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RU2010135869A - Офтальмологическая композиция с амфотерным поверхносто-активным веществом гиалуроновой кислотой - Google Patents

Офтальмологическая композиция с амфотерным поверхносто-активным веществом гиалуроновой кислотой Download PDF

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RU2010135869A
RU2010135869A RU2010135869/15A RU2010135869A RU2010135869A RU 2010135869 A RU2010135869 A RU 2010135869A RU 2010135869/15 A RU2010135869/15 A RU 2010135869/15A RU 2010135869 A RU2010135869 A RU 2010135869A RU 2010135869 A RU2010135869 A RU 2010135869A
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Ирнинг КСИА (US)
Ирнинг КСИА
Сьюзан И. БУРК (US)
Сьюзан И. БУРК
Срини ВЕНКАТЕШ (US)
Срини ВЕНКАТЕШ
Вики Л. БАРНИАК (US)
Вики Л. БАРНИАК
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БОШ энд ЛОМБ ИНКОРПОРЕЙТИД (US)
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Abstract

1. Офтальмологическая композиция, содержащая от 0,5 м.д. до 2 м.д. поли (гексаметиленбигаунида), 0,002-0,04 вес.% гиалуроновой кислоты и 0,01-1,0 вес.% амфотерного поверхностно-активного вещества формулы I ! ! где R1 обозначает линейный насыщенный алкил с 10 атомами углерода, R2 и R3 каждый обозначают метил и R4 обозначает пропил. ! 2. Композиция по п.1, в которой гиалуроновая кислота содержится в количестве от 0,005 вес.% до 0,03 вес.%. ! 3. Композиция по п.1, дополнительно содержащая α-[4-трис-(2-гидроксиэтил)-аммонийхлорид-2-бутенил]поли[1-диметиламмонийхлорид-2-бутенил]-ω-трис-(2-гидроксиэтил)-аммонийхлорид, который содержится в количестве от 0,5 м.д. до 3 м.д. ! 4. Композиция по п.1, дополнительно содержащая декспантенол, сорбит, гликолевую кислоту, 2-амино-2-метил-1,3-пропандиол или любую их смесь. ! 5. Композиция по п.1, дополнительно содержащая пропиленгликоль, гидроксипропилированный гуар или миристамидопропилдиметиламин. ! 6. Композиция по п.1, дополнительно содержащая гидроксипропилметилцеллюлозу. ! 7. Композиция по п.1, дополнительно содержащая борную кислоту / боратный буфер и полоксамин. ! 8. Композиция по п.4, в которой декспантенол содержится в количестве от 0,2 вес.% до 5 вес.%. ! 9. Композиция по п.8, дополнительно содержащая сорбит или ксилит в количестве от 0,4 вес.% до 5 вес.%. ! 10. Композиция по п.5, в которой пропиленгликоль присутствует в количестве от 0,01 вес.% до 1 вес.%. ! 11. Композиция по любому из пп.1-10, дополнительно содержащая дисукцинат формулы ! где R1 выбран из водорода, алкила или -С(O)алкила, при этом алкил содержит от 1 до 12 атомов углерода и, возможно, один или несколько атомов кислорода, А обозначает метиленовую группу или оксиалкиленовую группу и

Claims (14)

1. Офтальмологическая композиция, содержащая от 0,5 м.д. до 2 м.д. поли (гексаметиленбигаунида), 0,002-0,04 вес.% гиалуроновой кислоты и 0,01-1,0 вес.% амфотерного поверхностно-активного вещества формулы I
Figure 00000001
где R1 обозначает линейный насыщенный алкил с 10 атомами углерода, R2 и R3 каждый обозначают метил и R4 обозначает пропил.
2. Композиция по п.1, в которой гиалуроновая кислота содержится в количестве от 0,005 вес.% до 0,03 вес.%.
3. Композиция по п.1, дополнительно содержащая α-[4-трис-(2-гидроксиэтил)-аммонийхлорид-2-бутенил]поли[1-диметиламмонийхлорид-2-бутенил]-ω-трис-(2-гидроксиэтил)-аммонийхлорид, который содержится в количестве от 0,5 м.д. до 3 м.д.
4. Композиция по п.1, дополнительно содержащая декспантенол, сорбит, гликолевую кислоту, 2-амино-2-метил-1,3-пропандиол или любую их смесь.
5. Композиция по п.1, дополнительно содержащая пропиленгликоль, гидроксипропилированный гуар или миристамидопропилдиметиламин.
6. Композиция по п.1, дополнительно содержащая гидроксипропилметилцеллюлозу.
7. Композиция по п.1, дополнительно содержащая борную кислоту / боратный буфер и полоксамин.
8. Композиция по п.4, в которой декспантенол содержится в количестве от 0,2 вес.% до 5 вес.%.
9. Композиция по п.8, дополнительно содержащая сорбит или ксилит в количестве от 0,4 вес.% до 5 вес.%.
10. Композиция по п.5, в которой пропиленгликоль присутствует в количестве от 0,01 вес.% до 1 вес.%.
11. Композиция по любому из пп.1-10, дополнительно содержащая дисукцинат формулы
Figure 00000002
где R1 выбран из водорода, алкила или -С(O)алкила, при этом алкил содержит от 1 до 12 атомов углерода и, возможно, один или несколько атомов кислорода, А обозначает метиленовую группу или оксиалкиленовую группу и n равен от 2 до 8.
12. Применение офтальмологической композиции по любому из пп.1-11 для очистки и дезинфекции контактных линз.
13. Способ очистки и дезинфекции контактной линзы, включающий погружение контактной линзы в офтальмологическую композицию по любому из пп.1-11 по меньшей мере на два часа.
14. Способ по п.13, дополнительно включающий вставление очищенной и дезинфицированной контактной линзы в глаз без промывания линзы после погружения.
RU2010135869/15A 2008-01-31 2008-10-10 Офтальмологическая композиция с амфотерным поверхностно-активным веществом и гиалуроновой кислотой RU2448736C1 (ru)

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US12/023,509 2008-01-31
US12/023,509 US9096819B2 (en) 2008-01-31 2008-01-31 Ophthalmic compositions with an amphoteric surfactant and an anionic biopolymer
US12/203,384 US8119112B2 (en) 2008-01-31 2008-09-03 Ophthalmic compositions with an amphoteric surfactant and hyaluronic acid
US12/203,384 2008-09-03

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CA2713308C (en) 2014-07-08
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