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PL3489226T3 - Inhibitory kotransportera glukozowo-sodowego 1 - Google Patents

Inhibitory kotransportera glukozowo-sodowego 1

Info

Publication number
PL3489226T3
PL3489226T3 PL18213751T PL18213751T PL3489226T3 PL 3489226 T3 PL3489226 T3 PL 3489226T3 PL 18213751 T PL18213751 T PL 18213751T PL 18213751 T PL18213751 T PL 18213751T PL 3489226 T3 PL3489226 T3 PL 3489226T3
Authority
PL
Poland
Prior art keywords
inhibitors
glucose cotransporter
sodium glucose
sodium
cotransporter
Prior art date
Application number
PL18213751T
Other languages
English (en)
Inventor
Kenneth Gordon Carson
Nicole Cathleen Goodwin
Bryce Alden Harrison
David Brent Rawlins
Eric Strobel
Brian Zambrowicz
Original Assignee
Lexicon Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lexicon Pharmaceuticals, Inc. filed Critical Lexicon Pharmaceuticals, Inc.
Publication of PL3489226T3 publication Critical patent/PL3489226T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL18213751T 2012-11-20 2013-11-18 Inhibitory kotransportera glukozowo-sodowego 1 PL3489226T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261728373P 2012-11-20 2012-11-20
EP18213751.3A EP3489226B1 (en) 2012-11-20 2013-11-18 Inhibitors of sodium glucose cotransporter 1
PCT/US2013/070556 WO2014081660A1 (en) 2012-11-20 2013-11-18 Inhibitors of sodium glucose cotransporter 1
EP13802774.3A EP2925735B1 (en) 2012-11-20 2013-11-18 Inhibitors of sodium glucose cotransporter 1

Publications (1)

Publication Number Publication Date
PL3489226T3 true PL3489226T3 (pl) 2021-08-02

Family

ID=49753472

Family Applications (2)

Application Number Title Priority Date Filing Date
PL13802774T PL2925735T3 (pl) 2012-11-20 2013-11-18 Inhibitory kotransportera sodowo-glukozowego 1
PL18213751T PL3489226T3 (pl) 2012-11-20 2013-11-18 Inhibitory kotransportera glukozowo-sodowego 1

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL13802774T PL2925735T3 (pl) 2012-11-20 2013-11-18 Inhibitory kotransportera sodowo-glukozowego 1

Country Status (25)

Country Link
US (3) US9200025B2 (pl)
EP (2) EP3489226B1 (pl)
JP (1) JP6278971B2 (pl)
KR (1) KR102165224B1 (pl)
CN (1) CN108440614A (pl)
AR (1) AR093572A1 (pl)
AU (1) AU2013348233C1 (pl)
BR (1) BR112015011298B1 (pl)
CA (1) CA2891773C (pl)
DK (2) DK2925735T3 (pl)
ES (2) ES2869286T3 (pl)
HK (1) HK1252424A1 (pl)
HU (2) HUE054063T2 (pl)
IL (1) IL238590B (pl)
MX (1) MX365753B (pl)
NZ (1) NZ707859A (pl)
PL (2) PL2925735T3 (pl)
PT (2) PT2925735T (pl)
RU (1) RU2015123738A (pl)
SG (1) SG11201503923XA (pl)
TR (1) TR201908247T4 (pl)
TW (1) TWI636058B (pl)
UA (1) UA117574C2 (pl)
WO (1) WO2014081660A1 (pl)
ZA (1) ZA201503331B (pl)

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TWI499414B (zh) * 2006-09-29 2015-09-11 Lexicon Pharmaceuticals Inc 鈉與葡萄糖第２型共同運輸體（ｃｏ-ｔｒａｎｓｐｏｒｔｅｒ ２）的抑制物與其應用方法
UA117574C2 (uk) 2012-11-20 2018-08-27 Лексікон Фармасьютікалз, Інк. Інгібітори котранспортера натрій-глюкози 1
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CN104478671B (zh) * 2015-01-15 2016-03-09 佛山市赛维斯医药科技有限公司 一类双烷氧苯基丙二醇衍生物和用途
CN104478675B (zh) * 2015-01-15 2016-01-06 佛山市赛维斯医药科技有限公司 一类含烷氧苯基和三氟甲苯基丙二醇结构的衍生物和用途
CN104478674B (zh) * 2015-01-15 2016-03-09 佛山市赛维斯医药科技有限公司 一类烷氧苯基丙二醇衍生物和用途
CN107540685B (zh) * 2017-09-04 2020-05-05 杭州科巢生物科技有限公司 一种Sotagliflozin的制备方法及其中间体
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CN111630058B (zh) * 2018-01-31 2022-02-15 广东东阳光药业有限公司 吡喃葡萄糖基衍生物及其用途
BR112020019624A8 (pt) 2018-03-28 2022-03-03 Avolynt Método para tratar a hipoglicemia pós-prandial
KR20210065974A (ko) 2018-09-26 2021-06-04 렉시컨 파마슈티컬스 인코퍼레이티드 N-(1-((2-(디메틸아미노)에틸)아미노)-2-메틸-1-옥소프로판-2-일)-4-(4-(2-메틸-5-((2s,3r,4r,5s,6r)-3,4,5-트리히드록시-6-(메틸티오)테트라히드로-2h-피란-2-일)벤질)페닐)부탄아미드의 결정질 형태 및 그의 합성 방법
JP7210771B2 (ja) * 2019-03-29 2023-01-23 メッドシャイン ディスカバリー インコーポレイテッド Ｓｇｌｔ１阻害剤としてのグルコシド系誘導体およびその使用
TWI879781B (zh) * 2019-07-10 2025-04-11 大陸商廣東東陽光藥業股份有限公司 吡喃葡萄糖基衍生物及其用途
MX2022001044A (es) 2019-07-26 2022-04-06 Medshine Discovery Inc Inhibidor de sglt2/dpp4 y su aplicacion.
MY209787A (en) * 2019-07-26 2025-08-04 Dongbao Purple Star Hangzhou Biopharmaceutical Co Ltd Sglts/dpp4 inhibitor and application thereof
EP4166547A4 (en) * 2020-05-15 2025-07-09 Shanghai Zheye Biotechnology Co Ltd ARYLGLUCOSIDE DERIVATIVE
CN114423775B (zh) * 2020-05-15 2024-11-22 上海喆邺生物科技有限公司 一类芳基葡糖苷衍生物及其制备方法和应用
EP4119550B1 (en) 2020-05-15 2025-08-20 Shanghai Zheye Biotechnology Co., Ltd. Aryl glucoside derivative and use thereof in drug
CN113893351A (zh) * 2020-07-06 2022-01-07 诺未科技（北京）有限公司 组合物及其在制备治疗癌症的药物中的应用
WO2022063305A1 (zh) * 2020-09-27 2022-03-31 南京明德新药研发有限公司 葡糖苷类化合物的晶型及其应用
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WO2025245592A1 (en) * 2024-05-31 2025-12-04 Aché Laboratórios Farmacêuticos S.A. Multi-target compounds, process for the preparation of the compounds, intermediates, pharmaceutical composition, pharmaceutically acceptable salts, combination, medicament, use of a compound and method of treatment

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