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PH18529A - Anti-tumor quinazoline compounds - Google Patents

Anti-tumor quinazoline compounds

Info

Publication number
PH18529A
PH18529A PH26788A PH26788A PH18529A PH 18529 A PH18529 A PH 18529A PH 26788 A PH26788 A PH 26788A PH 26788 A PH26788 A PH 26788A PH 18529 A PH18529 A PH 18529A
Authority
PH
Philippines
Prior art keywords
tumor
quinazoline compounds
quinazoline
compounds
tumor quinazoline
Prior art date
Application number
PH26788A
Other languages
English (en)
Inventor
William E Kreighbaum
William T Comer
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of PH18529A publication Critical patent/PH18529A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PH26788A 1981-03-06 1982-01-25 Anti-tumor quinazoline compounds PH18529A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/241,317 US4343940A (en) 1979-02-13 1981-03-06 Anti-tumor quinazoline compounds

Publications (1)

Publication Number Publication Date
PH18529A true PH18529A (en) 1985-08-02

Family

ID=22910195

Family Applications (1)

Application Number Title Priority Date Filing Date
PH26788A PH18529A (en) 1981-03-06 1982-01-25 Anti-tumor quinazoline compounds

Country Status (31)

Country Link
US (1) US4343940A (fr)
JP (1) JPS57158780A (fr)
KR (1) KR880001852B1 (fr)
AR (1) AR231138A1 (fr)
AT (1) AT380476B (fr)
AU (1) AU556099B2 (fr)
BE (1) BE891936A (fr)
CA (1) CA1163995A (fr)
CH (1) CH647776A5 (fr)
CY (1) CY1371A (fr)
DE (1) DE3203770C2 (fr)
DK (1) DK159442C (fr)
ES (1) ES509434A0 (fr)
FI (1) FI71559C (fr)
FR (1) FR2501207B1 (fr)
GB (1) GB2094295B (fr)
GR (1) GR75903B (fr)
HK (1) HK4588A (fr)
HU (1) HU189997B (fr)
IE (1) IE52385B1 (fr)
IL (1) IL64875A0 (fr)
IT (1) IT1154272B (fr)
KE (1) KE3715A (fr)
LU (1) LU83903A1 (fr)
NL (1) NL8200473A (fr)
NZ (1) NZ199576A (fr)
PH (1) PH18529A (fr)
PT (1) PT74394B (fr)
SE (1) SE461732B (fr)
SG (1) SG30787G (fr)
YU (1) YU42031B (fr)

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DE3131365A1 (de) * 1981-08-07 1983-02-24 Henkel KGaA, 4000 Düsseldorf Neue diglycidyl-substituierte heterocyclische verbindungen, verfahren zu ihrer herstellung und ihre verwendung in arzneimittelzubereitungen mit cytostatischer wirksamkeit
US4963554A (en) * 1990-02-14 1990-10-16 Ortho Pharmaceutical Corporation 6,7-dimethoxy-1,2-dihydro-2-arylquinazoline-3-oxides
US5030635A (en) * 1990-02-14 1991-07-09 Ortho Pharmaceutical Corporation 6-7-dimethoxy-1,2-dihydro-2-arylquinazoline-3-oxides
US6645969B1 (en) 1991-05-10 2003-11-11 Aventis Pharmaceuticals Inc. Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase
US5714493A (en) * 1991-05-10 1998-02-03 Rhone-Poulenc Rorer Pharmaceuticals, Inc. Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase
USRE37650E1 (en) 1991-05-10 2002-04-09 Aventis Pharmacetical Products, Inc. Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase
US5710158A (en) * 1991-05-10 1998-01-20 Rhone-Poulenc Rorer Pharmaceuticals Inc. Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
US5480883A (en) * 1991-05-10 1996-01-02 Rhone-Poulenc Rorer Pharmaceuticals Inc. Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
PT100905A (pt) * 1991-09-30 1994-02-28 Eisai Co Ltd Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem
DE69422450T2 (de) * 1993-06-29 2000-06-08 Takeda Chemical Industries, Ltd. Chinoline oder Chinazolin-Derivate und deren Verwendung zur Herstellung eines Medikaments für die Behandlung von Osteoporose
WO1995023141A1 (fr) * 1994-02-23 1995-08-31 Pfizer Inc. Derives de la quinazoline a substitution 4-heterocyclyle, procedes d'elaboration et utilisations correspondantes comme agents anticancereux
US5804396A (en) * 1994-10-12 1998-09-08 Sugen, Inc. Assay for agents active in proliferative disorders
TW321649B (fr) * 1994-11-12 1997-12-01 Zeneca Ltd
GB9424233D0 (en) * 1994-11-30 1995-01-18 Zeneca Ltd Quinazoline derivatives
US5837815A (en) * 1994-12-15 1998-11-17 Sugen, Inc. PYK2 related polypeptide products
US5837524A (en) * 1994-12-15 1998-11-17 Sugen, Inc. PYK2 related polynucleotide products
GB9508538D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
GB9508565D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quiazoline derivative
GB9508535D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivative
GB9508537D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
US5932574A (en) * 1995-04-27 1999-08-03 Zeneca Limited Quinazoline derivatives
CA2222545A1 (fr) * 1995-06-07 1996-12-19 Sugen, Inc. Quinazolines et compositions pharmaceutiques
US6143764A (en) * 1995-11-07 2000-11-07 Kirin Beer Kabushiki Kaisha Quinoline and quinazoline derivatives inhibiting platelet-derived growth factor receptor autophosphorylation and pharmaceutical compositions containing the same
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
US6716575B2 (en) 1995-12-18 2004-04-06 Sugen, Inc. Diagnosis and treatment of AUR1 and/or AUR2 related disorders
US7119174B2 (en) * 1995-12-18 2006-10-10 Sugen, Inc. Diagnosis and treatment of AUR1 and/or AUR2 related disorders
AU719434B2 (en) 1996-02-13 2000-05-11 Astrazeneca Ab Quinazoline derivatives as VEGF inhibitors
GB9603095D0 (en) * 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline derivatives
GB9603097D0 (en) * 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline compounds
ES2169355T3 (es) 1996-03-05 2002-07-01 Astrazeneca Ab Derivados de 4-anilinoquinazolina.
GB9607729D0 (en) * 1996-04-13 1996-06-19 Zeneca Ltd Quinazoline derivatives
GB9718972D0 (en) * 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
DE69729954T2 (de) * 1996-12-11 2005-09-08 Sugen, Inc., San Francisco Identifizierungsverfahren für Substanzen die an das Pyk2 Polypeptid binden
US6818440B2 (en) * 1997-04-28 2004-11-16 Sugen, Inc. Diagnosis and treatment of alk-7 related disorders
US6228641B1 (en) 1997-05-20 2001-05-08 Sugen, Inc. Diagnosis and treatment of PTP04 related disorders
US7115710B2 (en) * 1997-06-11 2006-10-03 Sugen, Inc. Diagnosis and treatment of PTP related disorders
US6342593B1 (en) 1997-06-11 2002-01-29 Sugen, Inc. Diagnosis and treatment of ALP related disorders
US6388063B1 (en) 1997-06-18 2002-05-14 Sugen, Inc. Diagnosis and treatment of SAD related disorders
WO1999037787A2 (fr) * 1998-01-21 1999-07-29 Sugen, Inc. Orthologues humains du gene wart
CA2369172A1 (fr) 1998-04-14 1999-10-21 Sugen, Inc. Proteines kinases apparentees a la famille de ste20
HUP0102793A3 (en) 1998-05-28 2002-07-29 Parker Hughes Inst St Paul Quinazolines for treating brain tumor and medicaments containing them
US6800649B1 (en) 1998-06-30 2004-10-05 Parker Hughes Institute Method for inhibiting c-jun expression using JAK-3 inhibitors
KR20010089171A (ko) 1998-08-21 2001-09-29 추후제출 퀴나졸린 유도체
US6861442B1 (en) * 1998-12-30 2005-03-01 Sugen, Inc. PYK2 and inflammation
US6080747A (en) * 1999-03-05 2000-06-27 Hughes Institute JAK-3 inhibitors for treating allergic disorders
US6258820B1 (en) * 1999-03-19 2001-07-10 Parker Hughes Institute Synthesis and anti-tumor activity of 6,7-dialkoxy-4-phenylamino-quinazolines
US7364866B2 (en) * 1999-10-22 2008-04-29 Pharmacia & Upjohn Company Drosophila G protein coupled receptors, nucleic acids, and methods related to the same
JP2003512838A (ja) 1999-10-22 2003-04-08 ファルマシア・アンド・アップジョン・カンパニー ショウジョウバエｇタンパク質結合レセプター、核酸、およびそれに関連する方法。
US20030162223A1 (en) * 1999-10-22 2003-08-28 Lowery David E. Drosophila G protein coupled receptors, nucleic acids, and methods related to the same
EP1676845B1 (fr) 1999-11-05 2008-06-11 AstraZeneca AB Nouveaux dérivés de type quinazoline
WO2001036473A2 (fr) * 1999-11-16 2001-05-25 Pharmacia & Upjohn Company Recepteurs couples a une proteine g
US20030082534A1 (en) * 1999-11-16 2003-05-01 Peter Lind Novel G protein-coupled receptors
WO2001062797A2 (fr) * 2000-02-23 2001-08-30 Pharmacia & Upjohn Company Nouveaux recepteurs couples a la proteine g
DK1274692T3 (da) * 2000-04-07 2006-10-30 Astrazeneca Ab Quinazolinforbindelser
US20050069976A1 (en) * 2001-02-14 2005-03-31 Peter Lind Protein-coupled receptor
US8450302B2 (en) * 2002-08-02 2013-05-28 Ab Science 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors
US20050239852A1 (en) * 2002-08-02 2005-10-27 Ab Science 2-(3-aminoaryl)amino-4-aryl-thiazoles and their use as c-kit inhibitors
PL1684750T3 (pl) * 2003-10-23 2010-10-29 Ab Science 2-Aminoarylooksazole jako inhibitory kinazy tyrozynowej
MX2007012392A (es) 2005-04-04 2007-12-05 Ab Science Derivados de oxazol sustituidos y su uso como inhibidores de tirosina cinasa.
US8246966B2 (en) * 2006-08-07 2012-08-21 University Of Georgia Research Foundation, Inc. Trypanosome microsome system and uses thereof
MX2009003673A (es) 2006-10-04 2009-04-22 Pfizer Prod Inc Derivados de piridido[4,3-d]pirimidin-4(3h)-ona como antagonistas de los receptores de calcio.
EP2088863A2 (fr) 2006-11-22 2009-08-19 University Of Georgia Research Foundation, Inc. Inhibiteurs de tyrosine kinase en tant qu'agents anti-kinétolastides et anti-apicomplexes
JP2010511382A (ja) * 2006-12-01 2010-04-15 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ 癌関連タンパク質キナーゼ
SG10201913982WA (en) 2011-03-04 2020-03-30 Newgen Therapeutics Inc Alkyne Substituted Quinazoline Compound And Methods Of Use

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* Cited by examiner, † Cited by third party
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US3298291A (en) * 1965-12-28 1967-01-17 Jack D Layton Paver screed assembly
US3455920A (en) * 1967-01-13 1969-07-15 Squibb & Sons Inc 2,3-dihydro-5 and 6-substituted-2-phenyl-4(1h)-quinazolinones
US3637693A (en) * 1968-07-12 1972-01-25 Du Pont Hydroxyarylquinazolines and their use as uv-absorbers
DE2050092C3 (de) 1970-10-13 1980-04-24 Bayer Ag, 5090 Leverkusen Chinazolondiurethane, Verfahren zu ihrer Herstellung sowie Arzneimittel, die diese Verbindungen enthalten
DE2162327C3 (de) * 1970-12-23 1975-09-18 Sumitomo Chemical Co., Ltd., Osaka (Japan) Verfahren zur Herstellung von 3,4-Oihydro-2(1 H)-chinazolinonen
JPS6011032B2 (ja) 1975-12-16 1985-03-22 大鵬薬品工業株式会社 ２―置換―５―フルオルピリミジン―４―オン誘導体の製造法
US4080455A (en) * 1975-12-16 1978-03-21 Taisho Pharmaceutical Company Limited 5-Fluoropyrimidin-4-one compositions

Also Published As

Publication number Publication date
FI71559B (fi) 1986-10-10
FI71559C (fi) 1987-01-19
AR231138A1 (es) 1984-09-28
GB2094295B (en) 1984-09-12
SE461732B (sv) 1990-03-19
PT74394B (en) 1984-10-22
DE3203770C2 (de) 1993-11-04
CY1371A (en) 1987-08-07
FR2501207B1 (fr) 1985-12-06
IL64875A0 (en) 1982-03-31
LU83903A1 (fr) 1982-09-13
GB2094295A (en) 1982-09-15
IT8247713A1 (it) 1983-08-03
SE8200526L (sv) 1982-09-07
YU25682A (en) 1985-03-20
ES8304095A1 (es) 1983-02-16
KE3715A (en) 1987-04-16
IE52385B1 (en) 1987-10-14
KR830009050A (ko) 1983-12-17
AT380476B (de) 1986-05-26
IT8247713A0 (it) 1982-02-03
YU42031B (en) 1988-04-30
DK159442C (da) 1991-03-18
HK4588A (en) 1988-01-29
DE3203770A1 (de) 1982-11-11
AU556099B2 (en) 1986-10-23
HU189997B (en) 1986-08-28
KR880001852B1 (ko) 1988-09-22
NZ199576A (en) 1986-05-09
IT1154272B (it) 1987-01-21
DK159442B (da) 1990-10-15
JPS57158780A (en) 1982-09-30
FR2501207A1 (fr) 1982-09-10
DK50482A (da) 1982-09-07
JPH0337552B2 (fr) 1991-06-05
FI820399L (fi) 1982-09-07
PT74394A (en) 1982-03-01
AU7998182A (en) 1982-09-09
SG30787G (en) 1988-09-16
US4343940A (en) 1982-08-10
IE820163L (en) 1982-09-06
GR75903B (fr) 1984-08-02
CA1163995A (fr) 1984-03-20
ATA39582A (de) 1985-10-15
NL8200473A (nl) 1982-10-01
CH647776A5 (de) 1985-02-15
ES509434A0 (es) 1983-02-16
BE891936A (fr) 1982-07-28

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