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PE20181297A1 - Dinucleotidos de purino ciclico como moduladores de sting - Google Patents

Dinucleotidos de purino ciclico como moduladores de sting

Info

Publication number
PE20181297A1
PE20181297A1 PE2018000411A PE2018000411A PE20181297A1 PE 20181297 A1 PE20181297 A1 PE 20181297A1 PE 2018000411 A PE2018000411 A PE 2018000411A PE 2018000411 A PE2018000411 A PE 2018000411A PE 20181297 A1 PE20181297 A1 PE 20181297A1
Authority
PE
Peru
Prior art keywords
cyclic purine
purine dinucleotides
sting
sting modulators
compounds
Prior art date
Application number
PE2018000411A
Other languages
English (en)
Inventor
Jerry Leroy Adams
Kevin J Duffy
Yiqian Lian
Original Assignee
Glaxosmithkline Ip Dev Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Ip Dev Ltd filed Critical Glaxosmithkline Ip Dev Ltd
Publication of PE20181297A1 publication Critical patent/PE20181297A1/es

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    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
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    • A61P31/14—Antivirals for RNA viruses
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
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    • A61P37/00—Drugs for immunological or allergic disorders
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/6574—Esters of oxyacids of phosphorus
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    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se refiere a compuestos de formula (I), donde Y1 y Y2 son CH2 u O; X1 y X2 son S u O; R1 es OH o NH2; R2 es NH2 o H, R3 OH o NH2; R4 es NH2 o H; R5 y R6 son F, OH, entre otros; R8 y R9 son H, CH2OC(O)R7, entre otros; R7 es arilo, heteroarilo, entre otros. Tambien se refiere a una composicion farmaceutica. Dichos compuestos son agonistas de STING (estimulador de los genes del interferon) capaces mantener una respuesta de celulas T a antigenos tumorales y son utiles para el tratamiento de la inflamacion, enfermedades alergicas y autoinmunes, enfermedades infecciosas, entre otras
PE2018000411A 2015-12-03 2016-12-01 Dinucleotidos de purino ciclico como moduladores de sting PE20181297A1 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562262668P 2015-12-03 2015-12-03
US201662299253P 2016-02-24 2016-02-24
US201662299704P 2016-02-25 2016-02-25
US201662327579P 2016-04-26 2016-04-26
US201662332517P 2016-05-06 2016-05-06

Publications (1)

Publication Number Publication Date
PE20181297A1 true PE20181297A1 (es) 2018-08-07

Family

ID=57485836

Family Applications (1)

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PE2018000411A PE20181297A1 (es) 2015-12-03 2016-12-01 Dinucleotidos de purino ciclico como moduladores de sting

Country Status (23)

Country Link
US (4) US9718848B2 (es)
EP (2) EP3366691A1 (es)
JP (1) JP6411676B2 (es)
KR (1) KR101949108B1 (es)
CN (1) CN107849084B (es)
AU (1) AU2016362697B2 (es)
CA (1) CA3006930A1 (es)
CL (1) CL2018001484A1 (es)
CO (1) CO2017013310A2 (es)
CR (1) CR20180286A (es)
ES (1) ES2863225T3 (es)
HK (1) HK1250032A1 (es)
IL (1) IL255525B (es)
MA (1) MA52157A (es)
MX (1) MX363780B (es)
NZ (1) NZ738202A (es)
PE (1) PE20181297A1 (es)
PH (1) PH12017502332A1 (es)
RU (2) RU2020113165A (es)
TW (1) TWI704154B (es)
UY (1) UY37007A (es)
WO (1) WO2017093933A1 (es)
ZA (1) ZA201801631B (es)

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