[go: up one dir, main page]

PT1146863E - IMPROVED WITH AN IMPROVED RECONSTITUTION CAPACITY - Google Patents

IMPROVED WITH AN IMPROVED RECONSTITUTION CAPACITY

Info

Publication number
PT1146863E
PT1146863E PT00906226T PT00906226T PT1146863E PT 1146863 E PT1146863 E PT 1146863E PT 00906226 T PT00906226 T PT 00906226T PT 00906226 T PT00906226 T PT 00906226T PT 1146863 E PT1146863 E PT 1146863E
Authority
PT
Portugal
Prior art keywords
improved
reconstitution capacity
capacity
reconstitution
lyophilisates
Prior art date
Application number
PT00906226T
Other languages
Portuguese (pt)
Inventor
Thekla Kurz
Ludwig Kruger
Brigitte Hesse
Arnd Karnatz
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of PT1146863E publication Critical patent/PT1146863E/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B5/00—Drying solid materials or objects by processes not involving the application of heat
    • F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
    • F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/402—1-aryl substituted, e.g. piretanide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Mechanical Engineering (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Waveguide Aerials (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)

Abstract

The present invention relates to lyophilisates having an improved dissolution rate which can be reconstituted in a particle-free manner, which is achieved by re-warming the solutions already drawn off to from 30° to 95° C. directly in the freeze drier.
PT00906226T 1999-01-28 2000-01-26 IMPROVED WITH AN IMPROVED RECONSTITUTION CAPACITY PT1146863E (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19903275A DE19903275A1 (en) 1999-01-28 1999-01-28 Lyophilisates with improved reconstitutability

Publications (1)

Publication Number Publication Date
PT1146863E true PT1146863E (en) 2004-10-29

Family

ID=7895601

Family Applications (1)

Application Number Title Priority Date Filing Date
PT00906226T PT1146863E (en) 1999-01-28 2000-01-26 IMPROVED WITH AN IMPROVED RECONSTITUTION CAPACITY

Country Status (21)

Country Link
US (1) US6770678B1 (en)
EP (1) EP1146863B1 (en)
JP (2) JP4562288B2 (en)
KR (1) KR20010108136A (en)
AT (1) ATE266387T1 (en)
AU (1) AU757781B2 (en)
BR (1) BRPI0007714B8 (en)
CA (1) CA2361237C (en)
CZ (1) CZ20012693A3 (en)
DE (2) DE19903275A1 (en)
DK (1) DK1146863T3 (en)
ES (1) ES2220404T3 (en)
HU (1) HU226585B1 (en)
NO (1) NO331321B1 (en)
PL (1) PL351140A1 (en)
PT (1) PT1146863E (en)
RU (1) RU2225709C2 (en)
SK (1) SK10542001A3 (en)
UA (1) UA70351C2 (en)
WO (1) WO2000044354A1 (en)
ZA (1) ZA200107081B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2412306T3 (en) 2002-01-09 2013-07-11 Emisphere Technologies, Inc. Sodium 4 - ((4-Chloro-2-hydroxybenzoyl) amino) butanoate polymorphs
DE102004045825A1 (en) * 2004-09-22 2006-03-23 Merck Patent Gmbh Lyophilisate containing N-diaminomethylene-2-methyl-4,5-di (methylsulfonyl) benzamide
US8158152B2 (en) * 2005-11-18 2012-04-17 Scidose Llc Lyophilization process and products obtained thereby
RU2299063C1 (en) * 2006-03-03 2007-05-20 Федеральное государственное учреждение науки "Московский научно-исследовательский институт эпидемиологии и микробиологии имени Г.Н. Габричевского Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека" (ФГУН МНИИЭМ им. Г.Н. Габричевского Роспотребнадзора) Method for drying of thermolabile biologically active preparation
JP5634985B2 (en) 2008-05-09 2014-12-03 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ Pharmaceutical composition comprising limepolido for treating diseases associated with insulin resistance and β-cell dysfunction
WO2009152168A2 (en) * 2008-06-09 2009-12-17 Awd. Pharma Gmbh & Co. Kg Carboxylic acid salts of 2-amino-3-carbethoxyamino-6-(4-fluoro-benzylamino)-pyridine
US7795263B2 (en) * 2008-07-08 2010-09-14 Wildlife Laboratories, Inc. Pharmaceutical combination for and method of anesthetizing and immobilizing non-domesticated mammals
TW201920174A (en) * 2017-09-27 2019-06-01 瑞士商羅氏大藥廠股份有限公司 Pharmaceutical forms of diazabicyclooctane derivatives and manufacturing method thereof
US11679083B2 (en) 2017-12-28 2023-06-20 Fujifilm Toyama Chemical Co., Ltd. Method for producing freeze-dried formulation

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4002748A (en) * 1976-01-19 1977-01-11 Eli Lilly And Company Method of preparing sterile essentially amorphous cefazolin for reconstitution for parenteral administration
JPH07114946B2 (en) * 1988-10-24 1995-12-13 株式会社奈良機械製作所 Treatment method for sparingly soluble substances
US5066647A (en) * 1989-04-20 1991-11-19 Erbamont, Inc. Cyclophosphamide - alanine lyophilizates
ATE147375T1 (en) * 1992-09-22 1997-01-15 Hoechst Ag BENZOYLGUANIDINES, METHOD FOR THE PRODUCTION THEREOF, AND THEIR USE AS ANTIARRHYTHMICS
JP2747967B2 (en) * 1993-07-23 1998-05-06 雪印乳業株式会社 Sialic acid powder
ZA949182B (en) * 1993-12-02 1995-07-26 South African Druggists Ltd Pharmaceutical composition
DE4430861A1 (en) * 1994-08-31 1996-03-07 Merck Patent Gmbh Heterocyclyl-benzoylguanidines
RU2105569C1 (en) * 1995-06-05 1998-02-27 Индивидуальное частное предприятие Фирма "Брынцалов" Method of preparing medicinal formula of antitumor antibiotic
DE19529612A1 (en) * 1995-08-11 1997-02-13 Merck Patent Gmbh Sulfonyl or sulfinyl benzoylguanidine derivatives
RU2111426C1 (en) * 1995-11-03 1998-05-20 Государственный научный центр вирусологии и биотехнологии "Вектор" Method of lyophilic drying of biological preparation
JPH09183729A (en) * 1995-12-29 1997-07-15 Meiji Milk Prod Co Ltd Antitumor pharmaceutical composition containing lyophilized uracil

Also Published As

Publication number Publication date
EP1146863B1 (en) 2004-05-12
DK1146863T3 (en) 2004-08-30
NO20013703L (en) 2001-07-27
DE19903275A1 (en) 2000-08-03
HUP0105493A2 (en) 2002-06-29
KR20010108136A (en) 2001-12-07
AU757781B2 (en) 2003-03-06
JP4562288B2 (en) 2010-10-13
CZ20012693A3 (en) 2002-01-16
BR0007714A (en) 2001-11-27
JP2010264249A (en) 2010-11-25
ATE266387T1 (en) 2004-05-15
DE50006404D1 (en) 2004-06-17
JP2002535089A (en) 2002-10-22
US6770678B1 (en) 2004-08-03
PL351140A1 (en) 2003-03-24
BR0007714B1 (en) 2014-09-30
HUP0105493A3 (en) 2006-07-28
SK10542001A3 (en) 2002-01-07
NO20013703D0 (en) 2001-07-27
ES2220404T3 (en) 2004-12-16
NO331321B1 (en) 2011-11-21
RU2225709C2 (en) 2004-03-20
CA2361237A1 (en) 2000-08-03
BRPI0007714B8 (en) 2021-05-25
AU2798600A (en) 2000-08-18
UA70351C2 (en) 2004-10-15
WO2000044354A1 (en) 2000-08-03
CA2361237C (en) 2008-07-15
ZA200107081B (en) 2003-02-26
EP1146863A1 (en) 2001-10-24
HU226585B1 (en) 2009-04-28

Similar Documents

Publication Publication Date Title
DE60003687D1 (en) DISHWASHER WITH IMPROVED ARCHITECTURE
DE60045814D1 (en) VACUUM CLEANER WITH CYCLONE.AUMINATOR
PT1146863E (en) IMPROVED WITH AN IMPROVED RECONSTITUTION CAPACITY
ATE550618T1 (en) HEAT EXCHANGER ARRANGEMENT
ATE342957T1 (en) DETERGENT MOLDED BODY WITH VISCOELASTIC PHASE
GB9903285D0 (en) Self-sealing non drip,easy to store compact umbrella that rights itself when blown inside out in the wind
IT1318121B1 (en) INJECTION LANCE, PARTICULARLY FOR THE INJECTION OF DUST OR PARTICULATE SUBSTANCES, INSIDE ELECTRIC OVENS FOR THE
YU31697A (en) Aprotinin variants having improved properties
SE0001800D0 (en) Refrigerator with a shelf
ITMI20001498A0 (en) DEVICE FOR ALIGNMENT, WITH STRAIGHT ARRANGEMENT OF THE EDGES, OF PACKETS OF FLAT RECTANGULAR WORKPIECES.
ATE328145T1 (en) CLOTHING SHIELD
ZA997569B (en) Airtight high humidity cold storage with drawers.
ITRM990413A0 (en) DIFFERENTIAL FOR DOLLY, PARTICULARLY FOR SHOOTING IN THE CINEMATIC AND TELEVISION FIELD.
Fischer Ingvarsstenarna i tid och rum
IT1308806B1 (en) PADLOCK EQUIPPED WITH MEANS TO PREVENT THE INTRODUCTION OF CORPIOD FOREIGN AGENTS.
DK199900501A (en) Lid with suction & trachea
DK1068783T3 (en) Centrifugal spreader with two discs
TR199901459A3 (en) Vacuum cleaner mouth.
IT246612Y1 (en) STRUCTURE OF DISASSEMBLY TROLLEY EQUIPPED WITH MORE BASKETS PARTICULARLY STUDIED FOR DOMESTIC USE.
IT248329Y1 (en) PLASTIC ICE-STOP DISK WITH AIBICCHIERI APPLICATION HOOK, EVEN IN PLASTIC. ON ONE SIDE OF THE DISK, THERE WILL BE
IT1316542B1 (en) SKI ATTACK OF THE TYPE WITH BOOT HANGER PIN.
IT1310023B1 (en) REFRIGERATED COUNTER.
TR199902544A3 (en) Evaporation container that can be used in every model refrigerator.
ITVI990071A0 (en) VIDEO CASSETTE CONTAINER WITH HIGH RESISTANCE TO OPENING.
木村留美子 et al. The influence of experience on nurse self-evaluation, in the context of self-imag ePart1