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PT3060550T - Compostos de heteroarilo como inibidores de btk e utilizações dos mesmos - Google Patents

Compostos de heteroarilo como inibidores de btk e utilizações dos mesmos

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Publication number
PT3060550T
PT3060550T PT14799584T PT14799584T PT3060550T PT 3060550 T PT3060550 T PT 3060550T PT 14799584 T PT14799584 T PT 14799584T PT 14799584 T PT14799584 T PT 14799584T PT 3060550 T PT3060550 T PT 3060550T
Authority
PT
Portugal
Prior art keywords
heteroaryl compounds
btk inhibitors
btk
heteroaryl
inhibitors
Prior art date
Application number
PT14799584T
Other languages
English (en)
Inventor
Jones Reinaldo
Neagu Constantin
Liu-Bujalski Lesley
Qiu Hui
Mochalkin Igor
L Johnson Theresa
D Caldwell Richard
Tate Devon
Gardberg Anna
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of PT3060550T publication Critical patent/PT3060550T/pt

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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