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PE38697A1 - Agentes antifungicos de peptidos ciclicos - Google Patents

Agentes antifungicos de peptidos ciclicos

Info

Publication number
PE38697A1
PE38697A1 PE1996000372A PE00037296A PE38697A1 PE 38697 A1 PE38697 A1 PE 38697A1 PE 1996000372 A PE1996000372 A PE 1996000372A PE 00037296 A PE00037296 A PE 00037296A PE 38697 A1 PE38697 A1 PE 38697A1
Authority
PE
Peru
Prior art keywords
preferredly
alkyl
formula
refers
antifungal agents
Prior art date
Application number
PE1996000372A
Other languages
English (en)
Inventor
Michael John Rodriguez
James Andrew Jamison
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PE38697A1 publication Critical patent/PE38697A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A PEPTIDOS CICLICOS SEMISINTETICOS DE FORMULA (I), DONDE: R`, R" Y R"' SON CH3 O H; O R' PUEDE SER -CH2C(O)NH2; R1, R2, R3, R4 Y R1 SON OH O H; R1 ES H, OH O OR, DONDE R ES ALQUILO(C1-C6) (PREFERENTEMENTE -CH3), BENCILO, CH2CHOHCH2OH, (CH2)bNRz1Rz2 O (CH2)cPORz3Rz4, ENTRE OTROS, DONDE: Rz1 y Rz2 SON H, ALQUILO O SE UNEN PARA FORMAR -CH2(CH2)eCH2; Rz3 Y Rz4 SON OH O ALCOXI (C1-C6)(PREFERENTEMENTE -OCH3); b Y c SON 1, 2, 3, 4, 5 o 6; e ES 1, 2 o 3; Ro ES OH, -OP(O)(OH)2, OP(O)(OH)R1 O -OP(O)(OH)(OR1); R1 ES ALQUILO (C1-C6) (PREFERENTEMENTE -CH3) O FENILO, ENTRE OTROS; R2 TIENE FORMULAS PREFERIDAS (II) Y (III), Y ES -CH2-C6H4-R3, DONDE R3 ES C6H4-R3a, -C�C-C6H4-R3b, -C6H4-C�C-C6H4-R3c O -C6H4-C6H4-R3d; DONDE: R3a, R3b, R3c y R3d SON H O ALQUILO(C1-C12), ENTRE OTROS. TAMBIEN SE REFIERE AL PROCEDIMIENTO DE PREPARACION DE COMPUESTOS DE FORMULA (I), QUE COMPRENDE LA ACILACION DEL COMPUESTO (I) EN LA POSICION DEL SUSTITUYENTE R2, DONDE R2 ERA INICIALMENTE HIDROGENO. ESTOS COMPUESTOS DE FORMULA (I) TIENEN MAYOR ESTABILIDAD Y SOLUBILIDAD EN AGUA Y SON UTILES EN EL TRATAMIENTO DE INFECCIONES FUNGICAS POR CANDIDA ALBICANS O ASPERGILLUS FUMIGATUS, ENTRE OTROS ORGANISMOS TAL COMO LOS RESPONSABLES DE INFECCIONES OPORTUNISTAS EN INDIVIDUOS IMNUSUPRIMIDOS
PE1996000372A 1995-05-26 1996-05-22 Agentes antifungicos de peptidos ciclicos PE38697A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US45305095A 1995-05-26 1995-05-26

Publications (1)

Publication Number Publication Date
PE38697A1 true PE38697A1 (es) 1997-10-09

Family

ID=23799012

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1996000372A PE38697A1 (es) 1995-05-26 1996-05-22 Agentes antifungicos de peptidos ciclicos

Country Status (13)

Country Link
US (1) US5618787A (es)
EP (1) EP0744404B1 (es)
JP (1) JPH11505847A (es)
AT (1) ATE233786T1 (es)
AU (1) AU5799496A (es)
CA (1) CA2220944A1 (es)
CO (1) CO4700479A1 (es)
DE (1) DE69626439T2 (es)
ES (1) ES2188722T3 (es)
IL (1) IL118333A0 (es)
PE (1) PE38697A1 (es)
WO (1) WO1996037512A1 (es)
ZA (1) ZA964013B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6743777B1 (en) * 1992-03-19 2004-06-01 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
WO1997047738A1 (en) 1996-06-13 1997-12-18 Fujisawa Pharmaceutical Co., Ltd. Cyclic lipopeptide acylase
US6323176B1 (en) 1998-02-25 2001-11-27 Eli Lilly And Company Cyclic peptide antifungal agents
EP1107981B1 (en) 1998-08-20 2005-01-26 Eli Lilly & Company Synthesis of ring-modified cyclic peptide analogs
IL143563A0 (en) 1998-12-09 2002-04-21 Lilly Co Eli Purification of echinocandin cyclopeptide compounds
BR0008713A (pt) 1999-03-03 2001-12-26 Lilly Co Eli Processos para preparar formulações ecomposições farmacêuticas orais com ecb
WO2000051564A1 (en) * 1999-03-03 2000-09-08 Eli Lilly And Company Echinocandin pharmaceutical formulations containing micelle-forming surfactants
WO2000052037A1 (en) 1999-03-03 2000-09-08 Eli Lilly And Company Echinocandin/carbohydrate complexes
KR20020002476A (ko) 1999-03-03 2002-01-09 피터 지. 스트링거 결정질 에키노칸딘 암모늄염의 형성 및 음이온 교환
US6991800B2 (en) * 2002-06-13 2006-01-31 Vicuron Pharmaceuticals Inc. Antifungal parenteral products
US20090306115A1 (en) * 2005-04-22 2009-12-10 Cosford Nicholas D Phenyl ethyne compounds
US8064666B2 (en) * 2007-04-10 2011-11-22 Avantis Medical Systems, Inc. Method and device for examining or imaging an interior surface of a cavity

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4293488A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912B nucleus
US4293489A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912A nucleus
US4320052A (en) * 1979-12-13 1982-03-16 Eli Lilly And Company Derivatives of A-30912A nucleus
DK173802B1 (da) * 1988-09-12 2001-11-05 Merck & Co Inc Præparat til behandling af Pneumocystis carinii infeksioner og anvendelse af et cyclohexapeptid til fremstilling af et lægemiddel mod Pneumocystis carinii infektioner
US5166135A (en) * 1988-09-12 1992-11-24 Merck & Company, Inc. Method for the control of pneumocystis carinii
CA2037957A1 (en) * 1990-03-12 1991-09-13 Merck & Co., Inc. N-acylated cyclohexapeptide compounds
GB2241956A (en) * 1990-03-16 1991-09-18 Merck & Co Inc N-acylated cyclohexapeptide compounds
US5310726A (en) * 1990-03-19 1994-05-10 Merck & Co., Inc. Lipopeptide compounds
IE910892A1 (en) * 1990-03-19 1991-09-25 Merck & Co Inc Lipopeptide compounds
IL97347A0 (en) * 1990-03-19 1992-05-25 Merck & Co Inc Lipopeptide derivatives and antimicrobial compositions containing them
US5386009A (en) * 1990-03-19 1995-01-31 Merck & Co. Inc. Lipopeptide derivatives
US5049546A (en) * 1990-03-19 1991-09-17 Merck & Co., Inc. Antibiotic agents
US5330973A (en) * 1990-03-19 1994-07-19 Merck & Co., Inc. Lipopeptide derivatives
IE912046A1 (en) * 1990-06-18 1991-12-18 Fujisawa Pharmaceutical Co New polypeptide compound and a process for preparation¹thereof
US5369093A (en) * 1991-03-15 1994-11-29 Merck & Co., Inc. Lipopeptide derivatives
US5233023A (en) * 1991-07-30 1993-08-03 Merck & Co., Inc. Process for phosphate ester compounds of certain cyclohexapeptides
IL122315A (en) * 1992-03-19 2002-03-10 Lilly Co Eli Cyclic peptides and antifungal pharmaceutical compositions containing them

Also Published As

Publication number Publication date
CA2220944A1 (en) 1996-11-28
ATE233786T1 (de) 2003-03-15
CO4700479A1 (es) 1998-12-29
EP0744404A3 (en) 1998-05-20
ZA964013B (en) 1997-11-20
US5618787A (en) 1997-04-08
DE69626439D1 (de) 2003-04-10
IL118333A0 (en) 1996-09-12
WO1996037512A1 (en) 1996-11-28
ES2188722T3 (es) 2003-07-01
AU5799496A (en) 1996-12-11
EP0744404B1 (en) 2003-03-05
DE69626439T2 (de) 2003-10-02
JPH11505847A (ja) 1999-05-25
EP0744404A2 (en) 1996-11-27

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FA Abandonment or withdrawal