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PT3110961T - Modulação do crescimento celular e da glicosilação na produção de glicoproteínas recombinantes - Google Patents

Modulação do crescimento celular e da glicosilação na produção de glicoproteínas recombinantes

Info

Publication number
PT3110961T
PT3110961T PT157094301T PT15709430T PT3110961T PT 3110961 T PT3110961 T PT 3110961T PT 157094301 T PT157094301 T PT 157094301T PT 15709430 T PT15709430 T PT 15709430T PT 3110961 T PT3110961 T PT 3110961T
Authority
PT
Portugal
Prior art keywords
glycosylation
modulation
cell growth
recombinant glycoprotein
glycoprotein production
Prior art date
Application number
PT157094301T
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50184787&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT3110961(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PT3110961T publication Critical patent/PT3110961T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
PT157094301T 2014-02-27 2015-02-24 Modulação do crescimento celular e da glicosilação na produção de glicoproteínas recombinantes PT3110961T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP14157030 2014-02-27

Publications (1)

Publication Number Publication Date
PT3110961T true PT3110961T (pt) 2020-01-29

Family

ID=50184787

Family Applications (1)

Application Number Title Priority Date Filing Date
PT157094301T PT3110961T (pt) 2014-02-27 2015-02-24 Modulação do crescimento celular e da glicosilação na produção de glicoproteínas recombinantes

Country Status (20)

Country Link
US (3) US20170058309A1 (pt)
EP (1) EP3110961B1 (pt)
JP (2) JP6831702B2 (pt)
KR (1) KR102280638B1 (pt)
CN (1) CN106133146B (pt)
BR (1) BR112016017660B1 (pt)
CA (1) CA2937611C (pt)
DK (1) DK3110961T3 (pt)
ES (1) ES2769003T3 (pt)
HR (1) HRP20200100T1 (pt)
HU (1) HUE047575T2 (pt)
LT (1) LT3110961T (pt)
MX (1) MX369395B (pt)
PL (1) PL3110961T3 (pt)
PT (1) PT3110961T (pt)
RS (1) RS59881B1 (pt)
RU (1) RU2712562C2 (pt)
SG (1) SG11201606856SA (pt)
SI (1) SI3110961T1 (pt)
WO (1) WO2015128314A1 (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2782990B1 (en) 2011-11-21 2020-10-07 Innovation Hammer LLC Method for growing plants using silicate microbeads and photosafening by utilization of exogenous glycopyranosides
PT3110961T (pt) * 2014-02-27 2020-01-29 Hoffmann La Roche Modulação do crescimento celular e da glicosilação na produção de glicoproteínas recombinantes
HUE049201T2 (hu) * 2014-12-01 2020-09-28 Amgen Inc Eljárás glikoprotein glikántartalmának befolyásolására
CN109414027A (zh) * 2016-04-29 2019-03-01 创新汉玛有限责任公司 用聚糖复合物制剂处理光合生物和增加品质和产量的制剂和方法
US12503700B2 (en) 2017-03-14 2025-12-23 Amgen Inc. Control of total afucosylated glycoforms of antibodies produced in cell culture
WO2019077628A1 (en) * 2017-10-16 2019-04-25 Council Of Scientific & Industrial Research ZINC SUPPLEMENTATION TO DECREASE GALACTOSYLATION OF RECOMBINANT GLYCOPROTEINS
TW202513790A (zh) * 2018-03-16 2025-04-01 美商健臻公司 改善生產生物反應器中細胞存活力之方法
US12325737B2 (en) 2018-03-26 2025-06-10 Amgen Inc. Total afucosylated glycoforms of antibodies produced in cell culture
AU2019274782A1 (en) * 2018-05-24 2020-12-03 Ares Trading S.A. Method for controlling the afucosylation level of a glycoprotein composition
HU231514B1 (hu) 2018-11-07 2024-07-28 Richter Gedeon Nyrt. Sejttenyészetben előállított rekombináns glikoprotein glikozilációs mintázatának megváltoztatására szolgáló módszer
AU2019379858B2 (en) * 2018-11-13 2024-01-04 Janssen Biotech, Inc. Control of trace metals during production of anti-CD38 antibodies
JP2020188737A (ja) * 2019-05-23 2020-11-26 東ソー株式会社 抗体依存性細胞傷害活性が向上した抗体の製造方法
CR20220531A (es) * 2020-04-24 2022-11-28 Hoffmann La Roche Modulacion de enzimas y vías con compuestos de sulfhidrilo y sus derivados
WO2025036924A1 (en) * 2023-08-16 2025-02-20 Glaxosmithkline Intellectual Property Limited Method of controlling antibody glycosylation profile

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4767704A (en) 1983-10-07 1988-08-30 Columbia University In The City Of New York Protein-free culture medium
IL87737A (en) 1987-09-11 1993-08-18 Genentech Inc Method for culturing polypeptide factor dependent vertebrate recombinant cells
US5705364A (en) * 1995-06-06 1998-01-06 Genentech, Inc. Mammalian cell culture process
US6030945A (en) 1996-01-09 2000-02-29 Genentech, Inc. Apo-2 ligand
AU4330597A (en) 1996-08-30 1998-03-19 Life Technologies, Inc. Serum-free mammalian cell culture medium, and uses thereof
DE69929198T2 (de) * 1998-05-29 2006-08-10 Genentech, Inc., South San Francisco Zellkulturverfahren für die produktion von glycoproteinen
JP2001120262A (ja) * 1999-10-26 2001-05-08 Welfide Corp 生理活性物質の産生増強方法
US6900056B2 (en) 2001-02-15 2005-05-31 Centocor, Inc. Chemically defined medium for cultured mammalian cells
US20050287666A1 (en) * 2004-06-29 2005-12-29 Invitrogen Corporation Cell culture medium comprising transition metals or trace elements
TWI384069B (zh) 2004-08-27 2013-02-01 Pfizer Ireland Pharmaceuticals 多胜肽之製法
SI1807504T1 (sl) 2004-11-02 2011-05-31 Ares Trading Sa Brezserumski celiäśni kultivacijski medij za celice sesalcev
US20070231895A1 (en) 2005-11-02 2007-10-04 Lee Gene W Methods for adapting mammalian cells
ES2913277T3 (es) 2005-12-08 2022-06-01 Amgen Inc Producción mejorada de glicoproteínas utilizando manganeso
PT2495307T (pt) * 2006-07-13 2018-05-10 Wyeth Llc Produção do fator ix de coagulação com padrão melhorado de glicosilação
JP5401319B2 (ja) 2006-11-03 2014-01-29 ワイス・エルエルシー 細胞培養における解糖阻害物質
JP5586235B2 (ja) 2007-03-02 2014-09-10 ワイス・エルエルシー ポリペプチドの産生のための細胞培養における銅およびグルタミン酸塩の使用
WO2011019622A1 (en) 2009-08-14 2011-02-17 Genentech, Inc. Cell culture methods to make antibodies with enhanced adcc function
WO2011095596A1 (en) * 2010-02-04 2011-08-11 Vivalis Fed-batch process using concentrated cell culture medium for the efficient production of biologics in eb66 cells
KR101828624B1 (ko) 2010-04-26 2018-02-12 노파르티스 아게 개선된 세포 배양 방법
WO2012149197A2 (en) 2011-04-27 2012-11-01 Abbott Laboratories Methods for controlling the galactosylation profile of recombinantly-expressed proteins
US9670519B2 (en) 2011-04-29 2017-06-06 Biocon Limited Methods for reducing accumulation of lactate during culturing and method for producing polypeptide
WO2013114245A1 (en) * 2012-01-30 2013-08-08 Dr. Reddy's Laboratories Limited Process of modulating man5 and/or afucosylation content of glycoprotein composition
WO2015051293A2 (en) 2013-10-04 2015-04-09 Abbvie, Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
PT3110961T (pt) * 2014-02-27 2020-01-29 Hoffmann La Roche Modulação do crescimento celular e da glicosilação na produção de glicoproteínas recombinantes

Also Published As

Publication number Publication date
JP2017506515A (ja) 2017-03-09
US20210222220A1 (en) 2021-07-22
MX369395B (es) 2019-11-07
HUE047575T2 (hu) 2020-04-28
BR112016017660B1 (pt) 2022-04-19
MX2016010236A (es) 2016-10-13
CA2937611A1 (en) 2015-09-03
KR20160125514A (ko) 2016-10-31
EP3110961A1 (en) 2017-01-04
ES2769003T3 (es) 2020-06-24
US20170058309A1 (en) 2017-03-02
EP3110961B1 (en) 2019-11-27
PL3110961T3 (pl) 2020-04-30
CN106133146A (zh) 2016-11-16
RU2712562C2 (ru) 2020-01-29
CA2937611C (en) 2023-01-03
JP6831702B2 (ja) 2021-02-17
RU2016138176A (ru) 2018-03-29
KR102280638B1 (ko) 2021-07-22
JP2020054351A (ja) 2020-04-09
CN106133146B (zh) 2021-05-04
HRP20200100T1 (hr) 2020-04-03
US20240327890A1 (en) 2024-10-03
DK3110961T3 (da) 2020-02-03
SI3110961T1 (sl) 2020-03-31
JP6934507B2 (ja) 2021-09-15
WO2015128314A1 (en) 2015-09-03
BR112016017660A2 (pt) 2017-08-08
SG11201606856SA (en) 2016-09-29
RU2016138176A3 (pt) 2018-10-29
LT3110961T (lt) 2020-02-10
RS59881B1 (sr) 2020-03-31

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