PT2114921E - Derivado de oxindol substituído e sua utilização como ligante do recetor de vasopressina - Google Patents
Derivado de oxindol substituído e sua utilização como ligante do recetor de vasopressinaInfo
- Publication number
- PT2114921E PT2114921E PT78582129T PT07858212T PT2114921E PT 2114921 E PT2114921 E PT 2114921E PT 78582129 T PT78582129 T PT 78582129T PT 07858212 T PT07858212 T PT 07858212T PT 2114921 E PT2114921 E PT 2114921E
- Authority
- PT
- Portugal
- Prior art keywords
- receptor ligand
- vasopressin receptor
- oxindole derivative
- substituted oxindole
- substituted
- Prior art date
Links
- 102000004136 Vasopressin Receptors Human genes 0.000 title 1
- 108090000643 Vasopressin Receptors Proteins 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 125000004095 oxindolyl group Chemical class N1(C(CC2=CC=CC=C12)=O)* 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102006062508 | 2006-12-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2114921E true PT2114921E (pt) | 2013-03-26 |
Family
ID=39140670
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT78582129T PT2114921E (pt) | 2006-12-30 | 2007-12-28 | Derivado de oxindol substituído e sua utilização como ligante do recetor de vasopressina |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP2114921B1 (pt) |
| CY (1) | CY1114543T1 (pt) |
| DK (1) | DK2114921T3 (pt) |
| ES (1) | ES2401908T3 (pt) |
| PL (1) | PL2114921T3 (pt) |
| PT (1) | PT2114921E (pt) |
| RS (1) | RS52700B (pt) |
| SI (1) | SI2114921T1 (pt) |
| WO (1) | WO2008080970A1 (pt) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8580842B2 (en) | 2003-09-30 | 2013-11-12 | Abbott Gmbh & Co. Kg | Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them |
| US20080167286A1 (en) | 2006-12-12 | 2008-07-10 | Abbott Laboratories | Pharmaceutical compositions and their methods of use |
| US8486979B2 (en) | 2006-12-12 | 2013-07-16 | Abbvie Inc. | 1,2,4 oxadiazole compounds and methods of use thereof |
| UY30846A1 (es) | 2006-12-30 | 2008-07-31 | Abbott Gmbh & Amp | Derivados de oxindol sustituidos, medicamentos que los comprenden y uso de los mismos |
| WO2009071691A2 (de) * | 2007-12-07 | 2009-06-11 | Abbott Gmbh & Co. Kg | Oxindol-derivate und ihre verwendung als medikament |
| WO2010009775A1 (de) * | 2007-12-07 | 2010-01-28 | Abbott Gmbh & Co. Kg | Carbamat-substituierte oxindol-derivate und ihre verwendung zur behandlung von vasopressin-abhängigen erkrankungen |
| ES2455197T3 (es) | 2007-12-07 | 2014-04-14 | Abbvie Deutschland Gmbh & Co Kg | Derivados de oxindol 5,6-disustituidos y el uso de los mismos para la preparación de un medicamento para el tratamiento de enfermedades dependientes de vasopresina |
| CA2707667C (en) * | 2007-12-07 | 2016-02-23 | Abbott Gmbh & Co. Kg | Amidomethyl-substituted oxindole derivatives and the use thereof for the treatment of vasopressin-dependent illnesses |
| BRPI0820668A2 (pt) | 2007-12-07 | 2017-08-22 | Abbott Gmbh & Co Kg | Derivados de oxindol substituídos por 5-halogênio e seu uso para tratar doenças dependentes de vasopressina |
| US9040568B2 (en) | 2009-05-29 | 2015-05-26 | Abbvie Inc. | Pharmaceutical compositions for the treatment of pain |
| WO2010142739A1 (en) * | 2009-06-10 | 2010-12-16 | Abbott Gmbh & Co. Kg | Use of substituted oxindole derivatives for the treatment and prophylaxis of pain |
| TWI527807B (zh) | 2010-12-21 | 2016-04-01 | 拜耳智慧財產有限公司 | Ｎ－磺醯基取代的吲哚酮之製法 |
| CN105339366A (zh) | 2013-03-14 | 2016-02-17 | 艾伯维德国有限责任两合公司 | 带有取代的氧杂环丁烷的2-吲哚酮衍生物及其治疗血管加压素相关疾病的用途 |
| US9273036B2 (en) | 2013-03-14 | 2016-03-01 | AbbVie Deutschland GmbH & Co. KG | Oxindole derivatives carrying an oxetane substituent and use thereof for treating vasopressine-related diseases |
| US9840495B2 (en) | 2013-12-20 | 2017-12-12 | AbbVie Deutschland GmbH & Co. KG | Oxindole derivatives carrying a piperidyl-substituted azetidinyl substituent and use thereof for treating vasopressine-related diseases |
| US9862704B2 (en) | 2013-12-20 | 2018-01-09 | AbbVie Deutschland GmbH & Co. KG | Oxindole derivatives carrying an amine-substituted piperidyl-acetidinyl substituent and use thereof for treating vasopressine-related diseases |
| WO2015173392A1 (en) | 2014-05-15 | 2015-11-19 | AbbVie Deutschland GmbH & Co. KG | Oxindole compounds carrying a co-bound spiro substituent and use thereof for treating vasopressin-related diseases |
| AU2016348493B2 (en) | 2015-11-06 | 2021-02-25 | F. Hoffmann-La Roche Ag | Indolin-2-one derivatives |
| JP6839184B2 (ja) | 2015-11-06 | 2021-03-03 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | インドリン−２−オン誘導体 |
| WO2017076931A1 (en) | 2015-11-06 | 2017-05-11 | F. Hoffmann-La Roche Ag | Indolin-2-one derivatives for use in the treatment of cns and related disorders |
| CN108137555B (zh) | 2015-11-06 | 2021-02-19 | 豪夫迈·罗氏有限公司 | 可用于治疗cns疾病的二氢吲哚-2-酮衍生物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050070718A1 (en) * | 2003-09-30 | 2005-03-31 | Abbott Gmbh & Co. Kg | Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them |
| DE102004033834A1 (de) * | 2004-07-13 | 2006-02-02 | Abbott Gmbh & Co. Kg | Substituierte Oxindol-Derivate und diese enthaltende Arzneimittel |
| EP1861392A2 (de) * | 2005-03-24 | 2007-12-05 | Abbott GmbH & Co. KG | Substituierte oxindol-derivate, diese enthaltende arzneimittel und deren verwendung |
| DE102005014904A1 (de) * | 2005-03-26 | 2007-02-01 | Abbott Gmbh & Co. Kg | Substituierte Oxindol-Derivate, diese enthaltende Arzneimittel und deren Verwendung |
-
2007
- 2007-12-28 WO PCT/EP2007/064619 patent/WO2008080970A1/en not_active Ceased
- 2007-12-28 PL PL07858212T patent/PL2114921T3/pl unknown
- 2007-12-28 EP EP07858212A patent/EP2114921B1/en active Active
- 2007-12-28 RS RS20130093A patent/RS52700B/sr unknown
- 2007-12-28 PT PT78582129T patent/PT2114921E/pt unknown
- 2007-12-28 SI SI200731192T patent/SI2114921T1/sl unknown
- 2007-12-28 DK DK07858212.9T patent/DK2114921T3/da active
- 2007-12-28 ES ES07858212T patent/ES2401908T3/es active Active
-
2013
- 2013-03-26 CY CY20131100254T patent/CY1114543T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CY1114543T1 (el) | 2016-10-05 |
| RS52700B (sr) | 2013-08-30 |
| WO2008080970A1 (en) | 2008-07-10 |
| EP2114921B1 (en) | 2012-12-26 |
| SI2114921T1 (sl) | 2013-05-31 |
| EP2114921A1 (en) | 2009-11-11 |
| HK1132741A1 (en) | 2010-03-05 |
| DK2114921T3 (da) | 2013-03-25 |
| PL2114921T3 (pl) | 2013-05-31 |
| ES2401908T3 (es) | 2013-04-25 |
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