PL2968294T3 - 7-Benzylo-10-(2-metylobenzylo)-2,6,7,8,9,10-heksahydroimidazo[1,2-a]pirydo[4,3-d]pirymidyn-5(3H)-on do zastosowania w leczeniu nowotworu - Google Patents
7-Benzylo-10-(2-metylobenzylo)-2,6,7,8,9,10-heksahydroimidazo[1,2-a]pirydo[4,3-d]pirymidyn-5(3H)-on do zastosowania w leczeniu nowotworuInfo
- Publication number
- PL2968294T3 PL2968294T3 PL14775569T PL14775569T PL2968294T3 PL 2968294 T3 PL2968294 T3 PL 2968294T3 PL 14775569 T PL14775569 T PL 14775569T PL 14775569 T PL14775569 T PL 14775569T PL 2968294 T3 PL2968294 T3 PL 2968294T3
- Authority
- PL
- Poland
- Prior art keywords
- hexahydroimidazo
- pyrido
- methylbenzyl
- pyrimidin
- benzyl
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- RSAQARAFWMUYLL-UHFFFAOYSA-N tic-10 Chemical compound CC1=CC=CC=C1CN1C(CCN(CC=2C=CC=CC=2)C2)=C2C(=O)N2CCN=C21 RSAQARAFWMUYLL-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361779828P | 2013-03-13 | 2013-03-13 | |
| US201361904718P | 2013-11-15 | 2013-11-15 | |
| EP14775569.8A EP2968294B1 (en) | 2013-03-13 | 2014-03-13 | 7-benzyl-10-(2-methylbenzyl)-2,6,7,8,9,10-hexahydroimidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(3h)-on for use in the treatment of cancer |
| PCT/US2014/025885 WO2014160130A1 (en) | 2013-03-13 | 2014-03-13 | Combination therapy with 7-benzyl-10-(2-methylbenzyl)-2,6,7,8,9,10-hexahydroimidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(3h)-one |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2968294T3 true PL2968294T3 (pl) | 2019-10-31 |
Family
ID=51527915
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL14775569T PL2968294T3 (pl) | 2013-03-13 | 2014-03-13 | 7-Benzylo-10-(2-metylobenzylo)-2,6,7,8,9,10-heksahydroimidazo[1,2-a]pirydo[4,3-d]pirymidyn-5(3H)-on do zastosowania w leczeniu nowotworu |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US9265765B2 (pl) |
| EP (2) | EP3572083A1 (pl) |
| JP (3) | JP6446025B2 (pl) |
| KR (2) | KR102438135B1 (pl) |
| CN (2) | CN119954807A (pl) |
| AU (3) | AU2014244117B2 (pl) |
| BR (1) | BR112015023256A2 (pl) |
| CA (2) | CA3204801A1 (pl) |
| CY (1) | CY1121735T1 (pl) |
| DK (1) | DK2968294T3 (pl) |
| EA (1) | EA037937B1 (pl) |
| ES (1) | ES2734568T3 (pl) |
| HR (1) | HRP20191181T1 (pl) |
| HU (1) | HUE044238T2 (pl) |
| IL (2) | IL241452B (pl) |
| LT (1) | LT2968294T (pl) |
| ME (1) | ME03470B (pl) |
| MX (2) | MX2015012636A (pl) |
| NZ (2) | NZ711948A (pl) |
| PL (1) | PL2968294T3 (pl) |
| PT (1) | PT2968294T (pl) |
| RS (1) | RS59013B1 (pl) |
| SG (2) | SG11201507247WA (pl) |
| SI (1) | SI2968294T1 (pl) |
| SM (1) | SMT201900384T1 (pl) |
| WO (1) | WO2014160130A1 (pl) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE068623T2 (hu) | 2011-04-29 | 2025-01-28 | Penn State Res Found | Normál és tumorsejtek kismolekulás TRAIL-génindukclója rákellenes terápiaként |
| US9376437B2 (en) | 2013-03-13 | 2016-06-28 | Oncoceutics, Inc | 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one, salts thereof and methods of using the same in combination therapy |
| PL2968294T3 (pl) | 2013-03-13 | 2019-10-31 | Oncoceutics Inc | 7-Benzylo-10-(2-metylobenzylo)-2,6,7,8,9,10-heksahydroimidazo[1,2-a]pirydo[4,3-d]pirymidyn-5(3H)-on do zastosowania w leczeniu nowotworu |
| PL2970473T3 (pl) | 2013-03-14 | 2018-01-31 | Bristol Myers Squibb Co | Kombinacja agonisty dr5 i antagonisty anty-pd-1 oraz metody stosowania |
| BR112016011072B1 (pt) * | 2013-11-15 | 2022-06-21 | Oncoceutics, Inc. | Composto 7-benzil-4-(2-metilbenzil)-2,4,6,7,8,9- hexahidroimidazo[1,2-a]pirido[3,4-e]pirimidin-5(1h) -ona e composição farmacêutica contendo o referido composto |
| US9394365B1 (en) | 2014-03-12 | 2016-07-19 | Yeda Research And Development Co., Ltd | Reducing systemic regulatory T cell levels or activity for treatment of alzheimer's disease |
| RU2690670C2 (ru) | 2014-03-12 | 2019-06-05 | Ида Рисерч Энд Дивелопмент Ко., Лтд | Снижение уровней или активности системных регуляторных т-клеток для лечения заболевания или повреждения цнс |
| US10519237B2 (en) | 2014-03-12 | 2019-12-31 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
| US10618963B2 (en) | 2014-03-12 | 2020-04-14 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
| ES2779979T3 (es) * | 2014-03-31 | 2020-08-21 | Scripps Research Inst | Farmacóforo para inducción de TRAIL |
| MX2021001096A (es) * | 2015-01-30 | 2023-01-17 | Oncoceutics Inc | 7-bencil-4-(2-metilbencilo)-2,4,6,7,8,9-hexahidroimidazo [1,2-a]pirido[3,4-e]pirimidin-5(1h)-ona, analogos y sales del mismo y su uso en terapia. |
| CN104860948B (zh) | 2015-05-15 | 2017-09-26 | 南京盖特医药技术有限公司 | 咪唑并嘧啶酮类化合物及其制备方法和应用 |
| TWI621437B (zh) | 2015-08-17 | 2018-04-21 | 庫拉腫瘤技術股份有限公司 | 以法呢基轉移酶（farnesyltransferase）抑制劑治療癌症病患之方法 |
| KR20170037260A (ko) | 2015-09-25 | 2017-04-04 | 현대자동차주식회사 | 차량용 배터리 시스템 및 그 제어 방법 |
| ES3012491T3 (en) | 2016-01-29 | 2025-04-09 | Oncoceutics Inc | G protein-coupled receptor (gpcr) modulation by imipridones |
| CN114191428B (zh) | 2016-03-02 | 2024-09-24 | 卫材研究发展管理有限公司 | 基于艾日布林的抗体-药物偶联物和使用方法 |
| KR20170110520A (ko) * | 2016-03-23 | 2017-10-11 | 고려대학교 산학협력단 | mTOR 억제제 및 N-아세틸시스테인을 포함하는 간섬유화 억제용 조성물 |
| EP3439642A4 (en) * | 2016-04-06 | 2019-11-13 | Noxopharm Limited | IMPROVEMENTS IN RADIOTHERAPY |
| CA3058503A1 (en) | 2016-04-06 | 2017-10-12 | Noxopharm Limited | Isoflavonoid composition with improved pharmacokinetics |
| WO2018031987A1 (en) * | 2016-08-12 | 2018-02-15 | Nanjing Gator Meditech Company, Ltd. | Protein kinase regulators |
| LT3534885T (lt) | 2016-11-03 | 2021-07-12 | Kura Oncology, Inc. | Farneziltransferazės inhibitoriai, skirti naudoti vėžio gydymui |
| US11576912B2 (en) | 2017-01-04 | 2023-02-14 | The Board Of Trustees Of The Leland Stanford Junior University | Target genes in MYC-driven neoplasia |
| JP7300394B2 (ja) | 2017-01-17 | 2023-06-29 | ヘパリジェニックス ゲーエムベーハー | 肝再生の促進又は肝細胞死の低減もしくは予防のためのプロテインキナーゼ阻害 |
| US10172862B2 (en) | 2017-01-30 | 2019-01-08 | Oncoceutics, Inc. | Imipridones for gliomas |
| IT201800004082A1 (it) * | 2018-03-29 | 2019-09-29 | Berlin Chemie Ag | Composizioni farmaceutiche antitumorali per terapia combinata |
| US20200046703A1 (en) * | 2018-08-09 | 2020-02-13 | Asymmetric Therapeutics, Llc | Compositions and methods for treatment of the side-effects associated with administration of therapeutic agents |
| US11633399B2 (en) | 2018-12-25 | 2023-04-25 | Sol-Gel Technologies Ltd. | Treatment of skin disorders with compositions comprising an EGFR inhibitor |
| WO2020147842A1 (zh) * | 2019-01-18 | 2020-07-23 | 南京明德新药研发有限公司 | 吡啶并嘧啶类化合物在制备治疗鼻咽癌药物中的应用 |
| EP3725370A1 (en) | 2019-04-19 | 2020-10-21 | ImmunoBrain Checkpoint, Inc. | Modified anti-pd-l1 antibodies and methods and uses for treating a neurodegenerative disease |
| BR112022010319A2 (pt) | 2019-11-28 | 2022-08-16 | Inxmed Nanjing Co Ltd | Uso de bi853520 no tratamento de câncer |
| JP7582694B2 (ja) | 2020-01-10 | 2024-11-13 | イミューニヤリング コーポレーション | Ｍｅｋ阻害剤及びその治療的使用 |
| JP2023519990A (ja) | 2020-03-30 | 2023-05-15 | ノクソファーム リミティド | 感染に関連する炎症の治療のための方法 |
| CN117599041B (zh) * | 2024-01-22 | 2024-05-03 | 中国人民解放军军事科学院军事医学研究院 | 去氢雌马酚及其衍生物作为新型辐射防护剂和细胞保护剂的医药用途 |
| EP4684834A1 (de) | 2024-07-26 | 2026-01-28 | BRIU GmbH | Kristallformen onkologisch wirksamer imipridone und verfahren zu deren herstellung |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2150062A1 (de) | 1971-10-07 | 1973-04-12 | Boehringer Sohn Ingelheim | Imidazo- eckige klammer auf 1,2-a eckige klammer zu -pyrido- eckige klammer auf 4,3-d eckige klammer zu -pyrimidine, deren saeureadditionssalze und verfahren zu deren herstellung |
| US4642345A (en) | 1980-08-14 | 1987-02-10 | Mead Johnson & Company | 6,7-dihydro-3H-imidazo[1,2-a]-purine-9(4H)-ones |
| US7635690B2 (en) | 1999-01-22 | 2009-12-22 | Emory University | HIV-1 mutations selected for by β-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine |
| CA2478338A1 (en) | 2002-03-08 | 2003-09-18 | Signal Pharmaceuticals, Inc. | Combination therapy for treating, preventing or managing proliferative disorders and cancers |
| US20050043233A1 (en) * | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
| MX383644B (es) | 2005-02-18 | 2025-03-14 | Abraxis Bioscience Llc | Combinaciones y metodos de administracion de agentes terapeuticos y terapia de combinacion. |
| US20080221135A1 (en) | 2005-05-13 | 2008-09-11 | Bristol-Myers Squibb Company | Combination therapy |
| US20110287001A1 (en) * | 2008-09-22 | 2011-11-24 | Tetralogic Pharmaceuticals | Method of treatment |
| US20120128732A1 (en) | 2008-12-11 | 2012-05-24 | Vuong Trieu | Combinations and modes of administration of therapeutic agents and combination therapy |
| US9724337B2 (en) | 2009-04-21 | 2017-08-08 | University Of Kentucky Research Foundation | AG-205 for the treatment of breast cancer |
| DE102010014426A1 (de) * | 2010-04-01 | 2011-10-06 | Bayer Schering Pharma Aktiengesellschaft | Verwendung neuer pan-CDK-Inhibitoren zur Behandlung von Tumoren |
| HUE068623T2 (hu) | 2011-04-29 | 2025-01-28 | Penn State Res Found | Normál és tumorsejtek kismolekulás TRAIL-génindukclója rákellenes terápiaként |
| US8377946B1 (en) | 2011-12-30 | 2013-02-19 | Pharmacyclics, Inc. | Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors |
| PL2968294T3 (pl) | 2013-03-13 | 2019-10-31 | Oncoceutics Inc | 7-Benzylo-10-(2-metylobenzylo)-2,6,7,8,9,10-heksahydroimidazo[1,2-a]pirydo[4,3-d]pirymidyn-5(3H)-on do zastosowania w leczeniu nowotworu |
| ES2779979T3 (es) | 2014-03-31 | 2020-08-21 | Scripps Research Inst | Farmacóforo para inducción de TRAIL |
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2014
- 2014-03-13 PL PL14775569T patent/PL2968294T3/pl unknown
- 2014-03-13 ME MEP-2019-197A patent/ME03470B/me unknown
- 2014-03-13 EP EP19171477.3A patent/EP3572083A1/en not_active Withdrawn
- 2014-03-13 KR KR1020157028393A patent/KR102438135B1/ko active Active
- 2014-03-13 NZ NZ711948A patent/NZ711948A/en unknown
- 2014-03-13 ES ES14775569T patent/ES2734568T3/es active Active
- 2014-03-13 DK DK14775569.8T patent/DK2968294T3/da active
- 2014-03-13 CA CA3204801A patent/CA3204801A1/en active Pending
- 2014-03-13 SI SI201431257T patent/SI2968294T1/sl unknown
- 2014-03-13 HU HUE14775569 patent/HUE044238T2/hu unknown
- 2014-03-13 HR HRP20191181TT patent/HRP20191181T1/hr unknown
- 2014-03-13 LT LTEP14775569.8T patent/LT2968294T/lt unknown
- 2014-03-13 MX MX2015012636A patent/MX2015012636A/es active IP Right Grant
- 2014-03-13 BR BR112015023256A patent/BR112015023256A2/pt not_active Application Discontinuation
- 2014-03-13 US US14/208,657 patent/US9265765B2/en active Active
- 2014-03-13 RS RS20190874A patent/RS59013B1/sr unknown
- 2014-03-13 KR KR1020227029471A patent/KR20220123335A/ko not_active Ceased
- 2014-03-13 EA EA201591715A patent/EA037937B1/ru unknown
- 2014-03-13 EP EP14775569.8A patent/EP2968294B1/en active Active
- 2014-03-13 AU AU2014244117A patent/AU2014244117B2/en not_active Ceased
- 2014-03-13 SM SM20190384T patent/SMT201900384T1/it unknown
- 2014-03-13 NZ NZ751509A patent/NZ751509A/en active IP Right Revival
- 2014-03-13 CA CA2905037A patent/CA2905037C/en active Active
- 2014-03-13 CN CN202510107155.3A patent/CN119954807A/zh active Pending
- 2014-03-13 SG SG11201507247WA patent/SG11201507247WA/en unknown
- 2014-03-13 JP JP2016501988A patent/JP6446025B2/ja active Active
- 2014-03-13 PT PT14775569T patent/PT2968294T/pt unknown
- 2014-03-13 CN CN201480022856.7A patent/CN105530937A/zh active Pending
- 2014-03-13 WO PCT/US2014/025885 patent/WO2014160130A1/en not_active Ceased
- 2014-03-13 SG SG10201808496VA patent/SG10201808496VA/en unknown
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2015
- 2015-09-10 IL IL241452A patent/IL241452B/en active IP Right Grant
- 2015-09-11 MX MX2019013643A patent/MX2019013643A/es unknown
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2018
- 2018-06-22 JP JP2018119005A patent/JP2018184411A/ja active Pending
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2019
- 2019-03-19 AU AU2019201896A patent/AU2019201896A1/en not_active Abandoned
- 2019-07-01 CY CY20191100687T patent/CY1121735T1/el unknown
-
2020
- 2020-06-23 IL IL275623A patent/IL275623A/en unknown
- 2020-07-01 JP JP2020114024A patent/JP2020172510A/ja active Pending
- 2020-09-14 AU AU2020233606A patent/AU2020233606A1/en not_active Abandoned
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