PE23198A1 - Nuevos derivados de fenilamidina, procedimiento para su preparacion y su utilizacion como medicamentos - Google Patents
Nuevos derivados de fenilamidina, procedimiento para su preparacion y su utilizacion como medicamentosInfo
- Publication number
- PE23198A1 PE23198A1 PE1996000847A PE00084796A PE23198A1 PE 23198 A1 PE23198 A1 PE 23198A1 PE 1996000847 A PE1996000847 A PE 1996000847A PE 00084796 A PE00084796 A PE 00084796A PE 23198 A1 PE23198 A1 PE 23198A1
- Authority
- PE
- Peru
- Prior art keywords
- preparation
- alkyl
- hydrogen
- formula
- phenylamidine
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- PXXJHWLDUBFPOL-UHFFFAOYSA-N benzamidine Chemical class NC(=N)C1=CC=CC=C1 PXXJHWLDUBFPOL-UHFFFAOYSA-N 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical group [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 2
- 102000003680 Leukotriene B4 receptors Human genes 0.000 abstract 1
- 108090000093 Leukotriene B4 receptors Proteins 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
- 150000002463 imidates Chemical class 0.000 abstract 1
- 210000004072 lung Anatomy 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 230000000414 obstructive effect Effects 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
- C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE REFIEREN A COMPUESTOS DE FORMULA (I), EN DONDE: "A" ES EL COMPUESTO DE FORMULA X1-CmH2m-X2, EN DONDE m ES 2; 3; 4; 5 o 6; X1 PREFERENTEMENTE ES OXIGENO; X2 PREFERENTEMENTE ES -X1-C6H4- O EL COMPUESTO DE FORMULA (II), EN DONDE: X3 ES -X1-CnH2n; X4 ES -CnH2n-X1; n ES 1 o 2; R7 Y R8 SON HIDROGENO O HALOGENO, ENTRE OTROS; R1 ES CICLOALQUILO C5-C7, Ar1, O-Ar1, CH2-Ar2, CR4R5Ar3 o C(CH3)2R6, EN DONDE: Ar1, Ar2 Y Ar3 SON ARILO OPCIONALMENTE SUSTITUIDO CON HIDROXILO o CON HIDROXILO Y ALQUILO DE C1-C6; R4 Y R5 SON CH3 O CH2OH o PUEDEN FORMAR UN ALQUILENO DE C4-C6; R6 ES CH20H o COOH, ENTRE OTROS; R2 ES HIDROGENO, HIDROXILO o O-ALQUILO DE C1-C6, ENTRE OTROS; R3 ES HIDROGENO o ALQUILO DE C1-C6. TAMBIEN SE REFIEREN A LOS PROCEDIMIENTOS PARA LA PREPARACION DE (I), QUE COMPRENDEN: HACER REACCIONAR AMONIACO CON EL IMIDOESTER o EL IMIDOCLORURO DE (I), o REDUCIR LA IMIDOOXIMA DE (I), ENTRE OTROS. ACTUAN COMO ANTAGONISTAS DE LOS RECEPTORES LTB4, SIENDO UTILES EN EL TRATAMIENTO DEL ASMA, DE LAS ENFERMEDADES OBSTRUCTIVAS DE LOS PULMONES, ENTRE OTROS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19546452A DE19546452A1 (de) | 1995-12-13 | 1995-12-13 | Neue Phenylamidinderivate, Verfahren zu ihrer Herstelung und ihre Verwendung als Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE23198A1 true PE23198A1 (es) | 1998-05-13 |
Family
ID=7779950
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1996000847A PE23198A1 (es) | 1995-12-13 | 1996-11-27 | Nuevos derivados de fenilamidina, procedimiento para su preparacion y su utilizacion como medicamentos |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US6127423A (es) |
| EP (1) | EP1015421B1 (es) |
| JP (1) | JP4334016B2 (es) |
| KR (1) | KR100475207B1 (es) |
| CN (1) | CN100366606C (es) |
| AR (1) | AR005034A1 (es) |
| AT (1) | ATE263144T1 (es) |
| AU (1) | AU716473B2 (es) |
| BG (1) | BG64020B1 (es) |
| BR (1) | BR9611949A (es) |
| CO (1) | CO4750814A1 (es) |
| CZ (1) | CZ291860B6 (es) |
| DE (2) | DE19546452A1 (es) |
| DK (1) | DK1015421T3 (es) |
| EE (1) | EE04371B1 (es) |
| ES (1) | ES2218609T3 (es) |
| HR (1) | HRP960583B1 (es) |
| HU (1) | HUP9903733A3 (es) |
| IL (2) | IL123900A0 (es) |
| MX (1) | MX9803672A (es) |
| MY (1) | MY120683A (es) |
| NO (1) | NO311353B1 (es) |
| NZ (1) | NZ325235A (es) |
| PE (1) | PE23198A1 (es) |
| PL (1) | PL186720B1 (es) |
| PT (1) | PT1015421E (es) |
| RS (1) | RS49503B (es) |
| RU (1) | RU2184726C2 (es) |
| SI (1) | SI1015421T1 (es) |
| SK (1) | SK282212B6 (es) |
| TR (1) | TR199801039T2 (es) |
| TW (1) | TW438746B (es) |
| UA (1) | UA57013C2 (es) |
| WO (1) | WO1997021670A1 (es) |
| ZA (1) | ZA9610460B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19636689A1 (de) * | 1996-09-10 | 1998-03-12 | Boehringer Ingelheim Kg | Neue Benzamidinderivate |
| DE19637123A1 (de) * | 1996-09-12 | 1998-03-19 | Boehringer Ingelheim Kg | Neue Pyranosidderivate |
| UA52797C2 (uk) * | 1997-11-20 | 2003-01-15 | Тейдзін Лімітед | Похідне біфеніламідину, проліки, інгібітор коагуляції крові, агент для профілактики тромбозу або емболії та агент для терапії тромбозу або емболії |
| ID24720A (id) | 1997-12-12 | 2000-08-03 | Novartis Ag | Senyawa amidino tersubstitusi dalam perawatan penyakit gangguan paru-paru kronis |
| US6635668B1 (en) * | 1998-07-22 | 2003-10-21 | The University Of North Carolina At Chapel Hill | Imidazoline receptor binding compounds |
| ATE274491T1 (de) | 1998-12-14 | 2004-09-15 | Hoffmann La Roche | Phenylglycin-derivate |
| US6528491B2 (en) | 2000-10-24 | 2003-03-04 | Boehringer Ingelheim Pharma Kg | Pyranoside derivatives |
| DE10052333A1 (de) * | 2000-10-24 | 2002-05-02 | Boehringer Ingelheim Pharma | Neue Sulfooxybenzamide |
| US6489359B2 (en) | 2000-10-24 | 2002-12-03 | Boehringer Ingelheim Pharma Kg | Sulphoxybenzamides |
| MXPA03006328A (es) * | 2001-01-16 | 2004-04-05 | Boehringer Ingelheim Pharma | Uso de antagonista de ltb4 para tratamiento y/o prevencion de enfermedades causadas por aumento de expresion de genes de mucina. |
| US20030119901A1 (en) * | 2001-07-14 | 2003-06-26 | Boehringer Ingelheim Pharma Kg | Pharmaceutical formulation containing an LTB4 antagonist |
| PL368613A1 (en) * | 2001-07-14 | 2005-04-04 | Boehringer Ingelheim Pharma Gmbh & Co.Kg | Pharmaceutical formulation containing an ltb4 antagonist |
| US20040006092A1 (en) * | 2001-08-31 | 2004-01-08 | Neurochem, Inc. | Amidine derivatives for treating amyloidosis |
| RS20050390A (sr) * | 2002-11-26 | 2008-04-04 | Boehringer Ingelheim Pharma Gmbh. & Co.Kg., | Farmaceutska kompozicija koja obuhvata ltb4 antagonist i koks-2 inhibitor ili kombinovani koks1/2 inhibitor |
| US7262223B2 (en) * | 2004-01-23 | 2007-08-28 | Neurochem (International) Limited | Amidine derivatives for treating amyloidosis |
| US12275687B2 (en) * | 2017-05-12 | 2025-04-15 | Riken | Class A GPCR-binding compound modifier |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5246965A (en) * | 1991-06-11 | 1993-09-21 | Ciba-Geigy | Arylethers, their manufacture and methods of treatment |
| PL173781B1 (pl) * | 1992-02-05 | 1998-04-30 | Boehringer Ingelheim Kg | Sposób wytwarzania nowych pochodnych amidyny |
| DE4309285A1 (de) * | 1993-03-23 | 1994-09-29 | Boehringer Ingelheim Kg | Heterocyclen enthaltende Amidinderivate, ihre Herstellung und Verwendung |
| DE4424714A1 (de) * | 1994-07-13 | 1996-01-18 | Boehringer Ingelheim Kg | Neue chemische Verbindung, ihre Herstellung und ihre Verwendung als Arnzneistoff |
-
1995
- 1995-12-13 DE DE19546452A patent/DE19546452A1/de not_active Withdrawn
-
1996
- 1996-11-12 UA UA98073741A patent/UA57013C2/uk unknown
- 1996-11-18 TW TW085114139A patent/TW438746B/zh not_active IP Right Cessation
- 1996-11-27 PE PE1996000847A patent/PE23198A1/es not_active Application Discontinuation
- 1996-12-02 RS YU63696A patent/RS49503B/sr unknown
- 1996-12-11 DE DE59610963T patent/DE59610963D1/de not_active Expired - Lifetime
- 1996-12-11 RU RU98112918/04A patent/RU2184726C2/ru not_active IP Right Cessation
- 1996-12-11 AT AT96943916T patent/ATE263144T1/de active
- 1996-12-11 TR TR1998/01039T patent/TR199801039T2/xx unknown
- 1996-12-11 AU AU13699/97A patent/AU716473B2/en not_active Ceased
- 1996-12-11 PT PT96943916T patent/PT1015421E/pt unknown
- 1996-12-11 SI SI9630673T patent/SI1015421T1/xx unknown
- 1996-12-11 IL IL12390096A patent/IL123900A0/xx active IP Right Grant
- 1996-12-11 WO PCT/EP1996/005529 patent/WO1997021670A1/de not_active Ceased
- 1996-12-11 EP EP96943916A patent/EP1015421B1/de not_active Expired - Lifetime
- 1996-12-11 PL PL96327171A patent/PL186720B1/pl not_active IP Right Cessation
- 1996-12-11 KR KR10-1998-0704412A patent/KR100475207B1/ko not_active Expired - Fee Related
- 1996-12-11 NZ NZ325235A patent/NZ325235A/xx unknown
- 1996-12-11 AR ARP960105608A patent/AR005034A1/es active IP Right Grant
- 1996-12-11 CN CNB961989599A patent/CN100366606C/zh not_active Expired - Fee Related
- 1996-12-11 ES ES96943916T patent/ES2218609T3/es not_active Expired - Lifetime
- 1996-12-11 BR BR9611949A patent/BR9611949A/pt not_active Application Discontinuation
- 1996-12-11 CZ CZ19981836A patent/CZ291860B6/cs not_active IP Right Cessation
- 1996-12-11 DK DK96943916T patent/DK1015421T3/da active
- 1996-12-11 US US09/077,900 patent/US6127423A/en not_active Expired - Lifetime
- 1996-12-11 JP JP52173497A patent/JP4334016B2/ja not_active Expired - Fee Related
- 1996-12-11 HU HU9903733A patent/HUP9903733A3/hu unknown
- 1996-12-11 SK SK770-98A patent/SK282212B6/sk unknown
- 1996-12-11 EE EE9800145A patent/EE04371B1/xx not_active IP Right Cessation
- 1996-12-12 ZA ZA9610460A patent/ZA9610460B/xx unknown
- 1996-12-12 HR HR960583A patent/HRP960583B1/xx not_active IP Right Cessation
- 1996-12-12 CO CO96065302A patent/CO4750814A1/es unknown
- 1996-12-13 MY MYPI96005251A patent/MY120683A/en unknown
-
1998
- 1998-03-31 IL IL123900A patent/IL123900A/en not_active IP Right Cessation
- 1998-04-21 BG BG102395A patent/BG64020B1/bg unknown
- 1998-05-08 MX MX9803672A patent/MX9803672A/es not_active IP Right Cessation
- 1998-06-12 NO NO19982708A patent/NO311353B1/no unknown
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