PT1229040E - Derivados nucleosido-monofosfato processo para a sua producao e sua utilizacao como farmacos imunossupressores - Google Patents

Derivados nucleosido-monofosfato processo para a sua producao e sua utilizacao como farmacos imunossupressores

Info

Publication number: PT1229040E
Authority: PT; Portugal
Prior art keywords: desoxy; chain; immunosupressors; pharmacos; nucleoside
Prior art date: 1994-05-28

Application number

PT02008360T

Other languages

English (en)

Inventor

Harald Zilch

Dieter Herrmann

Alfred Mertens

Original Assignee

Heidelberg Pharma Holding Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-05-28

Filing date

1995-05-23

Publication date

2003-12-31

1995-05-23 Application filed by Heidelberg Pharma Holding Gmbh filed Critical Heidelberg Pharma Holding Gmbh

2003-12-31 Publication of PT1229040E publication Critical patent/PT1229040E/pt

Links

125000000217 alkyl group Chemical group 0.000 abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 2
229920006395 saturated elastomer Polymers 0.000 abstract 2
AYWFLOPQIYDGTP-RJDJZVBFSA-N (2R,3S,4R,5R)-4-amino-5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol 4-amino-1-[(2R,3R,4S,5R)-3-azido-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one (2R,3S,5R)-5-(6-amino-2-fluoropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol (2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-azido-2-(hydroxymethyl)oxolan-3-ol 5-fluoro-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione Chemical compound FC=1N=C(C=2N=CN([C@H]3C[C@H](O)[C@@H](CO)O3)C2N1)N.FC=1C(NC(N([C@H]2C[C@H](O)[C@@H](CO)O2)C1)=O)=O.N(=[N+]=[N-])[C@H]1[C@@H](O[C@@H]([C@H]1O)CO)N1C(=O)N=C(N)C=C1.N(=[N+]=[N-])[C@H]1[C@@H](O[C@@H]([C@H]1O)CO)N1C=NC=2C(N)=NC=NC12.N[C@H]1[C@@H](O[C@@H]([C@H]1O)CO)N1C=NC=2C(N)=NC=NC12 AYWFLOPQIYDGTP-RJDJZVBFSA-N 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
150000007522 mineralic acids Chemical class 0.000 abstract 1
239000002777 nucleoside Substances 0.000 abstract 1
-1 nucleoside monophosphate Chemical class 0.000 abstract 1
150000007524 organic acids Chemical class 0.000 abstract 1
235000005985 organic acids Nutrition 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 abstract 1
125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
239000011593 sulfur Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Oncology (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Hematology (AREA)
Transplantation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

PT02008360T 1994-05-28 1995-05-23 Derivados nucleosido-monofosfato processo para a sua producao e sua utilizacao como farmacos imunossupressores PT1229040E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4418690A DE4418690A1 (de)	1994-05-28	1994-05-28	Neue Lipidester von Nucleosid-Monophosphaten und deren Verwendung als immunsuppressive Arzneimittel

Publications (1)

Publication Number	Publication Date
PT1229040E true PT1229040E (pt)	2003-12-31

Family

ID=6519215

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PT95920864T PT763049E (pt)	1994-05-28	1995-05-23	DERIVADOS DE MONOFOSFATOS DE NUCLEóSIDOS, UM PROCESSO PARA A SUA PRODUCAO E O SEU USO COMO MEDICAMENTOS IMUNOSSUPRESSORES
PT02008360T PT1229040E (pt)	1994-05-28	1995-05-23	Derivados nucleosido-monofosfato processo para a sua producao e sua utilizacao como farmacos imunossupressores

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
PT95920864T PT763049E (pt)	1994-05-28	1995-05-23	DERIVADOS DE MONOFOSFATOS DE NUCLEóSIDOS, UM PROCESSO PARA A SUA PRODUCAO E O SEU USO COMO MEDICAMENTOS IMUNOSSUPRESSORES

Country Status (27)

Country	Link
US (1)	US6025343A (pt)
EP (2)	EP0763049B1 (pt)
JP (1)	JP3802057B2 (pt)
KR (1)	KR100279087B1 (pt)
CN (1)	CN1168735C (pt)
AT (2)	ATE249472T1 (pt)
AU (1)	AU688516B2 (pt)
BR (1)	BR9507785A (pt)
CA (1)	CA2190983C (pt)
CZ (1)	CZ291846B6 (pt)
DE (3)	DE4418690A1 (pt)
DK (2)	DK0763049T3 (pt)
ES (2)	ES2199250T3 (pt)
FI (1)	FI117673B (pt)
HU (1)	HU220336B (pt)
IL (1)	IL113865A (pt)
MX (1)	MX9605809A (pt)
NO (1)	NO308998B1 (pt)
NZ (1)	NZ287434A (pt)
PL (1)	PL185290B1 (pt)
PT (2)	PT763049E (pt)
RU (1)	RU2165429C2 (pt)
SK (1)	SK284207B6 (pt)
TW (1)	TW420686B (pt)
UA (1)	UA45339C2 (pt)
WO (1)	WO1995032984A1 (pt)
ZA (1)	ZA954374B (pt)

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US6734294B2 (en) *	2001-01-22	2004-05-11	Chad C. Nelson	Isotopically enriched nucleic acids and associated methods for the production and purification thereof
JP2005525991A (ja)	2001-05-16	2005-09-02	マイジェニックスインコーポレイテッド	核酸ベースの化合物およびその使用方法
CN1615314A (zh) *	2001-11-21	2005-05-11	海德堡医药有限责任公司	用作抗肿瘤药的核苷的磷脂衍生物
EP1831225A2 (en)	2004-11-19	2007-09-12	The Regents of the University of California	Anti-inflammatory pyrazolopyrimidines
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EP1831235B1 (en)	2004-12-16	2013-02-20	The Regents of The University of California	Lung-targeted drugs
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EP2004654B1 (en)	2006-04-04	2013-05-22	The Regents of the University of California	Pyrazolopyrimidine derivatives for use as kinase antagonists
GB0608876D0 (en)	2006-05-05	2006-06-14	Medivir Ab	Combination therapy
US7378401B2 (en) *	2006-07-14	2008-05-27	Heidelberg Pharma Gmbh	Use of Fosfluridine Tidoxil (FT) for the treatment of intraepithelial proliferative diseases
WO2009009625A2 (en)	2007-07-09	2009-01-15	Eastern Virginia Medical School	Substituted nucleoside derivatives with antiviral and antimicrobial properties
WO2009046448A1 (en)	2007-10-04	2009-04-09	Intellikine, Inc.	Chemical entities and therapeutic uses thereof
US8193182B2 (en)	2008-01-04	2012-06-05	Intellikine, Inc.	Substituted isoquinolin-1(2H)-ones, and methods of use thereof
MX2010007419A (es)	2008-01-04	2010-11-12	Intellikine Inc	Ciertas entidades quimicas, composiciones y metodos.
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JP5547099B2 (ja)	2008-03-14	2014-07-09	インテリカイン，エルエルシー	キナーゼ阻害剤および使用方法
US20110224223A1 (en)	2008-07-08	2011-09-15	The Regents Of The University Of California, A California Corporation	MTOR Modulators and Uses Thereof
US9096611B2 (en)	2008-07-08	2015-08-04	Intellikine Llc	Kinase inhibitors and methods of use
JP5731978B2 (ja)	2008-09-26	2015-06-10	インテリカイン，エルエルシー	複素環キナーゼ阻害剤
AU2009305669A1 (en)	2008-10-16	2010-04-22	The Regents Of The University Of California	Fused ring heteroaryl kinase inhibitors
US8476431B2 (en)	2008-11-03	2013-07-02	Itellikine LLC	Benzoxazole kinase inhibitors and methods of use
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WO2011047384A2 (en)	2009-10-16	2011-04-21	The Regents Of The University Of California	Methods of inhibiting ire1
CN103002738A (zh)	2010-05-21	2013-03-27	英特利凯恩有限责任公司	用于激酶调节的化学化合物、组合物和方法
JP2013545749A (ja)	2010-11-10	2013-12-26	インフィニティーファーマシューティカルズ，インコーポレイテッド	複素環化合物及びその使用
US8809349B2 (en)	2011-01-10	2014-08-19	Infinity Pharmaceuticals, Inc.	Processes for preparing isoquinolinones and solid forms of isoquinolinones
CN103491962B (zh)	2011-02-23	2016-10-12	因特利凯有限责任公司	激酶抑制剂的组合及其用途
TWI565709B (zh)	2011-07-19	2017-01-11	英菲尼提製藥股份有限公司	雜環化合物及其用途
US8969363B2 (en)	2011-07-19	2015-03-03	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof
SG11201400310WA (en)	2011-08-29	2014-06-27	Infinity Pharmaceuticals Inc	Heterocyclic compounds and uses thereof
EP2751112B1 (en)	2011-09-02	2019-10-09	The Regents of The University of California	Substituted pyrazolo[3,4-d]pyrimidines and uses thereof
US8940742B2 (en)	2012-04-10	2015-01-27	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof
US8828998B2 (en)	2012-06-25	2014-09-09	Infinity Pharmaceuticals, Inc.	Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
CA2886240A1 (en)	2012-09-26	2014-04-03	The Regents Of The University Of California	Modulation of ire1
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BR112015023705A8 (pt)	2013-03-15	2020-03-17	Univ California	compostos, composições farmacêuticas, usos de um composto, e método para síntese do composto da fórmula (ia)
WO2015051241A1 (en)	2013-10-04	2015-04-09	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof
CN105793255B (zh)	2013-10-04	2018-11-16	无限药品股份有限公司	杂环化合物及其用途
MX382033B (es)	2014-03-19	2025-03-13	Infinity Pharmaceuticals Inc	Compuestos heterocíclicos para utilizarlos en el tratamiento de trastornos mediados por pi3k-gamma.
US20150320755A1 (en)	2014-04-16	2015-11-12	Infinity Pharmaceuticals, Inc.	Combination therapies
DE102014112055A1 (de) *	2014-08-22	2016-02-25	Universität Hamburg	Di- und Triphosphat-Propharmaka
CN106795188B (zh)	2014-09-15	2021-02-09	加利福尼亚大学董事会	核苷酸类似物
WO2016054491A1 (en)	2014-10-03	2016-04-07	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof
US10160761B2 (en)	2015-09-14	2018-12-25	Infinity Pharmaceuticals, Inc.	Solid forms of isoquinolinones, and process of making, composition comprising, and methods of using the same
EP3350191B9 (en)	2015-09-15	2021-12-22	The Regents of the University of California	Nucleotide analogs
US10759806B2 (en)	2016-03-17	2020-09-01	Infinity Pharmaceuticals, Inc.	Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as PI3K kinase inhibitors
US10919914B2 (en)	2016-06-08	2021-02-16	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof
RU2754507C2 (ru)	2016-06-24	2021-09-02	Инфинити Фармасьютикалз, Инк.	Комбинированная терапия
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1994
- 1994-05-28 DE DE4418690A patent/DE4418690A1/de not_active Withdrawn
1995
- 1995-05-23 NZ NZ287434A patent/NZ287434A/en not_active IP Right Cessation
- 1995-05-23 DK DK95920864T patent/DK0763049T3/da active
- 1995-05-23 HU HU9603269A patent/HU220336B/hu not_active IP Right Cessation
- 1995-05-23 EP EP95920864A patent/EP0763049B1/en not_active Expired - Lifetime
- 1995-05-23 KR KR1019960706690A patent/KR100279087B1/ko not_active Expired - Fee Related
- 1995-05-23 DK DK02008360T patent/DK1229040T3/da active
- 1995-05-23 DE DE69530197T patent/DE69530197T2/de not_active Expired - Fee Related
- 1995-05-23 BR BR9507785A patent/BR9507785A/pt not_active Application Discontinuation
- 1995-05-23 RU RU96124383/04A patent/RU2165429C2/ru active
- 1995-05-23 PT PT95920864T patent/PT763049E/pt unknown
- 1995-05-23 AU AU26154/95A patent/AU688516B2/en not_active Ceased
- 1995-05-23 PT PT02008360T patent/PT1229040E/pt unknown
- 1995-05-23 MX MX9605809A patent/MX9605809A/es not_active IP Right Cessation
- 1995-05-23 CA CA002190983A patent/CA2190983C/en not_active Expired - Fee Related
- 1995-05-23 CZ CZ19963477A patent/CZ291846B6/cs not_active IP Right Cessation
- 1995-05-23 CN CNB951943715A patent/CN1168735C/zh not_active Expired - Fee Related
- 1995-05-23 SK SK1518-96A patent/SK284207B6/sk not_active IP Right Cessation
- 1995-05-23 JP JP50026296A patent/JP3802057B2/ja not_active Expired - Fee Related
- 1995-05-23 WO PCT/EP1995/001951 patent/WO1995032984A1/en not_active Ceased
- 1995-05-23 AT AT02008360T patent/ATE249472T1/de not_active IP Right Cessation
- 1995-05-23 EP EP02008360A patent/EP1229040B8/en not_active Expired - Lifetime
- 1995-05-23 AT AT95920864T patent/ATE236189T1/de not_active IP Right Cessation
- 1995-05-23 ES ES95920864T patent/ES2199250T3/es not_active Expired - Lifetime
- 1995-05-23 DE DE69531749T patent/DE69531749T2/de not_active Expired - Fee Related
- 1995-05-23 ES ES02008360T patent/ES2206429T3/es not_active Expired - Lifetime
- 1995-05-23 UA UA96114469A patent/UA45339C2/uk unknown
- 1995-05-24 TW TW084105233A patent/TW420686B/zh active
- 1995-05-25 IL IL113865A patent/IL113865A/en not_active IP Right Cessation
- 1995-05-29 ZA ZA954374A patent/ZA954374B/xx unknown
1996
- 1996-11-21 PL PL95317380A patent/PL185290B1/pl not_active IP Right Cessation
- 1996-11-27 NO NO965054A patent/NO308998B1/no not_active IP Right Cessation
- 1996-11-27 US US08/753,633 patent/US6025343A/en not_active Expired - Fee Related
- 1996-11-27 FI FI964727A patent/FI117673B/fi active IP Right Grant

Also Published As

Publication number	Publication date
CA2190983C (en)	2006-08-15
WO1995032984A8 (en)	2003-01-16
FI964727A0 (fi)	1996-11-27
PL185290B1 (pl)	2003-04-30
DE69531749T2 (de)	2004-07-29
EP1229040B8 (en)	2003-11-05
AU688516B2 (en)	1998-03-12
RU2165429C2 (ru)	2001-04-20
EP1229040A2 (en)	2002-08-07
FI117673B (fi)	2007-01-15
IL113865A0 (en)	1995-08-31
EP1229040B1 (en)	2003-09-10
ZA954374B (en)	1996-11-29
SK284207B6 (en)	2004-11-03
CZ347796A3 (en)	1997-04-16
SK151896A3 (en)	1997-06-04
ATE249472T1 (de)	2003-09-15
AU2615495A (en)	1995-12-21
NO965054L (no)	1997-01-28
UA45339C2 (uk)	2002-04-15
HU9603269D0 (en)	1997-01-28
PL317380A1 (en)	1997-04-01
WO1995032984A1 (en)	1995-12-07
MX9605809A (es)	1997-12-31
CN1168735C (zh)	2004-09-29
KR100279087B1 (ko)	2001-01-15
CZ291846B6 (cs)	2003-06-18
PT763049E (pt)	2003-08-29
DE4418690A1 (de)	1996-01-11
US6025343A (en)	2000-02-15
NO308998B1 (no)	2000-11-27
HU220336B (hu)	2001-12-28
JP3802057B2 (ja)	2006-07-26
DE69530197D1 (de)	2003-05-08
DE69530197T2 (de)	2004-01-29
TW420686B (en)	2001-02-01
BR9507785A (pt)	1997-09-23
ES2199250T3 (es)	2004-02-16
DK0763049T3 (da)	2003-07-28
JPH10500964A (ja)	1998-01-27
DE69531749D1 (de)	2003-10-16
EP0763049B1 (en)	2003-04-02
CA2190983A1 (en)	1995-12-07
HUT75340A (en)	1997-05-28
NO965054D0 (no)	1996-11-27
NZ287434A (en)	1998-01-26
KR970703354A (ko)	1997-07-03
CN1154111A (zh)	1997-07-09
IL113865A (en)	2008-12-29
ATE236189T1 (de)	2003-04-15
DK1229040T3 (da)	2003-12-22
ES2206429T3 (es)	2004-05-16
EP0763049A1 (en)	1997-03-19
EP1229040A3 (en)	2002-08-21
FI964727L (fi)	1996-11-27

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