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PE20200723A1 - Compuestos y composiciones para tratar afecciones asociadas con la actividad nlrp - Google Patents

Compuestos y composiciones para tratar afecciones asociadas con la actividad nlrp

Info

Publication number
PE20200723A1
PE20200723A1 PE2020000150A PE2020000150A PE20200723A1 PE 20200723 A1 PE20200723 A1 PE 20200723A1 PE 2020000150 A PE2020000150 A PE 2020000150A PE 2020000150 A PE2020000150 A PE 2020000150A PE 20200723 A1 PE20200723 A1 PE 20200723A1
Authority
PE
Peru
Prior art keywords
compounds
compositions
conditions associated
bicyclic
treat conditions
Prior art date
Application number
PE2020000150A
Other languages
English (en)
Inventor
Gary Glick
William R Roush
Shankar Venkatraman
Dong-Ming Shen
Shomir Ghosh
Jason Katz
Hans Martin Seidel
Luigi Franchi
David Guenther Winkler
Jr Anthony William Opipari
Original Assignee
Novartis Inflammasome Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Inflammasome Research Inc filed Critical Novartis Inflammasome Research Inc
Publication of PE20200723A1 publication Critical patent/PE20200723A1/es

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    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/36—Sulfur atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • C07C381/00—Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
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Abstract

Se refiere a compuestos de la Formula AA o una sal farmaceuticamente aceptable de los mismos, en donde m y n son 0, 1 o 2; o es 1 o 2; p es 0, 1, 2 o 3; A es un heteroarilo biciclico o monociclico de 5 a 10 miembros o un arilo biciclico o monociclico C6-C10; B es un heteroarilo de 5 miembros, un heteroarilo biciclico o monociclico de 7 a 10 miembros o un arilo biciclico o monociclico C6-C10; R1 y R2 son alquilo C1-C6, alcoxi C1-C6, entre otros; R6 y R7 son alquilo C1-C6, halo, CN, NO2, entre otros; R3 es H, CN, OH, entre otros. Dichos compuestos son moduladores de la actividad de NLRP3 (componente del proceso inflamatorio) y son utiles en el tratamiento de desordenes metabolicos tales como diabetes tipo 2, aterosclerosis, obesidad, entre otros.
PE2020000150A 2017-07-24 2018-07-23 Compuestos y composiciones para tratar afecciones asociadas con la actividad nlrp PE20200723A1 (es)

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