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PE55596A1 - Compuesto piperadinilo y piperazinilo anti-sida substituido con alquilo - Google Patents

Compuesto piperadinilo y piperazinilo anti-sida substituido con alquilo

Info

Publication number
PE55596A1
PE55596A1 PE1995286554A PE28655495A PE55596A1 PE 55596 A1 PE55596 A1 PE 55596A1 PE 1995286554 A PE1995286554 A PE 1995286554A PE 28655495 A PE28655495 A PE 28655495A PE 55596 A1 PE55596 A1 PE 55596A1
Authority
PE
Peru
Prior art keywords
piperadinyl
piperazinyl
aids
alkyl
substituted
Prior art date
Application number
PE1995286554A
Other languages
English (en)
Inventor
Richard C Thomas
Toni-Jo Poel
Donna L Romero
Paul D May
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26998606&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE55596(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of PE55596A1 publication Critical patent/PE55596A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

SE REFIERE AL COMPUESTO DE FORMULA I DONDE R1 PUEDE SER (A) o (B); SI ES (A): R1-1 ES H, F, Cl ENTRE OTROS; R1-2 ES H, F, Cl ENTRE OTROS; R1-3 ES H, F, Cl ENTRE OTROS, DE PREFERENCIA R1-1, R1-2 y R1-3 SON -H; SI ES (B): R1-4 ES H o CH3, DE PREFERENCIA EL PRIMERO; R1-5 ES H, F, Cl ENTRE OTROS; R1-6 ES H, F, Cl ENTRE OTROS, DE PREFERENCIA R1 ES (A); R2 ES -CO- o -CH2-; R3 ES (R3-I), (R3-II), (R3-III) ENTRE OTROS; R4 ES -N=, -CH=, -CF= ENTRE OTROS; R5 ES -N=, -CH=, -CF= ENTRE OTROS; R6 ES -N=, -CH=, -CF= ENTRE OTROS; R7 ES -N= o -CH=; R8 ES C1-C6 ALQUILO, C3-C5 CICLOALQUILO, -CH2-O-R8-1 EN DONDE R8-1 ES C1-C3 ALQUILO, -CH2-CH2-CF3 ENTRE OTROS
PE1995286554A 1994-12-13 1995-12-07 Compuesto piperadinilo y piperazinilo anti-sida substituido con alquilo PE55596A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35492594A 1994-12-13 1994-12-13
US40009595A 1995-03-07 1995-03-07

Publications (1)

Publication Number Publication Date
PE55596A1 true PE55596A1 (es) 1996-12-11

Family

ID=26998606

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1995286554A PE55596A1 (es) 1994-12-13 1995-12-07 Compuesto piperadinilo y piperazinilo anti-sida substituido con alquilo

Country Status (10)

Country Link
US (1) US5866589A (es)
EP (1) EP0797576A1 (es)
JP (1) JPH10510530A (es)
AR (1) AR003106A1 (es)
AU (1) AU4151696A (es)
CO (1) CO4700295A1 (es)
IL (1) IL116310A (es)
PE (1) PE55596A1 (es)
TW (1) TW406075B (es)
WO (1) WO1996018628A1 (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8457298A (en) * 1997-08-15 1999-03-08 Pfizer Products Inc. 2-(4-aryl or heteroaryl-piperazin-1-ylmethyl)-1H-indole derivatives interacting with the dopamine D4 receptor
US6251919B1 (en) * 1998-02-27 2001-06-26 Warner-Lambert Heterocyclic substituted aniline calcium channel blockers
SE9803773D0 (sv) * 1998-11-05 1998-11-05 Astra Pharma Prod Compounds
GB0016453D0 (en) * 2000-07-04 2000-08-23 Hoffmann La Roche Pyrrole derivatives
HU227197B1 (en) 2000-10-24 2010-10-28 Richter Gedeon Nyrt Nmda receptor antagonist carboxylic acid amide derivatives and pharmaceutical compositions containing them
DK1363705T3 (da) * 2001-02-02 2012-09-24 Bristol Myers Squibb Co Sammensætning og antiviral aktivitet i substituerede azaindoloxoeddikesurpiperazin-derivater
NZ532291A (en) * 2001-11-14 2005-11-25 Schering Corp Cannabinoid receptor ligands
CA2501547A1 (en) * 2002-10-15 2004-04-29 Rigel Pharmaceuticals, Inc. Substituted indoles and their use as hcv inhibitors
US20050075364A1 (en) * 2003-07-01 2005-04-07 Kap-Sun Yeung Indole, azaindole and related heterocyclic N-substituted piperazine derivatives
TW200630337A (en) 2004-10-14 2006-09-01 Euro Celtique Sa Piperidinyl compounds and the use thereof
JO2769B1 (en) 2005-10-26 2014-03-15 جانسين فارماسوتيكا ان. في Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor
WO2007110449A1 (en) * 2006-03-29 2007-10-04 Euro-Celtique S.A. Benzenesulfonamide compounds and their use
TW200815353A (en) * 2006-04-13 2008-04-01 Euro Celtique Sa Benzenesulfonamide compounds and their use
TW200812963A (en) * 2006-04-13 2008-03-16 Euro Celtique Sa Benzenesulfonamide compounds and the use thereof
JO2642B1 (en) * 2006-12-08 2012-06-17 جانسين فارماسوتيكا ان. في Dopamine 2 receptor antagonists are rapidly hydrolyzed
JO2849B1 (en) * 2007-02-13 2015-03-15 جانسين فارماسوتيكا ان. في Dopamine 2 receptor antagonists are rapidly hydrolyzed
WO2008124118A1 (en) * 2007-04-09 2008-10-16 Purdue Pharma L.P. Benzenesulfonyl compounds and the use therof
JP2010525013A (ja) * 2007-04-23 2010-07-22 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 高速解離性ドパミン２受容体アンタゴニストとしてのピリジン誘導体
CA2682671C (en) * 2007-04-23 2015-11-17 Janssen Pharmaceutica N.V. Thia(dia)zoles as fast dissociating dopamine 2 receptor antagonists
KR20100016620A (ko) 2007-04-23 2010-02-12 얀센 파마슈티카 엔.브이. 속해리성 도파민 2 수용체 길항제로서의 4-알콕시피리다진 유도체
US8765736B2 (en) * 2007-09-28 2014-07-01 Purdue Pharma L.P. Benzenesulfonamide compounds and the use thereof
EP2210886B1 (en) * 2007-10-16 2015-09-23 Daiichi Sankyo Company, Limited Pyrimidyl indoline compound
EP2310374B1 (en) * 2008-07-03 2012-10-31 Janssen Pharmaceutica N.V. Substituted 6- (1-piperazinyl) -pyridazines as 5-ht6 receptor antagonists
US8895562B2 (en) * 2008-07-31 2014-11-25 Janssen Pharmaceutica Nv Piperazin-1-yl-trifluoromethyl-substituted-pyridines as fast dissociating dopamine 2 receptor antagonists
PT3174858T (pt) 2014-07-31 2019-07-23 Basf Se Processo para preparar pirazoles
AU2016260784B2 (en) 2015-05-11 2020-03-12 Basf Se Process for preparing 4-amino-pyridazines
WO2018082964A1 (en) 2016-11-04 2018-05-11 Basf Se Process for the production of pyridazinyl-amides in a one-pot synthesis
CN114605303A (zh) * 2022-03-14 2022-06-10 武汉工程大学 一种地拉韦啶及其中间体的合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3686188A (en) * 1970-06-30 1972-08-22 Ciba Geigy Corp N-benzofurylmethyl-arylalkyleneimines
US5563142A (en) * 1989-12-28 1996-10-08 The Upjohn Company Diaromatic substituted compounds as anti-HIV-1 agents
HUT61296A (en) * 1989-12-28 1992-12-28 Upjohn Co Process for producing substituted diaromatic compounds against aids and pharmaceutical compositions comprising same
JPH06506937A (ja) * 1991-04-09 1994-08-04 ジ・アップジョン・カンパニー 多剤耐性細胞に感受性を付与するアミンの使用
DE69217224T2 (de) * 1991-07-03 1997-06-05 Pharmacia & Upjohn Co., Kalamazoo, Mich. Substituierte indole als anti-aids pharmaceutische zubereitungen
DE4307883A1 (en) * 1992-03-12 1993-09-23 Westarp Martin Egon Dr Med Use of anti-retroviral substances - to treat motor-neuronal diseases
JPH08502745A (ja) * 1992-10-28 1996-03-26 ジ・アップジョン・カンパニー Ｈｉｖ感染症治療用の他の非‐ヌクレオシド逆転写酵素阻害剤と組み合せてのｂｈａｐ化合物の使用
EP0757398A1 (de) * 1995-07-25 1997-02-05 DORNIER GmbH Anordnung von mehreren Brennstoffzellen-Stacks zu einem Modul

Also Published As

Publication number Publication date
AR003106A1 (es) 1998-07-08
JPH10510530A (ja) 1998-10-13
WO1996018628A1 (en) 1996-06-20
AU4151696A (en) 1996-07-03
TW406075B (en) 2000-09-21
IL116310A0 (en) 1996-03-31
IL116310A (en) 2000-08-31
CO4700295A1 (es) 1998-12-29
US5866589A (en) 1999-02-02
EP0797576A1 (en) 1997-10-01

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