ID17508A - Varian-varian aprotinin yang mempunyai sifat-sifat yang ditingkatkan - Google Patents

Varian-varian aprotinin yang mempunyai sifat-sifat yang ditingkatkan

Info

Publication number: ID17508A
Authority: ID; Indonesia
Prior art keywords: aprotinin; variants; enhanced properties; enhanced; properties
Prior art date: 1996-07-25

Application number

IDP972548A

Other languages

English (en)

Inventor

Werner Dr Schroder

Soren Bjorn

Kjeld Norris

Viggo Diness

Leif Norkskov Lauritsen

Niels Dyhr Christensen

Original Assignee

Bayer Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-25

Filing date

1997-07-22

Publication date

1998-01-08

1997-07-22 Application filed by Bayer Ag filed Critical Bayer Ag

1998-01-08 Publication of ID17508A publication Critical patent/ID17508A/id

Links

108010039627 Aprotinin Proteins 0.000 title 1
229960004405 aprotinin Drugs 0.000 title 1
ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Immunology (AREA)
Epidemiology (AREA)
Dermatology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Compounds Of Unknown Constitution (AREA)

IDP972548A 1996-07-25 1997-07-22 Varian-varian aprotinin yang mempunyai sifat-sifat yang ditingkatkan ID17508A (id)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19629982A DE19629982A1 (de)	1996-07-25	1996-07-25	Aprotinin-Varianten mit verbesserten Eigenschaften

Publications (1)

Publication Number	Publication Date
ID17508A true ID17508A (id)	1998-01-08

Family

ID=7800774

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IDP972548A ID17508A (id)	1996-07-25	1997-07-22	Varian-varian aprotinin yang mempunyai sifat-sifat yang ditingkatkan

Country Status (37)

Country	Link
US (2)	US6482798B2 (id)
EP (1)	EP0821007B1 (id)
JP (1)	JPH10101700A (id)
KR (1)	KR980009283A (id)
CN (1)	CN1172116A (id)
AR (1)	AR008783A1 (id)
AT (1)	ATE260975T1 (id)
AU (2)	AU2870197A (id)
BG (1)	BG101787A (id)
BR (1)	BR9704068A (id)
CA (1)	CA2207071A1 (id)
CO (1)	CO4890857A1 (id)
CZ (1)	CZ236797A3 (id)
DE (2)	DE19629982A1 (id)
DZ (1)	DZ2276A1 (id)
EE (1)	EE9700177A (id)
ES (1)	ES2217350T3 (id)
HN (1)	HN1997000094A (id)
HR (1)	HRP970384A2 (id)
HU (1)	HUP9701290A3 (id)
ID (1)	ID17508A (id)
IL (1)	IL121361A0 (id)
MA (1)	MA24279A1 (id)
NO (1)	NO973426L (id)
NZ (1)	NZ328402A (id)
PE (1)	PE92298A1 (id)
PL (1)	PL321341A1 (id)
RU (1)	RU2197983C2 (id)
SG (1)	SG71714A1 (id)
SK (1)	SK101997A3 (id)
SV (1)	SV1997000068A (id)
TN (1)	TNSN97130A1 (id)
TR (1)	TR199700688A2 (id)
TW (1)	TW480271B (id)
UA (1)	UA55380C2 (id)
YU (1)	YU31697A (id)
ZA (1)	ZA976585B (id)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19725014A1 (de) *	1997-06-13	1998-12-17	Bayer Ag	Aprotininvarianten mit verbesserten Eigenschaften und Bikunine von Aprotininvarianten
US6974188B2 (en) *	2003-08-13	2005-12-13	Cosco Management, Inc.	Chair with pivotable chair back
WO2006042327A2 (en) *	2004-10-12	2006-04-20	Large Scale Biology Corporation	Plant-produced recombinant aprotinin and aprotinin variants
US20060218667A1 (en) *	2004-10-12	2006-09-28	Vojdani Fakhrieh S	Plant-produced recombinant aprotinin and aprotinin variants
MX2007010113A (es) *	2005-02-18	2007-12-07	Angiochem Inc	Polipeptidos de aprotinina para transportar un compuesto a traves de la barrera hematoencefalica.
USD534019S1 (en) *	2005-02-18	2006-12-26	Atico International Usa, Inc.	Portion of an anti-pinching device of a folding chair in a stowed position
WO2008077478A1 (en) *	2006-12-22	2008-07-03	Bayer Schering Pharma Aktiengesellschaft	Preparation and use of variants of the kunitz domain 2 of the human placental bikunin gene
WO2008110301A1 (de) *	2007-03-13	2008-09-18	Bayer Schering Pharma Aktiengesellschaft	Aprotinin-varianten mit verbesserten eigenschaften
DE102007056231A1 (de)	2007-09-08	2009-03-12	Bayer Healthcare Ag	Herstellung und Verwendung von Varianten humander Kunitz-Typ Protease-Inhibitoren (hKTPI)
BRPI1103921A2 (pt)	2011-08-17	2013-08-06	Mahle Metal Leve Sa	camisa de cilindro e liga de ferro fundido
JP2025501887A (ja) *	2022-01-05	2025-01-24	ヘリックスナノテクノロジーズインコーポレイテッド	アルファ因子プレプロ配列を含む組成物及びその使用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU560584B2 (en) *	1983-07-28	1987-04-09	Bayer Aktiengesellschaft	Homologues of aprotinin
US4595974A (en) *	1984-09-10	1986-06-17	Burroughs Corporation	Base drive circuit for a switching power transistor
GB2208511A (en)	1987-08-07	1989-04-05	Bayer Ag	Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology
DK225488D0 (da) *	1988-04-26	1988-04-26	Novo Industri As	Polypeptid
US5591603A (en) *	1987-08-28	1997-01-07	Novo Nordisk A/S	Process for preparing aprotinin and aprotinin analogs in yeast cells
DK463887D0 (da)	1987-09-07	1987-09-07	Novo Industri As	Gaerleader
DK105489D0 (da)	1989-03-03	1989-03-03	Novo Nordisk As	Polypeptid
DE3930522A1 (de) *	1989-09-13	1991-03-21	Bayer Ag	Rekombinante aprotinin-varianten - gentechnisches verfahren zur mikrobiellen herstellung von homogen prozessierten aprotinin-varianten sowie die therapeutische anwendung derselben
US5231010A (en)	1989-09-13	1993-07-27	Bayer Aktiengesellschaft	Recombinant aprotinin variants genetically engineered process for the microbial preparation of homogeneously processed aprotinin variants and the therapeutic use thereof
IL99585A0 (en) *	1990-10-01	1992-08-18	Novo Nordisk As	Aprotinin analogues,their production and pharmaceutical compositions containing them
CA2139945A1 (en) *	1992-07-13	1994-01-20	Ignace Lasters	Bovine pancreatic trypsin inhibitor derived inhibitors of factor xa
KR100199565B1 (ko) *	1994-08-19	1999-06-15	차동천	승화형 감열전사 기록용 수용지의 중간층 제조방법

1996
- 1996-07-25 DE DE19629982A patent/DE19629982A1/de not_active Withdrawn
1997
- 1997-06-20 HN HN1997000094A patent/HN1997000094A/es unknown
- 1997-07-14 DE DE59711356T patent/DE59711356D1/de not_active Expired - Fee Related
- 1997-07-14 AT AT97111980T patent/ATE260975T1/de not_active IP Right Cessation
- 1997-07-14 ES ES97111980T patent/ES2217350T3/es not_active Expired - Lifetime
- 1997-07-14 EP EP97111980A patent/EP0821007B1/de not_active Expired - Lifetime
- 1997-07-15 HR HR19629982.9A patent/HRP970384A2/xx not_active Application Discontinuation
- 1997-07-17 US US08/896,322 patent/US6482798B2/en not_active Expired - Fee Related
- 1997-07-17 AU AU28701/97A patent/AU2870197A/en not_active Abandoned
- 1997-07-21 SV SV1997000068A patent/SV1997000068A/es unknown
- 1997-07-22 CA CA002207071A patent/CA2207071A1/en not_active Abandoned
- 1997-07-22 JP JP9210197A patent/JPH10101700A/ja active Pending
- 1997-07-22 BG BG101787A patent/BG101787A/xx unknown
- 1997-07-22 ID IDP972548A patent/ID17508A/id unknown
- 1997-07-22 IL IL12136197A patent/IL121361A0/xx unknown
- 1997-07-23 YU YU31697A patent/YU31697A/sh unknown
- 1997-07-23 NZ NZ328402A patent/NZ328402A/xx unknown
- 1997-07-23 DZ DZ970126A patent/DZ2276A1/fr active
- 1997-07-23 AR ARP970103329A patent/AR008783A1/es not_active Application Discontinuation
- 1997-07-24 KR KR1019970034643A patent/KR980009283A/ko not_active Ceased
- 1997-07-24 TN TNTNSN97130A patent/TNSN97130A1/fr unknown
- 1997-07-24 HU HU9701290A patent/HUP9701290A3/hu unknown
- 1997-07-24 BR BR9704068A patent/BR9704068A/pt not_active IP Right Cessation
- 1997-07-24 UA UA97073949A patent/UA55380C2/uk unknown
- 1997-07-24 EE EE9700177A patent/EE9700177A/xx unknown
- 1997-07-24 MA MA24733A patent/MA24279A1/fr unknown
- 1997-07-24 SK SK1019-97A patent/SK101997A3/sk unknown
- 1997-07-24 TW TW086110514A patent/TW480271B/zh not_active IP Right Cessation
- 1997-07-24 RU RU97112745/14A patent/RU2197983C2/ru not_active IP Right Cessation
- 1997-07-24 ZA ZA9706585A patent/ZA976585B/xx unknown
- 1997-07-24 SG SG1997002627A patent/SG71714A1/en unknown
- 1997-07-24 NO NO973426A patent/NO973426L/no not_active Application Discontinuation
- 1997-07-24 PE PE1997000661A patent/PE92298A1/es not_active Application Discontinuation
- 1997-07-24 CZ CZ972367A patent/CZ236797A3/cs unknown
- 1997-07-25 PL PL97321341A patent/PL321341A1/xx unknown
- 1997-07-25 CN CN97115348A patent/CN1172116A/zh active Pending
- 1997-07-25 CO CO97042648A patent/CO4890857A1/es unknown
- 1997-07-25 TR TR97/00688A patent/TR199700688A2/xx unknown
2001
- 2001-06-06 AU AU51787/01A patent/AU762041B2/en not_active Ceased
2002
- 2002-09-23 US US10/252,967 patent/US20030096752A1/en not_active Abandoned

Also Published As

Publication number	Publication date
CN1172116A (zh)	1998-02-04
HN1997000094A (es)	1997-12-26
SG71714A1 (en)	2000-04-18
TW480271B (en)	2002-03-21
IL121361A0 (en)	1998-01-04
ES2217350T3 (es)	2004-11-01
ZA976585B (en)	1998-02-03
SV1997000068A (es)	1998-07-09
TNSN97130A1 (fr)	2005-03-15
EP0821007A2 (de)	1998-01-28
MX9705605A (es)	1998-08-30
YU31697A (sh)	1999-07-28
UA55380C2 (uk)	2003-04-15
PL321341A1 (en)	1998-02-02
DE59711356D1 (de)	2004-04-08
AU2870197A (en)	1998-02-05
BR9704068A (pt)	1999-01-05
TR199700688A2 (xx)	1998-02-21
NZ328402A (en)	1999-03-29
NO973426D0 (no)	1997-07-24
HUP9701290A2 (hu)	1999-06-28
RU2197983C2 (ru)	2003-02-10
PE92298A1 (es)	1999-02-13
EP0821007A3 (de)	1998-11-18
AU5178701A (en)	2001-09-06
SK101997A3 (en)	1998-03-04
BG101787A (en)	1998-10-30
DZ2276A1 (fr)	2002-12-18
CO4890857A1 (es)	2000-02-28
HUP9701290A3 (en)	2000-08-28
AU762041B2 (en)	2003-06-19
ATE260975T1 (de)	2004-03-15
EP0821007B1 (de)	2004-03-03
NO973426L (no)	1998-01-26
EE9700177A (et)	1998-02-16
HRP970384A2 (en)	1998-04-30
US6482798B2 (en)	2002-11-19
CZ236797A3 (cs)	1998-02-18
JPH10101700A (ja)	1998-04-21
DE19629982A1 (de)	1998-01-29
AR008783A1 (es)	2000-02-23
CA2207071A1 (en)	1998-01-25
MA24279A1 (fr)	1998-04-01
KR980009283A (ko)	1998-04-30
US20020103334A1 (en)	2002-08-01
US20030096752A1 (en)	2003-05-22
HU9701290D0 (en)	1997-09-29

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DE69719519D1 (de)	2003-04-10	Kraniotomie abdecktuch
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DE69731542D1 (de)	2004-12-16	Photokatalytische zusammensetzung
ID21770A (id)	1999-07-22	Plester yang mengandung felbinak
ID17508A (id)	1998-01-08	Varian-varian aprotinin yang mempunyai sifat-sifat yang ditingkatkan
ID16154A (id)	1997-09-04	Komposisi monomer yang distabilisasi
TW321352U (en)	1997-11-21	Improved structure of the on-wire switch
ID28032A (id)	2001-05-03	TRISIKLIK PIPERIDIN-Δ3-SEBAGAI ANTAGONIS-α2
PL342733A1 (en)	2001-07-02	Biocement of improved properties
GB2328397B (en)	1999-08-11	Manufacture of elongate members
GB2311008B (en)	1999-11-17	Fire barriers of the flexible type
GB9722451D0 (en)	1997-12-24	The manufacture of gaskets
GB9700946D0 (en)	1997-03-05	Manufacture of elongate members
KR970060124U (ko)	1997-11-10	마이크로폰의 구조
EE200000184A (et)	2001-04-16	Lähikaja summutuse või sellega seotud täiustused
KR970062369U (ko)	1997-12-10	직기의 픽크 파인딩 장치
FIU970470U0 (fi)	1997-10-29	Hautakiven alusta
FI3524U1 (fi)	1998-08-13	Yhdistelmäkoura
KR980000376U (ko)	1998-03-30	휨성이 자유로운 밴드
KR970050425U (ko)	1997-08-12	인터버의 케이스
GB9606255D0 (en)	1996-05-29	The game of bridge companion
TW396919U (en)	2000-07-01	Improved structure of the screw-gun