PE20231435A1 - Inhibidores de factores del complemento y usos de los mismos - Google Patents
Inhibidores de factores del complemento y usos de los mismosInfo
- Publication number
- PE20231435A1 PE20231435A1 PE2023000109A PE2023000109A PE20231435A1 PE 20231435 A1 PE20231435 A1 PE 20231435A1 PE 2023000109 A PE2023000109 A PE 2023000109A PE 2023000109 A PE2023000109 A PE 2023000109A PE 20231435 A1 PE20231435 A1 PE 20231435A1
- Authority
- PE
- Peru
- Prior art keywords
- compounds
- halogen
- hydrogen
- independently
- cyano
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/650905—Six-membered rings having the nitrogen atoms in the positions 1 and 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/650905—Six-membered rings having the nitrogen atoms in the positions 1 and 2
- C07F9/650947—Six-membered rings having the nitrogen atoms in the positions 1 and 2 condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Ophthalmology & Optometry (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Transplantation (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Referido a compuestos de formula I o II, o una sal farmaceuticamente aceptable del mismo, en donde: R1 es H, halogeno, amino, hidroxilo, alcoxi o alquiltio; V y W son cada uno, independientemente, CRa o N; X es CRb o N; cada U es independientemente N o CRc; el anillo Z1 es un arilo o heteroarilo de cinco o seis miembros; el anillo Z2 es un heterociclo de cinco o seis miembros; cada R2 es independientemente halogeno, nitro, ciano, amino, entre otros; Ra es hidrogeno, halogeno, ciano, entre otros; Rb es hidrogeno, halogeno, nitro, entre otros; R3 es -B(OR3b)(OR3a), -B(OR3b)(OR3a)(M); R3a y R3b son hidrogeno, alquilo, acilo, alquenilo, entre otros; M es N(R8)3, entre otros; R8 es hidrogeno, alquilo, aralquilo, heteroaralquilo, entre otros; n es 0, 1, 2, 3 o 4; cada R6 es independientemente halogeno, nitro, ciano, entre otros; q es 0, 1, 2, 3 o 4. Estos compuestos son inhibidores de factores del complemento. Tambien se refiere a la preparacion de dichos compuestos, compuestos intermedios de los mismos, una composicion farmaceutica que comprende dichos compuestos, y su uso en el tratamiento de trastorno neurodegenerativas, enfermedad inflamatoria, autoinmunitaria, entre otros.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063054064P | 2020-07-20 | 2020-07-20 | |
| PCT/US2021/042198 WO2022020244A1 (en) | 2020-07-20 | 2021-07-19 | Inhibitors of complement factors and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20231435A1 true PE20231435A1 (es) | 2023-09-14 |
Family
ID=79729495
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2023000109A PE20231435A1 (es) | 2020-07-20 | 2021-07-19 | Inhibidores de factores del complemento y usos de los mismos |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US11814404B2 (es) |
| EP (1) | EP4185592A4 (es) |
| JP (1) | JP7793595B2 (es) |
| KR (1) | KR20230041758A (es) |
| CN (2) | CN116261564A (es) |
| AR (1) | AR123011A1 (es) |
| AU (1) | AU2021311455A1 (es) |
| BR (1) | BR112023001007A2 (es) |
| CA (1) | CA3186022A1 (es) |
| CL (1) | CL2023000191A1 (es) |
| CO (1) | CO2023000683A2 (es) |
| IL (1) | IL299840A (es) |
| MX (1) | MX2023000919A (es) |
| PE (1) | PE20231435A1 (es) |
| PH (1) | PH12023550153A1 (es) |
| TW (1) | TW202216168A (es) |
| UY (1) | UY39331A (es) |
| WO (1) | WO2022020244A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH12023550153A1 (en) | 2020-07-20 | 2024-03-18 | Annexon Inc | Inhibitors of complement factors and uses thereof |
| CN118715231A (zh) | 2022-01-14 | 2024-09-27 | 安尼艾克松股份有限公司 | 补体因子抑制剂及其用途 |
| WO2024163405A1 (en) * | 2023-01-30 | 2024-08-08 | 5Metis, Inc. | Boron containing compounds and their uses |
| WO2024254704A1 (en) * | 2023-06-15 | 2024-12-19 | The Governors Of The University Of Alberta | Hemiboronic heterocyclic compounds and uses thereof |
| EP4553080A1 (en) | 2023-11-07 | 2025-05-14 | Ustav Organicke Chemie a Biochemie AV CR, v.v.i. | Nucleoside derivatives as antiviral agents against coronaviruses |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU7138298A (en) | 1997-04-24 | 1998-11-13 | Ortho-Mcneil Corporation, Inc. | Substituted imidazoles useful in the treatment of inflammatory diseases |
| JP5120957B2 (ja) * | 2006-01-13 | 2013-01-16 | エルジー・ケム・リミテッド | 発光物質およびこれを用いた有機発光素子 |
| US8221907B2 (en) | 2007-07-07 | 2012-07-17 | Idemitsu Kosan Co., Ltd. | Chrysene derivative and organic electroluminescent device using the same |
| KR101233377B1 (ko) | 2008-12-30 | 2013-02-18 | 제일모직주식회사 | 신규한 유기광전소자용 화합물 및 이를 포함하는 유기광전소자 |
| WO2013049332A1 (en) | 2011-09-29 | 2013-04-04 | Infinity Pharmaceuticals, Inc. | Inhibitors of monoacylglycerol lipase and methods of their use |
| WO2015003146A1 (en) | 2013-07-03 | 2015-01-08 | Georgetown University | Boronic acid derivatives of resveratrol for activating deacetylase enzymes |
| EA037325B1 (ru) | 2013-07-09 | 2021-03-12 | Аннексон, Инк. | Антитела против фактора комплемента c1q и их применения |
| TWI532741B (zh) | 2013-09-04 | 2016-05-11 | 喜星素材股份有限公司 | 含吡唑之多環化合物及使用其之有機發光裝置 |
| KR101635154B1 (ko) * | 2014-08-28 | 2016-06-30 | (주)더블유에스 | 피리딜기가 결합된 트리아진 유도체 및 이를 포함한 유기 전계발광 소자 |
| KR102233296B1 (ko) * | 2014-11-18 | 2021-03-29 | 덕산네오룩스 주식회사 | 유기전기 소자용 화합물, 이를 이용한 유기전기소자 및 그 전자 장치 |
| AR103397A1 (es) * | 2015-01-13 | 2017-05-10 | Syngenta Participations Ag | Oxoborazoles microbicidas |
| CN107530356A (zh) * | 2015-03-13 | 2018-01-02 | 雷斯韦洛吉克斯公司 | 用于治疗补体相关疾病之组合物及治疗方法 |
| KR101981245B1 (ko) | 2015-10-27 | 2019-05-22 | 주식회사 엘지화학 | 고리 화합물 및 이를 포함하는 유기 발광 소자 |
| KR101806464B1 (ko) | 2015-11-19 | 2017-12-07 | (주)랩토 | 피리딜기가 결합된 피리미딘 유도체 및 이를 이용한 유기 전계 발광 소자 |
| KR102496411B1 (ko) | 2016-01-06 | 2023-02-06 | 덕산네오룩스 주식회사 | 유기전기 소자용 화합물, 이를 이용한 유기전기소자 및 그 전자 장치 |
| US10646488B2 (en) | 2016-07-13 | 2020-05-12 | Araxes Pharma Llc | Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof |
| KR102238925B1 (ko) * | 2018-06-11 | 2021-04-12 | 주식회사 엘지화학 | 헤테로고리 화합물 및 이를 포함하는 유기 발광 소자 |
| WO2020032428A1 (ko) * | 2018-08-09 | 2020-02-13 | 덕산네오룩스 주식회사 | 유기전기 소자용 화합물을 포함하는 유기전기소자 및 그 전자 장치 |
| CN109574917B (zh) | 2018-12-03 | 2020-12-08 | 武汉尚赛光电科技有限公司 | 一种芴酮衍生物及其制备和应用 |
| CN109574910B (zh) * | 2018-12-19 | 2021-07-02 | 山西大学 | 一种咔唑衍生物mcab及其制备方法和应用 |
| CN111087387B (zh) * | 2019-12-26 | 2022-04-29 | 厦门天马微电子有限公司 | 一种有机化合物、显示面板及显示装置 |
| CN111423390A (zh) | 2020-03-30 | 2020-07-17 | 北京燕化集联光电技术有限公司 | 一种新型结构化合物及其应用 |
| CN111662309B (zh) | 2020-07-10 | 2021-11-09 | 北京燕化集联光电技术有限公司 | 一种多杂环结构化合物及其应用 |
| PH12023550153A1 (en) | 2020-07-20 | 2024-03-18 | Annexon Inc | Inhibitors of complement factors and uses thereof |
| CN113045585A (zh) | 2021-03-16 | 2021-06-29 | 吉林奥来德光电材料股份有限公司 | 一种有机稠环化合物及其制备方法和应用 |
| CN113831332B (zh) | 2021-10-29 | 2024-06-18 | 长春海谱润斯科技股份有限公司 | 一种含氮杂环衍生物及其在有机电致发光器件中的应用 |
| CN118715231A (zh) | 2022-01-14 | 2024-09-27 | 安尼艾克松股份有限公司 | 补体因子抑制剂及其用途 |
-
2021
- 2021-07-19 PH PH1/2023/550153A patent/PH12023550153A1/en unknown
- 2021-07-19 KR KR1020237005805A patent/KR20230041758A/ko active Pending
- 2021-07-19 EP EP21845924.6A patent/EP4185592A4/en active Pending
- 2021-07-19 US US17/379,334 patent/US11814404B2/en active Active
- 2021-07-19 PE PE2023000109A patent/PE20231435A1/es unknown
- 2021-07-19 CN CN202180059041.6A patent/CN116261564A/zh active Pending
- 2021-07-19 IL IL299840A patent/IL299840A/en unknown
- 2021-07-19 MX MX2023000919A patent/MX2023000919A/es unknown
- 2021-07-19 WO PCT/US2021/042198 patent/WO2022020244A1/en not_active Ceased
- 2021-07-19 CA CA3186022A patent/CA3186022A1/en active Pending
- 2021-07-19 AR ARP210102028A patent/AR123011A1/es unknown
- 2021-07-19 JP JP2023503413A patent/JP7793595B2/ja active Active
- 2021-07-19 AU AU2021311455A patent/AU2021311455A1/en active Pending
- 2021-07-19 CN CN202310870524.5A patent/CN116947903A/zh active Pending
- 2021-07-19 BR BR112023001007A patent/BR112023001007A2/pt unknown
- 2021-07-20 UY UY0001039331A patent/UY39331A/es unknown
- 2021-07-20 TW TW110126637A patent/TW202216168A/zh unknown
-
2023
- 2023-01-19 CL CL2023000191A patent/CL2023000191A1/es unknown
- 2023-01-20 CO CONC2023/0000683A patent/CO2023000683A2/es unknown
- 2023-10-04 US US18/376,526 patent/US12509474B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| MX2023000919A (es) | 2023-04-19 |
| TW202216168A (zh) | 2022-05-01 |
| AU2021311455A1 (en) | 2023-02-16 |
| EP4185592A4 (en) | 2024-08-21 |
| PH12023550153A1 (en) | 2024-03-18 |
| CN116261564A (zh) | 2023-06-13 |
| CO2023000683A2 (es) | 2023-01-26 |
| BR112023001007A2 (pt) | 2023-03-28 |
| US20220048930A1 (en) | 2022-02-17 |
| JP7793595B2 (ja) | 2026-01-05 |
| AR123011A1 (es) | 2022-10-19 |
| UY39331A (es) | 2022-02-25 |
| IL299840A (en) | 2023-03-01 |
| JP2023534974A (ja) | 2023-08-15 |
| US20240109920A1 (en) | 2024-04-04 |
| CN116947903A (zh) | 2023-10-27 |
| CL2023000191A1 (es) | 2023-09-08 |
| CA3186022A1 (en) | 2022-01-27 |
| US12509474B2 (en) | 2025-12-30 |
| WO2022020244A1 (en) | 2022-01-27 |
| US11814404B2 (en) | 2023-11-14 |
| KR20230041758A (ko) | 2023-03-24 |
| EP4185592A1 (en) | 2023-05-31 |
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