PL184399B1 - Ciekła detergentowa kompozycja - Google Patents

Ciekła detergentowa kompozycja

Info

Publication number: PL184399B1
Authority: PL; Poland
Prior art keywords: subtilase; subtilisin; enzyme; acid; protease
Prior art date: 1995-05-05

Application number

PL96323188A

Other languages

English (en)

Polish (pl)

Other versions

PL323188A1 (en

Inventor

Jan Klugkist

Peter Markvardsen

Der Osten Claus Von

Laurens N. Sierkstra

Peter Bauditz

Original Assignee

Unilever Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-05-05

Filing date

1996-04-12

Publication date

2002-10-31

1996-04-12 Application filed by Unilever Nv filed Critical Unilever Nv

1998-03-16 Publication of PL323188A1 publication Critical patent/PL323188A1/xx

2002-10-31 Publication of PL184399B1 publication Critical patent/PL184399B1/pl

Links

108090000787 Subtilisin Proteins 0.000 title description 59
239000000203 mixture Substances 0.000 claims abstract description 128
101710135785 Subtilisin-like protease Proteins 0.000 claims abstract description 95
239000003599 detergent Substances 0.000 claims abstract description 82
239000007788 liquid Substances 0.000 claims abstract description 35
102220489310 Melanoma-associated antigen 11_S57P_mutation Human genes 0.000 claims description 60
238000000034 method Methods 0.000 claims description 40
102220252848 rs1381356440 Human genes 0.000 claims description 26
102200025035 rs786203989 Human genes 0.000 claims description 26
125000000539 amino acid group Chemical group 0.000 claims description 19
238000006467 substitution reaction Methods 0.000 claims description 18
230000002209 hydrophobic effect Effects 0.000 claims description 17
229920000642 polymer Polymers 0.000 claims description 11
238000012217 deletion Methods 0.000 claims description 10
230000037430 deletion Effects 0.000 claims description 10
238000003780 insertion Methods 0.000 claims description 8
230000037431 insertion Effects 0.000 claims description 8
102220613710 Semaphorin-3D_G97N_mutation Human genes 0.000 claims description 2
108090000790 Enzymes Proteins 0.000 abstract description 111
102000004190 Enzymes Human genes 0.000 abstract description 110
108090000623 proteins and genes Proteins 0.000 abstract description 39
239000000344 soap Substances 0.000 abstract description 13
229940088598 enzyme Drugs 0.000 description 106
102000035195 Peptidases Human genes 0.000 description 60
108091005804 Peptidases Proteins 0.000 description 60
239000004365 Protease Substances 0.000 description 52
230000035772 mutation Effects 0.000 description 46
235000019419 proteases Nutrition 0.000 description 39
150000001413 amino acids Chemical class 0.000 description 36
239000004094 surface-active agent Substances 0.000 description 29
108020004414 DNA Proteins 0.000 description 27
238000005406 washing Methods 0.000 description 26
-1 etc.) Substances 0.000 description 25
102000005158 Subtilisins Human genes 0.000 description 24
108010056079 Subtilisins Proteins 0.000 description 24
238000003860 storage Methods 0.000 description 24
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 23
239000002253 acid Substances 0.000 description 23
102000004882 Lipase Human genes 0.000 description 22
108090001060 Lipase Proteins 0.000 description 22
239000004367 Lipase Substances 0.000 description 22
235000001014 amino acid Nutrition 0.000 description 22
230000000694 effects Effects 0.000 description 22
235000019421 lipase Nutrition 0.000 description 22
229940024606 amino acid Drugs 0.000 description 21
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 21
125000004432 carbon atom Chemical group C* 0.000 description 20
239000004615 ingredient Substances 0.000 description 17
239000003795 chemical substances by application Substances 0.000 description 15
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 15
239000000945 filler Substances 0.000 description 15
239000012634 fragment Substances 0.000 description 15
108010020132 microbial serine proteinases Proteins 0.000 description 15
229920005646 polycarboxylate Polymers 0.000 description 15
150000003839 salts Chemical class 0.000 description 14
239000000758 substrate Substances 0.000 description 14
108091034117 Oligonucleotide Proteins 0.000 description 13
239000002736 nonionic surfactant Substances 0.000 description 13
125000000217 alkyl group Chemical group 0.000 description 12
238000009472 formulation Methods 0.000 description 12
OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 11
239000003945 anionic surfactant Substances 0.000 description 11
230000006872 improvement Effects 0.000 description 11
WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 10
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 10
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 10
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 10
102000004169 proteins and genes Human genes 0.000 description 10
239000011734 sodium Substances 0.000 description 10
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 9
CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 9
125000003275 alpha amino acid group Chemical group 0.000 description 9
239000007844 bleaching agent Substances 0.000 description 9
235000014113 dietary fatty acids Nutrition 0.000 description 9
239000000194 fatty acid Substances 0.000 description 9
229930195729 fatty acid Natural products 0.000 description 9
239000000463 material Substances 0.000 description 9
239000013612 plasmid Substances 0.000 description 9
229920001296 polysiloxane Polymers 0.000 description 9
235000018102 proteins Nutrition 0.000 description 9
229910052708 sodium Inorganic materials 0.000 description 9
239000013598 vector Substances 0.000 description 9
108091005658 Basic proteases Proteins 0.000 description 8
241000588724 Escherichia coli Species 0.000 description 8
IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical group C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 8
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 8
102000012479 Serine Proteases Human genes 0.000 description 8
108010022999 Serine Proteases Proteins 0.000 description 8
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 8
235000010338 boric acid Nutrition 0.000 description 8
125000001165 hydrophobic group Chemical group 0.000 description 8
BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 8
239000000047 product Substances 0.000 description 8
238000012163 sequencing technique Methods 0.000 description 8
239000000243 solution Substances 0.000 description 8
241000193830 Bacillus <bacterium> Species 0.000 description 7
235000014469 Bacillus subtilis Nutrition 0.000 description 7
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 7
KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 7
239000004327 boric acid Substances 0.000 description 7
239000013604 expression vector Substances 0.000 description 7
150000004665 fatty acids Chemical class 0.000 description 7
238000012360 testing method Methods 0.000 description 7
241000193422 Bacillus lentus Species 0.000 description 6
AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 6
WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 6
DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 description 6
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
150000001298 alcohols Chemical class 0.000 description 6
239000002585 base Substances 0.000 description 6
OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 description 6
230000002255 enzymatic effect Effects 0.000 description 6
238000006460 hydrolysis reaction Methods 0.000 description 6
238000012986 modification Methods 0.000 description 6
230000004048 modification Effects 0.000 description 6
235000010267 sodium hydrogen sulphite Nutrition 0.000 description 6
235000019832 sodium triphosphate Nutrition 0.000 description 6
239000010457 zeolite Substances 0.000 description 6
241000894006 Bacteria Species 0.000 description 5
244000060011 Cocos nucifera Species 0.000 description 5
235000013162 Cocos nucifera Nutrition 0.000 description 5
102000004594 DNA Polymerase I Human genes 0.000 description 5
108010017826 DNA Polymerase I Proteins 0.000 description 5
ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 5
150000007513 acids Chemical class 0.000 description 5
229910052783 alkali metal Inorganic materials 0.000 description 5
239000011575 calcium Substances 0.000 description 5
238000004140 cleaning Methods 0.000 description 5
HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 5
125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 description 5
108010003855 mesentericopeptidase Proteins 0.000 description 5
238000000746 purification Methods 0.000 description 5
OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 4
244000063299 Bacillus subtilis Species 0.000 description 4
BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 4
108091026890 Coding region Proteins 0.000 description 4
241000233866 Fungi Species 0.000 description 4
239000004471 Glycine Substances 0.000 description 4
IOVCWXUNBOPUCH-UHFFFAOYSA-N Nitrous acid Chemical compound ON=O IOVCWXUNBOPUCH-UHFFFAOYSA-N 0.000 description 4
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 4
CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 4
108700005078 Synthetic Genes Proteins 0.000 description 4
229910021536 Zeolite Inorganic materials 0.000 description 4
150000008051 alkyl sulfates Chemical class 0.000 description 4
150000001408 amides Chemical class 0.000 description 4
150000001412 amines Chemical class 0.000 description 4
230000001580 bacterial effect Effects 0.000 description 4
HXDRSFFFXJISME-UHFFFAOYSA-N butanedioic acid;2,3-dihydroxybutanedioic acid Chemical compound OC(=O)CCC(O)=O.OC(=O)C(O)C(O)C(O)=O HXDRSFFFXJISME-UHFFFAOYSA-N 0.000 description 4
229910001424 calcium ion Inorganic materials 0.000 description 4
230000015556 catabolic process Effects 0.000 description 4
230000003197 catalytic effect Effects 0.000 description 4
238000006243 chemical reaction Methods 0.000 description 4
238000010367 cloning Methods 0.000 description 4
238000006731 degradation reaction Methods 0.000 description 4
239000004744 fabric Substances 0.000 description 4
235000019253 formic acid Nutrition 0.000 description 4
230000007062 hydrolysis Effects 0.000 description 4
230000000977 initiatory effect Effects 0.000 description 4
238000005259 measurement Methods 0.000 description 4
244000005700 microbiome Species 0.000 description 4
231100000350 mutagenesis Toxicity 0.000 description 4
238000002703 mutagenesis Methods 0.000 description 4
230000007935 neutral effect Effects 0.000 description 4
229920001983 poloxamer Polymers 0.000 description 4
229910052700 potassium Inorganic materials 0.000 description 4
239000011591 potassium Substances 0.000 description 4
239000002243 precursor Substances 0.000 description 4
235000013772 propylene glycol Nutrition 0.000 description 4
230000035484 reaction time Effects 0.000 description 4
230000010076 replication Effects 0.000 description 4
239000000377 silicon dioxide Substances 0.000 description 4
230000000087 stabilizing effect Effects 0.000 description 4
239000000126 substance Substances 0.000 description 4
239000003784 tall oil Substances 0.000 description 4
URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 4
BTUDGPVTCYNYLK-UHFFFAOYSA-N 2,2-dimethylglutaric acid Chemical compound OC(=O)C(C)(C)CCC(O)=O BTUDGPVTCYNYLK-UHFFFAOYSA-N 0.000 description 3
HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 3
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
229920001817 Agar Polymers 0.000 description 3
QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 3
102000013142 Amylases Human genes 0.000 description 3
108010065511 Amylases Proteins 0.000 description 3
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
241000192125 Firmicutes Species 0.000 description 3
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 3
229910019142 PO4 Inorganic materials 0.000 description 3
241001523956 Parengyodontium album Species 0.000 description 3
108010076504 Protein Sorting Signals Proteins 0.000 description 3
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 3
KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 3
230000009471 action Effects 0.000 description 3
235000019418 amylase Nutrition 0.000 description 3
229940025131 amylases Drugs 0.000 description 3
230000015572 biosynthetic process Effects 0.000 description 3
150000001768 cations Chemical class 0.000 description 3
210000004027 cell Anatomy 0.000 description 3
210000002421 cell wall Anatomy 0.000 description 3
239000000460 chlorine Substances 0.000 description 3
239000003240 coconut oil Substances 0.000 description 3
235000019864 coconut oil Nutrition 0.000 description 3
239000002299 complementary DNA Substances 0.000 description 3
150000001875 compounds Chemical class 0.000 description 3
238000010276 construction Methods 0.000 description 3
229940104302 cytosine Drugs 0.000 description 3
230000001747 exhibiting effect Effects 0.000 description 3
238000002474 experimental method Methods 0.000 description 3
238000000855 fermentation Methods 0.000 description 3
230000004151 fermentation Effects 0.000 description 3
235000013922 glutamic acid Nutrition 0.000 description 3
239000004220 glutamic acid Substances 0.000 description 3
239000001257 hydrogen Substances 0.000 description 3
229910052739 hydrogen Inorganic materials 0.000 description 3
239000000693 micelle Substances 0.000 description 3
230000003505 mutagenic effect Effects 0.000 description 3
239000002773 nucleotide Substances 0.000 description 3
125000003729 nucleotide group Chemical group 0.000 description 3
ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 3
HWGNBUXHKFFFIH-UHFFFAOYSA-I pentasodium;[oxido(phosphonatooxy)phosphoryl] phosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O HWGNBUXHKFFFIH-UHFFFAOYSA-I 0.000 description 3
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 3
239000010452 phosphate Substances 0.000 description 3
229920005862 polyol Polymers 0.000 description 3
150000003077 polyols Chemical class 0.000 description 3
239000001103 potassium chloride Substances 0.000 description 3
235000011164 potassium chloride Nutrition 0.000 description 3
239000000843 powder Substances 0.000 description 3
235000019833 protease Nutrition 0.000 description 3
230000002797 proteolythic effect Effects 0.000 description 3
229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 3
150000003254 radicals Chemical class 0.000 description 3
108091008146 restriction endonucleases Proteins 0.000 description 3
235000003441 saturated fatty acids Nutrition 0.000 description 3
150000004671 saturated fatty acids Chemical class 0.000 description 3
230000028327 secretion Effects 0.000 description 3
239000011780 sodium chloride Substances 0.000 description 3
NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 description 3
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 3
CIOXZGOUEYHNBF-UHFFFAOYSA-N (carboxymethoxy)succinic acid Chemical class OC(=O)COC(C(O)=O)CC(O)=O CIOXZGOUEYHNBF-UHFFFAOYSA-N 0.000 description 2
108091032973 (ribonucleotides)n+m Proteins 0.000 description 2
DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 2
241000194110 Bacillus sp. (in: Bacteria) Species 0.000 description 2
241000276408 Bacillus subtilis subsp. subtilis str. 168 Species 0.000 description 2
108010001478 Bacitracin Proteins 0.000 description 2
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
CBOCVOKPQGJKKJ-UHFFFAOYSA-L Calcium formate Chemical compound [Ca+2].[O-]C=O.[O-]C=O CBOCVOKPQGJKKJ-UHFFFAOYSA-L 0.000 description 2
102000005701 Calcium-Binding Proteins Human genes 0.000 description 2
108010045403 Calcium-Binding Proteins Proteins 0.000 description 2
102000005575 Cellulases Human genes 0.000 description 2
108010084185 Cellulases Proteins 0.000 description 2
229920000742 Cotton Polymers 0.000 description 2
244000241257 Cucumis melo Species 0.000 description 2
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
102000053602 DNA Human genes 0.000 description 2
241000255581 Drosophila <fruit fly, genus> Species 0.000 description 2
241000196324 Embryophyta Species 0.000 description 2
108010067770 Endopeptidase K Proteins 0.000 description 2
RPTUSVTUFVMDQK-UHFFFAOYSA-N Hidralazin Chemical compound C1=CC=C2C(NN)=NN=CC2=C1 RPTUSVTUFVMDQK-UHFFFAOYSA-N 0.000 description 2
IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 description 2
239000004472 Lysine Substances 0.000 description 2
108091028043 Nucleic acid sequence Proteins 0.000 description 2
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
229920000388 Polyphosphate Polymers 0.000 description 2
229920005654 Sephadex Polymers 0.000 description 2
239000012507 Sephadex™ Substances 0.000 description 2
229920002684 Sepharose Polymers 0.000 description 2
241000255588 Tephritidae Species 0.000 description 2
GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 2
ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical group O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 description 2
KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Chemical compound CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 2
239000012190 activator Substances 0.000 description 2
239000008272 agar Substances 0.000 description 2
150000001335 aliphatic alkanes Chemical group 0.000 description 2
150000001340 alkali metals Chemical class 0.000 description 2
150000004996 alkyl benzenes Chemical class 0.000 description 2
MTHSVFCYNBDYFN-UHFFFAOYSA-N anhydrous diethylene glycol Natural products OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 2
239000002518 antifoaming agent Substances 0.000 description 2
239000008346 aqueous phase Substances 0.000 description 2
235000003704 aspartic acid Nutrition 0.000 description 2
229960003071 bacitracin Drugs 0.000 description 2
229930184125 bacitracin Natural products 0.000 description 2
CLKOFPXJLQSYAH-ABRJDSQDSA-N bacitracin A Chemical compound C1SC([C@@H](N)[C@@H](C)CC)=N[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]1C(=O)N[C@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2N=CNC=2)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCC1 CLKOFPXJLQSYAH-ABRJDSQDSA-N 0.000 description 2
230000009286 beneficial effect Effects 0.000 description 2
230000008901 benefit Effects 0.000 description 2
OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 2
238000004061 bleaching Methods 0.000 description 2
102220350531 c.80A>G Human genes 0.000 description 2
229910052791 calcium Inorganic materials 0.000 description 2
235000019255 calcium formate Nutrition 0.000 description 2
239000004281 calcium formate Substances 0.000 description 2
229940044172 calcium formate Drugs 0.000 description 2
229910052799 carbon Inorganic materials 0.000 description 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
150000007942 carboxylates Chemical class 0.000 description 2
239000012876 carrier material Substances 0.000 description 2
239000005018 casein Substances 0.000 description 2
235000021240 caseins Nutrition 0.000 description 2
108020001778 catalytic domains Proteins 0.000 description 2
235000013351 cheese Nutrition 0.000 description 2
239000013599 cloning vector Substances 0.000 description 2
239000004205 dimethyl polysiloxane Substances 0.000 description 2
PMPJQLCPEQFEJW-HPKCLRQXSA-L disodium;2-[(e)-2-[4-[4-[(e)-2-(2-sulfonatophenyl)ethenyl]phenyl]phenyl]ethenyl]benzenesulfonate Chemical compound [Na+].[Na+].[O-]S(=O)(=O)C1=CC=CC=C1\C=C\C1=CC=C(C=2C=CC(\C=C\C=3C(=CC=CC=3)S([O-])(=O)=O)=CC=2)C=C1 PMPJQLCPEQFEJW-HPKCLRQXSA-L 0.000 description 2
239000012153 distilled water Substances 0.000 description 2
230000002708 enhancing effect Effects 0.000 description 2
150000002148 esters Chemical group 0.000 description 2
239000000706 filtrate Substances 0.000 description 2
235000013773 glyceryl triacetate Nutrition 0.000 description 2
239000001087 glyceryl triacetate Substances 0.000 description 2
230000012010 growth Effects 0.000 description 2
239000003906 humectant Substances 0.000 description 2
238000009396 hybridization Methods 0.000 description 2
125000004435 hydrogen atom Chemical class [H]* 0.000 description 2
230000001900 immune effect Effects 0.000 description 2
238000011534 incubation Methods 0.000 description 2
238000004519 manufacturing process Methods 0.000 description 2
230000007246 mechanism Effects 0.000 description 2
YDSWCNNOKPMOTP-UHFFFAOYSA-N mellitic acid Chemical class OC(=O)C1=C(C(O)=O)C(C(O)=O)=C(C(O)=O)C(C(O)=O)=C1C(O)=O YDSWCNNOKPMOTP-UHFFFAOYSA-N 0.000 description 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 2
231100000219 mutagenic Toxicity 0.000 description 2
230000036438 mutation frequency Effects 0.000 description 2
230000003472 neutralizing effect Effects 0.000 description 2
102000039446 nucleic acids Human genes 0.000 description 2
108020004707 nucleic acids Proteins 0.000 description 2
150000007523 nucleic acids Chemical class 0.000 description 2
HXITXNWTGFUOAU-UHFFFAOYSA-N phenylboronic acid Chemical compound OB(O)C1=CC=CC=C1 HXITXNWTGFUOAU-UHFFFAOYSA-N 0.000 description 2
229910052698 phosphorus Inorganic materials 0.000 description 2
230000000704 physical effect Effects 0.000 description 2
235000002949 phytic acid Nutrition 0.000 description 2
230000001817 pituitary effect Effects 0.000 description 2
239000013600 plasmid vector Substances 0.000 description 2
229920000435 poly(dimethylsiloxane) Polymers 0.000 description 2
229920000058 polyacrylate Polymers 0.000 description 2
239000001205 polyphosphate Substances 0.000 description 2
235000011176 polyphosphates Nutrition 0.000 description 2
235000019353 potassium silicate Nutrition 0.000 description 2
230000008569 process Effects 0.000 description 2
CYIDZMCFTVVTJO-UHFFFAOYSA-N pyromellitic acid Chemical class OC(=O)C1=CC(C(O)=O)=C(C(O)=O)C=C1C(O)=O CYIDZMCFTVVTJO-UHFFFAOYSA-N 0.000 description 2
230000001105 regulatory effect Effects 0.000 description 2
238000011160 research Methods 0.000 description 2
102220010259 rs202247806 Human genes 0.000 description 2
102200089422 rs2634041 Human genes 0.000 description 2
102220113656 rs886039149 Human genes 0.000 description 2
235000020183 skimmed milk Nutrition 0.000 description 2
239000002002 slurry Substances 0.000 description 2
229910000029 sodium carbonate Inorganic materials 0.000 description 2
235000017550 sodium carbonate Nutrition 0.000 description 2
239000001509 sodium citrate Substances 0.000 description 2
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 2
235000011121 sodium hydroxide Nutrition 0.000 description 2
239000007787 solid Substances 0.000 description 2
239000000600 sorbitol Substances 0.000 description 2
230000006641 stabilisation Effects 0.000 description 2
238000011105 stabilization Methods 0.000 description 2
238000010561 standard procedure Methods 0.000 description 2
150000003467 sulfuric acid derivatives Chemical class 0.000 description 2
238000003786 synthesis reaction Methods 0.000 description 2
238000010998 test method Methods 0.000 description 2
239000004753 textile Substances 0.000 description 2
RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical group CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 description 2
229960002622 triacetin Drugs 0.000 description 2
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 2
125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 2
IQVLXQGNLCPZCL-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 2,6-bis[(2-methylpropan-2-yl)oxycarbonylamino]hexanoate Chemical class CC(C)(C)OC(=O)NCCCCC(NC(=O)OC(C)(C)C)C(=O)ON1C(=O)CCC1=O IQVLXQGNLCPZCL-UHFFFAOYSA-N 0.000 description 1
OIXLLKLZKCBCPS-RZVRUWJTSA-N (2s)-2-azanyl-5-[bis(azanyl)methylideneamino]pentanoic acid Chemical compound OC(=O)[C@@H](N)CCCNC(N)=N.OC(=O)[C@@H](N)CCCNC(N)=N OIXLLKLZKCBCPS-RZVRUWJTSA-N 0.000 description 1
QBLFZIBJXUQVRF-UHFFFAOYSA-N (4-bromophenyl)boronic acid Chemical compound OB(O)C1=CC=C(Br)C=C1 QBLFZIBJXUQVRF-UHFFFAOYSA-N 0.000 description 1
WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 description 1
OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
YVOOPGWEIRIUOX-UHFFFAOYSA-N 2-azanyl-3-sulfanyl-propanoic acid Chemical compound SCC(N)C(O)=O.SCC(N)C(O)=O YVOOPGWEIRIUOX-UHFFFAOYSA-N 0.000 description 1
MPNXSZJPSVBLHP-UHFFFAOYSA-N 2-chloro-n-phenylpyridine-3-carboxamide Chemical compound ClC1=NC=CC=C1C(=O)NC1=CC=CC=C1 MPNXSZJPSVBLHP-UHFFFAOYSA-N 0.000 description 1
JVTIXNMXDLQEJE-UHFFFAOYSA-N 2-decanoyloxypropyl decanoate 2-octanoyloxypropyl octanoate Chemical compound C(CCCCCCC)(=O)OCC(C)OC(CCCCCCC)=O.C(=O)(CCCCCCCCC)OCC(C)OC(=O)CCCCCCCCC JVTIXNMXDLQEJE-UHFFFAOYSA-N 0.000 description 1
PDYVDBABVOYHAU-UHFFFAOYSA-N 2-hydroxy-1,3,2-dioxaborepane Chemical compound OB1OCCCCO1 PDYVDBABVOYHAU-UHFFFAOYSA-N 0.000 description 1
125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 description 1
LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
GDTSJMKGXGJFGQ-UHFFFAOYSA-N 3,7-dioxido-2,4,6,8,9-pentaoxa-1,3,5,7-tetraborabicyclo[3.3.1]nonane Chemical compound O1B([O-])OB2OB([O-])OB1O2 GDTSJMKGXGJFGQ-UHFFFAOYSA-N 0.000 description 1
QOXOZONBQWIKDA-UHFFFAOYSA-N 3-hydroxypropyl Chemical group [CH2]CCO QOXOZONBQWIKDA-UHFFFAOYSA-N 0.000 description 1
LWYAUHJRUCQFCX-UHFFFAOYSA-N 4-dodecoxy-4-oxobutanoic acid Chemical compound CCCCCCCCCCCCOC(=O)CCC(O)=O LWYAUHJRUCQFCX-UHFFFAOYSA-N 0.000 description 1
LSWKXNPXIJXDHU-UHFFFAOYSA-N 4-oxo-4-tetradecoxybutanoic acid Chemical compound CCCCCCCCCCCCCCOC(=O)CCC(O)=O LSWKXNPXIJXDHU-UHFFFAOYSA-N 0.000 description 1
CNGYZEMWVAWWOB-VAWYXSNFSA-N 5-[[4-anilino-6-[bis(2-hydroxyethyl)amino]-1,3,5-triazin-2-yl]amino]-2-[(e)-2-[4-[[4-anilino-6-[bis(2-hydroxyethyl)amino]-1,3,5-triazin-2-yl]amino]-2-sulfophenyl]ethenyl]benzenesulfonic acid Chemical compound N=1C(NC=2C=C(C(\C=C\C=3C(=CC(NC=4N=C(N=C(NC=5C=CC=CC=5)N=4)N(CCO)CCO)=CC=3)S(O)(=O)=O)=CC=2)S(O)(=O)=O)=NC(N(CCO)CCO)=NC=1NC1=CC=CC=C1 CNGYZEMWVAWWOB-VAWYXSNFSA-N 0.000 description 1
XSVSPKKXQGNHMD-UHFFFAOYSA-N 5-bromo-3-methyl-1,2-thiazole Chemical compound CC=1C=C(Br)SN=1 XSVSPKKXQGNHMD-UHFFFAOYSA-N 0.000 description 1
NRTLIYOWLVMQBO-UHFFFAOYSA-N 5-chloro-1,3-dimethyl-N-(1,1,3-trimethyl-1,3-dihydro-2-benzofuran-4-yl)pyrazole-4-carboxamide Chemical compound C=12C(C)OC(C)(C)C2=CC=CC=1NC(=O)C=1C(C)=NN(C)C=1Cl NRTLIYOWLVMQBO-UHFFFAOYSA-N 0.000 description 1
HOSGXJWQVBHGLT-UHFFFAOYSA-N 6-hydroxy-3,4-dihydro-1h-quinolin-2-one Chemical group N1C(=O)CCC2=CC(O)=CC=C21 HOSGXJWQVBHGLT-UHFFFAOYSA-N 0.000 description 1
QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
101000779579 Acremonium chrysogenum Alkaline proteinase Proteins 0.000 description 1
241000186361 Actinobacteria <class> Species 0.000 description 1
229930024421 Adenine Natural products 0.000 description 1
GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 1
229910002012 Aerosil® Inorganic materials 0.000 description 1
235000001674 Agaricus brunnescens Nutrition 0.000 description 1
241000588986 Alcaligenes Species 0.000 description 1
101100398412 Arabidopsis thaliana ASK1 gene Proteins 0.000 description 1
XVPZRKIQCKKYNE-UHFFFAOYSA-N Arborine Chemical compound N=1C(=O)C2=CC=CC=C2N(C)C=1CC1=CC=CC=C1 XVPZRKIQCKKYNE-UHFFFAOYSA-N 0.000 description 1
241000203069 Archaea Species 0.000 description 1
239000004475 Arginine Substances 0.000 description 1
KLKHFFMNGWULBN-VKHMYHEASA-N Asn-Gly Chemical group NC(=O)C[C@H](N)C(=O)NCC(O)=O KLKHFFMNGWULBN-VKHMYHEASA-N 0.000 description 1
240000006439 Aspergillus oryzae Species 0.000 description 1
235000002247 Aspergillus oryzae Nutrition 0.000 description 1
208000035404 Autolysis Diseases 0.000 description 1
241000271566 Aves Species 0.000 description 1
108090000145 Bacillolysin Proteins 0.000 description 1
241000193375 Bacillus alcalophilus Species 0.000 description 1
101100043766 Bacillus amyloliquefaciens apr gene Proteins 0.000 description 1
241000193755 Bacillus cereus Species 0.000 description 1
244000055982 Bacillus subtilis subsp amylosacchariticus Species 0.000 description 1
241000193388 Bacillus thuringiensis Species 0.000 description 1
108020000946 Bacterial DNA Proteins 0.000 description 1
LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
240000001889 Brahea edulis Species 0.000 description 1
102220522812 Brain acid soluble protein 1_S85A_mutation Human genes 0.000 description 1
102220522865 Brain acid soluble protein 1_S89A_mutation Human genes 0.000 description 1
CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
125000001433 C-terminal amino-acid group Chemical group 0.000 description 1
108010059574 C5a peptidase Proteins 0.000 description 1
229910021532 Calcite Inorganic materials 0.000 description 1
UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
244000025254 Cannabis sativa Species 0.000 description 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 description 1
229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
206010057248 Cell death Diseases 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
RKWGIWYCVPQPMF-UHFFFAOYSA-N Chloropropamide Chemical compound CCCNC(=O)NS(=O)(=O)C1=CC=C(Cl)C=C1 RKWGIWYCVPQPMF-UHFFFAOYSA-N 0.000 description 1
108090000317 Chymotrypsin Proteins 0.000 description 1
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
108020004705 Codon Proteins 0.000 description 1
241000252095 Congridae Species 0.000 description 1
235000009842 Cucumis melo Nutrition 0.000 description 1
235000015510 Cucumis melo subsp melo Nutrition 0.000 description 1
241000192700 Cyanobacteria Species 0.000 description 1
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
102000012410 DNA Ligases Human genes 0.000 description 1
108010061982 DNA Ligases Proteins 0.000 description 1
102000016928 DNA-directed DNA polymerase Human genes 0.000 description 1
108010014303 DNA-directed DNA polymerase Proteins 0.000 description 1
241000605721 Dichelobacter nodosus Species 0.000 description 1
QEVGZEDELICMKH-UHFFFAOYSA-N Diglycolic acid Chemical class OC(=O)COCC(O)=O QEVGZEDELICMKH-UHFFFAOYSA-N 0.000 description 1
108090000204 Dipeptidase 1 Proteins 0.000 description 1
101000893771 Drosophila melanogaster Furin-like protease 2 Proteins 0.000 description 1
108010083608 Durazym Proteins 0.000 description 1
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
241000194032 Enterococcus faecalis Species 0.000 description 1
GDSYPXWUHMRTHT-UHFFFAOYSA-N Epidermin Natural products N#CCC(C)(C)OC1OC(CO)C(O)C(O)C1O GDSYPXWUHMRTHT-UHFFFAOYSA-N 0.000 description 1
241001517212 Euglenaria anabaena Species 0.000 description 1
108060002716 Exonuclease Proteins 0.000 description 1
101710089384 Extracellular protease Proteins 0.000 description 1
108090001126 Furin Proteins 0.000 description 1
102000004961 Furin Human genes 0.000 description 1
101710094892 Furin-1 Proteins 0.000 description 1
230000005526 G1 to G0 transition Effects 0.000 description 1
102100037948 GTP-binding protein Di-Ras3 Human genes 0.000 description 1
102220498664 General transcription factor IIE subunit 1_S183T_mutation Human genes 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
IKAIKUBBJHFNBZ-LURJTMIESA-N Gly-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)CN IKAIKUBBJHFNBZ-LURJTMIESA-N 0.000 description 1
244000068988 Glycine max Species 0.000 description 1
235000010469 Glycine max Nutrition 0.000 description 1
101100277820 Homo sapiens DIRAS3 gene Proteins 0.000 description 1
101100087527 Homo sapiens RHOJ gene Proteins 0.000 description 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
102000004157 Hydrolases Human genes 0.000 description 1
108090000604 Hydrolases Proteins 0.000 description 1
AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 description 1
QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
102000003960 Ligases Human genes 0.000 description 1
108090000364 Ligases Proteins 0.000 description 1
241001154030 Malbranchea pulchella Species 0.000 description 1
GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
229930195725 Mannitol Natural products 0.000 description 1
102000005741 Metalloproteases Human genes 0.000 description 1
108010006035 Metalloproteases Proteins 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
241001529936 Murinae Species 0.000 description 1
241000234295 Musa Species 0.000 description 1
235000021360 Myristic acid Nutrition 0.000 description 1
239000007832 Na2SO4 Substances 0.000 description 1
229910021333 Na2Si Inorganic materials 0.000 description 1
102000035092 Neutral proteases Human genes 0.000 description 1
108091005507 Neutral proteases Proteins 0.000 description 1
241000203619 Nocardiopsis dassonvillei Species 0.000 description 1
239000005642 Oleic acid Substances 0.000 description 1
ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
108700026244 Open Reading Frames Proteins 0.000 description 1
102000004316 Oxidoreductases Human genes 0.000 description 1
108090000854 Oxidoreductases Proteins 0.000 description 1
235000019482 Palm oil Nutrition 0.000 description 1
102220546387 Pancreatic alpha-amylase_D133E_mutation Human genes 0.000 description 1
108010067372 Pancreatic elastase Proteins 0.000 description 1
102000016387 Pancreatic elastase Human genes 0.000 description 1
102000004503 Perforin Human genes 0.000 description 1
108010056995 Perforin Proteins 0.000 description 1
OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
IMQLKJBTEOYOSI-UHFFFAOYSA-N Phytic acid Natural products OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 description 1
102100038946 Proprotein convertase subtilisin/kexin type 6 Human genes 0.000 description 1
GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 1
101710180012 Protease 7 Proteins 0.000 description 1
101710194948 Protein phosphatase PhpP Proteins 0.000 description 1
102220543874 Protocadherin-10_E45D_mutation Human genes 0.000 description 1
101001022147 Rattus norvegicus Furin Proteins 0.000 description 1
108020004511 Recombinant DNA Proteins 0.000 description 1
102220528606 Ribonuclease P/MRP protein subunit POP5_S99D_mutation Human genes 0.000 description 1
GBFLZEXEOZUWRN-VKHMYHEASA-N S-carboxymethyl-L-cysteine Chemical compound OC(=O)[C@@H](N)CSCC(O)=O GBFLZEXEOZUWRN-VKHMYHEASA-N 0.000 description 1
101150088541 SCPA gene Proteins 0.000 description 1
240000004808 Saccharomyces cerevisiae Species 0.000 description 1
102000003667 Serine Endopeptidases Human genes 0.000 description 1
108090000083 Serine Endopeptidases Proteins 0.000 description 1
241000607715 Serratia marcescens Species 0.000 description 1
229910004298 SiO 2 Inorganic materials 0.000 description 1
239000004115 Sodium Silicate Substances 0.000 description 1
PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 description 1
239000004280 Sodium formate Substances 0.000 description 1
101100118963 Staphylococcus epidermidis epiP gene Proteins 0.000 description 1
244000057717 Streptococcus lactis Species 0.000 description 1
235000014897 Streptococcus lactis Nutrition 0.000 description 1
241000193996 Streptococcus pyogenes Species 0.000 description 1
241000520756 Streptomyces rutgersensis Species 0.000 description 1
108700037663 Subtilisin-like proteases Proteins 0.000 description 1
206010042566 Superinfection Diseases 0.000 description 1
241001414947 Tegeticula yuccasella Species 0.000 description 1
BGRWYDHXPHLNKA-UHFFFAOYSA-N Tetraacetylethylenediamine Chemical compound CC(=O)N(C(C)=O)CCN(C(C)=O)C(C)=O BGRWYDHXPHLNKA-UHFFFAOYSA-N 0.000 description 1
244000299461 Theobroma cacao Species 0.000 description 1
235000009470 Theobroma cacao Nutrition 0.000 description 1
241000203770 Thermoactinomyces vulgaris Species 0.000 description 1
241000223258 Thermomyces lanuginosus Species 0.000 description 1
241000589500 Thermus aquaticus Species 0.000 description 1
101100002024 Thermus aquaticus pstI gene Proteins 0.000 description 1
241001453174 Thermus sp. Rt41A Species 0.000 description 1
QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
101100409361 Vibrio alginolyticus proA gene Proteins 0.000 description 1
241000589636 Xanthomonas campestris Species 0.000 description 1
241000235013 Yarrowia Species 0.000 description 1
FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
230000003213 activating effect Effects 0.000 description 1
125000002252 acyl group Chemical group 0.000 description 1
230000006978 adaptation Effects 0.000 description 1
238000007792 addition Methods 0.000 description 1
229960000643 adenine Drugs 0.000 description 1
235000004279 alanine Nutrition 0.000 description 1
125000001931 aliphatic group Chemical group 0.000 description 1
229910000288 alkali metal carbonate Inorganic materials 0.000 description 1
150000008041 alkali metal carbonates Chemical class 0.000 description 1
108010083498 alkaline elastase Proteins 0.000 description 1
125000005210 alkyl ammonium group Chemical group 0.000 description 1
125000005037 alkyl phenyl group Chemical group 0.000 description 1
229910000147 aluminium phosphate Inorganic materials 0.000 description 1
229910000323 aluminium silicate Inorganic materials 0.000 description 1
AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 1
229960000723 ampicillin Drugs 0.000 description 1
238000004458 analytical method Methods 0.000 description 1
125000000129 anionic group Chemical group 0.000 description 1
238000000137 annealing Methods 0.000 description 1
230000000844 anti-bacterial effect Effects 0.000 description 1
108010091359 aqualysin I Proteins 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
125000003118 aryl group Chemical group 0.000 description 1
235000009582 asparagine Nutrition 0.000 description 1
229960001230 asparagine Drugs 0.000 description 1
238000003556 assay Methods 0.000 description 1
125000004429 atom Chemical group 0.000 description 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
230000002358 autolytic effect Effects 0.000 description 1
108010005097 bacillopeptidase F Proteins 0.000 description 1
229940097012 bacillus thuringiensis Drugs 0.000 description 1
239000003899 bactericide agent Substances 0.000 description 1
230000000721 bacterilogical effect Effects 0.000 description 1
QNSOHXTZPUMONC-UHFFFAOYSA-N benzene pentacarboxylic acid Chemical class OC(=O)C1=CC(C(O)=O)=C(C(O)=O)C(C(O)=O)=C1C(O)=O QNSOHXTZPUMONC-UHFFFAOYSA-N 0.000 description 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
102000006635 beta-lactamase Human genes 0.000 description 1
229910021538 borax Inorganic materials 0.000 description 1
125000005619 boric acid group Chemical class 0.000 description 1
201000004050 brachyolmia-amelogenesis imperfecta syndrome Diseases 0.000 description 1
KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical class O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
102220401446 c.262G>T Human genes 0.000 description 1
102200057186 c.301A>C Human genes 0.000 description 1
102220366376 c.62A>T Human genes 0.000 description 1
VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 description 1
239000001639 calcium acetate Substances 0.000 description 1
235000011092 calcium acetate Nutrition 0.000 description 1
229960005147 calcium acetate Drugs 0.000 description 1
239000001110 calcium chloride Substances 0.000 description 1
229910001628 calcium chloride Inorganic materials 0.000 description 1
229960002713 calcium chloride Drugs 0.000 description 1
235000011148 calcium chloride Nutrition 0.000 description 1
229910002091 carbon monoxide Inorganic materials 0.000 description 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
150000001735 carboxylic acids Chemical class 0.000 description 1
BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
238000005341 cation exchange Methods 0.000 description 1
125000002091 cationic group Chemical group 0.000 description 1
239000003093 cationic surfactant Substances 0.000 description 1
239000002962 chemical mutagen Substances 0.000 description 1
239000007795 chemical reaction product Substances 0.000 description 1
229910052801 chlorine Inorganic materials 0.000 description 1
239000013611 chromosomal DNA Substances 0.000 description 1
229960002376 chymotrypsin Drugs 0.000 description 1
HNEGQIOMVPPMNR-IHWYPQMZSA-N citraconic acid Chemical compound OC(=O)C(/C)=C\C(O)=O HNEGQIOMVPPMNR-IHWYPQMZSA-N 0.000 description 1
229940018557 citraconic acid Drugs 0.000 description 1
150000001860 citric acid derivatives Chemical class 0.000 description 1
238000003776 cleavage reaction Methods 0.000 description 1
230000000295 complement effect Effects 0.000 description 1
238000010668 complexation reaction Methods 0.000 description 1
238000009833 condensation Methods 0.000 description 1
230000005494 condensation Effects 0.000 description 1
230000001276 controlling effect Effects 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
229920001577 copolymer Polymers 0.000 description 1
238000005260 corrosion Methods 0.000 description 1
239000010779 crude oil Substances 0.000 description 1
150000001924 cycloalkanes Chemical class 0.000 description 1
125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
238000013461 design Methods 0.000 description 1
238000011161 development Methods 0.000 description 1
230000018109 developmental process Effects 0.000 description 1
JKWMSGQKBLHBQQ-UHFFFAOYSA-N diboron trioxide Chemical compound O=BOB=O JKWMSGQKBLHBQQ-UHFFFAOYSA-N 0.000 description 1
239000005546 dideoxynucleotide Substances 0.000 description 1
ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
230000029087 digestion Effects 0.000 description 1
MUCZHBLJLSDCSD-UHFFFAOYSA-N diisopropyl fluorophosphate Chemical compound CC(C)OP(F)(=O)OC(C)C MUCZHBLJLSDCSD-UHFFFAOYSA-N 0.000 description 1
238000010790 dilution Methods 0.000 description 1
239000012895 dilution Substances 0.000 description 1
229940042399 direct acting antivirals protease inhibitors Drugs 0.000 description 1
KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 description 1
239000006185 dispersion Substances 0.000 description 1
DDXLVDQZPFLQMZ-UHFFFAOYSA-M dodecyl(trimethyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+](C)(C)C DDXLVDQZPFLQMZ-UHFFFAOYSA-M 0.000 description 1
239000000428 dust Substances 0.000 description 1
239000000975 dye Substances 0.000 description 1
230000001516 effect on protein Effects 0.000 description 1
239000003792 electrolyte Substances 0.000 description 1
230000008030 elimination Effects 0.000 description 1
238000003379 elimination reaction Methods 0.000 description 1
238000005516 engineering process Methods 0.000 description 1
229940032049 enterococcus faecalis Drugs 0.000 description 1
230000009088 enzymatic function Effects 0.000 description 1
238000006911 enzymatic reaction Methods 0.000 description 1
CXTXHTVXPMOOSW-JUEJINBGSA-N epidermin Chemical compound C([C@H]1C(=O)N[C@H](C(=O)N[C@@H](CSC[C@H](C(N[C@@H](CCCCN)C(=O)N1)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)[C@@H](C)CC)C(=O)N[C@H]1C(N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](CS[C@H]1C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N\C(=C/C)C(=O)NCC(=O)N[C@H]1C(N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H]2C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@H](C(N\C=C/SC2)=O)CSC1)=O)=O)[C@@H](C)CC)C1=CC=CC=C1 CXTXHTVXPMOOSW-JUEJINBGSA-N 0.000 description 1
108010064962 epidermin Proteins 0.000 description 1
125000004185 ester group Chemical group 0.000 description 1
RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
AIGRXSNSLVJMEA-FQEVSTJZSA-N ethoxy-(4-nitrophenoxy)-phenyl-sulfanylidene-$l^{5}-phosphane Chemical compound O([P@@](=S)(OCC)C=1C=CC=CC=1)C1=CC=C([N+]([O-])=O)C=C1 AIGRXSNSLVJMEA-FQEVSTJZSA-N 0.000 description 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
102000013165 exonuclease Human genes 0.000 description 1
125000005313 fatty acid group Chemical group 0.000 description 1
230000002349 favourable effect Effects 0.000 description 1
238000005189 flocculation Methods 0.000 description 1
239000012530 fluid Substances 0.000 description 1
229960005051 fluostigmine Drugs 0.000 description 1
239000006260 foam Substances 0.000 description 1
150000004675 formic acid derivatives Chemical class 0.000 description 1
239000003205 fragrance Substances 0.000 description 1
230000006870 function Effects 0.000 description 1
230000002538 fungal effect Effects 0.000 description 1
201000011243 gastrointestinal stromal tumor Diseases 0.000 description 1
102000054767 gene variant Human genes 0.000 description 1
239000011521 glass Substances 0.000 description 1
239000008103 glucose Substances 0.000 description 1
ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
125000005456 glyceride group Chemical group 0.000 description 1
108010015792 glycyllysine Proteins 0.000 description 1
125000001475 halogen functional group Chemical group 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
XLYOFNOQVPJJNP-ZSJDYOACSA-N heavy water Substances [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 description 1
HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
229960002474 hydralazine Drugs 0.000 description 1
230000036571 hydration Effects 0.000 description 1
238000006703 hydration reaction Methods 0.000 description 1
239000003752 hydrotrope Substances 0.000 description 1
125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
125000002768 hydroxyalkyl group Chemical group 0.000 description 1
238000000338 in vitro Methods 0.000 description 1
239000011256 inorganic filler Substances 0.000 description 1
229910003475 inorganic filler Inorganic materials 0.000 description 1
206010022498 insulinoma Diseases 0.000 description 1
238000005342 ion exchange Methods 0.000 description 1
239000002563 ionic surfactant Substances 0.000 description 1
238000002955 isolation Methods 0.000 description 1
229960000310 isoleucine Drugs 0.000 description 1
AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
101150107787 kex1 gene Proteins 0.000 description 1
235000019626 lipase activity Nutrition 0.000 description 1
150000002632 lipids Chemical class 0.000 description 1
230000002366 lipolytic effect Effects 0.000 description 1
125000003071 maltose group Chemical group 0.000 description 1
210000004962 mammalian cell Anatomy 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
239000003550 marker Substances 0.000 description 1
230000010534 mechanism of action Effects 0.000 description 1
239000012528 membrane Substances 0.000 description 1
229930182817 methionine Natural products 0.000 description 1
JZMJDSHXVKJFKW-UHFFFAOYSA-M methyl sulfate(1-) Chemical compound COS([O-])(=O)=O JZMJDSHXVKJFKW-UHFFFAOYSA-M 0.000 description 1
238000002156 mixing Methods 0.000 description 1
150000004682 monohydrates Chemical class 0.000 description 1
239000003471 mutagenic agent Substances 0.000 description 1
231100000707 mutagenic chemical Toxicity 0.000 description 1
IAIWVQXQOWNYOU-FPYGCLRLSA-N nitrofural Chemical compound NC(=O)N\N=C\C1=CC=C([N+]([O-])=O)O1 IAIWVQXQOWNYOU-FPYGCLRLSA-N 0.000 description 1
239000002777 nucleoside Substances 0.000 description 1
150000003833 nucleoside derivatives Chemical class 0.000 description 1
JPMIIZHYYWMHDT-UHFFFAOYSA-N octhilinone Chemical compound CCCCCCCCN1SC=CC1=O JPMIIZHYYWMHDT-UHFFFAOYSA-N 0.000 description 1
239000003921 oil Substances 0.000 description 1
235000019198 oils Nutrition 0.000 description 1
JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 1
238000002515 oligonucleotide synthesis Methods 0.000 description 1
239000003605 opacifier Substances 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
150000002894 organic compounds Chemical class 0.000 description 1
239000012766 organic filler Substances 0.000 description 1
239000007800 oxidant agent Substances 0.000 description 1
230000003647 oxidation Effects 0.000 description 1
238000007254 oxidation reaction Methods 0.000 description 1
230000001590 oxidative effect Effects 0.000 description 1
239000001301 oxygen Substances 0.000 description 1
229910052760 oxygen Inorganic materials 0.000 description 1
125000004430 oxygen atom Chemical group O* 0.000 description 1
239000003346 palm kernel oil Substances 0.000 description 1
235000019865 palm kernel oil Nutrition 0.000 description 1
239000002540 palm oil Substances 0.000 description 1
IPCSVZSSVZVIGE-UHFFFAOYSA-N palmitic acid group Chemical group C(CCCCCCCCCCCCCCC)(=O)O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 1
208000021255 pancreatic insulinoma Diseases 0.000 description 1
239000012188 paraffin wax Substances 0.000 description 1
239000002245 particle Substances 0.000 description 1
239000000137 peptide hydrolase inhibitor Substances 0.000 description 1
238000011056 performance test Methods 0.000 description 1
239000002304 perfume Substances 0.000 description 1
239000012071 phase Substances 0.000 description 1
239000011574 phosphorus Substances 0.000 description 1
239000000467 phytic acid Substances 0.000 description 1
229940068041 phytic acid Drugs 0.000 description 1
229920000728 polyester Polymers 0.000 description 1
229910001414 potassium ion Inorganic materials 0.000 description 1
159000000001 potassium salts Chemical class 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000002335 preservative effect Effects 0.000 description 1
150000003138 primary alcohols Chemical class 0.000 description 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
108010056608 proteinase D Proteins 0.000 description 1
108010056508 proteinase R Proteins 0.000 description 1
108010056534 proteinase T Proteins 0.000 description 1
125000001453 quaternary ammonium group Chemical group 0.000 description 1
230000005855 radiation Effects 0.000 description 1
230000009467 reduction Effects 0.000 description 1
230000008439 repair process Effects 0.000 description 1
239000011347 resin Substances 0.000 description 1
229920005989 resin Polymers 0.000 description 1
238000012552 review Methods 0.000 description 1
102220216845 rs1060503163 Human genes 0.000 description 1
102200131574 rs11556620 Human genes 0.000 description 1
102200044888 rs121913412 Human genes 0.000 description 1
102220078934 rs144054843 Human genes 0.000 description 1
102220317648 rs1553902415 Human genes 0.000 description 1
102200060515 rs1555688659 Human genes 0.000 description 1
102200114227 rs199588390 Human genes 0.000 description 1
102220121464 rs201796375 Human genes 0.000 description 1
102220075487 rs201956727 Human genes 0.000 description 1
102200117949 rs34095019 Human genes 0.000 description 1
102200158370 rs868333 Human genes 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
230000007017 scission Effects 0.000 description 1
230000003248 secreting effect Effects 0.000 description 1
230000028043 self proteolysis Effects 0.000 description 1
239000003352 sequestering agent Substances 0.000 description 1
230000009919 sequestration Effects 0.000 description 1
125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 1
230000011664 signaling Effects 0.000 description 1
239000000741 silica gel Substances 0.000 description 1
229910002027 silica gel Inorganic materials 0.000 description 1
HLBBKKJFGFRGMU-UHFFFAOYSA-M sodium formate Chemical compound [Na+].[O-]C=O HLBBKKJFGFRGMU-UHFFFAOYSA-M 0.000 description 1
235000019254 sodium formate Nutrition 0.000 description 1
229910001415 sodium ion Inorganic materials 0.000 description 1
KKCBUQHMOMHUOY-UHFFFAOYSA-N sodium oxide Chemical compound [O-2].[Na+].[Na+] KKCBUQHMOMHUOY-UHFFFAOYSA-N 0.000 description 1
229910001948 sodium oxide Inorganic materials 0.000 description 1
229910052911 sodium silicate Inorganic materials 0.000 description 1
229910052938 sodium sulfate Inorganic materials 0.000 description 1
235000011152 sodium sulphate Nutrition 0.000 description 1
239000004328 sodium tetraborate Substances 0.000 description 1
235000010339 sodium tetraborate Nutrition 0.000 description 1
239000002689 soil Substances 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
241000894007 species Species 0.000 description 1
230000028070 sporulation Effects 0.000 description 1
101150033155 sspP gene Proteins 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
239000001384 succinic acid Substances 0.000 description 1
238000006277 sulfonation reaction Methods 0.000 description 1
150000003457 sulfones Chemical class 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
239000000271 synthetic detergent Substances 0.000 description 1
108010075550 termamyl Proteins 0.000 description 1
TUNFSRHWOTWDNC-UHFFFAOYSA-N tetradecanoic acid Chemical class CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 description 1
JZBRFIUYUGTUGG-UHFFFAOYSA-J tetrapotassium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [K+].[K+].[K+].[K+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O JZBRFIUYUGTUGG-UHFFFAOYSA-J 0.000 description 1
108010031354 thermitase Proteins 0.000 description 1
239000002562 thickening agent Substances 0.000 description 1
229960002898 threonine Drugs 0.000 description 1
229940113082 thymine Drugs 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
238000013518 transcription Methods 0.000 description 1
230000035897 transcription Effects 0.000 description 1
238000005809 transesterification reaction Methods 0.000 description 1
238000012546 transfer Methods 0.000 description 1
230000001131 transforming effect Effects 0.000 description 1
230000007704 transition Effects 0.000 description 1
238000013519 translation Methods 0.000 description 1
230000014616 translation Effects 0.000 description 1
230000014621 translational initiation Effects 0.000 description 1
JEVFKQIDHQGBFB-UHFFFAOYSA-K tripotassium;2-[bis(carboxylatomethyl)amino]acetate Chemical compound [K+].[K+].[K+].[O-]C(=O)CN(CC([O-])=O)CC([O-])=O JEVFKQIDHQGBFB-UHFFFAOYSA-K 0.000 description 1
238000000108 ultra-filtration Methods 0.000 description 1
238000011144 upstream manufacturing Methods 0.000 description 1
229940035893 uracil Drugs 0.000 description 1
235000013311 vegetables Nutrition 0.000 description 1
101150061972 zur gene Proteins 0.000 description 1
239000002888 zwitterionic surfactant Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
- C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Chemical Kinetics & Catalysis (AREA)
Oil, Petroleum & Natural Gas (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Microbiology (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Detergent Compositions (AREA)
Enzymes And Modification Thereof (AREA)

PL96323188A 1995-05-05 1996-04-12 Ciekła detergentowa kompozycja PL184399B1 (pl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP95201161		1995-05-05
PCT/EP1996/001610 WO1996034935A2 (en)	1995-05-05	1996-04-12	Subtilisin variants

Publications (2)

Publication Number	Publication Date
PL323188A1 PL323188A1 (en)	1998-03-16
PL184399B1 true PL184399B1 (pl)	2002-10-31

Family

ID=8220259

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL96323188A PL184399B1 (pl)	1995-05-05	1996-04-12	Ciekła detergentowa kompozycja

Country Status (12)

Country	Link
EP (1)	EP0827531A2 (es)
JP (1)	JPH11505275A (es)
AR (1)	AR001863A1 (es)
AU (1)	AU5646596A (es)
BR (1)	BR9608126A (es)
CA (1)	CA2217162A1 (es)
CZ (1)	CZ349797A3 (es)
HU (1)	HUP9901725A3 (es)
PL (1)	PL184399B1 (es)
SK (1)	SK284609B6 (es)
WO (1)	WO1996034935A2 (es)
ZA (1)	ZA963567B (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9621436D0 (en) *	1996-10-15	1996-12-04	Unilever Plc	Enzymatic compositions
AU4772697A (en) *	1996-11-04	1998-05-29	Novo Nordisk A/S	Subtilase variants and compositions
KR20010023468A (ko)	1997-08-29	2001-03-26	한센 핀 베네드, 안네 제헤르, 웨이콥 마리안느	프로테아제 변이체 및 조성물
US6780629B2 (en)	1997-11-21	2004-08-24	Novozymes A/S	Subtilase enzymes
US6773907B2 (en)	1997-11-21	2004-08-10	Peter Kamp Hansen	Subtilase enzymes
BR9814236A (pt) *	1997-11-21	2000-10-03	Novo Nordisk As	Enzima subtilase, sua variante, sequência de dna isolada, vetor de expressão, célula microbiana hospedeira, processo para produzir uma subtilase ou uma variante de subtilase, composição, e, uso de uma subtilase ou de uma variante de subtilase.
BRPI9916352B1 (pt) *	1998-12-18	2016-04-19	Novozymes As	enzima de subtilase isolada dos subgrupos i-s1 e i-s2, subtilase, seqüência isolada de dna, vetor de expressão, célula hospedeira microbiana, método para produzir uma subtilase ou uma variante de subtilase, composição, e, uso de uma subtilase ou de uma variante de subtilase ou de uma composição de enzima
DE69937160T2 (de) *	1998-12-18	2008-06-19	Novozymes A/S	Subtilase enzyme der i-s1 und i-s2 untergruppen, mit einem zusätzlichen aminosäurerest in einer aktiven schleifenregion
AU772347B2 (en) *	1998-12-18	2004-04-22	Novozymes A/S	Subtilase enzymes of the I-S1 and I-S2 sub-groups having an additional amino acid residue in an active site loop region
JP4647788B2 (ja) *	1998-12-18	2011-03-09	ノボザイムスアクティーゼルスカブ	活性部位ループ領域中に追加のアミノ酸残基を有するサブチラーゼ酵素サブグループｉ−ｓ１及びｉ−ｓ２
CN1333822A (zh) *	1998-12-18	2002-01-30	诺沃奇梅兹有限公司	在活性位点环区具有额外氨基酸残基的i－s1和i－s2亚族枯草杆菌酶
ATE408680T1 (de) *	1999-05-20	2008-10-15	Novozymes As	Subtilase enzyme der i-s1 und i-s2 untergruppen mit mindestens einer zusätzlichen aminosäure zwischen position 128 und 129
ATE408678T1 (de) *	1999-05-20	2008-10-15	Novozymes As	Subtilase enzyme der i-s1 und i-s2 untergruppen mit mindestens einer zusätzlichen aminosäure zwischen position 129 und 130
EP1183343B2 (en) *	1999-05-20	2013-11-27	Novozymes A/S	Subtilase enzymes of the i-s1 and i-s2 sub-groups having at least one additional amino acid residue between positions 125 and 126
AU4392500A (en) *	1999-05-20	2000-12-12	Novozymes A/S	Subtilase enzymes of the i-s1 and i-s2 sub-groups having at least one additionalamino acid residue between positions 132 and 133
BR0010738A (pt) *	1999-05-20	2002-02-19	Novozymes As	Enzima subtilase do sub gupo i-s1 ou i-s20, enazima subtilase isolada, variante de subtilase, sequência de dna isolada, vetor de expressão, célula hospedeira microbiana, hospedeiro microbiano, método para a produção de uma subtilase ou uma variante de subtilase, composição, e, uso de uma subtilase ou uma variante de subtilase
EP1183336B2 (en) *	1999-05-20	2012-12-19	Novozymes A/S	Subtilase enzymes of the i-s1 and i-s2 sub-groups having at least one additional amino acid residue between positions 131 and 132
DE60040285D1 (de) *	1999-05-20	2008-10-30	Novozymes As	Subtilase enzyme der i-s1 und i-s2 untergruppen mit mindestens einer zusätzlichen aminosäure zwischen position 127 und 128
WO2000071688A1 (en) *	1999-05-20	2000-11-30	Novozymes A/S	Subtilase enzymes of the i-s1 and i-s2 sub-groups having at least one additional amino acid residue between positions 126 and 127
EP1183335B2 (en) *	1999-05-20	2014-03-05	Novozymes A/S	Subtilase enzymes of the i-s1 and i-s2 sub-groups having at least one additional amino acid residue between positions 130 and 131
CN101974375B (zh) *	1999-12-15	2014-07-02	诺沃奇梅兹有限公司	对蛋渍具有改进洗涤性能的枯草杆菌酶变体
DE10153792A1 (de)	2001-10-31	2003-05-22	Henkel Kgaa	Neue Alkalische Protease-Varianten und Wasch- und Reinigungsmittel enthaltend diese neuen Alkalischen Protease-Varianten
DE10162727A1 (de)	2001-12-20	2003-07-10	Henkel Kgaa	Neue Alkalische Protease aus Bacillus gibsonii (DSM 14391) und Wasch-und Reinigungsmittel enthaltend diese neue Alkalische Protease
DE10162728A1 (de)	2001-12-20	2003-07-10	Henkel Kgaa	Neue Alkalische Protease aus Bacillus gibsonii (DSM 14393) und Wasch-und Reinigungsmittel enthaltend diese neue Alkalische Protease
DE10163884A1 (de)	2001-12-22	2003-07-10	Henkel Kgaa	Neue Alkalische Protease aus Bacillus sp. (DSM 14392) und Wasch- und Reinigungsmittel enthaltend diese neue Alkalische Protease
US7888093B2 (en)	2002-11-06	2011-02-15	Novozymes A/S	Subtilase variants
EP2074205B2 (en) *	2006-10-06	2016-11-23	Novozymes A/S	Detergent compositions and the use of enzyme combinations therein
EP2589651A3 (en)	2008-11-11	2013-08-28	Danisco US Inc.	Compositions and methods comprising serine protease variants
CN103361196B (zh)	2008-11-11	2016-01-27	宝洁公司	包含一种或多种可组合的突变的芽孢杆菌属枯草杆菌蛋白酶
EP4525615A2 (en)	2022-05-14	2025-03-26	Novozymes A/S	Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2227508T3 (es) *	1989-06-26	2005-04-01	Unilever N.V.	Composiciones detergentes enzimaticas.
EP0516200B1 (en) *	1991-05-01	1996-07-24	Unilever N.V.	Detergent compositions containing stabilized enzymes
EP0525610A3 (en) *	1991-07-27	1993-03-24	Solvay Enzymes Gmbh & Co. Kg	Process for increasing the stability of enzymes and stabilized enzymes
DE4231726A1 (de) *	1992-09-23	1994-03-24	Cognis Bio Umwelt	Mutierte subtilisinartige Serinproteasen
DK39093D0 (da) *	1993-04-01	1993-04-01	Novo Nordisk As	Enzym
MA23346A1 (fr) *	1993-10-14	1995-04-01	Genencor Int	Variantes de la subtilisine

1996
- 1996-04-12 AU AU56465/96A patent/AU5646596A/en not_active Abandoned
- 1996-04-12 CA CA002217162A patent/CA2217162A1/en not_active Abandoned
- 1996-04-12 HU HU9901725A patent/HUP9901725A3/hu unknown
- 1996-04-12 SK SK1467-97A patent/SK284609B6/sk unknown
- 1996-04-12 WO PCT/EP1996/001610 patent/WO1996034935A2/en not_active Ceased
- 1996-04-12 JP JP8532961A patent/JPH11505275A/ja not_active Ceased
- 1996-04-12 EP EP96913508A patent/EP0827531A2/en not_active Withdrawn
- 1996-04-12 BR BR9608126A patent/BR9608126A/pt not_active IP Right Cessation
- 1996-04-12 PL PL96323188A patent/PL184399B1/pl not_active IP Right Cessation
- 1996-04-12 CZ CZ973497A patent/CZ349797A3/cs unknown
- 1996-05-06 AR AR33641396A patent/AR001863A1/es unknown
- 1996-05-06 ZA ZA9603567A patent/ZA963567B/xx unknown

Also Published As

Publication number	Publication date
JPH11505275A (ja)	1999-05-18
SK146797A3 (en)	1998-03-04
CZ349797A3 (cs)	1998-04-15
WO1996034935A2 (en)	1996-11-07
SK284609B6 (sk)	2005-07-01
WO1996034935A3 (en)	1997-01-16
PL323188A1 (en)	1998-03-16
BR9608126A (pt)	1999-02-09
HUP9901725A2 (hu)	1999-09-28
ZA963567B (en)	1997-11-06
AR001863A1 (es)	1997-12-10
HUP9901725A3 (en)	2001-09-28
EP0827531A2 (en)	1998-03-11
CA2217162A1 (en)	1996-11-07
AU5646596A (en)	1996-11-21

Publication	Publication Date	Title
KR100380006B1 (ko)	2004-05-27	프로테아제변이체와조성물
US5837517A (en)	1998-11-17	Protease variants and compositions
PL184399B1 (pl)	2002-10-31	Ciekła detergentowa kompozycja
US20110230386A1 (en)	2011-09-22	Protease Variants and Compositions
US6632646B1 (en)	2003-10-14	Modified subtilisins and detergent compositions containing same
KR100591553B1 (ko)	2006-06-19	섭틸라제 변종과 조성물
AU2001279614B2 (en)	2006-08-17	Subtilase enzymes
EP1553173B1 (en)	2007-05-16	Enzymes and detergent compositions
EP0769549A2 (en)	1997-04-23	Enzyme mutants having a low degree of variation of the molecular charge over a pH range
CA2098703A1 (en)	1992-06-22	Enzymes and enzymatic detergent compositions
CN1342199B (zh)	2010-12-08	在活性位点环区具有额外氨基酸残基的i-s1和i-s2亚族枯草杆菌酶
CN100497617C (zh)	2009-06-10	枯草杆菌酶变体
JP5563180B2 (ja)	2014-07-30	９７位と９８位との間に少なくとも１個の追加のアミノ酸残基を有するｉ−ｓ１及びｉ−ｓ２サブグループのズブチラーゼ酵素
US20140073552A1 (en)	2014-03-13	Subtilase Vairants
CN101275127A (zh)	2008-10-01	在活性位点环区中具有额外氨基酸残基的i-s1和i-s2亚组枯草杆菌酶
HK1026225A (en)	2000-12-08	A mutated subtilisin protease

Legal Events

Date	Code	Title	Description
2007-10-31	LAPS	Decisions on the lapse of the protection rights	Effective date: 20060412