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PE20190513A1 - Compuestos y metodos para la modulacion de smn2 - Google Patents

Compuestos y metodos para la modulacion de smn2

Info

Publication number
PE20190513A1
PE20190513A1 PE2019000045A PE2019000045A PE20190513A1 PE 20190513 A1 PE20190513 A1 PE 20190513A1 PE 2019000045 A PE2019000045 A PE 2019000045A PE 2019000045 A PE2019000045 A PE 2019000045A PE 20190513 A1 PE20190513 A1 PE 20190513A1
Authority
PE
Peru
Prior art keywords
smn2
compounds
modified oligonucleotide
modulation
methods
Prior art date
Application number
PE2019000045A
Other languages
English (en)
Inventor
Thazha P Prakash
Punit P Seth
Original Assignee
Ionis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=60952211&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20190513(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ionis Pharmaceuticals Inc filed Critical Ionis Pharmaceuticals Inc
Publication of PE20190513A1 publication Critical patent/PE20190513A1/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C12N2310/11—Antisense
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    • C12N2310/30—Chemical structure
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/3521—Methyl
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    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
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    • C12N2310/3525—MOE, methoxyethoxy
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/33—Alteration of splicing

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  • Pain & Pain Management (AREA)
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  • Saccharide Compounds (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se refiere a un compuesto oligomerico compuesto de un oligonucleotido modificado que consiste en 14 a 25 nucleosidos enlazados, donde el oligonucleotido modificado es complementario a un pre-ARNm de la neurona motora de supervivencia 2 (SMN2) y el nucleosido del oligonucleotido modificado tiene a formula II, donde Bx es una nucleobase; R1 y R2 son hidrogeno o metilo. tambien esta referida a una composicion farmaceutica. Dichos compuestos son utiles para el tratamiento de la atrofia muscular espinal y sus tipos
PE2019000045A 2016-07-15 2017-07-17 Compuestos y metodos para la modulacion de smn2 PE20190513A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662363195P 2016-07-15 2016-07-15

Publications (1)

Publication Number Publication Date
PE20190513A1 true PE20190513A1 (es) 2019-04-10

Family

ID=60952211

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2019000045A PE20190513A1 (es) 2016-07-15 2017-07-17 Compuestos y metodos para la modulacion de smn2

Country Status (27)

Country Link
US (3) US20190323006A1 (es)
EP (2) EP4206213A1 (es)
JP (3) JP7197463B2 (es)
KR (1) KR102556825B1 (es)
CN (1) CN109844115B (es)
AU (2) AU2017297622A1 (es)
BR (1) BR112019000356A2 (es)
CA (1) CA3030864A1 (es)
CL (2) CL2019000115A1 (es)
CO (1) CO2019001236A2 (es)
DK (1) DK3484524T3 (es)
ES (1) ES2935658T3 (es)
FI (1) FI3484524T3 (es)
HR (1) HRP20221378T1 (es)
HU (1) HUE060831T2 (es)
IL (2) IL308256A (es)
LT (1) LT3484524T (es)
MX (1) MX2019000619A (es)
NZ (1) NZ750713A (es)
PE (1) PE20190513A1 (es)
PL (1) PL3484524T3 (es)
PT (1) PT3484524T (es)
RS (1) RS63928B1 (es)
SG (1) SG11201900238UA (es)
SI (1) SI3484524T1 (es)
SM (1) SMT202200489T1 (es)
WO (1) WO2018014041A2 (es)

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EP2983676B1 (en) 2013-04-12 2019-03-20 The Curators of the University of Missouri Smn2 element 1 antisense compositions and methods and uses thereof
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WO2017035366A1 (en) 2015-08-26 2017-03-02 Incyte Corporation Pyrrolopyrimidine derivatives as tam inhibitors
HUE064656T2 (hu) 2016-03-28 2024-04-28 Incyte Corp Pirrolotriazin vegyületek mint TAM inhibitorok
KR102739325B1 (ko) 2017-09-27 2024-12-09 인사이트 코포레이션 Tam 억제제로서 유용한 피롤로트리아진 유도체의 염
ES3031110T3 (en) 2018-06-29 2025-07-04 Incyte Corp Formulations of an axl/mer inhibitor
PL3999643T3 (pl) * 2019-07-19 2024-02-19 Biogen Ma Inc. Sposoby leczenia rdzeniowego zaniku mięśni i zapobiegania mu
JP7689110B2 (ja) * 2019-08-15 2025-06-05 バイオジェン・エムエイ・インコーポレイテッド 脊髄性筋萎縮症のための併用療法
WO2021054370A1 (ja) * 2019-09-18 2021-03-25 国立大学法人東京医科歯科大学 核酸複合体
CA3173034A1 (en) * 2020-02-28 2021-09-02 Ionis Pharmaceuticals, Inc. Compounds and methods for modulating smn2
TW202140788A (zh) * 2020-02-28 2021-11-01 美商Ionis製藥公司 用於調節ｓｃｎ１ａ表現之化合物及方法
AU2021230385A1 (en) 2020-03-06 2022-09-22 Incyte Corporation Combination therapy comprising AXL/MER and PD-1/PD-L1 inhibitors
WO2022226377A1 (en) * 2021-04-22 2022-10-27 Molecular Axiom, Llc Compositions and methods for modulating sos gene expressions
FR3128873B1 (fr) 2021-11-10 2026-01-16 Biophytis Phytoecdysones et/ou dérivés de 20-hydroxyecdysone en combinaison avec un principe actif visant à restaurer l’expression SMN pour leur utilisation dans le traitement de l’amyotrophie spinale

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