PE20220427A1 - Compuestos triciclicos - Google Patents
Compuestos triciclicosInfo
- Publication number
- PE20220427A1 PE20220427A1 PE2021001952A PE2021001952A PE20220427A1 PE 20220427 A1 PE20220427 A1 PE 20220427A1 PE 2021001952 A PE2021001952 A PE 2021001952A PE 2021001952 A PE2021001952 A PE 2021001952A PE 20220427 A1 PE20220427 A1 PE 20220427A1
- Authority
- PE
- Peru
- Prior art keywords
- options
- alkyl
- haloalkyl
- hepatitis
- aryl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Esta referido a compuestos triciclicos de Formula I, en donde: R1 es arilo, heteroarilo, entre otras opciones; R2 y R3 son H, alquilo, haloalquilo, arilo, entre otras opciones; R4 y R5 son H, alquilo, heteroarilo, heterociclilo, entre otras opciones; R6 y R7 son H, alaquilo o haloalquilo; R8 es H, alquilo, alquenilo, alquinilo, haloalquilo, entre otras opciones; R9 es H, alquilo, cicloalquilo, arilo, entre otras opciones; X1 es N, CR14; Z1 es -C(=O)-, -NH-C(=O)- o -O- C(=O)-; n es 0, 1. Entre los compuestos preferidos tenemos los siguientes: N-(3-cloro-4-fluorofenil)-4-metil-5-oxo-5,6,7,9-tetrahidropirazolo[1,5-a]pirido[4,3- e]pirimidina-8(4H)-carboxamida; 4-bencil-N-(3-cloro-4-fluorofenil)-5-oxo-5,6,7,9-tetrahidropirazolo[1,5-a]pirido[4,3- e]pirimidina-8(4H)-carboxamida; entre otros. Estos compuestos inhiben la replicacion del virus de la hepatitis B (HBV) y/o del virus de la hepatitis D (HDV), por lo que se emplean en el tratamiento de la hepatitis.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962854597P | 2019-05-30 | 2019-05-30 | |
| PCT/US2020/034746 WO2020243199A1 (en) | 2019-05-30 | 2020-05-27 | Tricyclic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20220427A1 true PE20220427A1 (es) | 2022-03-29 |
Family
ID=73552666
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2021001952A PE20220427A1 (es) | 2019-05-30 | 2020-05-27 | Compuestos triciclicos |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US11136321B2 (es) |
| EP (1) | EP3976618A4 (es) |
| JP (1) | JP2022534501A (es) |
| KR (1) | KR20220016177A (es) |
| CN (1) | CN113906029A (es) |
| AU (1) | AU2020282707B2 (es) |
| BR (1) | BR112021023967A2 (es) |
| CA (1) | CA3138938A1 (es) |
| CL (1) | CL2021003139A1 (es) |
| CO (1) | CO2021017202A2 (es) |
| EA (1) | EA202192760A1 (es) |
| IL (1) | IL287813A (es) |
| MA (1) | MA56058A (es) |
| MX (1) | MX2021014458A (es) |
| PE (1) | PE20220427A1 (es) |
| PH (1) | PH12021552953A1 (es) |
| SG (1) | SG11202113214QA (es) |
| TW (1) | TW202110845A (es) |
| WO (1) | WO2020243199A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20220000874A1 (en) * | 2019-05-30 | 2022-01-06 | Aligos Therapeutics, Inc. | Tricyclic compounds |
| KR20220113385A (ko) * | 2019-12-10 | 2022-08-12 | 상하이 한서 바이오메디컬 컴퍼니 리미티드 | 피라졸-함유 다환식 유도체 억제제, 그의 제조 방법 및 그의 적용 |
| GB202103704D0 (en) * | 2021-03-17 | 2021-04-28 | Pathios Therapeutics Ltd | Compounds |
| CA3201456A1 (en) * | 2020-11-24 | 2022-06-02 | Aligos Therapeutics, Inc. | Tricyclic compounds |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0701273D0 (en) * | 2007-01-24 | 2007-02-28 | Angeletti P Ist Richerche Bio | New compounds |
| WO2008157273A1 (en) | 2007-06-14 | 2008-12-24 | Smithkline Beecham Corporation | Chemical compounds |
| US9708332B2 (en) | 2013-10-29 | 2017-07-18 | Medivir Ab | Respiratory syncytial virus inhibitors |
| SG11201807569WA (en) | 2016-03-09 | 2018-10-30 | Univ Emory | Elimination of hepatitis b virus with antiviral agents |
| CN110066278B (zh) * | 2017-06-01 | 2021-06-08 | 广东东阳光药业有限公司 | 稠合三环类化合物及其在药物中的应用 |
-
2020
- 2020-05-27 BR BR112021023967A patent/BR112021023967A2/pt not_active IP Right Cessation
- 2020-05-27 PH PH1/2021/552953A patent/PH12021552953A1/en unknown
- 2020-05-27 KR KR1020217042967A patent/KR20220016177A/ko not_active Ceased
- 2020-05-27 MA MA056058A patent/MA56058A/fr unknown
- 2020-05-27 CA CA3138938A patent/CA3138938A1/en active Pending
- 2020-05-27 WO PCT/US2020/034746 patent/WO2020243199A1/en not_active Ceased
- 2020-05-27 SG SG11202113214QA patent/SG11202113214QA/en unknown
- 2020-05-27 PE PE2021001952A patent/PE20220427A1/es unknown
- 2020-05-27 EP EP20812759.7A patent/EP3976618A4/en active Pending
- 2020-05-27 CN CN202080040114.2A patent/CN113906029A/zh active Pending
- 2020-05-27 JP JP2021570378A patent/JP2022534501A/ja active Pending
- 2020-05-27 EA EA202192760A patent/EA202192760A1/ru unknown
- 2020-05-27 US US16/885,128 patent/US11136321B2/en active Active
- 2020-05-27 AU AU2020282707A patent/AU2020282707B2/en not_active Expired - Fee Related
- 2020-05-27 MX MX2021014458A patent/MX2021014458A/es unknown
- 2020-05-29 TW TW109118090A patent/TW202110845A/zh unknown
-
2021
- 2021-11-03 IL IL287813A patent/IL287813A/en unknown
- 2021-11-25 CL CL2021003139A patent/CL2021003139A1/es unknown
- 2021-12-15 CO CONC2021/0017202A patent/CO2021017202A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3976618A4 (en) | 2023-01-04 |
| MX2021014458A (es) | 2022-01-06 |
| EA202192760A1 (ru) | 2022-03-05 |
| WO2020243199A1 (en) | 2020-12-03 |
| TW202110845A (zh) | 2021-03-16 |
| PH12021552953A1 (en) | 2022-07-25 |
| CO2021017202A2 (es) | 2022-01-17 |
| US11136321B2 (en) | 2021-10-05 |
| EP3976618A1 (en) | 2022-04-06 |
| CN113906029A (zh) | 2022-01-07 |
| JP2022534501A (ja) | 2022-08-01 |
| KR20220016177A (ko) | 2022-02-08 |
| US20200407361A1 (en) | 2020-12-31 |
| IL287813A (en) | 2022-01-01 |
| CA3138938A1 (en) | 2020-12-03 |
| BR112021023967A2 (pt) | 2022-03-08 |
| AU2020282707A1 (en) | 2021-12-02 |
| MA56058A (fr) | 2022-04-06 |
| AU2020282707B2 (en) | 2025-06-19 |
| CL2021003139A1 (es) | 2022-09-23 |
| SG11202113214QA (en) | 2021-12-30 |
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