PE92298A1 - Variantes de aprotinina con propiedades mejoradas - Google Patents
Variantes de aprotinina con propiedades mejoradasInfo
- Publication number
- PE92298A1 PE92298A1 PE1997000661A PE00066197A PE92298A1 PE 92298 A1 PE92298 A1 PE 92298A1 PE 1997000661 A PE1997000661 A PE 1997000661A PE 00066197 A PE00066197 A PE 00066197A PE 92298 A1 PE92298 A1 PE 92298A1
- Authority
- PE
- Peru
- Prior art keywords
- aprotinin
- variants
- improved properties
- mostrum
- modified
- Prior art date
Links
- 229960004405 aprotinin Drugs 0.000 title abstract 12
- 108010039627 Aprotinin Proteins 0.000 title abstract 2
- ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 title abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 238000001356 surgical procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
SE REFIEREN A VARIANTES DE APROTININA CARACTERIZADAS PORQUE COMPRENDEN AMINOACIDOS ARG 15 o ARG 15-ALA 17 CON UNA CARGA NETA DE +3 A -3 A pH 7, ADEMAS PUEDEN CONTENER UNA SECUENCIA N-TERMINAL MODIFICADA (ELONGADA, ACORTADA O DELECIONADA); SON PREFERIDAS LAS SIGUIENTES VARIANTES: DesPro2Ser10Arg15Ala17Asp24Thr26Glu31Asn41Glu53-APROTININA, DesPro2Ser10Arg15Asp24Thr26Glu31Asn41Glu53-APROTININA, DesPro2Ser10Arg15Ser17Asp24Thr26Glu31Asn41Glu53-APROTININA, DesPro2Ser10Arg15Ala17Thr26Glu31Asn41Glu53-APROTININA, DesPro2Ser10Arg15Ala17Asp24Thr26Asn41Glu53-APROTININA, Ser10Arg15Ala17Asp24Thr26Glu31Asn41Glu53-APROTININA, Ser10Arg15Asp24Thr26Glu31Asn41Glu53-APROTININA, Ser10Arg15Ser17Asp24Thr26Glu31Asn41Glu53-APROTININA,Ser10Arg15Ala17Thr26Glu31Asn41Glu53-APROTININA, Ser10Arg15Ala17Asp24Thr26Asn41Glu53-APROTININA. ESTAS VARIANTES MODIFICADAS PRESENTAN ACTIVIDAD MEJORADA PARA LA INHIBICION DE LA CALICREINA DEL PLASMA, DE LOS TEJIDOS Y DE LA PLASMINA, SIENDO UTILES PARA REDUCIR LA PERDIDA DE SANGRE EN CIRUGIA, POLITRAUMATISMO, ENTRE OTROS, ADEMAS DE MOSTRAR MENOR INMUNOGENICIDAD Y ACUMULACION RENAL
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19629982A DE19629982A1 (de) | 1996-07-25 | 1996-07-25 | Aprotinin-Varianten mit verbesserten Eigenschaften |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE92298A1 true PE92298A1 (es) | 1999-02-13 |
Family
ID=7800774
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1997000661A PE92298A1 (es) | 1996-07-25 | 1997-07-24 | Variantes de aprotinina con propiedades mejoradas |
Country Status (37)
| Country | Link |
|---|---|
| US (2) | US6482798B2 (es) |
| EP (1) | EP0821007B1 (es) |
| JP (1) | JPH10101700A (es) |
| KR (1) | KR980009283A (es) |
| CN (1) | CN1172116A (es) |
| AR (1) | AR008783A1 (es) |
| AT (1) | ATE260975T1 (es) |
| AU (2) | AU2870197A (es) |
| BG (1) | BG101787A (es) |
| BR (1) | BR9704068A (es) |
| CA (1) | CA2207071A1 (es) |
| CO (1) | CO4890857A1 (es) |
| CZ (1) | CZ236797A3 (es) |
| DE (2) | DE19629982A1 (es) |
| DZ (1) | DZ2276A1 (es) |
| EE (1) | EE9700177A (es) |
| ES (1) | ES2217350T3 (es) |
| HN (1) | HN1997000094A (es) |
| HR (1) | HRP970384A2 (es) |
| HU (1) | HUP9701290A3 (es) |
| ID (1) | ID17508A (es) |
| IL (1) | IL121361A0 (es) |
| MA (1) | MA24279A1 (es) |
| NO (1) | NO973426L (es) |
| NZ (1) | NZ328402A (es) |
| PE (1) | PE92298A1 (es) |
| PL (1) | PL321341A1 (es) |
| RU (1) | RU2197983C2 (es) |
| SG (1) | SG71714A1 (es) |
| SK (1) | SK101997A3 (es) |
| SV (1) | SV1997000068A (es) |
| TN (1) | TNSN97130A1 (es) |
| TR (1) | TR199700688A2 (es) |
| TW (1) | TW480271B (es) |
| UA (1) | UA55380C2 (es) |
| YU (1) | YU31697A (es) |
| ZA (1) | ZA976585B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19725014A1 (de) * | 1997-06-13 | 1998-12-17 | Bayer Ag | Aprotininvarianten mit verbesserten Eigenschaften und Bikunine von Aprotininvarianten |
| US6974188B2 (en) * | 2003-08-13 | 2005-12-13 | Cosco Management, Inc. | Chair with pivotable chair back |
| WO2006042327A2 (en) * | 2004-10-12 | 2006-04-20 | Large Scale Biology Corporation | Plant-produced recombinant aprotinin and aprotinin variants |
| US20060218667A1 (en) * | 2004-10-12 | 2006-09-28 | Vojdani Fakhrieh S | Plant-produced recombinant aprotinin and aprotinin variants |
| USD534019S1 (en) * | 2005-02-18 | 2006-12-26 | Atico International Usa, Inc. | Portion of an anti-pinching device of a folding chair in a stowed position |
| EP1859041B2 (en) * | 2005-02-18 | 2014-11-19 | Angiochem Inc. | Aprotinin polypeptides for transporting a compound across the blood-brain barrier |
| WO2008077478A1 (en) * | 2006-12-22 | 2008-07-03 | Bayer Schering Pharma Aktiengesellschaft | Preparation and use of variants of the kunitz domain 2 of the human placental bikunin gene |
| WO2008110301A1 (de) * | 2007-03-13 | 2008-09-18 | Bayer Schering Pharma Aktiengesellschaft | Aprotinin-varianten mit verbesserten eigenschaften |
| DE102007056231A1 (de) | 2007-09-08 | 2009-03-12 | Bayer Healthcare Ag | Herstellung und Verwendung von Varianten humander Kunitz-Typ Protease-Inhibitoren (hKTPI) |
| BRPI1103921A2 (pt) | 2011-08-17 | 2013-08-06 | Mahle Metal Leve Sa | camisa de cilindro e liga de ferro fundido |
| MX2024008082A (es) * | 2022-01-05 | 2024-07-15 | Helix Nanotechnologies Inc | Composiciones que comprenden la preprosecuencia del factor-alfa y sus usos. |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU560584B2 (en) | 1983-07-28 | 1987-04-09 | Bayer Aktiengesellschaft | Homologues of aprotinin |
| US4595974A (en) * | 1984-09-10 | 1986-06-17 | Burroughs Corporation | Base drive circuit for a switching power transistor |
| GB2208511A (en) | 1987-08-07 | 1989-04-05 | Bayer Ag | Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology |
| US5591603A (en) * | 1987-08-28 | 1997-01-07 | Novo Nordisk A/S | Process for preparing aprotinin and aprotinin analogs in yeast cells |
| DK225488D0 (da) * | 1988-04-26 | 1988-04-26 | Novo Industri As | Polypeptid |
| DK463887D0 (da) | 1987-09-07 | 1987-09-07 | Novo Industri As | Gaerleader |
| DK105489D0 (da) | 1989-03-03 | 1989-03-03 | Novo Nordisk As | Polypeptid |
| DE3930522A1 (de) * | 1989-09-13 | 1991-03-21 | Bayer Ag | Rekombinante aprotinin-varianten - gentechnisches verfahren zur mikrobiellen herstellung von homogen prozessierten aprotinin-varianten sowie die therapeutische anwendung derselben |
| US5231010A (en) | 1989-09-13 | 1993-07-27 | Bayer Aktiengesellschaft | Recombinant aprotinin variants genetically engineered process for the microbial preparation of homogeneously processed aprotinin variants and the therapeutic use thereof |
| IL99585A0 (en) * | 1990-10-01 | 1992-08-18 | Novo Nordisk As | Aprotinin analogues,their production and pharmaceutical compositions containing them |
| EP0651766A4 (en) * | 1992-07-13 | 1996-07-31 | Corvas Int Inc | INHIBITORS OF FACTOR Xa, DERIVED FROM THE INHIBITOR OF THE PANCREATIC TRYPSON FROM BEEF. |
| KR100199565B1 (ko) * | 1994-08-19 | 1999-06-15 | 차동천 | 승화형 감열전사 기록용 수용지의 중간층 제조방법 |
-
1996
- 1996-07-25 DE DE19629982A patent/DE19629982A1/de not_active Withdrawn
-
1997
- 1997-06-20 HN HN1997000094A patent/HN1997000094A/es unknown
- 1997-07-14 ES ES97111980T patent/ES2217350T3/es not_active Expired - Lifetime
- 1997-07-14 AT AT97111980T patent/ATE260975T1/de not_active IP Right Cessation
- 1997-07-14 DE DE59711356T patent/DE59711356D1/de not_active Expired - Fee Related
- 1997-07-14 EP EP97111980A patent/EP0821007B1/de not_active Expired - Lifetime
- 1997-07-15 HR HR19629982.9A patent/HRP970384A2/xx not_active Application Discontinuation
- 1997-07-17 AU AU28701/97A patent/AU2870197A/en not_active Abandoned
- 1997-07-17 US US08/896,322 patent/US6482798B2/en not_active Expired - Fee Related
- 1997-07-21 SV SV1997000068A patent/SV1997000068A/es unknown
- 1997-07-22 JP JP9210197A patent/JPH10101700A/ja active Pending
- 1997-07-22 IL IL12136197A patent/IL121361A0/xx unknown
- 1997-07-22 CA CA002207071A patent/CA2207071A1/en not_active Abandoned
- 1997-07-22 BG BG101787A patent/BG101787A/xx unknown
- 1997-07-22 ID IDP972548A patent/ID17508A/id unknown
- 1997-07-23 AR ARP970103329A patent/AR008783A1/es not_active Application Discontinuation
- 1997-07-23 YU YU31697A patent/YU31697A/sh unknown
- 1997-07-23 DZ DZ970126A patent/DZ2276A1/fr active
- 1997-07-23 NZ NZ328402A patent/NZ328402A/xx unknown
- 1997-07-24 PE PE1997000661A patent/PE92298A1/es not_active Application Discontinuation
- 1997-07-24 TW TW086110514A patent/TW480271B/zh not_active IP Right Cessation
- 1997-07-24 NO NO973426A patent/NO973426L/no not_active Application Discontinuation
- 1997-07-24 BR BR9704068A patent/BR9704068A/pt not_active IP Right Cessation
- 1997-07-24 KR KR1019970034643A patent/KR980009283A/ko not_active Ceased
- 1997-07-24 TN TNTNSN97130A patent/TNSN97130A1/fr unknown
- 1997-07-24 HU HU9701290A patent/HUP9701290A3/hu unknown
- 1997-07-24 CZ CZ972367A patent/CZ236797A3/cs unknown
- 1997-07-24 SG SG1997002627A patent/SG71714A1/en unknown
- 1997-07-24 EE EE9700177A patent/EE9700177A/xx unknown
- 1997-07-24 MA MA24733A patent/MA24279A1/fr unknown
- 1997-07-24 UA UA97073949A patent/UA55380C2/uk unknown
- 1997-07-24 ZA ZA9706585A patent/ZA976585B/xx unknown
- 1997-07-24 SK SK1019-97A patent/SK101997A3/sk unknown
- 1997-07-24 RU RU97112745/14A patent/RU2197983C2/ru not_active IP Right Cessation
- 1997-07-25 TR TR97/00688A patent/TR199700688A2/xx unknown
- 1997-07-25 PL PL97321341A patent/PL321341A1/xx unknown
- 1997-07-25 CO CO97042648A patent/CO4890857A1/es unknown
- 1997-07-25 CN CN97115348A patent/CN1172116A/zh active Pending
-
2001
- 2001-06-06 AU AU51787/01A patent/AU762041B2/en not_active Ceased
-
2002
- 2002-09-23 US US10/252,967 patent/US20030096752A1/en not_active Abandoned
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |