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PE20240765A1 - Compuestos para la inhibicion de nlrp3 y usos de estos - Google Patents

Compuestos para la inhibicion de nlrp3 y usos de estos

Info

Publication number
PE20240765A1
PE20240765A1 PE2023002788A PE2023002788A PE20240765A1 PE 20240765 A1 PE20240765 A1 PE 20240765A1 PE 2023002788 A PE2023002788 A PE 2023002788A PE 2023002788 A PE2023002788 A PE 2023002788A PE 20240765 A1 PE20240765 A1 PE 20240765A1
Authority
PE
Peru
Prior art keywords
nlrp3
alkyl
compounds
cycloalkyl
halo
Prior art date
Application number
PE2023002788A
Other languages
English (en)
Inventor
Stephane Dorich
Jason Burch
Miguel St-Onge
Amandine Chefson
Alexandre Côte
Ramsay Beveridge
Stephane Ciblat
Original Assignee
Ventus Therapeutics U S Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ventus Therapeutics U S Inc filed Critical Ventus Therapeutics U S Inc
Publication of PE20240765A1 publication Critical patent/PE20240765A1/es

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

La presente invencion esta relacionada con inhibidores de NLRP3 utiles en el tratamiento de enfermedades y trastornos asociados con la modulacion de las proteinas NLRP3. En particular, la presente invencion se refiere a un compuesto con la Formula (I) o una sal, un solvato, un clatrato, entre otros; donde: X es N(Ra), O, S o C(Rb)(Rc); Ra es H, alquilo C1-C6, haloalquilo C1-C6, entre otros; o Ra se cicla con R1 para formar un heterocicloalquilo de 3 a 8 miembros; Rb es H o alquilo C1-C6; Rc es H o alquilo C1-C6; o Rb y Rc, junto con los atomos a los que estan unidos, forman un cicloalquilo C3-C8; Y es cicloalquilo C3-C8, heterocicloalquilo de 3 a 8 miembros, arilo C6-C10, entre otros; R1 es alquilo C1-C6, alquenilo C2-C6, alquinilo C2-C6, entre otros; R2 es H, halo, ciano, entre otros; R3 es H, halo, ciano, entre otros; o R2 y R3, junto con los atomos a los que estan unidos, forman un cicloalquilo C3-C8, heterocicloalquilo de 3 a 8 miembros, arilo C6-C10 o heteroarilo de 5 a 9 miembros, donde el cicloalquilo C3-C8, heterocicloalquilo de 3 a 8 miembros, arilo C6-C10 o heteroarilo de 5 a 9 miembros esta opcionalmente sustituido con uno o mas R2a; R2a es hidrogeno, deuterio, alquilo C1-C6, halo o haloalquilo C1-C6. Ademas, se refiere a compuestos y composiciones farmaceuticas que inhiben NLRP3, metodos para el tratamiento de enfermedades y trastornos asociados con NLRP3 mediante el uso de dichos compuestos y composiciones farmaceuticas, y metodos para sintetizar dichos compuestos y composiciones.
PE2023002788A 2021-04-07 2022-04-07 Compuestos para la inhibicion de nlrp3 y usos de estos PE20240765A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163171932P 2021-04-07 2021-04-07
US17/528,928 US11319319B1 (en) 2021-04-07 2021-11-17 Compounds for inhibiting NLRP3 and uses thereof
PCT/US2022/023893 WO2022216971A1 (en) 2021-04-07 2022-04-07 Pyridazine compounds for inhibiting nlrp3

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PE20240765A1 true PE20240765A1 (es) 2024-04-17

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PE2023002788A PE20240765A1 (es) 2021-04-07 2022-04-07 Compuestos para la inhibicion de nlrp3 y usos de estos

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US (10) US11319319B1 (es)
EP (3) EP4537900A3 (es)
JP (2) JP7620120B2 (es)
KR (1) KR20230167394A (es)
CN (2) CN117500792A (es)
AU (3) AU2022256052B2 (es)
BR (1) BR112023020483A2 (es)
CA (1) CA3214676A1 (es)
CL (2) CL2023002973A1 (es)
CO (1) CO2023013356A2 (es)
IL (2) IL308378A (es)
MX (2) MX2023011576A (es)
PE (1) PE20240765A1 (es)
TW (1) TW202304905A (es)
WO (1) WO2022216971A1 (es)

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KR20250069659A (ko) 2022-09-23 2025-05-19 머크 샤프 앤드 돔 엘엘씨 Nod-유사 수용체 단백질 3의 억제제로서 유용한 프탈라진 유도체
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