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PE20191786A1 - Anticuerpo monoclonal para pd-l1 - Google Patents

Anticuerpo monoclonal para pd-l1

Info

Publication number
PE20191786A1
PE20191786A1 PE2019002020A PE2019002020A PE20191786A1 PE 20191786 A1 PE20191786 A1 PE 20191786A1 PE 2019002020 A PE2019002020 A PE 2019002020A PE 2019002020 A PE2019002020 A PE 2019002020A PE 20191786 A1 PE20191786 A1 PE 20191786A1
Authority
PE
Peru
Prior art keywords
antibody
homologous
seq
refers
chain variable
Prior art date
Application number
PE2019002020A
Other languages
English (en)
Inventor
Aleksei Aleksandrovich Aleksandrov
Andrei Borisovich Ulitin
Viktoriia Mikhailovna Ekimova
Ekaterina Vladimirovna Sofronova
Yulia Sergeevna Chernykh
Sergei Andreevich Ageev
Anna Konstantinovna Vladimirova
Pavel Alekseevich Grebnev
Valery Vladimirovich Solovyev
Iakov Iurevich Ustiugov
Pavel Anadreevich Iakovlev
Timofey Aleksandrovich Nemankin
Dmitry Valentinovich Morozov
Original Assignee
Biocad Joint Stock Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocad Joint Stock Co filed Critical Biocad Joint Stock Co
Publication of PE20191786A1 publication Critical patent/PE20191786A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Referido a un anticuerpo monoclonal o fragmento de union de antigeno de este, que se une especificamente a PD-L1, incluyendo un dominio variable de cadena pesada que incluye una secuencia de aminoacidos, homologa a la SEQ ID NO:3 en al menos 90%; un dominio variable de cadena ligera que incluye una secuencia de aminoacidos, homologa a la SEQ ID NO:7 en al menos 90%. Tambien se refiere a acido nucleico que codifica el anticuerpo o su fragmento de union, vectores de expresion, celula huesped y metodos de produccion del anticuerpo, compuesto farmaceutico, en combinacion con un compuesto terapeutico activo de funcion tumoral, metodos de tratamiento o prevencion de enfermedades mediados por PD-L1 como carcinoma de celulas escamosas de cabeza y cuello (SCCHN), cancer de cuello de utero, glioblastoma, entre otros.
PE2019002020A 2017-04-17 2018-04-11 Anticuerpo monoclonal para pd-l1 PE20191786A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2017113141A RU2665790C1 (ru) 2017-04-17 2017-04-17 Моноклональное антитело к pd-l1
PCT/RU2018/050039 WO2018194496A2 (ru) 2017-04-17 2018-04-11 Моноклональное антитело к pd-l1

Publications (1)

Publication Number Publication Date
PE20191786A1 true PE20191786A1 (es) 2019-12-24

Family

ID=63459922

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2019002020A PE20191786A1 (es) 2017-04-17 2018-04-11 Anticuerpo monoclonal para pd-l1

Country Status (21)

Country Link
US (1) US11236167B2 (es)
EP (1) EP3613770A4 (es)
JP (2) JP2020516323A (es)
KR (1) KR102679554B1 (es)
CN (1) CN111247166B (es)
AR (1) AR113223A1 (es)
AU (1) AU2018255132C1 (es)
BR (1) BR112019021781A2 (es)
CA (1) CA3060395A1 (es)
CL (1) CL2019002894A1 (es)
CO (1) CO2019011458A2 (es)
EA (1) EA201992206A1 (es)
JO (1) JOP20190246A1 (es)
MA (1) MA47221A1 (es)
NZ (1) NZ758093A (es)
PE (1) PE20191786A1 (es)
PH (1) PH12019502298A1 (es)
RU (1) RU2665790C1 (es)
UY (1) UY37683A (es)
WO (1) WO2018194496A2 (es)
ZA (1) ZA201907065B (es)

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MX2017011644A (es) 2015-03-13 2017-12-04 Cytomx Therapeutics Inc Anticuerpos anti-pdl1, anticuerpos anti-pdl1 activables y metodos de uso de los mismos.
BR112019025188A2 (pt) 2017-06-01 2020-06-23 Cytomx Therapeutics, Inc. Anticorpos anti-pdl1 ativáveis e métodos de uso dos mesmos
EA039662B1 (ru) * 2017-10-03 2022-02-24 Закрытое Акционерное Общество "Биокад" Антитела, специфичные к cd47 и pd-l1
MX2021008207A (es) 2019-01-07 2021-11-04 Univ Jefferson Proteínas de fusión multifuncionales y usos de las mismas.
CN109929037B (zh) 2019-04-01 2023-03-17 华博生物医药技术（上海）有限公司 针对程序性死亡配体的结合物及其应用
RU2753282C2 (ru) 2019-09-19 2021-08-12 Закрытое Акционерное Общество "Биокад" ИММУНОЦИТОКИН, ВКЛЮЧАЮЩИЙ ГЕТЕРОДИМЕРНЫЙ БЕЛКОВЫЙ КОМПЛЕКС НА ОСНОВЕ IL-15/IL-15Rα, И ЕГО ПРИМЕНЕНИЕ
WO2022121846A1 (zh) * 2020-12-08 2022-06-16 博际生物医药科技(杭州)有限公司 Pd-l1抗体及其应用
EP4359445A4 (en) * 2021-06-21 2025-07-02 Biocad Joint Stock Co ISOLATED BISPECIFIC ANTIBODY SPECIFICALLY BINDING TO CD47 AND PD-L1
US20250223361A1 (en) * 2022-04-01 2025-07-10 Mabtree Biologics Ag Human antibody or antigen binding fragment thereof specific against pd-l1 to enhance t-cell function
KR20250140097A (ko) 2023-01-30 2025-09-24 키맵 리미티드 항체

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Also Published As

Publication number Publication date
JP7600285B2 (ja) 2024-12-16
ZA201907065B (en) 2020-09-30
EP3613770A2 (en) 2020-02-26
EP3613770A4 (en) 2021-01-27
US11236167B2 (en) 2022-02-01
AU2018255132A1 (en) 2019-10-31
PH12019502298A1 (en) 2020-07-06
AU2018255132B2 (en) 2025-04-17
WO2018194496A3 (ru) 2019-01-10
AR113223A1 (es) 2020-02-19
WO2018194496A2 (ru) 2018-10-25
JP2020516323A (ja) 2020-06-11
CN111247166A (zh) 2020-06-05
CO2019011458A2 (es) 2020-01-17
CL2019002894A1 (es) 2020-03-13
AU2018255132C1 (en) 2025-08-07
MA47221A1 (fr) 2020-04-30
EA201992206A1 (ru) 2020-02-21
JP2023081942A (ja) 2023-06-13
CA3060395A1 (en) 2019-11-18
CN111247166B (zh) 2024-03-26
RU2665790C1 (ru) 2018-09-04
AU2018255132A2 (en) 2019-11-07
BR112019021781A2 (pt) 2020-05-05
UY37683A (es) 2018-11-30
KR20190140979A (ko) 2019-12-20
NZ758093A (en) 2022-09-30
KR102679554B1 (ko) 2024-07-01
JOP20190246A1 (ar) 2019-10-16
US20200369771A1 (en) 2020-11-26

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