PE20211461A1 - Compuestos de heteroarilo sustituidos con alquilamida de piridinsulfona - Google Patents
Compuestos de heteroarilo sustituidos con alquilamida de piridinsulfonaInfo
- Publication number
- PE20211461A1 PE20211461A1 PE2020000703A PE2020000703A PE20211461A1 PE 20211461 A1 PE20211461 A1 PE 20211461A1 PE 2020000703 A PE2020000703 A PE 2020000703A PE 2020000703 A PE2020000703 A PE 2020000703A PE 20211461 A1 PE20211461 A1 PE 20211461A1
- Authority
- PE
- Peru
- Prior art keywords
- substituted
- alkyl
- pyridinsulfone
- alkylamide
- heteroaryl compounds
- Prior art date
Links
- 150000001875 compounds Chemical group 0.000 title abstract 4
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- BDGMPXXWWCGWLG-FIBGUPNXSA-N 6-(cyclopropanecarbonylamino)-4-[(3-methylsulfonylpyridin-2-yl)amino]-N-(trideuteriomethyl)pyridazine-3-carboxamide Chemical compound C1(CC1)C(=O)NC1=CC(=C(N=N1)C(=O)NC([2H])([2H])[2H])NC1=NC=CC=C1S(=O)(=O)C BDGMPXXWWCGWLG-FIBGUPNXSA-N 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000011234 negative regulation of signal transduction Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Referido a un compuesto de formula I, en donde Y es N o CR6; R1 es H, CD3 o C1-3 alquilo; R2 es -C(O)R2a; o C1-6 alquilo, -(CH2)r-carbociclo de 3-14 miembros sustituido con 0-1 R2a, entre otros; R4 y R5 son independientemente hidrogeno, C1-4 alquilo sustituido con 0-1 Rf, (CH2)r-fenilo sustituido con 0-3 Rd, entre otros. Un compuesto seleccionado es 6-ciclopropanamido-4-[(3-metansulfonilpiridin-2-il)amino]-N-(2H3)metilpiridazin-3-carboxamida. Estos compuestos de heterarilo sustituidos modulan IL-12, IL-23 y/o IFNalfa que actuan en Tyk-2 para generar la inhibicion de la transduccion de senal. Tambien se refiere a procedimiento para su elaboracion y compuestos intermediarios de los mismo, composicion farmaceutica, y su uso en el tratamiento de afecciones relacionadas con la modulacion de IL-12, IL-23 y/o IFNalfa.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762589165P | 2017-11-21 | 2017-11-21 | |
| PCT/US2018/061726 WO2019103952A1 (en) | 2017-11-21 | 2018-11-19 | Sulfone pyridine alkyl amide-substituted heteroaryl compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20211461A1 true PE20211461A1 (es) | 2021-08-05 |
Family
ID=65036887
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2020000703A PE20211461A1 (es) | 2017-11-21 | 2018-11-19 | Compuestos de heteroarilo sustituidos con alquilamida de piridinsulfona |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US11021462B2 (es) |
| EP (1) | EP3713930A1 (es) |
| JP (2) | JP7258903B2 (es) |
| KR (1) | KR102702228B1 (es) |
| CN (1) | CN111315737B (es) |
| AR (1) | AR113895A1 (es) |
| AU (3) | AU2018371010C1 (es) |
| BR (1) | BR112020009606A2 (es) |
| CA (1) | CA3083122A1 (es) |
| CL (1) | CL2020001338A1 (es) |
| CO (1) | CO2020006139A2 (es) |
| EA (1) | EA202091269A1 (es) |
| IL (1) | IL274816B2 (es) |
| MX (1) | MX2020005210A (es) |
| MY (1) | MY202167A (es) |
| PE (1) | PE20211461A1 (es) |
| SG (1) | SG11202004592TA (es) |
| TW (1) | TWI776994B (es) |
| WO (1) | WO2019103952A1 (es) |
| ZA (1) | ZA202003717B (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3713930A1 (en) * | 2017-11-21 | 2020-09-30 | Bristol-Myers Squibb Company | Sulfone pyridine alkyl amide-substituted heteroaryl compounds |
| CN111484480B (zh) * | 2019-01-29 | 2023-08-11 | 上海翰森生物医药科技有限公司 | 一种多环类衍生物抑制剂、其制备方法和应用 |
| US12428395B2 (en) | 2019-08-01 | 2025-09-30 | Sperogenix Therapeutics Limited | Heterocyclic compounds as kinase inhibitor and uses thereof |
| CN114981262A (zh) * | 2020-12-22 | 2022-08-30 | 益方生物科技(上海)股份有限公司 | 杂芳基化合物及其制备方法和用途 |
| IL305165A (en) | 2021-02-19 | 2023-10-01 | Sudo Biosciences Ltd | Tyk2 inhibitors and uses thereof |
| MX2023009682A (es) | 2021-02-19 | 2023-10-30 | Sudo Biosciences Ltd | Inhibidores de tyk2 y sus usos. |
| WO2022193499A1 (en) | 2021-03-16 | 2022-09-22 | Anrui Biomedical Technology (Guangzhou) Co., Ltd. | Amino heteroaryl compounds and compositions |
| US20240226106A1 (en) * | 2021-03-17 | 2024-07-11 | Shire Human Genetic Therapies, Inc. | Inhibitors of plasma kallikrein |
| CN115141149A (zh) * | 2021-03-30 | 2022-10-04 | 浙江文达医药科技有限公司 | 作为tyk2假激酶结构域抑制剂的杂环化合物及合成方法和用途 |
| US20250066322A1 (en) * | 2021-05-14 | 2025-02-27 | Bristol-Myers Squibb Company | Substituted heterocyclic compounds |
| CN115466289A (zh) * | 2021-06-11 | 2022-12-13 | 爱科诺生物医药(香港)有限公司 | 具有tyk2抑制活性的化合物，包含其的药物组合物，及其应用 |
| CN115724830A (zh) * | 2021-08-31 | 2023-03-03 | 浙江文达医药科技有限公司 | 作为tyk2/jak1假激酶结构域(jh2)抑制剂的化合物及合成和使用方法 |
| WO2023109954A1 (en) | 2021-12-16 | 2023-06-22 | Lynk Pharmaceuticals Co. Ltd. | Tyk2 inhibitors and compositions and methods thereof |
| CN116693449A (zh) | 2022-03-04 | 2023-09-05 | 上海致根医药科技有限公司 | 用作tyk2抑制剂的化合物、其制备方法及其在医药上的应用 |
| CN117257752A (zh) * | 2022-06-20 | 2023-12-22 | 益方生物科技(上海)股份有限公司 | 药物组合物及其用途 |
| CN120757533A (zh) * | 2022-06-20 | 2025-10-10 | 益方生物科技(上海)股份有限公司 | 杂芳基化合物、固体形式、制备方法及其用途 |
| CN120303268A (zh) * | 2022-12-16 | 2025-07-11 | 津药生物科技（天津）有限公司 | 新型含杂环取代的丙烯酸衍生物及其用途 |
| CN121057725A (zh) | 2023-04-19 | 2025-12-02 | 上海复宏汉霖生物技术股份有限公司 | 一种杂环取代的芳香化合物、其制备方法及用途 |
| US20250230251A1 (en) | 2023-12-20 | 2025-07-17 | Bristol-Myers Squibb Company | Antibodies targeting il-18 receptor beta (il-18rb) and related methods |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20140108594A (ko) * | 2012-01-10 | 2014-09-11 | 에프. 호프만-라 로슈 아게 | 피리다진 아미드 화합물 및 syk 저해제로서의 이의 용도 |
| KR20150068484A (ko) * | 2012-10-19 | 2015-06-19 | 에프. 호프만-라 로슈 아게 | Syk 억제제 |
| TR201820824T4 (tr) * | 2012-11-08 | 2019-01-21 | Squibb Bristol Myers Co | IL-12, IL-23 ve/veya IFN-alfa'nın modülatörleri olarak faydalı amid ile sübstitüe edilmiş heterosiklik bileşikler. |
| KR102233252B1 (ko) * | 2012-11-08 | 2021-03-26 | 브리스톨-마이어스 스큅 컴퍼니 | ＩＬ-12, ＩＬ-23 및/또는 ＩＦＮα 반응의 조절제로서 유용한 알킬-아미드-치환된 피리딜 화합물 |
| TWI582077B (zh) * | 2013-11-07 | 2017-05-11 | 必治妥美雅史谷比公司 | 作爲ＩＬ－１２、ＩＬ－２３及／或ＩＦＮα反應調節劑之經烷基－醯胺取代之吡啶化合物 |
| CA2932609A1 (en) * | 2013-12-05 | 2015-06-11 | Pharmacyclics Llc | Inhibitors of bruton's tyrosine kinase |
| ES2907008T3 (es) | 2016-12-13 | 2022-04-21 | Bristol Myers Squibb Co | Compuestos de heteroarilo sustituidos con fosfinóxido alquilamida como moduladores de respuestas de IL-12, IL-23 y/o IFN alfa |
| EP3713930A1 (en) * | 2017-11-21 | 2020-09-30 | Bristol-Myers Squibb Company | Sulfone pyridine alkyl amide-substituted heteroaryl compounds |
-
2018
- 2018-11-19 EP EP18836556.3A patent/EP3713930A1/en active Pending
- 2018-11-19 WO PCT/US2018/061726 patent/WO2019103952A1/en not_active Ceased
- 2018-11-19 MX MX2020005210A patent/MX2020005210A/es unknown
- 2018-11-19 BR BR112020009606-7A patent/BR112020009606A2/pt unknown
- 2018-11-19 AU AU2018371010A patent/AU2018371010C1/en active Active
- 2018-11-19 MY MYPI2020002150A patent/MY202167A/en unknown
- 2018-11-19 IL IL274816A patent/IL274816B2/en unknown
- 2018-11-19 JP JP2020545054A patent/JP7258903B2/ja active Active
- 2018-11-19 PE PE2020000703A patent/PE20211461A1/es unknown
- 2018-11-19 EA EA202091269A patent/EA202091269A1/ru unknown
- 2018-11-19 SG SG11202004592TA patent/SG11202004592TA/en unknown
- 2018-11-19 CA CA3083122A patent/CA3083122A1/en active Pending
- 2018-11-19 KR KR1020207017459A patent/KR102702228B1/ko active Active
- 2018-11-19 CN CN201880072389.7A patent/CN111315737B/zh active Active
- 2018-11-20 TW TW107141159A patent/TWI776994B/zh active
- 2018-11-20 US US16/195,951 patent/US11021462B2/en active Active
- 2018-11-20 AR ARP180103395A patent/AR113895A1/es unknown
-
2020
- 2020-05-19 CO CONC2020/0006139A patent/CO2020006139A2/es unknown
- 2020-05-20 CL CL2020001338A patent/CL2020001338A1/es unknown
- 2020-06-19 ZA ZA2020/03717A patent/ZA202003717B/en unknown
-
2021
- 2021-04-28 US US17/242,428 patent/US11787779B2/en active Active
-
2022
- 2022-09-06 AU AU2022228101A patent/AU2022228101B2/en active Active
-
2023
- 2023-04-05 JP JP2023061359A patent/JP7490107B2/ja active Active
- 2023-09-05 US US18/461,093 patent/US12365667B2/en active Active
- 2023-10-27 AU AU2023255024A patent/AU2023255024B2/en active Active
-
2025
- 2025-06-11 US US19/234,470 patent/US20250304555A1/en active Pending
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