PT1344779E - Azolo-pirimidinas - Google Patents

Azolo-pirimidinas

Info

Publication number: PT1344779E
Authority: PT; Portugal
Prior art keywords: azolo; pyrimidines; crf; psychiatric; immunological
Prior art date: 1998-01-28

Application number

PT03075887T

Other languages

English (en)

Inventor

Argyrios Georgios Arvanitis

Liqi He

Paul Gilligan

Robert Chorvat

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-01-28

Filing date

1999-01-28

Publication date

2005-10-31

1998-01-28 Priority claimed from US09/015,002 external-priority patent/US6191131B1/en

1998-01-28 Priority claimed from US09/015,001 external-priority patent/US6060478A/en

1998-01-28 Priority claimed from US09/014,734 external-priority patent/US6313124B1/en

1999-01-28 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

2005-10-31 Publication of PT1344779E publication Critical patent/PT1344779E/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Psychiatry (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Hematology (AREA)
Obesity (AREA)
Virology (AREA)
Transplantation (AREA)
Addiction (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Hospice & Palliative Care (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Cardiology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Child & Adolescent Psychology (AREA)
Gynecology & Obstetrics (AREA)

PT03075887T 1998-01-28 1999-01-28 Azolo-pirimidinas PT1344779E (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US09/015,002 US6191131B1 (en)	1997-07-23	1998-01-28	Azolo triazines and pyrimidines
US09/015,001 US6060478A (en)	1996-07-24	1998-01-28	Azolo triazines and pyrimidines
US09/014,734 US6313124B1 (en)	1997-07-23	1998-01-28	Tetrazine bicyclic compounds

Publications (1)

Publication Number	Publication Date
PT1344779E true PT1344779E (pt)	2005-10-31

Family

ID=27360164

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PT99904382T PT1049699E (pt)	1998-01-28	1999-01-28	Pirazolotriazinas como antagonistas de flc
PT03075887T PT1344779E (pt)	1998-01-28	1999-01-28	Azolo-pirimidinas

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
PT99904382T PT1049699E (pt)	1998-01-28	1999-01-28	Pirazolotriazinas como antagonistas de flc

Country Status (19)

Country	Link
EP (2)	EP1049699B1 (pt)
JP (1)	JP4228332B2 (pt)
KR (1)	KR100574313B1 (pt)
CN (2)	CN1542010A (pt)
AT (2)	ATE264860T1 (pt)
AU (1)	AU748818C (pt)
BR (1)	BR9908206A (pt)
CA (2)	CA2614603C (pt)
DE (2)	DE69926665T2 (pt)
DK (2)	DK1344779T3 (pt)
ES (2)	ES2218991T3 (pt)
IL (1)	IL137019A0 (pt)
NZ (2)	NZ524842A (pt)
PL (1)	PL200939B1 (pt)
PT (2)	PT1049699E (pt)
SG (1)	SG111076A1 (pt)
SI (2)	SI1049699T1 (pt)
TW (1)	TW520372B (pt)
WO (1)	WO1999038868A1 (pt)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU4331500A (en)	1999-04-06	2000-10-23	Du Pont Pharmaceuticals Company	Pyrazolotriazines as crf antagonists
US6432989B1 (en)	1999-08-27	2002-08-13	Pfizer Inc	Use of CRF antagonists to treat circadian rhythm disorders
PL354784A1 (en)	1999-09-30	2004-02-23	Neurogen Corporation	Certain alkylene diamine-substituted heterocycles
WO2001023387A2 (en)	1999-09-30	2001-04-05	Neurogen Corporation	CERTAIN ALKYLENE DIAMINE-SUBSTITUTED PYRAZOLO[1,5,-a]-1,5-PYRIMIDINES AND PYRAZOLO[1,5-a]-1,3,5-TRIAZINES
US6525067B1 (en)	1999-11-23	2003-02-25	Pfizer Inc	Substituted heterocyclic derivatives
JP2003533527A (ja) *	2000-05-18	2003-11-11	ニューロクラインバイオサイエンシーズ，インコーポレイテッド	Ｃｒｆレセプターアンタゴニストおよびそれに関連する方法
WO2002010756A2 (en) *	2000-08-02	2002-02-07	Malope Company Limited	Diagnosis and treatment of non-ulcer dyspepsia based on hypothalamic-pituitary-adrenal axis abnormality
ES2282401T3 (es) *	2001-03-13	2007-10-16	Bristol-Myers Squibb Pharma Company	4-(2-butilamino)-2,7-dimetil-8-(2-metil-6-metoxipirid-3-il) pirazolo - 1,5-a-1,3,5-triazina, sus enantiomeros y sales farmaceuticamente aceptables como ligandos del receptor del factor liberador de croticotropina.
FR2842809A1 (fr) *	2002-07-26	2004-01-30	Greenpharma Sas	NOUVELLES PYRAZOLO[1,5-a]-1,3,5-TRIAZINES SUBSTITUEES ET LEURS ANALOGUES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, UTILISATION A TITRE DE MEDICAMENT ET PROCEDES POUR LEUR PREPARATION
US7056920B2 (en) *	2003-04-04	2006-06-06	Pfizer Inc	Pyrrolo[1,2-B]pyridazine compounds and their uses
US7034023B2 (en) *	2003-04-04	2006-04-25	Pfizer Inc	Pyrrolo[1,2-B]pyridazine compounds and their uses
US7737154B2 (en) *	2003-12-22	2010-06-15	Smithkline Beecham (Cork) Limited	CRF receptor antagonists and methods relating thereto
WO2005063756A1 (en) *	2003-12-22	2005-07-14	Sb Pharmco Puerto Rico Inc	Crf receptor antagonists and methods relating thereto
WO2005079868A2 (en) *	2004-02-13	2005-09-01	Sb Pharmco Puerto Rico Inc	Crf receptor antagonists, their preparations, their pharmaceutical composition and their uses
GB0519957D0 (en) *	2005-09-30	2005-11-09	Sb Pharmco Inc	Chemical compound
PE20070855A1 (es) *	2005-12-02	2007-10-14	Bayer Pharmaceuticals Corp	Derivados de 4-amino-pirrolotriazina sustituida como inhibidores de quinasas
US7851468B2 (en) *	2006-05-15	2010-12-14	Cephalon, Inc.	Substituted pyrazolo[3,4-d]pyrimidines
WO2007149938A2 (en)	2006-06-21	2007-12-27	The Salk Institute Biological Studies	Methods for promoting hair growth
CA2672213C (en)	2006-12-22	2016-02-16	Astex Therapeutics Limited	Bicyclic amine derivatives as protein tyrosine kinase inhibitors
MX2009006706A (es)	2006-12-22	2009-07-02	Astex Therapeutics Ltd	Compuestos heterociclicos biciclicos como inhibidores del receptor del factor de crecimiento de fibroblastos.
GB0720038D0 (en)	2007-10-12	2007-11-21	Astex Therapeutics Ltd	New compounds
GB0720041D0 (en)	2007-10-12	2007-11-21	Astex Therapeutics Ltd	New Compounds
GB0810902D0 (en)	2008-06-13	2008-07-23	Astex Therapeutics Ltd	New compounds
GB0906472D0 (en)	2009-04-15	2009-05-20	Astex Therapeutics Ltd	New compounds
GB0906470D0 (en)	2009-04-15	2009-05-20	Astex Therapeutics Ltd	New compounds
US20140206667A1 (en)	2012-11-14	2014-07-24	Michela Gallagher	Methods and compositions for treating schizophrenia
CN104876935B (zh) *	2015-05-18	2017-04-19	南方医科大学	2‑氨基吡咯并[1,2‑f][1,2,4]三嗪类化合物、合成方法及应用
US10407429B2 (en) *	2015-06-24	2019-09-10	Curovir Ab	Pyrazolo[1,5-a]triazin-4-amine derivatives useful in therapy
US20210361664A1 (en)	2017-08-14	2021-11-25	Spruce Biosciences, Inc.	Corticotropin releasing factor receptor antagonists
MX2019015318A (es) *	2017-08-14	2020-07-20	Spruce Biosciences Inc	Antagonistas del receptor del factor liberador de corticotropina.
CN112608316B (zh) *	2019-07-30	2022-10-21	厦门宝太生物科技股份有限公司	一种吡唑并三嗪类腺苷受体拮抗剂
MX2023001688A (es)	2020-08-12	2023-02-22	Spruce Biosciences Inc	Metodos y composiciones para tratar el sindrome de ovario poliquistico.
US11708372B2 (en)	2021-11-19	2023-07-25	Spruce Biosciences, Inc.	Crystalline composition of tildacerfont and methods of use and preparation thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW574214B (en) *	1994-06-08	2004-02-01	Pfizer	Corticotropin releasing factor antagonists
AU716993B2 (en) *	1995-05-12	2000-03-16	Neurogen Corporation	Novel deazapurine derivatives; a new class of CRF1 specific ligands
PT880523E (pt) *	1996-02-07	2007-01-31	Neurocrine Biosciences Inc	Pirazolopirimidinas com antagonistas dos receptores de crf
HU229024B1 (en) *	1996-07-24	2013-07-29	Bristol Myers Squibb Pharma Co	Azolo-pyridimidines, pharmaceutical compositions containing the same and use thereof
JP3621706B2 (ja) *	1996-08-28	2005-02-16	ファイザー・インク	置換された６，５―ヘテロ―二環式誘導体

1999
- 1999-01-28 CA CA2614603A patent/CA2614603C/en not_active Expired - Fee Related
- 1999-01-28 PT PT99904382T patent/PT1049699E/pt unknown
- 1999-01-28 DK DK03075887T patent/DK1344779T3/da active
- 1999-01-28 PT PT03075887T patent/PT1344779E/pt unknown
- 1999-01-28 SG SG200204556A patent/SG111076A1/en unknown
- 1999-01-28 SI SI9930578T patent/SI1049699T1/xx unknown
- 1999-01-28 DK DK99904382T patent/DK1049699T3/da active
- 1999-01-28 BR BR9908206-3A patent/BR9908206A/pt not_active Application Discontinuation
- 1999-01-28 DE DE69926665T patent/DE69926665T2/de not_active Expired - Lifetime
- 1999-01-28 IL IL13701999A patent/IL137019A0/xx unknown
- 1999-01-28 AT AT99904382T patent/ATE264860T1/de active
- 1999-01-28 AU AU24787/99A patent/AU748818C/en not_active Ceased
- 1999-01-28 SI SI9930817T patent/SI1344779T1/sl unknown
- 1999-01-28 PL PL342183A patent/PL200939B1/pl unknown
- 1999-01-28 KR KR1020007008188A patent/KR100574313B1/ko not_active Expired - Fee Related
- 1999-01-28 ES ES99904382T patent/ES2218991T3/es not_active Expired - Lifetime
- 1999-01-28 ES ES03075887T patent/ES2247478T3/es not_active Expired - Lifetime
- 1999-01-28 JP JP2000529335A patent/JP4228332B2/ja not_active Expired - Fee Related
- 1999-01-28 NZ NZ524842A patent/NZ524842A/en not_active IP Right Cessation
- 1999-01-28 AT AT03075887T patent/ATE301657T1/de active
- 1999-01-28 DE DE69916578T patent/DE69916578T2/de not_active Expired - Lifetime
- 1999-01-28 NZ NZ505079A patent/NZ505079A/en not_active IP Right Cessation
- 1999-01-28 WO PCT/US1999/001824 patent/WO1999038868A1/en not_active Ceased
- 1999-01-28 CN CNA2003101225466A patent/CN1542010A/zh active Pending
- 1999-01-28 CA CA002314613A patent/CA2314613C/en not_active Expired - Fee Related
- 1999-01-28 EP EP99904382A patent/EP1049699B1/en not_active Expired - Lifetime
- 1999-01-28 EP EP03075887A patent/EP1344779B1/en not_active Expired - Lifetime
- 1999-01-28 CN CNB998023639A patent/CN1137123C/zh not_active Expired - Fee Related
- 1999-02-23 TW TW088102636A patent/TW520372B/zh not_active IP Right Cessation

Also Published As

Publication number	Publication date
CA2614603C (en)	2011-08-16
IL137019A0 (en)	2001-06-14
JP4228332B2 (ja)	2009-02-25
DK1344779T3 (da)	2005-09-05
SI1049699T1 (en)	2004-10-31
KR100574313B1 (ko)	2006-04-27
WO1999038868A1 (en)	1999-08-05
DK1049699T3 (da)	2004-07-05
SG111076A1 (en)	2005-05-30
CN1289335A (zh)	2001-03-28
CN1137123C (zh)	2004-02-04
BR9908206A (pt)	2000-12-05
PL342183A1 (en)	2001-05-21
AU2478799A (en)	1999-08-16
EP1049699B1 (en)	2004-04-21
SI1344779T1 (sl)	2006-02-28
ES2247478T3 (es)	2006-03-01
JP2002501922A (ja)	2002-01-22
HK1060348A1 (en)	2004-08-06
DE69926665D1 (de)	2005-09-15
ES2218991T3 (es)	2004-11-16
PL200939B1 (pl)	2009-02-27
ATE301657T1 (de)	2005-08-15
NZ524842A (en)	2003-10-31
DE69926665T2 (de)	2006-06-08
KR20010040426A (ko)	2001-05-15
CN1542010A (zh)	2004-11-03
EP1049699A1 (en)	2000-11-08
CA2614603A1 (en)	1999-08-05
CA2314613C (en)	2009-12-08
DE69916578T2 (de)	2005-03-31
TW520372B (en)	2003-02-11
ATE264860T1 (de)	2004-05-15
CA2314613A1 (en)	1999-08-05
AU748818B2 (en)	2002-06-13
EP1344779A1 (en)	2003-09-17
NZ505079A (en)	2003-08-29
AU748818C (en)	2003-11-20
PT1049699E (pt)	2004-08-31
EP1344779B1 (en)	2005-08-10
DE69916578D1 (de)	2004-05-27

Publication	Publication Date	Title
ATE301657T1 (de)	2005-08-15	Azolo-pyrimidine
LV12292A (lv)	1999-06-20	Triazinu un pirimidinu azoloatvasinajumi
ATE255896T1 (de)	2003-12-15	Tetrahydropteridine und pyridylpiperazine zur behandlung von neurologischen störungen
BR9814458A (pt)	2001-10-23	Composto, composição farmacêutica e método de tratamento de disfunções afetivas
MY132871A (en)	2007-10-31	Imidazopyrimidines and imidazopyridines for the treatment of neurological disorders
LV12262A (lv)	1999-04-20	Ar arilaminu kondenseti piridini un pirimidini
BR9307646A (pt)	1999-05-25	Pirrolopirimidinas como antagonistas de crf
PT1140929E (pt)	2004-02-27	1h-imidazo¬4,5-d\|piridazin-7-onas 3h-imidazo¬4,5-c\|piridin-4-onas e as tionas correspondentes como ligandos receptores do factor de libertacao de corticotrofina (flc)
DE69519997D1 (de)	2001-03-01	Verwendung von bindungsreagenzien gegen cd23 in der behandlung von autoimmunkrankheiten
MY146935A (en)	2012-10-15	4-(2-BUTYLAMINO-2, 7-DIMETHYL-8-(2-METHYL-6-METHOXYPYRID-3-yl) PYRAZOLO-[1,5-a]-1,3,5-TRIAZINE, ITS ENANTIOMERS AND PHARMACEUTICALLY ACCEPTABLE SALTS AS CORTICOTROPIN RELEASING FACTOR RECEPTOR LIGANDS
WO2002004453A3 (en)	2002-06-13	PYRROLO[3,4-d]PYRIMIDINES AS CORTICOTROPIN RELEASING FACTOR (CRF) ANTAGONISTS
ATE113591T1 (de)	1994-11-15	4-benzyl-5-phenyl-2,4-dihydro-3h-1,2,4-triazol- - one und ihre verwendung als antikonvulsiva.
MY141752A (en)	2010-06-30	Pyrazolotriazines as crf antagonists
MY141976A (en)	2010-08-16	Azolo triazines and pyrimidines
MY141511A (en)	2010-05-14	Azolo triazines and pyrimidines
Manelis et al.	2000	Neuropsychological model of brain organization of higher psychic functions in children suffering bronchial asthma