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PE20211469A1 - Proteinas f de prefusion del vrs estabilizadas - Google Patents

Proteinas f de prefusion del vrs estabilizadas

Info

Publication number
PE20211469A1
PE20211469A1 PE2021000680A PE2021000680A PE20211469A1 PE 20211469 A1 PE20211469 A1 PE 20211469A1 PE 2021000680 A PE2021000680 A PE 2021000680A PE 2021000680 A PE2021000680 A PE 2021000680A PE 20211469 A1 PE20211469 A1 PE 20211469A1
Authority
PE
Peru
Prior art keywords
proteins
prefusion
stabilizing amino
stabilized rsv
rsv prefusion
Prior art date
Application number
PE2021000680A
Other languages
English (en)
Inventor
Johannes Petrus Maria Langedijk
Original Assignee
Janssen Vaccines And Prevention B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Vaccines And Prevention B V filed Critical Janssen Vaccines And Prevention B V
Publication of PE20211469A1 publication Critical patent/PE20211469A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18522—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invencion proporciona proteinas de fusion del virus respiratorio sincitial (VRS) de prefusion recombinante que comprende uno o mas aminoacidos estabilizantes, donde dichos uno o mas aminoacidos estabilizantes estan presentes en la posicion 79, 101, 152, 226 y/o en la posicion 354, opcionalmente en combinacion con un aminoacido estabilizante en la posicion 486. Tambien esta referida a composiciones inmunogenas que comprenden dichas proteinas y usos de estas para la prevencion y/o el tratamiento de una infeccion por VRS.
PE2021000680A 2018-11-13 2019-11-12 Proteinas f de prefusion del vrs estabilizadas PE20211469A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18205863 2018-11-13
PCT/EP2019/080989 WO2020099383A1 (en) 2018-11-13 2019-11-12 Stabilized pre-fusion rsv f proteins

Publications (1)

Publication Number Publication Date
PE20211469A1 true PE20211469A1 (es) 2021-08-05

Family

ID=64308587

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2021000680A PE20211469A1 (es) 2018-11-13 2019-11-12 Proteinas f de prefusion del vrs estabilizadas

Country Status (20)

Country Link
US (1) US12331077B2 (es)
EP (1) EP3880243A1 (es)
JP (1) JP2022513025A (es)
KR (1) KR20210091749A (es)
CN (1) CN113164583A (es)
AU (1) AU2019377989A1 (es)
BR (1) BR112021008975A2 (es)
CA (1) CA3117275A1 (es)
CL (1) CL2021001212A1 (es)
CO (1) CO2021006308A2 (es)
CR (1) CR20210306A (es)
EA (1) EA202191355A1 (es)
EC (1) ECSP21042554A (es)
IL (1) IL282892A (es)
JO (1) JOP20210106A1 (es)
MX (1) MX2021005607A (es)
PE (1) PE20211469A1 (es)
PH (1) PH12021550974A1 (es)
SG (1) SG11202104522UA (es)
WO (1) WO2020099383A1 (es)

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KR102638978B1 (ko) 2015-07-07 2024-02-22 얀센 백신스 앤드 프리벤션 비.브이. Rsv에 대한 백신
PH12022552125A1 (en) 2016-04-05 2023-04-12 Janssen Vaccines & Prevention Bv Stabilized soluble pre-fusion rsv f proteins
EA201892250A1 (ru) 2016-04-05 2019-03-29 Янссен Вэксинс Энд Превеншн Б.В. Вакцина против rsv
EA039124B1 (ru) 2016-05-30 2021-12-08 Янссен Вэксинс Энд Превеншн Б.В. Стабилизированные f-белки rsv до слияния
MX2021005607A (es) 2018-11-13 2021-06-30 Janssen Vaccines & Prevention Bv Proteinas f de prefusion del vrs estabilizadas.
AU2021302535A1 (en) * 2020-06-29 2023-02-09 Janssen Vaccines & Prevention B.V. Vaccine combination against respiratory syncytial virus infection
EP4294436A1 (en) * 2021-02-19 2023-12-27 Janssen Vaccines & Prevention B.V. Stabilized pre-fusion rsv fb fantigens
US20250127872A1 (en) * 2021-09-29 2025-04-24 Sk Bioscience Co., Ltd. Recombinant live attenuated rsv vaccine strain and production method therefor
EP4578870A1 (en) * 2022-09-29 2025-07-02 Beijing Benewill Technology Development Co., Ltd. Respiratory syncytial virus recombinant fusion protein with prefusion conformation, and preparation method therefor and use thereof
CN115850396B (zh) * 2022-12-22 2024-02-06 北京吉诺卫生物科技有限公司 一种rsv纳米颗粒疫苗及其制备方法与应用
AU2024224721A1 (en) 2023-02-21 2025-10-09 Msd International Business Gmbh Stabilized trimeric rsv fusion proteins without a heterologous trimerzation domain
CN119264267A (zh) * 2023-09-22 2025-01-07 北京微星生物科技有限公司 稳定的融合前rsv f蛋白及其应用
CN117304280B (zh) * 2023-11-28 2024-04-16 江苏瑞科生物技术股份有限公司 一种重组rsv f蛋白及其应用
CN117304279B (zh) * 2023-11-28 2024-04-16 江苏瑞科生物技术股份有限公司 一种重组rsv f蛋白及其应用
US12383614B2 (en) 2023-12-21 2025-08-12 Yikang Biotech (Suzhou) Co., Ltd. Mutants of respiratory syncytial virus fusion proteins
CN117886902B (zh) * 2023-12-21 2024-11-26 易康生物(苏州)有限公司 改良的呼吸道合胞病毒融合f蛋白突变体及其应用
CN117777251B (zh) * 2024-02-27 2024-06-04 普大生物科技(泰州)有限公司 一种rsv纳米颗粒疫苗及其制备方法
CN120000775B (zh) * 2025-04-16 2025-08-01 普大生物科技(泰州)有限公司 多价肺炎球菌多糖-蛋白结合疫苗及其制备方法和应用

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