23 维泰瑞隆(北京)生物科技有限公司 Rip1激酶抑制剂及其用途
CA3256884A1 (en) * 2022-05-19 2023-11-23 Merck Sharp & Dohme Llc RIPK1 INHIBITORS AND METHODS OF USE
WO2024260932A2 (en) * 2023-06-19 2024-12-26 F. Hoffmann-La Roche Ag Process for the preparation of a chiral pyrrolo triazole alcohol

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Also Published As

Publication number Publication date
CA3185865A1 (en) 2019-01-17
WO2019012063A1 (en) 2019-01-17
US20240300974A1 (en) 2024-09-12
AU2018300043A1 (en) 2020-01-16
US20190100530A1 (en) 2019-04-04
HUE065793T2 (hu) 2024-06-28
IL294961A (en) 2022-09-01
BR112020000771A2 (pt) 2020-07-14
SG11202000333UA (en) 2020-02-27
CL2020000101A1 (es) 2020-07-17
MA49560A (fr) 2020-05-20
TW201920149A (zh) 2019-06-01
PL3652178T3 (pl) 2024-05-06
JP2023085449A (ja) 2023-06-20
CN110914271B (zh) 2024-12-10
RU2020106375A3 (pt) 2022-03-25
CA3067944C (en) 2023-03-14
UA125448C2 (uk) 2022-03-09
EP3652178A1 (en) 2020-05-20
JP7734163B2 (ja) 2025-09-04
KR102664604B1 (ko) 2024-05-14
KR20200030558A (ko) 2020-03-20
AR112274A1 (es) 2019-10-09
AU2023203292A1 (en) 2023-06-22
NZ760749A (en) 2024-08-30
TWI805595B (zh) 2023-06-21
PH12020500105A1 (en) 2020-11-09
EP4397309A2 (en) 2024-07-10
RU2020106375A (ru) 2021-08-16
AU2018300043B2 (en) 2021-04-01
CA3067944A1 (en) 2019-01-17
AU2023203292B2 (en) 2025-01-30
AU2021204369A1 (en) 2021-07-29
PE20200793A1 (es) 2020-08-10
IL271981A (en) 2020-02-27
US11098058B2 (en) 2021-08-24
KR20240065201A (ko) 2024-05-14
LT3652178T (lt) 2024-04-10
CN119613408A (zh) 2025-03-14
ES2973661T3 (es) 2024-06-21
EP3652178B1 (en) 2024-01-24
US20210139504A1 (en) 2021-05-13
DK3652178T3 (da) 2024-03-25
EP4397309A3 (en) 2024-09-04
CN110914271A (zh) 2020-03-24
FI3652178T3 (fi) 2024-03-19
CR20200002A (es) 2020-02-10
CO2020000134A2 (es) 2020-01-17
HRP20240354T1 (hr) 2024-06-07
US11834461B2 (en) 2023-12-05
IL271981B (en) 2022-09-01
JP7258843B2 (ja) 2023-04-17
RS65308B1 (sr) 2024-04-30
JP2020526549A (ja) 2020-08-31
MA49560B1 (fr) 2024-05-31
SI3652178T1 (sl) 2024-05-31

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