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PE20181045A1 - Compuestos utiles como inmunomoduladores - Google Patents

Compuestos utiles como inmunomoduladores

Info

Publication number
PE20181045A1
PE20181045A1 PE2018000533A PE2018000533A PE20181045A1 PE 20181045 A1 PE20181045 A1 PE 20181045A1 PE 2018000533 A PE2018000533 A PE 2018000533A PE 2018000533 A PE2018000533 A PE 2018000533A PE 20181045 A1 PE20181045 A1 PE 20181045A1
Authority
PE
Peru
Prior art keywords
hydrogen
immunomodulators
useful compounds
compound
compounds
Prior art date
Application number
PE2018000533A
Other languages
English (en)
Inventor
Timothy P Connolly
David B Frennesson
Katharine A Grant-Young
Piyasena Hewawasam
David R Langley
Zhaoxing Meng
Eric Mull
Kyle E Parcella
Mark George Saulnier
Li-Qiang Sun
Alan Xiangdong Wang
Juliang Zhu
Paul Michael Scola
Ningning Xu
Kap-Sun Yeung
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PE20181045A1 publication Critical patent/PE20181045A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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Abstract

Referido a un compuesto de Formula (I), en donde m es 0, 1 o 2; Z es hidrogeno, CH3 o -OR1, en donde R1 se selecciona de hidrogeno, C3-C6alquenilo, haloC1-C4alquilo, -(CH2)nX, entre otros; n es 1, 2, 3 o 4; X se selecciona de hidrogeno, -CH3, -CF3, C1-C4alcoxi, -N(CH3)2, entre otros; A se selecciona de -CH2O-, -OCH2-, -(CH2)2-, entre otros; y R2 se selecciona de (II) y (III). Estos compuestos son inmunomoduladores, utiles para el tratamiento de diversas enfermedades, incluyendo cancer y enfermedades infecciosas. Tambien se refiere a composiciones farmaceuticas, que comprenden este compuesto y un agente farmaceuticamente aceptable.
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