PE56198A1 - Derivados de piperidina - Google Patents
Derivados de piperidinaInfo
- Publication number
- PE56198A1 PE56198A1 PE1997000202A PE00020297A PE56198A1 PE 56198 A1 PE56198 A1 PE 56198A1 PE 1997000202 A PE1997000202 A PE 1997000202A PE 00020297 A PE00020297 A PE 00020297A PE 56198 A1 PE56198 A1 PE 56198A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- disorders
- formula
- oxygen
- hydrogen
- Prior art date
Links
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical class C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- 239000001301 oxygen Substances 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000003951 lactams Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229940076279 serotonin Drugs 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Reproductive Health (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
SE REFIEREN A COMPUESTOS DE FORMULA (I), EN DONDE: "B" ES OXIGENO O AZUFRE; "D" ES NITROGENO O CH; "E" ES OXIGENO, CR18R19 O NR20, ENTRE OTROS; "G" ES CO O CR21R22; "X" E "Y" SON CR9R10; R ES NR1COR2 O UN ANILLO DE LACTAMA DE FORMULA (i) EN DONDE "Z" ES DE PREFERENCIA OXIGENO; p ES 1 o 2; "P" ES UN ANILLO BICICLO O UN ANILLO MONOCICLO C5-C7 QUE CONTIENEN OPCIONALMENTE UNO O DOS HETEROATOMOS; R1 ES HIDROGENO O ALQUILO C1-C6, O JUNTO CON R3 FORMAN (CH2)k, EN DONDE k ES 2; 3 o 4; R2 ES HIDROGENO, ALQUILO C1-C6 O ARILO OPCIONALMENTE SUSTITUIDO; R6 ES H O ALQUILO C1-C6 Y R7 ES H, ALQUILO C1-C6, ALCOXI C1-C6 O HALOGENO, O R6 JUNTO CON R7 FORMAN DE PREFERENCIA -(CH2)2-; R8 ES H O ALQUILO C1-C6, ENTRE OTROS; R9, R10, R20, R21 Y R22 SON PREFERENTEMENTE HIDROGENO; m ES 1; 2 o 3. TAMBIEN SE REFIERE A LOS PROCEDIMIENTOS DE PREPARACION DE LOS COMPUESTOS DE FORMULA (I), LOS CUALES ACTUAN COMO ANTAGONISTAS DE LA SEROTONINA 5HT1B, SIENDO UTILES EN EL TRATAMIENTO DE TRANSTORNOS DEL SISTEMA NERVIOSO CENTRAL, TRANSTORNOS ENDOCRINOS Y GASTROINTESTINALES
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9605883.9A GB9605883D0 (en) | 1996-03-20 | 1996-03-20 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE56198A1 true PE56198A1 (es) | 1998-12-10 |
Family
ID=10790741
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1997000202A PE56198A1 (es) | 1996-03-20 | 1997-03-18 | Derivados de piperidina |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6100272A (es) |
| EP (1) | EP0888358A1 (es) |
| JP (1) | JP2000507240A (es) |
| AR (1) | AR007766A1 (es) |
| AU (1) | AU2158197A (es) |
| CA (1) | CA2250016A1 (es) |
| GB (1) | GB9605883D0 (es) |
| ID (1) | ID16373A (es) |
| PE (1) | PE56198A1 (es) |
| UY (1) | UY24491A1 (es) |
| WO (1) | WO1997034901A1 (es) |
| ZA (1) | ZA972329B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0200481A3 (en) | 1998-12-23 | 2002-12-28 | Aventis Pharma Ltd West Mallin | Dihydro-benzo(1,4)oxazines and tetrahydroquinoxalines, process for their preparation and pharmaceutical compositions containing them |
| AU2001243394A1 (en) * | 2000-03-02 | 2001-09-12 | Smith Kline Beecham Corporation | Compounds and methods |
| ATE416168T1 (de) | 2002-02-15 | 2008-12-15 | Glaxo Group Ltd | Modulatoren des vanilloidrezeptors |
| WO2020183011A1 (en) | 2019-03-14 | 2020-09-17 | Institut Curie | Htr1d inhibitors and uses thereof in the treatment of cancer |
| TW202515885A (zh) * | 2023-08-18 | 2025-04-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | 稠合雜芳基類化合物、其製備方法及其在醫藥上的應用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9119920D0 (en) * | 1991-09-18 | 1991-10-30 | Glaxo Group Ltd | Chemical compounds |
| PT533268E (pt) * | 1991-09-18 | 2002-02-28 | Glaxo Group Ltd | Derivados de benzanilida como antagonistas de 5-ht1d |
| FR2699918B1 (fr) * | 1992-12-30 | 1995-03-17 | Pf Medicament | Ligands sélectifs des récepteurs 5HY1D-5HT1B dérivés d'indole-pipérazine utiles comme médicaments. |
| GB9326008D0 (en) * | 1993-12-21 | 1994-02-23 | Smithkline Beecham Plc | Novel compounds |
| EP0670313A1 (en) * | 1994-03-04 | 1995-09-06 | Takeda Chemical Industries, Ltd. | Spiro compounds, their production and use |
| GB9421003D0 (en) * | 1994-10-18 | 1994-12-07 | Smithkline Beecham Plc | Novel compounds |
| CA2208244A1 (en) * | 1994-12-22 | 1996-06-27 | Laramie Mary Gaster | Tetracyclic spiro compounds, process for their preparation and their use as 5ht1d receptor antagonists |
| GB9519033D0 (en) * | 1995-09-18 | 1995-11-15 | Smithkline Beecham Plc | Treatment |
| FR2761069A1 (fr) * | 1997-03-20 | 1998-09-25 | Pf Medicament | Spiroamines derivees de dihydrobenzofuranes, leur preparation et leur application comme medicaments |
-
1996
- 1996-03-20 GB GBGB9605883.9A patent/GB9605883D0/en active Pending
-
1997
- 1997-03-18 UY UY24491A patent/UY24491A1/es unknown
- 1997-03-18 AR ARP970101069A patent/AR007766A1/es unknown
- 1997-03-18 ZA ZA972329A patent/ZA972329B/xx unknown
- 1997-03-18 ID IDP970881A patent/ID16373A/id unknown
- 1997-03-18 PE PE1997000202A patent/PE56198A1/es not_active Application Discontinuation
- 1997-03-19 JP JP9533157A patent/JP2000507240A/ja active Pending
- 1997-03-19 CA CA002250016A patent/CA2250016A1/en not_active Abandoned
- 1997-03-19 US US09/142,988 patent/US6100272A/en not_active Expired - Fee Related
- 1997-03-19 AU AU21581/97A patent/AU2158197A/en not_active Abandoned
- 1997-03-19 EP EP97914271A patent/EP0888358A1/en not_active Withdrawn
- 1997-03-19 WO PCT/EP1997/001404 patent/WO1997034901A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JP2000507240A (ja) | 2000-06-13 |
| AU2158197A (en) | 1997-10-10 |
| CA2250016A1 (en) | 1997-09-25 |
| US6100272A (en) | 2000-08-08 |
| ID16373A (id) | 1997-09-25 |
| UY24491A1 (es) | 1997-09-12 |
| GB9605883D0 (en) | 1996-05-22 |
| EP0888358A1 (en) | 1999-01-07 |
| WO1997034901A1 (en) | 1997-09-25 |
| AR007766A1 (es) | 1999-11-24 |
| ZA972329B (en) | 1998-09-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |