CY1121600T1 - Σταθεροποιημενα διαλυτα πολυπεπτιδια rsv f προσυντηξης - Google Patents
Σταθεροποιημενα διαλυτα πολυπεπτιδια rsv f προσυντηξηςInfo
- Publication number
- CY1121600T1 CY1121600T1 CY20191100303T CY191100303T CY1121600T1 CY 1121600 T1 CY1121600 T1 CY 1121600T1 CY 20191100303 T CY20191100303 T CY 20191100303T CY 191100303 T CY191100303 T CY 191100303T CY 1121600 T1 CY1121600 T1 CY 1121600T1
- Authority
- CY
- Cyprus
- Prior art keywords
- rsv
- polypeptides
- stabilized solutions
- adhesion polypeptides
- adhesion
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 241000725643 Respiratory syncytial virus Species 0.000 abstract 2
- 206010061603 Respiratory syncytial virus infection Diseases 0.000 abstract 1
- 230000004927 fusion Effects 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/08—RNA viruses
- C07K14/115—Paramyxoviridae, e.g. parainfluenza virus
- C07K14/135—Respiratory syncytial virus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18522—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Genetics & Genomics (AREA)
- Pulmonology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Η παρούσα εφεύρεση παρέχει σταθερά πολυπεπτίδια F αναπνευστικού συνκυτιακού ιού (RSV) προσύντηξης, ανοσογόνες συνθέσεις που περιλαμβάνουν τα εν λόγω πολυπεπτίδια και χρήσεις αυτών για την πρόληψη και/ή αγωγή RSV λοίμωξης.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13165402 | 2013-04-25 | ||
| PCT/EP2014/058353 WO2014174018A1 (en) | 2013-04-25 | 2014-04-24 | Stabilized soluble prefusion rsv f polypeptides |
| EP14719022.7A EP2988780B1 (en) | 2013-04-25 | 2014-04-24 | Stabilized soluble prefusion rsv f polypeptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1121600T1 true CY1121600T1 (el) | 2020-05-29 |
Family
ID=48326107
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20191100303T CY1121600T1 (el) | 2013-04-25 | 2019-03-13 | Σταθεροποιημενα διαλυτα πολυπεπτιδια rsv f προσυντηξης |
Country Status (33)
| Country | Link |
|---|---|
| US (3) | US10899800B2 (el) |
| EP (2) | EP3488864A1 (el) |
| JP (1) | JP6469081B2 (el) |
| KR (1) | KR102236497B1 (el) |
| CN (2) | CN105188745B (el) |
| AP (1) | AP2015008815A0 (el) |
| AR (1) | AR096113A1 (el) |
| AU (1) | AU2014259474B2 (el) |
| CA (1) | CA2910067C (el) |
| CL (1) | CL2015003124A1 (el) |
| CY (1) | CY1121600T1 (el) |
| DK (1) | DK2988780T3 (el) |
| EA (2) | EA039803B1 (el) |
| ES (1) | ES2715378T3 (el) |
| HR (1) | HRP20190175T1 (el) |
| HU (1) | HUE041659T2 (el) |
| IL (1) | IL242186B (el) |
| LT (1) | LT2988780T (el) |
| ME (1) | ME03442B (el) |
| MX (1) | MX361774B (el) |
| MY (2) | MY181066A (el) |
| PE (1) | PE20151867A1 (el) |
| PH (1) | PH12015502377B1 (el) |
| PL (1) | PL2988780T3 (el) |
| PT (1) | PT2988780T (el) |
| RS (1) | RS58436B1 (el) |
| SG (1) | SG11201508567XA (el) |
| SI (1) | SI2988780T1 (el) |
| SM (1) | SMT201900138T1 (el) |
| TR (1) | TR201902513T4 (el) |
| TW (1) | TWI663175B (el) |
| WO (1) | WO2014174018A1 (el) |
| ZA (1) | ZA201507912B (el) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2370099T1 (sl) | 2008-12-09 | 2016-08-31 | Novavax, Inc. | Modificirani proteini RSV F in postopki njihove uporabe |
| US11446374B2 (en) | 2008-12-09 | 2022-09-20 | Novavax, Inc. | Modified RSV F proteins and methods of their use |
| US10017543B2 (en) | 2013-03-13 | 2018-07-10 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Prefusion RSV F proteins and their use |
| US9738689B2 (en) | 2013-03-13 | 2017-08-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Prefusion RSV F proteins and their use |
| US10899800B2 (en) | 2013-04-25 | 2021-01-26 | Janssen Vaccines & Prevention B.V. | Stabilized soluble pre-fusion RSV F polypeptides |
| KR102313153B1 (ko) | 2013-06-17 | 2021-10-15 | 얀센 백신스 앤드 프리벤션 비.브이. | 안정화된 가용성 예비융합 rsv f 폴리펩타이드 |
| US10744193B2 (en) | 2015-03-30 | 2020-08-18 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Immunogenic RSV polypeptides |
| US10457708B2 (en) * | 2015-07-07 | 2019-10-29 | Janssen Vaccines & Prevention B.V. | Stabilized soluble pre-fusion RSV F polypeptides |
| ES2839880T3 (es) | 2015-07-07 | 2021-07-06 | Janssen Vaccines & Prevention Bv | Vacuna contra el VRS |
| CA2997181A1 (en) | 2015-09-02 | 2017-03-09 | Janssen Vaccines & Prevention B.V. | Stabilized viral class i fusion proteins |
| CN108697790B (zh) * | 2015-09-03 | 2022-02-18 | 诺瓦瓦克斯股份有限公司 | 具有改进的稳定性和免疫原性的疫苗组合物 |
| KR20230035429A (ko) | 2015-12-23 | 2023-03-13 | 화이자 인코포레이티드 | Rsv f 단백질 돌연변이체 |
| ES2877808T3 (es) * | 2016-02-03 | 2021-11-17 | Janssen Sciences Ireland Unlimited Co | Producto combinado para tratar o mejorar una infección por virus respiratorio sincicial |
| AU2017242020B2 (en) | 2016-03-29 | 2021-08-05 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Substitutions-modified prefusion RSV F proteins and their use |
| BR112018070013A2 (pt) | 2016-04-05 | 2019-02-05 | Janssen Vaccines & Prevention Bv | proteínas f do rsv pré-fusão solúveis estabilizadas |
| JP7233928B2 (ja) | 2016-04-05 | 2023-03-07 | ヤンセン ファッシンズ アンド プリベンション ベーフェー | Rsvに対するワクチン |
| WO2017207477A1 (en) | 2016-05-30 | 2017-12-07 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion rsv f proteins |
| KR102421049B1 (ko) | 2016-05-30 | 2022-07-15 | 얀센 백신스 앤드 프리벤션 비.브이. | 안정화된 융합-전 rsv f 단백질 |
| CN108265079A (zh) * | 2017-01-02 | 2018-07-10 | 刘昕 | 一种新型呼吸道合胞体病毒pre-F融合蛋白载体的制备方法 |
| WO2018170260A1 (en) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Respiratory syncytial virus vaccine |
| MA47790A (fr) | 2017-03-17 | 2021-05-05 | Modernatx Inc | Vaccins à base d'arn contre des maladies zoonotiques |
| SI3606942T1 (sl) | 2017-04-04 | 2025-11-28 | University Of Washington | Samo-sestavljajoče se proteinske nanostrukture, ki prikazujejo paramiksovirusne in/ali pnevmovirusne f proteine, in njihova uporaba |
| US11229692B2 (en) | 2017-05-17 | 2022-01-25 | Janssen Vaccines & Prevention B.V. | Methods and compositions for inducing protective immunity against RSV infection |
| WO2019023196A1 (en) | 2017-07-24 | 2019-01-31 | Novavax, Inc. | METHODS AND COMPOSITIONS FOR TREATING RESPIRATORY DISEASE |
| JP2020533367A (ja) | 2017-09-15 | 2020-11-19 | ヤンセン ファッシンズ アンド プリベンション ベーフェーJanssen Vaccines & Prevention B.V. | Rsvに対する免疫の安全な誘導方法 |
| KR102700187B1 (ko) * | 2017-09-29 | 2024-08-28 | 에스케이바이오사이언스(주) | 가용성 변형 호흡기 융합세포 바이러스 (rsv) f 단백질 항원 |
| MA54676A (fr) | 2018-01-29 | 2021-11-17 | Modernatx Inc | Vaccins à base d'arn contre le vrs |
| MX2020009682A (es) | 2018-03-19 | 2020-10-12 | Novavax Inc | Vacunas de nanoparticulas multivalentes contra la influenza. |
| US12370252B2 (en) * | 2018-10-29 | 2025-07-29 | Emory University | RSV virus-like particles and methods of use thereof |
| JOP20210106A1 (ar) | 2018-11-13 | 2023-01-30 | Janssen Vaccines And Prevention B V | بروتينات rsv f سابقة الاندماج مستقرة |
| CN109851678A (zh) * | 2019-03-07 | 2019-06-07 | 苏州宇之波生物科技有限公司 | 一种改良的亚稳定态牛呼吸道合胞病毒融合前体f蛋白质及编码的dna分子和其应用 |
| WO2020229577A1 (en) | 2019-05-15 | 2020-11-19 | Janssen Vaccines & Prevention B.V. | Co-administration of seasonal influenza vaccine and an adenovirus based respiratory syncytial virus vaccine |
| KR20220008816A (ko) | 2019-05-15 | 2022-01-21 | 얀센 백신스 앤드 프리벤션 비.브이. | 아데노바이러스 기반 백신을 사용한 호흡기 세포융합 바이러스 감염의 예방적 치료 |
| CN114502572A (zh) | 2019-09-04 | 2022-05-13 | 华盛顿大学 | 展示副粘病毒和/或肺炎病毒f蛋白的自组装蛋白纳米结构及其用途 |
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| KR20230028517A (ko) | 2020-06-29 | 2023-02-28 | 얀센 백신스 앤드 프리벤션 비.브이. | 호흡기 세포융합 바이러스 감염에 대한 백신 조합물 |
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| AU2023351828A1 (en) | 2022-09-29 | 2025-03-13 | Pfizer Inc. | Immunogenic compositions comprising an rsv f protein trimer |
| WO2024067725A1 (zh) * | 2022-09-29 | 2024-04-04 | 北京百邑无忧科技发展有限公司 | 一种融合前构象的呼吸道合胞病毒重组融合蛋白、其制备方法及用途 |
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| PE20251592A1 (es) | 2022-10-27 | 2025-06-16 | Pfizer | Moleculas de rna que codifican rsv-f y vacunas que las contienen |
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