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PT1697345E - Benzimidazóis contendo morfolinilo como inibidores da replicação do vírus sincicial respiratório - Google Patents

Benzimidazóis contendo morfolinilo como inibidores da replicação do vírus sincicial respiratório Download PDF

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Publication number
PT1697345E
PT1697345E PT04817576T PT04817576T PT1697345E PT 1697345 E PT1697345 E PT 1697345E PT 04817576 T PT04817576 T PT 04817576T PT 04817576 T PT04817576 T PT 04817576T PT 1697345 E PT1697345 E PT 1697345E
Authority
PT
Portugal
Prior art keywords
inhibitors
respiratory syncytial
syncytial virus
virus replication
containing benzimidazoles
Prior art date
Application number
PT04817576T
Other languages
English (en)
Inventor
Jean-Francois Bonfanti
Koenraad Jozef Lodewijk Andries
Jerome Michel Claude Fortin
Philippe Muller
Frederic Marc Maurice Doublet
Christophe Meyer
Rudy Edmond Willebrords
Tom Valerius Josepha Gevers
Philip Maria Martha Bern Timmerman
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34704695&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT1697345(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Publication of PT1697345E publication Critical patent/PT1697345E/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30Nitrogen atoms not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41841,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT04817576T 2003-12-18 2004-12-20 Benzimidazóis contendo morfolinilo como inibidores da replicação do vírus sincicial respiratório PT1697345E (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03104810 2003-12-18
US56718204P 2004-04-30 2004-04-30
EP04105312 2004-10-26

Publications (1)

Publication Number Publication Date
PT1697345E true PT1697345E (pt) 2008-06-12

Family

ID=34704695

Family Applications (1)

Application Number Title Priority Date Filing Date
PT04817576T PT1697345E (pt) 2003-12-18 2004-12-20 Benzimidazóis contendo morfolinilo como inibidores da replicação do vírus sincicial respiratório

Country Status (32)

Country Link
US (2) US7449463B2 (pt)
EP (1) EP1697345B1 (pt)
JP (1) JP4951348B2 (pt)
KR (1) KR100967406B1 (pt)
CN (2) CN1894237A (pt)
AP (1) AP2150A (pt)
AR (1) AR046959A1 (pt)
AT (1) ATE388950T1 (pt)
AU (1) AU2004298460B2 (pt)
BR (1) BRPI0417268B8 (pt)
CA (1) CA2548668C (pt)
CY (1) CY1108142T1 (pt)
DE (1) DE602004012448T2 (pt)
DK (1) DK1697345T3 (pt)
EA (1) EA009876B1 (pt)
EG (1) EG25799A (pt)
ES (1) ES2303653T3 (pt)
HR (1) HRP20080245T3 (pt)
IL (1) IL175910A (pt)
ME (1) ME01042B (pt)
MX (1) MXPA06007112A (pt)
MY (1) MY143573A (pt)
NO (1) NO339314B1 (pt)
NZ (1) NZ547479A (pt)
PL (1) PL1697345T3 (pt)
PT (1) PT1697345E (pt)
RS (1) RS50584B (pt)
SI (1) SI1697345T1 (pt)
TW (1) TWI351401B (pt)
UA (1) UA84718C2 (pt)
WO (1) WO2005058871A1 (pt)
ZA (1) ZA200605894B (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR046959A1 (es) * 2003-12-18 2006-01-04 Tibotec Pharm Ltd Morfolinilo que contiene bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio
TWI370820B (en) 2005-04-27 2012-08-21 Takeda Pharmaceutical Fused heterocyclic compounds
US8034835B2 (en) * 2005-06-20 2011-10-11 Tibotec Pharmaceuticals Ltd. 1-[[2-amino-3-(substituted alkyl)-3H-benzimidazolyl[methyl]-3-substituted-1,3-dihydro-benzoimidazol-2-ones and structural analogs
WO2006136562A1 (en) * 2005-06-20 2006-12-28 Tibotec Pharmaceuticals Ltd Heterocyclylaminoalkyl substituted benzimidazoles
US20120148678A1 (en) 2010-12-08 2012-06-14 Advanced Technologies And Regenerative Medicine, Llc. Sustained release of poorly water soluble active compounds
SI2766359T1 (sl) 2011-10-14 2016-09-30 Ambit Biosciences Corporation Heterociklične spojine in njihova uporaba kot modulatorjev receptorja tirozin kinaze tipa III
UA119050C2 (uk) * 2013-11-11 2019-04-25 Ґілеад Саєнсиз, Інк. ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ
JO3637B1 (ar) * 2015-04-28 2020-08-27 Janssen Sciences Ireland Uc مركبات بيرازولو- وترايازولو- بيريميدين مضادة للفيروسات rsv
EP3454897A4 (en) * 2016-05-10 2020-01-15 Georgia State University Research Foundation, Inc. BICYCLIC CONDENSED PYRAZOLE DERIVATIVES FOR THE TREATMENT OF RSV
TW201825465A (zh) 2016-09-23 2018-07-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201815787A (zh) 2016-09-23 2018-05-01 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201813963A (zh) 2016-09-23 2018-04-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
SMT201900517T1 (it) 2017-03-20 2019-11-13 Forma Therapeutics Inc Composizioni di pirrolopirrolo come attivatori di piruvato chinasi (pkr)
TW201932470A (zh) 2017-11-29 2019-08-16 愛爾蘭商健生科學愛爾蘭無限公司 具有抗rsv活性之吡唑并嘧啶
EP3746444B1 (en) 2018-01-31 2023-09-27 Janssen Sciences Ireland Unlimited Company Cycloalkyl substituted pyrazolopyrimidines having activity against rsv
CA3095277A1 (en) 2018-04-23 2019-10-31 Janssen Sciences Ireland Unlimited Company Heteroaromatic compounds having activity against rsv
CN113226356B (zh) 2018-09-19 2025-03-04 诺沃挪第克健康护理股份公司 活化丙酮酸激酶r
US20200129485A1 (en) 2018-09-19 2020-04-30 Forma Therapeutics, Inc. Treating sickle cell disease with a pyruvate kinase r activating compound
GB201820751D0 (en) * 2018-12-19 2019-01-30 Bp Oil Int Methods for preparing intermediates
RS66126B1 (sr) 2019-07-22 2024-11-29 Lupin Ltd Makrociklična jedinjenja kao agonisti uboda i njihove metode i upotreba
CN114615977B (zh) 2019-09-19 2025-01-14 诺沃挪第克健康护理股份公司 丙酮酸激酶r(pkr)活化组合物
EP4243813A4 (en) 2020-11-13 2024-07-17 Calcimedica, Inc. IMPROVED SYNTHESIS OF CRAC CHANNEL INHIBITORS
US12128035B2 (en) 2021-03-19 2024-10-29 Novo Nordisk Health Care Ag Activating pyruvate kinase R
US20240352013A1 (en) * 2021-08-13 2024-10-24 Georgia State University Research Foundation, Inc. Bicyclic fused pyrazole derivatives for the treatment of respiratory infections including rsv
CN119118850B (zh) * 2023-06-13 2025-12-12 中国科学院兰州化学物理研究所 一种吲哚类化合物结构重整制备胺基苯乙醇类化合物的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EE04590B1 (et) * 1999-06-28 2006-02-15 Janssen Pharmaceutica N.V. Respiratoorse süntsütiaalviiruse replikatsiooni inhibiitorid, nende kasutamine ja valmistamismeetod, farmatseutiline kompositsioon ja selle valmistamismeetod ning produkt
EP1196410B1 (en) * 1999-06-28 2004-02-18 Janssen Pharmaceutica N.V. Respiratory syncytial virus replication inhibitors
WO2001000612A2 (en) * 1999-06-28 2001-01-04 Janssen Pharmaceutica N.V. Respiratory syncytial virus replication inhibitors
AR046959A1 (es) * 2003-12-18 2006-01-04 Tibotec Pharm Ltd Morfolinilo que contiene bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio
ES2328700T3 (es) * 2003-12-18 2009-11-17 Tibotec Pharmaceuticals Ltd. Aminobenzimidazoles y benzimidazoles como inhibidores de la replicacion del virus respiratorio sincital.

Also Published As

Publication number Publication date
CN101412709B (zh) 2015-03-25
DE602004012448T2 (de) 2009-03-26
JP2007514720A (ja) 2007-06-07
PL1697345T3 (pl) 2008-08-29
DK1697345T3 (da) 2008-06-23
EG25799A (en) 2012-08-06
US20080280881A1 (en) 2008-11-13
CA2548668A1 (en) 2005-06-30
RS50584B (sr) 2010-05-07
US8883837B2 (en) 2014-11-11
MY143573A (en) 2011-05-31
AP2006003640A0 (en) 2006-06-30
US20070043022A1 (en) 2007-02-22
NO339314B1 (no) 2016-11-28
UA84718C2 (ru) 2008-11-25
KR20070015507A (ko) 2007-02-05
CY1108142T1 (el) 2014-02-12
EP1697345A1 (en) 2006-09-06
EA200601178A1 (ru) 2006-10-27
CA2548668C (en) 2011-09-20
TW200531972A (en) 2005-10-01
NZ547479A (en) 2009-03-31
WO2005058871A1 (en) 2005-06-30
JP4951348B2 (ja) 2012-06-13
EP1697345B1 (en) 2008-03-12
BRPI0417268A (pt) 2007-03-13
ZA200605894B (en) 2008-01-08
BRPI0417268B1 (pt) 2018-10-23
BRPI0417268B8 (pt) 2021-05-25
CN1894237A (zh) 2007-01-10
AU2004298460A1 (en) 2005-06-30
TWI351401B (en) 2011-11-01
ME01042B (me) 2012-10-20
AP2150A (en) 2010-09-04
AU2004298460B2 (en) 2009-03-19
CN101412709A (zh) 2009-04-22
AR046959A1 (es) 2006-01-04
HK1130799A1 (en) 2010-01-08
EA009876B1 (ru) 2008-04-28
DE602004012448D1 (de) 2008-04-24
SI1697345T1 (sl) 2008-08-31
IL175910A0 (en) 2006-10-05
NO20063322L (no) 2006-09-18
KR100967406B1 (ko) 2010-07-01
HRP20080245T3 (hr) 2008-07-31
ES2303653T3 (es) 2008-08-16
US7449463B2 (en) 2008-11-11
IL175910A (en) 2013-08-29
MXPA06007112A (es) 2006-08-23
ATE388950T1 (de) 2008-03-15

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