AR112274A1 - Compuestos bicíclicos de cetona y sus métodos de uso - Google Patents
Compuestos bicíclicos de cetona y sus métodos de usoInfo
- Publication number
- AR112274A1 AR112274A1 ARP180101941A AR112274A1 AR 112274 A1 AR112274 A1 AR 112274A1 AR P180101941 A ARP180101941 A AR P180101941A AR 112274 A1 AR112274 A1 AR 112274A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- cycloalkyl
- ring
- alkoxy
- membered
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/12—Radicals substituted by oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Composiciones farmacéuticas que incluyen los compuestos y su uso en el tratamiento de enfermedades mediadas por RIP1. Reivindicación 1: Un compuesto de fórmula (1), o sus sales farmacéuticamente aceptables, caracterizado porque: R¹ se selecciona entre el grupo que consiste en alquilo C₁₋₆ cicloalquilo C₃₋₆, alcoxi C₁₋₆, haloalquilo C₁₋₆, haloalcoxi C₁₋₆, alquilo C₁₋₆-N(RN)₂, fenilo, bencilo, heterociclilo de 4 a 8 miembros y heteroarilo de 5 a 6 miembros; en donde R¹ está unido a un carbonilo adyacente por un átomo de carbono, y en donde R¹ está opcionalmente sustituido con uno o dos sustituyentes seleccionados entre el grupo que consiste en F, Cl, Br, alquilo C₁₋₆, cicloalquilo C₃₋₆, alcoxi C₁₋₆, haloalquilo C₁₋₆, haloalcoxi C₁₋₆, alquilo C₁₋₆-N(RN)₂, hidroxilo, hidroximetilo, ciano, cianometilo, cianoetilo, alquilo C(O)C₁₋₆ fenilo, bencilo, CH₂-(cicloalquilo C₃₋₆), heteroarilo de 5 a 6 miembros, y CH₂-(heteroarilo de 5 a 6 miembros); cada RN se selecciona en forma independiente entre el grupo que consiste en H, alquilo C₁₋₆, cicloalquilo C₃₋₆, alcoxi C₁₋₆, y haloalquilo C₁₋₆; o dos RN, junto con el N adyacente, pueden formar un anillo de 4 a 6 miembros; un anillo A es un heteroarilo de 5 miembros que tiene los únicos heteroátomos, ya sea (i) dos o tres átomos de nitrógeno, (ii) un átomo de nitrógeno y un átomo de oxígeno, o (iii) un átomo de nitrógeno y un átomo de azufre; en donde el anillo A está unido al carbonilo adyacente por un átomo de carbono; y el anillo B es un cicloalquilo de 4 a 8 miembros, o un heterociclilo de 4 a 8 miembros que tiene entre 1 y 3 heteroátomos seleccionados entre el grupo que consiste en nitrógeno, oxígeno y azufre; en donde el anillo B está sustituido de acuerdo con (a), (b) o ambos, (a) y (b): (a) de 1 a 2 sustituyentes seleccionados entre el grupo que consiste en halógeno, deuterio, hidroxi, alquilo C₁₋₆, haloalquilo C₁₋₆, cicloalquilo C₁₋₆, alcoxi C₁₋₆, haloalcoxi C₁₋₆, tioalquilo C₁₋₆, alquilo C₁₋₆-N(RN)₂, y ciano; en donde, dos sustituyentes de alquilo C₁₋₆ pueden formar, juntos, un anillo espirocíclico o en puente; y en donde si se sustituye un átomo de nitrógeno en el anillo B, el sustituyente no es halógeno, ciano, ni un alcoxi C₁₋₆, haloalcoxi C₁₋₆ ni tioalquilo C₁₋₆ con un átomo de oxígeno o de azufre directamente unido al átomo de nitrógeno; (b) sustituyente seleccionado entre el grupo que consisten en alquilo C₁₋₆, haloalquilo C₁₋₆, cicloalquilo C₃₋₆, alcoxi C₁₋₆, haloalcoxi C₁₋₆, tioalquilo C₁₋₆, alquilo C₁₋₆-N(RN)₂, fenilo, bencilo, CH₂-(cicloalquilo C₃₋₆), CH₂CH₂-(cicloalquilo C₃₋₆), CH₂-(heterociclilo de 4 a 6 miembros), CH₂CH₂-(heterociclilo de 4 a 6 miembros), heteroarilo de 5 a 6 miembros, y CH₂-(heteroarilo de 5 a 6 miembros); en donde, cuando está presente un anillo de fenilo o un anillo de heteroarilo de 5 a 6 miembros, este puede sustituirse por 1 a 3 sustituyentes seleccionados entre el grupo que consiste en halógeno, alquilo C₁₋₄, haloalquilo C₁₋₄, alcoxi C₁₋₄, haloalcoxi C₁₋₄, ciano, y ciclopropilo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762532767P | 2017-07-14 | 2017-07-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR112274A1 true AR112274A1 (es) | 2019-10-09 |
Family
ID=62916677
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP180101941 AR112274A1 (es) | 2017-07-14 | 2018-07-12 | Compuestos bicíclicos de cetona y sus métodos de uso |
Country Status (30)
| Country | Link |
|---|---|
| US (3) | US11098058B2 (es) |
| EP (2) | EP3652178B1 (es) |
| JP (2) | JP7258843B2 (es) |
| KR (2) | KR20240065201A (es) |
| CN (2) | CN119613408A (es) |
| AR (1) | AR112274A1 (es) |
| AU (3) | AU2018300043B2 (es) |
| BR (1) | BR112020000771A2 (es) |
| CA (2) | CA3185865A1 (es) |
| CL (1) | CL2020000101A1 (es) |
| CO (1) | CO2020000134A2 (es) |
| CR (1) | CR20200002A (es) |
| DK (1) | DK3652178T3 (es) |
| ES (1) | ES2973661T3 (es) |
| FI (1) | FI3652178T3 (es) |
| HR (1) | HRP20240354T1 (es) |
| HU (1) | HUE065793T2 (es) |
| IL (2) | IL271981B (es) |
| LT (1) | LT3652178T (es) |
| MA (1) | MA49560B1 (es) |
| PE (1) | PE20200793A1 (es) |
| PH (1) | PH12020500105A1 (es) |
| PL (1) | PL3652178T3 (es) |
| PT (1) | PT3652178T (es) |
| RS (1) | RS65308B1 (es) |
| SG (1) | SG11202000333UA (es) |
| SI (1) | SI3652178T1 (es) |
| TW (1) | TWI805595B (es) |
| UA (1) | UA125448C2 (es) |
| WO (1) | WO2019012063A1 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3548484B1 (en) * | 2016-12-02 | 2025-04-30 | F. Hoffmann-La Roche AG | Bicyclic amide compounds and methods of use thereof |
| RS65308B1 (sr) | 2017-07-14 | 2024-04-30 | Hoffmann La Roche | Biciklična ketonska jedinjenja i postupci za njihovu upotrebu |
| PE20211247A1 (es) | 2017-10-31 | 2021-07-13 | Hoffmann La Roche | Sulfonas y sulfoxidos biciclicos y metodos de usos de los mismos |
| EP3908586B1 (en) | 2019-01-11 | 2022-12-21 | F. Hoffmann-La Roche AG | Bicyclic pyrrolotriazolr ketone compounds and methods of use thereof |
| WO2021198981A1 (en) | 2020-04-01 | 2021-10-07 | Janssen Biopharma, Inc. | Antiviral compounds and uses thereof |
| KR102891700B1 (ko) | 2020-04-27 | 2025-11-28 | 주식회사 오토텍바이오 | Ubr 박스 도메인 리간드로의 화합물 |
| JP2024513394A (ja) | 2021-04-02 | 2024-03-25 | ジェネンテック， インコーポレイテッド | 二環式ケトン化合物を作製するための方法 |
| WO2023039795A1 (zh) * | 2021-09-16 | 2023-03-23 | 维泰瑞隆（北京）生物科技有限公司 | Rip1激酶抑制剂及其用途 |
| CN119585270A (zh) | 2022-05-19 | 2025-03-07 | 默沙东有限责任公司 | Ripk1抑制剂及其使用方法 |
| CN121399104A (zh) * | 2023-06-19 | 2026-01-23 | 豪夫迈·罗氏有限公司 | 用于制备手性吡咯并三唑醇的方法 |
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| JP6974331B2 (ja) | 2016-02-05 | 2021-12-01 | デナリ セラピューティクス インコーポレイテッドDenali Therapeutics Inc. | 化合物、組成物及び方法 |
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