[go: up one dir, main page]

PL3597038T3 - Humanizowane gryzonie wykazujące ekspresję łańcuchów ciężkich zawierających domeny vl - Google Patents

Humanizowane gryzonie wykazujące ekspresję łańcuchów ciężkich zawierających domeny vl

Info

Publication number
PL3597038T3
PL3597038T3 PL19191081T PL19191081T PL3597038T3 PL 3597038 T3 PL3597038 T3 PL 3597038T3 PL 19191081 T PL19191081 T PL 19191081T PL 19191081 T PL19191081 T PL 19191081T PL 3597038 T3 PL3597038 T3 PL 3597038T3
Authority
PL
Poland
Prior art keywords
domains
heavy chains
chains containing
express heavy
humanized rodents
Prior art date
Application number
PL19191081T
Other languages
English (en)
Inventor
Lynn Macdonald
Cagan Gurer
Karolina A Meagher
Sean Stevens
Andrew J Murphy
Original Assignee
Regeneron Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharmaceuticals, Inc. filed Critical Regeneron Pharmaceuticals, Inc.
Publication of PL3597038T3 publication Critical patent/PL3597038T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/462—Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2318/00—Antibody mimetics or scaffolds
    • C07K2318/10—Immunoglobulin or domain(s) thereof as scaffolds for inserted non-Ig peptide sequences, e.g. for vaccination purposes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/20—Pseudochromosomes, minichrosomosomes
    • C12N2800/204—Pseudochromosomes, minichrosomosomes of bacterial origin, e.g. BAC
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24046—Adamalysin (3.4.24.46)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Environmental Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Steroid Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Central Heating Systems (AREA)
  • Housing For Livestock And Birds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PL19191081T 2012-02-01 2013-02-01 Humanizowane gryzonie wykazujące ekspresję łańcuchów ciężkich zawierających domeny vl PL3597038T3 (pl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261593463P 2012-02-01 2012-02-01
US201261677538P 2012-07-31 2012-07-31
EP19191081.9A EP3597038B1 (en) 2012-02-01 2013-02-01 Humanized rodents that express heavy chains containing vl domains
EP13704329.5A EP2809150B1 (en) 2012-02-01 2013-02-01 Humanized mice that express heavy chains containing vl domains
PCT/US2013/024295 WO2013116609A1 (en) 2012-02-01 2013-02-01 Humanized rodents that express heavy chains containing vl domains

Publications (1)

Publication Number Publication Date
PL3597038T3 true PL3597038T3 (pl) 2021-11-08

Family

ID=47714588

Family Applications (2)

Application Number Title Priority Date Filing Date
PL13704329T PL2809150T3 (pl) 2012-02-01 2013-02-01 Humanizowane myszy wykazujące ekspresję łańcuchów ciężkich zawierających domeny VL
PL19191081T PL3597038T3 (pl) 2012-02-01 2013-02-01 Humanizowane gryzonie wykazujące ekspresję łańcuchów ciężkich zawierających domeny vl

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL13704329T PL2809150T3 (pl) 2012-02-01 2013-02-01 Humanizowane myszy wykazujące ekspresję łańcuchów ciężkich zawierających domeny VL

Country Status (26)

Country Link
US (3) US20130212719A1 (pl)
EP (3) EP3912465A1 (pl)
JP (6) JP2015505477A (pl)
KR (2) KR20140123983A (pl)
CN (2) CN104202971B (pl)
AU (3) AU2013204758B2 (pl)
BR (1) BR112014018843B1 (pl)
CA (1) CA2863175A1 (pl)
CY (2) CY1122419T1 (pl)
DK (2) DK3597038T3 (pl)
ES (2) ES2870703T3 (pl)
HR (2) HRP20192218T1 (pl)
HU (2) HUE055610T2 (pl)
IL (3) IL233827A0 (pl)
LT (2) LT3597038T (pl)
ME (1) ME03611B (pl)
MX (2) MX2020003491A (pl)
NZ (5) NZ810648A (pl)
PL (2) PL2809150T3 (pl)
PT (2) PT2809150T (pl)
RS (2) RS62023B1 (pl)
RU (2) RU2664185C2 (pl)
SG (3) SG10201913428QA (pl)
SI (2) SI3597038T1 (pl)
SM (2) SMT201900685T1 (pl)
WO (1) WO2013116609A1 (pl)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20110020860A (ko) * 2008-05-23 2011-03-03 알리바 바이오파마수티컬스, 아이엔씨. 유전자 삽입동물에서 단일 ｖｌ 도메인 항체를 생산하는 방법
EP2798950B2 (en) 2009-07-08 2023-03-22 Kymab Limited Animal models and therapeutic molecules
US9445581B2 (en) 2012-03-28 2016-09-20 Kymab Limited Animal models and therapeutic molecules
CN103154255B (zh) 2010-08-02 2016-04-06 瑞泽恩制药公司 制造包含vl结构域的结合蛋白的小鼠
SI2739740T1 (sl) 2011-08-05 2019-12-31 Regeneron Pharmaceuticals, Inc. Humanizirane univerzalne lahkoverižne miši
BR112014006390A2 (pt) 2011-09-19 2017-03-28 Kymab Ltd anticorpos, domínios variáveis e cadeias feitos especialmente para uso humano
EP2761008A1 (en) 2011-09-26 2014-08-06 Kymab Limited Chimaeric surrogate light chains (slc) comprising human vpreb
US9253965B2 (en) 2012-03-28 2016-02-09 Kymab Limited Animal models and therapeutic molecules
GB201122047D0 (en) * 2011-12-21 2012-02-01 Kymab Ltd Transgenic animals
HRP20190897T1 (hr) 2011-12-20 2019-09-20 Regeneron Pharmaceuticals, Inc. Laki lanac humaniziranih miševa
ME03611B (me) * 2012-02-01 2020-07-20 Regeneron Pharma Humanizovani miševi koji eksprimiraju teške lance koji sadrže vl domene
US10251377B2 (en) 2012-03-28 2019-04-09 Kymab Limited Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies
GB2502127A (en) 2012-05-17 2013-11-20 Kymab Ltd Multivalent antibodies and in vivo methods for their production
KR102484480B1 (ko) 2012-06-12 2023-01-04 리제너론 파마슈티칼스 인코포레이티드 제한된 면역글로불린 중쇄 유전자좌를 가지는 인간화된 비-인간 동물
HRP20181151T1 (hr) 2013-02-20 2018-09-21 Regeneron Pharmaceuticals, Inc. Neljudske životinje s modificiranim sekvencama imunoglobulinskog teškog lanca
US9788534B2 (en) 2013-03-18 2017-10-17 Kymab Limited Animal models and therapeutic molecules
US9783618B2 (en) 2013-05-01 2017-10-10 Kymab Limited Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics
US11707056B2 (en) 2013-05-02 2023-07-25 Kymab Limited Animals, repertoires and methods
US9783593B2 (en) 2013-05-02 2017-10-10 Kymab Limited Antibodies, variable domains and chains tailored for human use
EP3051942B1 (en) 2013-10-01 2020-09-02 Kymab Limited Animal models and therapeutic molecules
CA3124228C (en) 2014-03-21 2024-05-14 Regeneron Pharmaceuticals, Inc. Non-human animals that make single domain binding proteins
SG11201607015VA (en) 2014-03-21 2016-09-29 Regeneron Pharma V<sb>L</sb> ANTIGEN BINDING PROTEINS EXHIBITING DISTINCT BINDING CHARACTERISTICS
EP3271403A1 (en) * 2015-03-19 2018-01-24 Regeneron Pharmaceuticals, Inc. Non-human animals that select for light chain variable regions that bind antigen
EP4335918A3 (en) * 2015-04-03 2024-04-17 Dana-Farber Cancer Institute, Inc. Composition and methods of genome editing of b-cells
CA3017678A1 (en) * 2016-04-04 2017-10-12 Eth Zurich Mammalian cell line for protein production and library generation
ES2977547T3 (es) 2016-05-20 2024-08-26 Regeneron Pharma Métodos para romper la tolerancia inmunológica utilizando múltiples ARN guía
WO2018183946A1 (en) * 2017-03-30 2018-10-04 Utah State University Transgenic silkworms expressing spider silk
CA3084049A1 (en) * 2017-12-05 2019-06-13 Regeneron Pharmaceuticals, Inc. Non-human animals having an engineered immunoglobulin lambda light chain and uses thereof
HRP20250232T1 (hr) * 2018-03-24 2025-04-11 Regeneron Pharmaceuticals, Inc. Genetski modificirani miševi ili štakori za dobijanje terapeutskih antitijela protiv peptid‑mhc kompleksa, postupci za njihovo dobijanje i upotrebe
IL318469A (en) * 2018-06-14 2025-03-01 Regeneron Pharma Non-human animals capable of reorganizing transgenic DH-DH, and their uses
CA3187680A1 (en) 2020-09-11 2022-03-17 Yashu Liu Identification and production of antigen-specific antibodies
CN116848254A (zh) 2020-12-16 2023-10-03 瑞泽恩制药公司 表达人源化Fcα受体的小鼠
CN114645042A (zh) * 2020-12-18 2022-06-21 中国食品药品检定研究院 一种构建具有表达荧光素酶和红色荧光蛋白的重组巨噬细胞的转基因小鼠的方法
CN114196626A (zh) * 2022-02-16 2022-03-18 北京国卫生物科技有限公司 脐带间充质干细胞及其分离培养扩增方法
AU2024329875A1 (en) * 2024-01-02 2025-07-17 Gempharmatech Co., Ltd Animal model generating humanized antibody and construction method thereof

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6774279B2 (en) 1997-05-30 2004-08-10 Carnegie Institution Of Washington Use of FLP recombinase in mice
AU8470301A (en) * 2000-08-03 2002-02-18 Wim-Van Schooten Production of humanized antibodies in transgenic animals
US6586251B2 (en) 2000-10-31 2003-07-01 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US6596541B2 (en) * 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US7105348B2 (en) 2000-10-31 2006-09-12 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
CN101016543A (zh) * 2000-11-17 2007-08-15 罗切斯特大学 筛选编码抗原特异性免疫球蛋白分子或其抗原特异性片段的多核苷酸的方法
US7473557B2 (en) 2001-06-06 2009-01-06 Regeneron Pharmaceuticals, Inc. Method for targeting transcriptionally active loci
ATE501167T1 (de) * 2001-12-21 2011-03-15 Thrombogenics Nv Zusammensetzungen für die in vitro herleitung und kultur embryonaler stammzellinien mit keimbahnübertragungsfähigkeit und für die kultur adulter stammzellen
US20050246782A1 (en) * 2002-03-22 2005-11-03 Origen Therapeutics Transgenic aves producing human polyclonal antibodies
CN1852925A (zh) * 2003-07-15 2006-10-25 人类多克隆治疗公司 人源化免疫球蛋白基因座
ES2463476T3 (es) 2004-10-19 2014-05-28 Regeneron Pharmaceuticals, Inc. Método para generar un ratón homocigótico para una modificación genética
WO2006047367A2 (en) * 2004-10-22 2006-05-04 Therapeutic Human Polyclonals, Inc. Suppression of endogenous immunoglubolin expression in non-human transgenic animals
AU2007235496B2 (en) * 2006-03-31 2013-11-21 E. R. Squibb & Sons, L.L.C. Transgenic animals expressing chimeric antibodies for use in preparing human antibodies
EP2064325B1 (en) * 2006-09-01 2011-12-07 Therapeutic Human Polyclonals, Inc. Enhanced expression of human or humanized immunoglobulin in non-human transgenic animals
BRPI0815848A2 (pt) * 2007-08-30 2017-06-06 The Burnet Inst composto, linhagem de célula que produz anticorpo estável, composição, métodos para modular uma resposta imune em um indivíduo e para tratar e/ou prevenir uma doença, usos de um composto e/ou uma composição e de células dendríticas ou precursores das mesmas, métodos para enriquecer e detectar células dendríticas ou um subconjunto ou precursores das mesmas, polipeptídeo, polinucleotídeo vetor, célula hospedeira, planta transgênica, animal não humano transgênico, extrato, processo para preparar um composto ou um polipeptídeo, população enriquecida de células dendríticas e/ou precursores das mesmas, população de célula dendrítica expandida e/ou precursores das mesmas, métodos para identificar uma molécula que se liga a um polipeptídeo e para triar quanto a um composto que se liga a um polipeptídeo, uso de um polipeptídeo, um polinucleotídeo, um vetor, uma célula hospedeira, uma planta transgênica, um extrato, uma população de célula e/ou uma composição, método para produzir um composto, e, kit.
CN101874041B (zh) * 2007-09-26 2013-06-19 中外制药株式会社 抗体恒定区修饰体
US7659842B2 (en) 2007-10-24 2010-02-09 Infineon Technologies Ag Quantization error reduction in PWM full-MASH converters
KR20110020860A (ko) * 2008-05-23 2011-03-03 알리바 바이오파마수티컬스, 아이엔씨. 유전자 삽입동물에서 단일 ｖｌ 도메인 항체를 생산하는 방법
WO2009157771A2 (en) * 2008-06-27 2009-12-30 Merus B.V. Antibody producing non-human mammals
NZ590562A (en) * 2008-08-29 2012-08-31 Symphogen As Method for cloning avian-derived antibodies
US9085795B2 (en) * 2009-02-04 2015-07-21 Molecular Innovations, Inc. Methods for screening candidate agents for modulating prorenin and renin, assays for detecting prorenin and antibodies
EP2798950B2 (en) * 2009-07-08 2023-03-22 Kymab Limited Animal models and therapeutic molecules
RU2425880C2 (ru) * 2009-07-30 2011-08-10 Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН Способ получения трансгенных мышей
NZ605966A (en) * 2010-06-17 2015-04-24 Kymab Ltd Animal models and therapeutic molecules
CN103154255B (zh) * 2010-08-02 2016-04-06 瑞泽恩制药公司 制造包含vl结构域的结合蛋白的小鼠
RU2722373C2 (ru) * 2011-02-25 2020-05-29 Редженерон Фармасьютикалс, Инк. Мыши adam6
SI2739740T1 (sl) * 2011-08-05 2019-12-31 Regeneron Pharmaceuticals, Inc. Humanizirane univerzalne lahkoverižne miši
HRP20190897T1 (hr) * 2011-12-20 2019-09-20 Regeneron Pharmaceuticals, Inc. Laki lanac humaniziranih miševa
ME03611B (me) * 2012-02-01 2020-07-20 Regeneron Pharma Humanizovani miševi koji eksprimiraju teške lance koji sadrže vl domene
KR102484480B1 (ko) * 2012-06-12 2023-01-04 리제너론 파마슈티칼스 인코포레이티드 제한된 면역글로불린 중쇄 유전자좌를 가지는 인간화된 비-인간 동물
EP4567119A3 (en) * 2016-11-04 2025-09-24 Regeneron Pharmaceuticals, Inc. Non-human animals having an engineered immunoglobulin lambda light chain locus

Also Published As

Publication number Publication date
BR112014018843A8 (pt) 2019-01-29
CY1122419T1 (el) 2021-01-27
SI2809150T1 (sl) 2019-11-29
NZ719228A (en) 2022-08-26
RU2770016C2 (ru) 2022-04-14
NZ793447A (en) 2024-05-31
CY1124361T1 (el) 2022-07-22
IL268675B (en) 2020-11-30
AU2015246154B2 (en) 2017-11-23
EP3597038B1 (en) 2021-04-21
LT3597038T (lt) 2021-05-25
SG10201913428QA (en) 2020-03-30
ES2870703T3 (es) 2021-10-27
IL261280A (en) 2018-10-31
JP2019170395A (ja) 2019-10-10
PL2809150T3 (pl) 2020-04-30
NZ734504A (en) 2022-10-28
HRP20210987T1 (hr) 2021-09-17
RU2018122695A (ru) 2019-03-06
HK1202771A1 (en) 2015-10-09
US20130212719A1 (en) 2013-08-15
CN104202971A (zh) 2014-12-10
MX373286B (es) 2020-05-20
AU2017251848B2 (en) 2020-02-20
AU2013204758B2 (en) 2015-07-23
CN106117364B (zh) 2021-08-31
RU2014133653A (ru) 2016-03-20
SMT202100401T1 (it) 2021-09-14
RU2664185C2 (ru) 2018-08-15
JP7525579B2 (ja) 2024-07-30
JP2023014242A (ja) 2023-01-26
SG11201404477YA (en) 2014-08-28
JP2018075041A (ja) 2018-05-17
CN104202971B (zh) 2016-07-06
JP6698718B2 (ja) 2020-05-27
MX2020003491A (es) 2022-10-25
RS59699B1 (sr) 2020-01-31
PT2809150T (pt) 2019-12-09
IL233827A0 (en) 2014-09-30
ME03611B (me) 2020-07-20
DK3597038T3 (da) 2021-06-28
KR20190006029A (ko) 2019-01-16
EP3597038A1 (en) 2020-01-22
IL268675A (en) 2019-10-31
CA2863175A1 (en) 2013-08-08
DK2809150T3 (da) 2019-12-09
IL261280B (en) 2019-08-29
EP2809150A1 (en) 2014-12-10
EP2809150B1 (en) 2019-09-18
PT3597038T (pt) 2021-05-10
MX2019002517A (es) 2019-06-17
EP3912465A1 (en) 2021-11-24
JP6942757B2 (ja) 2021-09-29
JP2015505477A (ja) 2015-02-23
HUE055610T2 (hu) 2021-12-28
SI3597038T1 (sl) 2021-07-30
SG10201606256TA (en) 2016-09-29
LT2809150T (lt) 2019-10-25
HRP20192218T1 (hr) 2020-03-06
RU2018122695A3 (pl) 2021-10-06
HUE046744T2 (hu) 2020-03-30
JP2023168590A (ja) 2023-11-24
US20210368751A1 (en) 2021-12-02
RS62023B1 (sr) 2021-07-30
WO2013116609A1 (en) 2013-08-08
ES2753774T3 (es) 2020-04-14
KR20140123983A (ko) 2014-10-23
SMT201900685T1 (it) 2020-01-14
US20170094955A1 (en) 2017-04-06
JP7187615B2 (ja) 2022-12-12
NZ810648A (en) 2025-11-28
AU2017251848A1 (en) 2017-11-16
NZ627977A (en) 2016-06-24
BR112014018843B1 (pt) 2024-02-20
AU2013204758A1 (en) 2013-08-15
BR112014018843A2 (pt) 2017-07-04
AU2015246154A1 (en) 2015-11-12
CN106117364A (zh) 2016-11-16
JP2021137030A (ja) 2021-09-16

Similar Documents

Publication Publication Date Title
IL268675B (en) Humanized rodents expressing heavy chains comprising vl complexes
IL268674A (en) Rodents with humanized IL-7
ZA201407272B (en) Anti-baff-anti-il-17 bispecific antibodies
PT3058134T (pt) Polímeros extracelulares de lama granular como agentes de colagem
GB201320357D0 (en) Improved closure apparatus
GB201321446D0 (en) Multi-sash closure system
SI2746185T1 (sl) Zaporni šarnir
ZA201306526B (en) Roll-open closure
AU342768S (en) Latch for lunchbox
GB201321568D0 (en) Chain stopper
ZA201301102B (en) Closure arrangement
AU346180S (en) Spout
GB201214914D0 (en) Eye cab