[go: up one dir, main page]

PT2558105T - Bardoxolona metílico para o tratamento da obesidade - Google Patents

Bardoxolona metílico para o tratamento da obesidade

Info

Publication number
PT2558105T
PT2558105T PT117156455T PT11715645T PT2558105T PT 2558105 T PT2558105 T PT 2558105T PT 117156455 T PT117156455 T PT 117156455T PT 11715645 T PT11715645 T PT 11715645T PT 2558105 T PT2558105 T PT 2558105T
Authority
PT
Portugal
Prior art keywords
treating obesity
antioxidant inflammation
inflammation modulators
modulators
antioxidant
Prior art date
Application number
PT117156455T
Other languages
English (en)
Original Assignee
Reata Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44259866&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2558105(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Reata Pharmaceuticals Inc filed Critical Reata Pharmaceuticals Inc
Publication of PT2558105T publication Critical patent/PT2558105T/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
PT117156455T 2010-04-12 2011-04-12 Bardoxolona metílico para o tratamento da obesidade PT2558105T (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32327610P 2010-04-12 2010-04-12
US38909010P 2010-10-01 2010-10-01

Publications (1)

Publication Number Publication Date
PT2558105T true PT2558105T (pt) 2020-01-30

Family

ID=44259866

Family Applications (1)

Application Number Title Priority Date Filing Date
PT117156455T PT2558105T (pt) 2010-04-12 2011-04-12 Bardoxolona metílico para o tratamento da obesidade

Country Status (31)

Country Link
US (3) US10105372B2 (pt)
EP (1) EP2558105B1 (pt)
JP (1) JP5990160B2 (pt)
KR (1) KR101819699B1 (pt)
CN (1) CN102939089B (pt)
AU (1) AU2011240690C1 (pt)
BR (1) BR112012026112B1 (pt)
CA (1) CA2795320C (pt)
CL (1) CL2012002859A1 (pt)
CY (1) CY1122480T1 (pt)
DK (1) DK2558105T3 (pt)
EA (1) EA026567B1 (pt)
ES (1) ES2768204T3 (pt)
HR (1) HRP20192291T1 (pt)
HU (1) HUE047994T2 (pt)
IL (1) IL222273B (pt)
LT (1) LT2558105T (pt)
ME (1) ME03713B (pt)
MX (1) MX357596B (pt)
MY (1) MY163031A (pt)
NZ (1) NZ602826A (pt)
PH (1) PH12012502041B1 (pt)
PL (1) PL2558105T3 (pt)
PT (1) PT2558105T (pt)
RS (1) RS59850B1 (pt)
SG (2) SG10201808661XA (pt)
SI (1) SI2558105T1 (pt)
SM (1) SMT202000086T1 (pt)
TW (1) TWI558724B (pt)
WO (1) WO2011130302A2 (pt)
ZA (1) ZA201207518B (pt)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6326507B1 (en) 1998-06-19 2001-12-04 Trustees Of Dartmouth College Therapeutic compounds and methods of use
LT2252283T (lt) 2008-01-11 2019-03-25 Reata Pharmaceuticals, Inc. Sintetiniai triterpenoidai ir jų panaudojimo būdai gydant ligą
EA022588B1 (ru) 2008-04-18 2016-01-29 Ритэ Фамэсутикл, Инк. Антиоксидантные модуляторы воспаления: производные олеанолевой кислоты с насыщением в с-кольце
JP5529851B2 (ja) 2008-04-18 2014-06-25 リアタ ファーマシューティカルズ インコーポレイテッド 抗酸化炎症モジュレーター：ｃ−１７においてアミノ改変およびその他の改変を加えたオレアノール酸誘導体
CN103588678A (zh) 2008-04-18 2014-02-19 里亚塔医药公司 包含抗炎症药效团的化合物以及使用方法
LT2271658T (lt) 2008-04-18 2017-02-27 Reata Pharmaceuticals, Inc. Antioksidantai uždegimo moduliatoriai:oleanolio rūgšties c-17 patvirtinti dariniai
US8314137B2 (en) 2008-07-22 2012-11-20 Trustess Of Dartmouth College Monocyclic cyanoenones and methods of use thereof
MY163031A (en) * 2010-04-12 2017-07-31 Reata Pharmaceuticals Inc Method of treating obesity using antioxidant inflammation modulators
HRP20171859T1 (hr) 2010-12-17 2018-01-26 Reata Pharmaceuticals, Inc. Pirazolil i pirimidinil triciklički enoni kao antioksidacijski modulatori upale
SMT201900433T1 (it) 2011-03-11 2019-09-09 Reata Pharmaceuticals Inc Derivati di c4-monometil triterpenoidi e metodi del loro uso
KR101174701B1 (ko) * 2011-12-29 2012-08-17 서울대학교산학협력단 진저레논 에이를 포함하는 비만 예방용 식품 조성물, 비만 치료용 약학조성물 및 비만 치료용 동물용 의약품
LT2841445T (lt) 2012-04-27 2017-09-11 Reata Pharmaceuticals, Inc. Bardoksolonmetilo 2,2-difluorpropionamido dariniai, polimorfinės formos ir jų panaudojimo būdai
US9556222B2 (en) 2012-06-15 2017-01-31 Reata Pharmaceuticals, Inc. A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof
WO2014040073A1 (en) 2012-09-10 2014-03-13 Reata Pharmaceuticals, Inc. C13-hydroxy derivatives of oleanolic acid and methods of use thereof
CN104936972A (zh) 2012-09-10 2015-09-23 艾伯维公司 具有抗炎活性的甘草次酸衍生物
MY180903A (en) 2012-09-10 2020-12-11 Reata Pharmaceuticals Inc C17-alkanediyl and alkenediyl derivatives of oleanolic acid and methods of use thereof
US9512094B2 (en) 2012-09-10 2016-12-06 Reata Pharmaceuticals, Inc. C17-heteroaryl derivatives of oleanolic acid and methods of use thereof
HUE040496T2 (hu) 2012-09-27 2019-03-28 Childrens Medical Ct Corp Vegyületek elhízás kezelésére és alkalmazási eljárásaik
US9796752B2 (en) 2013-03-19 2017-10-24 Daiichi Sankyo Company, Limited Terpenoid derivatives
UY39092A (es) * 2013-04-24 2021-03-26 Abbvie Inc Derivados de 2,2-difluoropropanamida y metil bardoxolona, formas polimórficas y métodos de uso
WO2015027206A1 (en) * 2013-08-23 2015-02-26 Reata Pharmaceuticals, Inc. Methods of treating and preventing endothelial dysfunction using bardoxololone methyl or analogs thereof
WO2015112792A1 (en) 2014-01-24 2015-07-30 Abbvie Inc. Aryl and arylalkyl substituted pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators
EP3139910B1 (en) 2014-05-05 2019-11-27 The Board of Regents of The University of Texas System Compositions comprising ursolic acid and/or resveratrol for treating obesity
EP3192875B1 (en) 2014-09-10 2019-12-18 Daiichi Sankyo Company, Limited Sustained-release pharmaceutical composition for treating and preventing ophthalmic diseases
CN107428698B (zh) 2015-02-12 2021-10-26 里亚塔医药公司 作为抗氧化炎症调节剂的咪唑基三环烯酮
CN105017374B (zh) * 2015-07-20 2017-03-01 山西大学 一种齐墩果酸内酯类衍生物及其制备方法和应用
US20170056373A1 (en) * 2015-09-01 2017-03-02 Syracuse University Ghrelin o-acyltransferase inhibitors
NZ741082A (en) 2015-09-23 2023-06-30 Reata Pharmaceuticals Inc C4-modified oleanolic acid derivatives for inhibition of il-17 and other uses
JP7012379B2 (ja) 2016-09-08 2022-01-28 レジネラ ファーマ リミテッド 視神経症を処置するためのトリテルペノイドを含む組成物およびその使用
NZ753546A (en) 2016-11-08 2022-10-28 Reata Pharmaceuticals Holdings Llc Methods of treating alport syndrome using bardoxolone methyl or analogs thereof
TWI831738B (zh) 2016-12-16 2024-02-11 美商瑞塔醫藥有限責任公司 用於抑制ＲＯＲγ及其他用途的嘧啶三環烯酮衍生物
MX2020013692A (es) 2018-06-15 2021-02-26 Reata Pharmaceuticals Inc Compuestos de pirazol e imidazol para la inhibicion de il-17 y rorgamma.
WO2019246461A1 (en) 2018-06-20 2019-12-26 Reata Pharmaceuticals, Inc. Cysteine-dependent inverse agonists of nuclear receptors ror-gamma/ror-gamma-t and methods of treating diseases or disorders therewith
CA3249188A1 (en) 2019-07-19 2025-06-05 Reata Pharmaceuticals, Inc. C17 Polar Substitution Hetero-Romatic Synthetic Triterpenoids and Their Methods of Use
KR20230017204A (ko) * 2020-04-29 2023-02-03 바이오에이지 랩스, 인코포레이티드 노화-관련 질환 치료용 저산소증-유도 인자 프롤릴 히드록실라제 억제제
CA3177913A1 (en) * 2020-05-09 2021-11-18 Deborah FERGUSON Methods of treating covid-19 using bardoxolone methyl or analogs thereof
EP4642462A1 (en) * 2022-12-29 2025-11-05 The Board Of Regents Of The University Of Texas System Synthetic triterpenoids and compositions thereof in weight management, skeletal muscle function, and appetite suppression

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ191586A (en) 1978-10-10 1981-10-19 Sterling Drug Inc Cyanoketones derived from glycyrrhetinic acid and pharmaceutical compositions
US4395423A (en) 1978-10-10 1983-07-26 Sterling Drug Inc. Polycyclic cyanoketones
US6025395A (en) 1994-04-15 2000-02-15 Duke University Method of preventing or delaying the onset and progression of Alzheimer's disease and related disorders
US6326507B1 (en) 1998-06-19 2001-12-04 Trustees Of Dartmouth College Therapeutic compounds and methods of use
US6369101B1 (en) 1999-02-26 2002-04-09 Regents Of The University Of Minnesota Therapeutic method to treat herpes virus infection
CA2372962C (en) 1999-05-14 2008-04-08 Nereus Pharmaceuticals, Inc. Novel interleukin-1 and tumor necrosis factor-.alpha. modulators, syntheses of said modulators and methods of using said modulators
US6890946B2 (en) 1999-12-23 2005-05-10 Indiana University Research And Technology Corporation Use of parthenolide to inhibit cancer
WO2002003996A1 (en) 2000-07-12 2002-01-17 RAJKUMAR, Sujatha Use of dammarane-type tritepenoid saporins
WO2002026761A1 (en) 2000-09-29 2002-04-04 Regents Of The University Of Minnesota Triterpenes having fungicidal activity against yeast
US6878751B1 (en) 2000-10-19 2005-04-12 Imperial College Of Science Technology And Medicine Administration of resveratrol to treat inflammatory respiratory disorders
US7435755B2 (en) 2000-11-28 2008-10-14 The Trustees Of Dartmouth College CDDO-compounds and combination therapies thereof
CA2430454A1 (en) 2000-11-28 2002-06-20 Board Of Regents, The University Of Texas System Cddo-compounds and combination therapies thereof
CA2441568A1 (en) * 2001-03-23 2002-10-03 Shire Biochem Inc. Pharmaceutical combinations for the treatment of cancer
AU2002308701A1 (en) 2001-05-14 2002-11-25 University Of Maryland, Baltimore Novel alanine transaminase enzyme and methods of use
AU2003235676A1 (en) 2002-01-15 2003-07-30 Trustees Of Dartmouth College Tricyclic-bis-enone derivatives and methods of use thereof
CA2485565A1 (en) 2002-05-13 2004-08-05 Trustees Of Dartmouth College Inhibitors and methods of use thereof
EP1457206A1 (en) * 2003-03-13 2004-09-15 Fournier Laboratories Ireland Limited Combined use of a fibrate and orlistat for the treatment of obesity
WO2004089357A2 (en) 2003-04-02 2004-10-21 Regents Of The University Of Minnesota Anti-fungal formulation of triterpene and essential oil
RU2005133970A (ru) * 2003-05-09 2007-06-20 Ново Нордиск А/С (DK) Пептиды, применяемые для лечения ожирения
BRPI0409976A (pt) 2003-05-09 2006-05-09 Novo Nordisk As composto, métodos para retardar a progressão de igt diabetes do tipo 2, para retardar a progressão de diabetes do tipo 2 para diabetes que requer insulina, para tratar obesidade ou prevenir excesso de peso para regular o apetite para induzir saciedade, para prevenir ganho de peso após se ter tido sucesso em perder peso, para aumentar dispêndio de energia, para tratar uma doença ou estado e para tratar bulimia, composição farmacêutica, e, uso de um composto
DK2218342T3 (en) 2003-05-27 2018-10-22 Dsm Ip Assets Bv New nutraceutical compositions and their use
AU2005282437B2 (en) 2004-09-07 2013-01-10 Pacific Arrow Limited Anti-tumor compounds with angeloyl groups
WO2005042002A2 (en) 2003-10-30 2005-05-12 Entelos, Inc. Treatment of rhematoid arthritis with flip antagonists
WO2005046732A2 (en) 2003-11-04 2005-05-26 THE UNITED SATES OF AMERICA as represented by THE SECRETARY OF HEALTH AND HUMAN SERVICES, NIH Methods and compositions for the inhibition of hiv-1 replication
ATE523208T1 (de) 2003-12-22 2011-09-15 Novartis Ag Mittel zur behandlung von glaukomatöser retinopathie und optischer neuropathie
JP2005314381A (ja) 2004-03-30 2005-11-10 Anges Mg Inc 増殖性腎疾患の予防・治療・改善剤
WO2005113761A2 (en) 2004-04-19 2005-12-01 University Of Maryland, Baltimore Novel alanine transaminase enzymes and methods of use
US7772195B2 (en) * 2004-07-29 2010-08-10 Board Of Trustees Of Michigan State University Methods and compositions for the treatment of obesity, insulin related diseases and hypercholesterolemia
AU2006265113A1 (en) 2005-07-01 2007-01-11 The Johns Hopkins University Compositions and methods for the treatment or prevention of disorders relating to oxidative stress
WO2007127791A2 (en) 2006-04-25 2007-11-08 The Administrators Of The Tulane Educational Fund New pharmacological method for treatment of neuropathic pain
WO2008000070A1 (en) 2006-06-27 2008-01-03 Wellington Laboratories Inc. Glycyrrhetinic acid derivatives
WO2008016095A1 (en) 2006-08-02 2008-02-07 Santen Pharmaceutical Co., Ltd. PREVENTIVE OR REMEDY FOR KERATOCONJUNCTIVAL DISORDERS CONTAINING Nrf2 ACTIVATOR AS THE ACTIVE INGREDIENT
JP2008110962A (ja) 2006-08-02 2008-05-15 Santen Pharmaceut Co Ltd Ｎｒｆ２活性化物質を有効成分として含む角結膜障害の予防または治療剤
CA2670099A1 (en) 2006-11-17 2008-05-29 Trustees Of Dartmouth College Synthesis and biological activities of new tricyclic-bis-enones (tbes)
WO2008064132A2 (en) 2006-11-17 2008-05-29 Trustees Of Dartmouth College Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth
JP2008247898A (ja) 2007-03-08 2008-10-16 Santen Pharmaceut Co Ltd トリテルペノイドを有効成分として含有する酸化ストレスが関連する眼疾患の予防又は治療剤
WO2008136838A1 (en) 2007-05-04 2008-11-13 Trustees Of Dartmouth College Novel amide derivatives of cddo and methods of use thereof
US8088824B2 (en) 2007-08-15 2012-01-03 Reata Pharmaceuticals Inc. Forms of CDDO methyl ester
WO2009023845A2 (en) 2007-08-15 2009-02-19 The Board Of Regents Of The University Of Texas System Combination therapy with synthetic triterpenoids and gemcitabine
WO2009058849A1 (en) 2007-10-29 2009-05-07 University Of Rochester Use of electrophilic compounds for inducing platelet production or maintaining platelet function
LT2252283T (lt) * 2008-01-11 2019-03-25 Reata Pharmaceuticals, Inc. Sintetiniai triterpenoidai ir jų panaudojimo būdai gydant ligą
CN103588678A (zh) * 2008-04-18 2014-02-19 里亚塔医药公司 包含抗炎症药效团的化合物以及使用方法
WO2009146216A2 (en) * 2008-04-18 2009-12-03 Reata Pharmaceuticals. Inc. Antioxidant inflammation modulators: novel derivatives of oleanolic acid
JP5529851B2 (ja) 2008-04-18 2014-06-25 リアタ ファーマシューティカルズ インコーポレイテッド 抗酸化炎症モジュレーター：ｃ−１７においてアミノ改変およびその他の改変を加えたオレアノール酸誘導体
LT2271658T (lt) 2008-04-18 2017-02-27 Reata Pharmaceuticals, Inc. Antioksidantai uždegimo moduliatoriai:oleanolio rūgšties c-17 patvirtinti dariniai
EA022588B1 (ru) 2008-04-18 2016-01-29 Ритэ Фамэсутикл, Инк. Антиоксидантные модуляторы воспаления: производные олеанолевой кислоты с насыщением в с-кольце
US8314137B2 (en) 2008-07-22 2012-11-20 Trustess Of Dartmouth College Monocyclic cyanoenones and methods of use thereof
US8747901B2 (en) 2009-02-13 2014-06-10 Reata Pharmaceuticals, Inc. Delayed release, oral dosage compositions that contain amorphous CDDO-Me
MY163031A (en) 2010-04-12 2017-07-31 Reata Pharmaceuticals Inc Method of treating obesity using antioxidant inflammation modulators
US8618125B2 (en) 2011-01-14 2013-12-31 Heptiva LLC Composition comprising hepatic therapeutic active for treating liver diseases, certain cancers and liver health maintenance
CN102887936A (zh) 2012-10-24 2013-01-23 苏州晶云药物科技有限公司 2-氰基-3,12-二氧代齐墩果-1,9(11)-二烯-28-酸甲酯晶型
CN102875634B (zh) 2012-10-24 2014-08-20 苏州晶云药物科技有限公司 2-氰基-3,12-二氧代齐墩果-1,9(11)-二烯-28-酸甲酯的几种晶型

Also Published As

Publication number Publication date
CA2795320C (en) 2019-01-22
ME03713B (me) 2021-01-20
KR101819699B1 (ko) 2018-01-17
US20190076443A1 (en) 2019-03-14
MY163031A (en) 2017-07-31
WO2011130302A2 (en) 2011-10-20
BR112012026112B1 (pt) 2020-03-17
CN102939089A (zh) 2013-02-20
IL222273B (en) 2019-03-31
SG10201808661XA (en) 2018-11-29
HRP20192291T1 (hr) 2020-03-20
PH12012502041A1 (en) 2013-01-21
EA201291031A1 (ru) 2013-04-30
IL222273A0 (en) 2012-12-31
DK2558105T3 (da) 2020-01-27
SG184830A1 (en) 2012-11-29
ZA201207518B (en) 2017-08-30
RS59850B1 (sr) 2020-02-28
AU2011240690C1 (en) 2014-11-06
EP2558105B1 (en) 2019-11-20
US11911395B2 (en) 2024-02-27
US20110281955A1 (en) 2011-11-17
SMT202000086T1 (it) 2020-03-13
WO2011130302A3 (en) 2012-01-05
AU2011240690A1 (en) 2012-10-25
NZ602826A (en) 2014-11-28
CL2012002859A1 (es) 2013-08-02
US10105372B2 (en) 2018-10-23
LT2558105T (lt) 2020-02-10
CY1122480T1 (el) 2021-01-27
EP2558105A2 (en) 2013-02-20
PL2558105T3 (pl) 2020-04-30
MX357596B (es) 2018-07-16
HUE047994T2 (hu) 2020-05-28
EA026567B1 (ru) 2017-04-28
CA2795320A1 (en) 2011-10-20
JP2013523888A (ja) 2013-06-17
ES2768204T3 (es) 2020-06-22
TWI558724B (zh) 2016-11-21
AU2011240690B2 (en) 2014-06-19
BR112012026112A2 (pt) 2016-06-28
KR20130096635A (ko) 2013-08-30
CN102939089B (zh) 2018-04-10
MX2012011892A (es) 2012-11-30
PH12012502041B1 (en) 2020-02-26
JP5990160B2 (ja) 2016-09-07
SI2558105T1 (sl) 2020-02-28
TW201139458A (en) 2011-11-16
US20240335457A1 (en) 2024-10-10

Similar Documents

Publication Publication Date Title
IL222273A0 (en) Method of treating obesity using antioxidant inflammation modulators
EP2585075B8 (en) Methods of treatment for esophageal inflammation
IL207752A0 (en) Methods of treating inflammation
SI2600812T1 (sl) Naprava za zdravljenje očesa
IL226351A0 (en) A method for induced renal treatment-contrast
EP2331564A4 (en) PROCESS FOR TREATMENT OF IGNITION
EP2830654B8 (en) Methods and compositions for treating inflammation
IL233111A0 (en) Preparations for the treatment of inflammation
GB201018147D0 (en) Method of treatment
EP2643001A4 (en) METHOD OF TREATING CANCER
EP2480579A4 (en) METHODS OF TREATING INFLAMMATION
EP2574172A4 (en) MATERIALS AND METHOD FOR TREATING INFLAMMATION
HUE068372T2 (hu) Eljárás bõr kezelésére mikroRNS-modulátorokkal
GB201003920D0 (en) Method of treatment
PL2655923T3 (pl) Sposób i urządzenie do stosowania łańcucha
GB201018149D0 (en) Method of treatment
EP2585103A4 (en) METHOD OF TREATMENT
GB201020015D0 (en) Method of treatment
EP2747968B8 (de) Vorrichtung und verfahren zum künstlichen altern von steinen
IL216629A0 (en) Methods of treating inflammation
GB201005071D0 (en) Method of treatment
GB201003917D0 (en) Method of treatment
GB201000318D0 (en) Method of treatment
GB201100651D0 (en) Treatment of inflammation
GB201005495D0 (en) Compounds for treatment of inflammation