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PE56894A1 - Benzopirano - Google Patents

Benzopirano

Info

Publication number
PE56894A1
PE56894A1 PE1994247480A PE24748094A PE56894A1 PE 56894 A1 PE56894 A1 PE 56894A1 PE 1994247480 A PE1994247480 A PE 1994247480A PE 24748094 A PE24748094 A PE 24748094A PE 56894 A1 PE56894 A1 PE 56894A1
Authority
PE
Peru
Prior art keywords
alkyl
cyan
disease
substituted
nhr9
Prior art date
Application number
PE1994247480A
Other languages
English (en)
Inventor
Sandra Marina Monaghan
Alexander Roderick Mackenzie
Original Assignee
Pfizer Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Res & Dev filed Critical Pfizer Res & Dev
Publication of PE56894A1 publication Critical patent/PE56894A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I DONDE 1) X ES OXIGENO, AZUFRE, NH; 2) R Y R1 SON INDEPENDIENTEMENTE HIDROGENO, ALQUILO C1-C4 o JUNTOS SON UN ALQUILENO C2-C6; 3) R2 ES HIDROGENO, ALQUILO C1-C4; 4) R3 ES UN HETEROCICLO DE SEIS MIEMBROS CON 1 o 2 ATOMOS DE NITROGENO QUE ESTA UNIDO A X POR UN ATOMO DE CARBONO DEL ANILLO Y PUEDE ESTAR OPCIONALMENTE FUNDIDO AL GRUPO BENZO Y SUSTITUIDO; o CUANDO X ES NH, R3 PUEDE SER -C(=R7)(R6) o UN CICLOBUTENO SUSTITUIDO POR DOS GRUPOS CETO Y UN RADICAL R8; 5) R4 ES UN FENILO SUSTITUIDO POR OH Y ADEMAS OPCIONALMENTE POR 1 o 2 GRUPOS OH, ALQUILO C1-C6, OR5, HALOGENO, CIANO, NITRO; 6) R5 ES UN ALQUILO C1-C6; 7) R6 ES -OR5, -NHR5, -N(R5)2, -SR5, -NHR9; 8) R7 ES CIANO; 9) R8 ES -OR5, -NHR5, -N(R5)2, -NHR9; 10) R9 ES FENILO SUSTITUIDO POR ALQUILO C1-C6, OH, -OR5, HALOGENO, CIANO, NITRO; 11) m VARIA DE CERO A DOS; EL CUAL PUEDE RELAJAR LA MUSCULATURA LISA POR APERTURA DE LOS CANALES DE POTASIO Y UTILIZARSE EN EL TRATAMIENTO DE LA ENFERMEDAD OBSTRUCTIVA CRONICA DE LAS VIAS RESPIRATORIAS, ASMA, INCONTINENCIA URINARIA, SINDROME DE COLON IRRITABLE, ENFERMEDAD DIVERTICULAR, ACALASIA ESOFAGICA, HIPERTENSION
PE1994247480A 1993-08-04 1994-07-25 Benzopirano PE56894A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939316111A GB9316111D0 (en) 1993-08-04 1993-08-04 Benzopyrans

Publications (1)

Publication Number Publication Date
PE56894A1 true PE56894A1 (es) 1995-02-07

Family

ID=10739921

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1994247480A PE56894A1 (es) 1993-08-04 1994-07-25 Benzopirano

Country Status (28)

Country Link
US (2) US5912244A (es)
EP (1) EP0712398B1 (es)
JP (1) JP2871098B2 (es)
KR (1) KR0175532B1 (es)
CN (1) CN1128536A (es)
AT (1) ATE152716T1 (es)
AU (1) AU684817B2 (es)
CA (1) CA2168563C (es)
CO (1) CO4230234A1 (es)
CZ (1) CZ281853B6 (es)
DE (1) DE69403084T2 (es)
DK (1) DK0712398T3 (es)
EC (1) ECSP941140A (es)
EG (1) EG20525A (es)
ES (1) ES2102870T3 (es)
FI (1) FI960487A0 (es)
GB (1) GB9316111D0 (es)
GR (1) GR3023521T3 (es)
HU (1) HUT75120A (es)
IL (1) IL110488A (es)
NO (1) NO960441D0 (es)
NZ (1) NZ271344A (es)
PE (1) PE56894A1 (es)
PL (1) PL312788A1 (es)
SG (1) SG42817A1 (es)
TW (1) TW333532B (es)
WO (1) WO1995004730A1 (es)
ZA (1) ZA945774B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5573758A (en) * 1995-04-28 1996-11-12 Allergan Method for reducing intraocular pressure in the mammalian eye by administration of potassium channel blockers
US5869478A (en) * 1995-06-07 1999-02-09 Bristol-Myers Squibb Company Sulfonamido substituted benzopyran derivatives
DK0907646T3 (da) * 1996-06-07 2003-09-15 Univ Vanderbilt Dihydrobenzopyren og lignende forbindelser anvendelige som middel mod betændelse
US6333352B1 (en) * 2000-04-05 2001-12-25 Mimicking Man Manually, Inc. Method of treating benign positional vertigo
PL208928B1 (pl) * 2001-04-16 2011-06-30 Pharmacopeia 3, 4-di-podstawione cyklobuten-1, 2-diony jako ligandy receptora CXC chemokiny
JP2005505586A (ja) * 2001-10-04 2005-02-24 ワイス ５−ヒドロキシトリプタミン−６リガンドとしてのクロマン誘導体
AU2003274569B2 (en) * 2002-11-12 2008-07-31 Warner-Lambert Company Llc Method of stimulating hair growth using benzopyrans
EP1715869A1 (en) * 2004-02-12 2006-11-02 Warner-Lambert Company LLC Method of stimulating hair growth
US20090110892A1 (en) * 2004-06-30 2009-04-30 General Electric Company System and method for making a graded barrier coating
EP1773820A1 (en) * 2004-07-16 2007-04-18 Warner-Lambert Company LLC Hair growth promoting agents
JP2008506767A (ja) * 2004-07-19 2008-03-06 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー 発毛を刺激する製剤
CN101119989B (zh) * 2004-12-21 2010-06-09 弗·哈夫曼-拉罗切有限公司 色满衍生物及其在治疗cns疾病中的用途

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3835011A1 (de) * 1988-10-14 1990-04-19 Merck Patent Gmbh Chromanderivate
EP0277611B1 (de) * 1987-02-04 1993-06-16 Hoechst Aktiengesellschaft Alkylsubstituierte N-Benzopyranyllactame, Verfahren zu ihrer Herstellung, ihre Verwendung sowie pharmazeutische Präparate auf Basis dieser Verbindungen
DE3703227A1 (de) * 1987-02-04 1988-08-18 Hoechst Ag Substituierte 3,4-dihydro-2h-benzopyrane, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen
DE3811017A1 (de) * 1988-03-31 1989-10-19 Hoechst Ag Ungesaettigte n-benzopyranyllactame
AU628331B2 (en) * 1988-05-06 1992-09-17 Merck Patent Gesellschaft Mit Beschrankter Haftung Chroman derivatives
EP0346724A1 (de) * 1988-06-16 1989-12-20 MERCK PATENT GmbH Chromanderivate
DE3824446A1 (de) * 1988-07-19 1990-01-25 Hoechst Ag, 6230 Frankfurt Verwendung substituierter 3,4-dihydro-2h-benzopyrane als heilmittel gegen obstruktive funktionsstoerungen der lunge und/oder stoerungen der ableitenden harnwege
DE3827532A1 (de) * 1988-08-13 1990-03-01 Hoechst Ag 6-aroyl-substituierte 3,4-dihydro-2h-benzopyrane, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen
DE3918041A1 (de) * 1989-06-02 1990-12-06 Merck Patent Gmbh Chromanderivate
US5061813A (en) * 1990-04-02 1991-10-29 E. R. Squibb & Sons, Inc. Substituted cyanoimino benzopyranes
GB2242628A (en) * 1990-04-06 1991-10-09 Sandoz Ltd Asthma prophylactic use of K+ channel activators
TW244350B (es) * 1991-12-14 1995-04-01 Hoechst Ag
JPH0673061A (ja) * 1992-01-18 1994-03-15 Hoechst Ag ６−置換クロメン類のエナンチオ選択的エポキシ化方法

Also Published As

Publication number Publication date
AU7494894A (en) 1995-02-28
PL312788A1 (en) 1996-05-13
EP0712398B1 (en) 1997-05-07
CA2168563C (en) 1999-09-07
CN1128536A (zh) 1996-08-07
EG20525A (en) 1999-06-30
CZ33196A3 (en) 1996-05-15
US6071938A (en) 2000-06-06
FI960487L (fi) 1996-02-02
FI960487A7 (fi) 1996-02-02
CO4230234A1 (es) 1995-10-19
ES2102870T3 (es) 1997-08-01
DK0712398T3 (da) 1997-10-27
JPH08508042A (ja) 1996-08-27
AU684817B2 (en) 1998-01-08
ECSP941140A (es) 1995-01-16
KR0175532B1 (ko) 1999-02-18
WO1995004730A1 (en) 1995-02-16
US5912244A (en) 1999-06-15
EP0712398A1 (en) 1996-05-22
JP2871098B2 (ja) 1999-03-17
NO960441L (no) 1996-02-02
GR3023521T3 (en) 1997-08-29
GB9316111D0 (en) 1993-09-22
ZA945774B (en) 1996-02-05
NO960441D0 (no) 1996-02-02
TW333532B (en) 1998-06-11
CA2168563A1 (en) 1995-02-16
DE69403084T2 (de) 1997-08-14
DE69403084D1 (de) 1997-06-12
IL110488A0 (en) 1994-10-21
NZ271344A (en) 1997-10-24
IL110488A (en) 1999-08-17
CZ281853B6 (cs) 1997-02-12
FI960487A0 (fi) 1996-02-02
ATE152716T1 (de) 1997-05-15
SG42817A1 (en) 1997-10-17
HUT75120A (en) 1997-04-28

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Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed