[go: up one dir, main page]

PE20181884A1 - Amidas heterociclicas utiles como moduladores de proteinas - Google Patents

Amidas heterociclicas utiles como moduladores de proteinas

Info

Publication number
PE20181884A1
PE20181884A1 PE2018001834A PE2018001834A PE20181884A1 PE 20181884 A1 PE20181884 A1 PE 20181884A1 PE 2018001834 A PE2018001834 A PE 2018001834A PE 2018001834 A PE2018001834 A PE 2018001834A PE 20181884 A1 PE20181884 A1 PE 20181884A1
Authority
PE
Peru
Prior art keywords
carboxamide
protein modulators
heterocyclic amides
useful heterocyclic
imidazol
Prior art date
Application number
PE2018001834A
Other languages
English (en)
Inventor
Adam Kenneth Charnley
Michael G Darcy
Jason W Dodson
Xiaoyang Dong
Terry V Hughes
Jianxing Kang
Lara Kathryn Leister
Yiqian Lian
Yue Li
John F Mehlmann
Neysa Nevins
Joshi M Ramanjulu
Joseph J Romano
Gren Z Wang
Guosen Ye
Daohua Zhang
Original Assignee
Glaxosmithkline Ip Dev Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Ip Dev Ltd filed Critical Glaxosmithkline Ip Dev Ltd
Publication of PE20181884A1 publication Critical patent/PE20181884A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pulmonology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)
  • Financial Or Insurance-Related Operations Such As Payment And Settlement (AREA)
  • Information Retrieval, Db Structures And Fs Structures Therefor (AREA)

Abstract

Se refiere a un compuesto que es (E)-1-(4-(5-CARBAMOIL-2-(1-ETIL-3-METIL-1H-PIRAZOL-5-CARBOXAMIDO)-7-(3-MORFOLINOPROPOXI)-1H-BENZO[D]IMIDAZOL-1-IL)BUT-2-EN-1-IL)-2-(1-ETIL-3-METIL-1H-PIRAZOL-5-CARBOXAMIDO)-7-METOXI-1H-BENZO[D]IMIDAZOL-5-CARBOXAMIDA que tiene la estructura de un tautomero, una sal farmaceuticamente aceptable del mismo. Dichos compuestos activan a la proteina adaptadora STING (estimulador de genes de interferon) que da como resultado a la induccion de interferon-b y otras citosinas.
PE2018001834A 2016-04-07 2017-04-05 Amidas heterociclicas utiles como moduladores de proteinas PE20181884A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662319358P 2016-04-07 2016-04-07
US201762461301P 2017-02-21 2017-02-21
US201762461975P 2017-02-22 2017-02-22

Publications (1)

Publication Number Publication Date
PE20181884A1 true PE20181884A1 (es) 2018-12-07

Family

ID=58503675

Family Applications (3)

Application Number Title Priority Date Filing Date
PE2018001834A PE20181884A1 (es) 2016-04-07 2017-04-05 Amidas heterociclicas utiles como moduladores de proteinas
PE2018002322A PE20181920A1 (es) 2016-04-07 2017-04-05 Amidas heterociclicas utiles como moduladores de proteinas
PE2018002003A PE20181919A1 (es) 2016-04-07 2017-04-05 Amidas heterociclicas utiles como moduladores de proteinas

Family Applications After (2)

Application Number Title Priority Date Filing Date
PE2018002322A PE20181920A1 (es) 2016-04-07 2017-04-05 Amidas heterociclicas utiles como moduladores de proteinas
PE2018002003A PE20181919A1 (es) 2016-04-07 2017-04-05 Amidas heterociclicas utiles como moduladores de proteinas

Country Status (33)

Country Link
US (4) US10981901B1 (es)
EP (2) EP4032885A1 (es)
JP (4) JP6746712B2 (es)
KR (2) KR102527784B1 (es)
CN (3) CN109608443B (es)
AU (4) AU2017247798C1 (es)
CA (1) CA3019630A1 (es)
CL (3) CL2018002850A1 (es)
CO (1) CO2018010727A2 (es)
CR (2) CR20200045A (es)
DK (1) DK3440076T3 (es)
DO (3) DOP2018000217A (es)
ES (1) ES2921855T3 (es)
HR (1) HRP20220936T1 (es)
HU (1) HUE058932T2 (es)
IL (4) IL285702B (es)
JO (1) JOP20170083B1 (es)
LT (1) LT3440076T (es)
MX (3) MX387353B (es)
MY (1) MY189100A (es)
NZ (1) NZ745957A (es)
PE (3) PE20181884A1 (es)
PH (3) PH12018502151B1 (es)
PL (1) PL3440076T3 (es)
PT (1) PT3440076T (es)
RS (1) RS63462B1 (es)
SG (3) SG11201808621TA (es)
SI (1) SI3440076T1 (es)
SM (1) SMT202200339T1 (es)
TW (3) TWI868471B (es)
UA (1) UA123407C2 (es)
UY (1) UY37195A (es)
WO (1) WO2017175147A1 (es)

Families Citing this family (124)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20180688A1 (es) 2015-08-13 2018-04-23 Merck Sharp & Dohme Compuestos di-nucleotidos ciclicos como agonistas de sting
US11453697B1 (en) 2015-08-13 2022-09-27 Merck Sharp & Dohme Llc Cyclic di-nucleotide compounds as sting agonists
LT3429596T (lt) 2016-03-18 2022-12-12 Immune Sensor, Llc Cikliniai dinukleotidų junginiai ir panaudojimo būdai
PE20181884A1 (es) 2016-04-07 2018-12-07 Glaxosmithkline Ip Dev Ltd Amidas heterociclicas utiles como moduladores de proteinas
JOP20190070B1 (ar) 2016-10-04 2023-09-17 Merck Sharp And Dohme Llc مركبات بنزو[b] ثيوفين كناهضات محفزة لبروتين جينات الإنترفيرون
JOP20170192A1 (ar) 2016-12-01 2019-01-30 Takeda Pharmaceuticals Co داي نوكليوتيد حلقي
KR101938800B1 (ko) 2017-03-29 2019-04-10 주식회사 레고켐 바이오사이언스 피롤로벤조디아제핀 이량체 전구체 및 이의 리간드-링커 접합체 화합물
AU2018252546B2 (en) 2017-04-13 2025-03-13 Sairopa B.V. Anti-SIRPα antibodies
EP3621624B1 (en) 2017-05-12 2023-08-30 Merck Sharp & Dohme LLC Cyclic di-nucleotide compounds as sting agonists
WO2019027858A1 (en) 2017-08-04 2019-02-07 Merck Sharp & Dohme Corp. BENZO [B] STING THIOPHEN AGONISTS FOR THE TREATMENT OF CANCER
MA49773A (fr) 2017-08-04 2021-04-21 Merck Sharp & Dohme Combinaisons d'antagonistes de pd-1 et d'agonistes de sting benzo[b
US11377440B2 (en) * 2017-10-05 2022-07-05 Glaxosmithkline Intellectual Property Development Limited Modulators of stimulator of interferon genes (STING)
JP2020536106A (ja) * 2017-10-05 2020-12-10 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ Ｈｉｖの処置に有用なインターフェロン遺伝子の刺激物質（ｓｔｉｎｇ）の調節物質
BR112020006761A2 (pt) * 2017-10-05 2020-10-06 Glaxosmithkline Intellectual Property Development Limited métodos para administrar agonistas de sting
CN111566119A (zh) 2017-11-10 2020-08-21 武田药品工业有限公司 Sting调节剂化合物以及制备和使用方法
US11685761B2 (en) 2017-12-20 2023-06-27 Merck Sharp & Dohme Llc Cyclic di-nucleotide compounds as sting agonists
CA3084582A1 (en) 2017-12-20 2019-06-27 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 2'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein
CN111566120B (zh) 2017-12-20 2023-09-29 捷克共和国有机化学与生物化学研究所 活化sting转接蛋白的具有膦酸酯键的3’3’环状二核苷酸
CN110016025B (zh) * 2018-01-08 2021-08-06 成都先导药物开发股份有限公司 一种免疫调节剂
CN110016021B (zh) * 2018-01-08 2021-05-07 成都先导药物开发股份有限公司 一种免疫调节剂
EP3752150A1 (en) * 2018-02-16 2020-12-23 UCB Biopharma SRL Pharmaceutical 6,5 heterobicyclic ring derivatives
EP3768266A4 (en) * 2018-03-20 2021-12-22 Merck Sharp & Dohme Corp. OXO-TETRAHYDRO-ISOCHINOLINE-CARBOXYLIC ACIDS AS STING INHIBITORS
IL277344B2 (en) 2018-03-23 2024-05-01 Codiak Biosciences Inc Extracellular vesicles comprising sting-agonist
US11702430B2 (en) 2018-04-03 2023-07-18 Merck Sharp & Dohme Llc Aza-benzothiophene compounds as STING agonists
EP3774764A1 (en) 2018-04-03 2021-02-17 Merck Sharp&Dohme Corp. Benzothiophenes and related compounds as sting agonists
TWI818007B (zh) 2018-04-06 2023-10-11 捷克科學院有機化學與生物化學研究所 2'3'-環二核苷酸
TW202005654A (zh) 2018-04-06 2020-02-01 捷克科學院有機化學與生物化學研究所 ２，２，─環二核苷酸
TWI833744B (zh) 2018-04-06 2024-03-01 捷克科學院有機化學與生物化學研究所 3'3'-環二核苷酸
WO2019211799A1 (en) 2018-05-03 2019-11-07 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 2'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide
GB201807924D0 (en) 2018-05-16 2018-06-27 Ctxt Pty Ltd Compounds
MA52754A (fr) * 2018-05-25 2021-04-14 Incyte Corp Composés hétérocycliques tricycliques en tant qu'activateurs de sting
CN112351778B (zh) * 2018-06-28 2023-04-04 江苏恒瑞医药股份有限公司 稠合三环杂环类化合物及其治疗用途
WO2020010451A1 (en) * 2018-07-10 2020-01-16 Trillium Therapeutics Inc. Heteroaromatic-fused imidazolyl amides, compositions and uses thereof as sting agonists
US10875872B2 (en) 2018-07-31 2020-12-29 Incyte Corporation Heteroaryl amide compounds as sting activators
WO2020028565A1 (en) * 2018-07-31 2020-02-06 Incyte Corporation Tricyclic heteraryl compounds as sting activators
WO2020041720A1 (en) 2018-08-24 2020-02-27 Codiak Biosciences, Inc. Extracellular vesicles targeting dendritic cells and uses thereof
CN111386275B (zh) 2018-08-24 2023-03-10 杭州阿诺生物医药科技有限公司 高活性sting蛋白激动剂
JP7166028B2 (ja) * 2018-08-29 2022-11-07 アドライ・ノーティ・バイオファーマ・カンパニー・リミテッド 高活性ｓｔｉｎｇタンパク質アゴニスト化合物
SMT202500141T1 (it) 2018-09-06 2025-05-12 Daiichi Sankyo Co Ltd Coniugati farmaco-anticorpo di derivati dinucleotidici ciclici
US11596692B1 (en) 2018-11-21 2023-03-07 Incyte Corporation PD-L1/STING conjugates and methods of use
JP7469308B2 (ja) * 2018-12-06 2024-04-16 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド 新規の医薬製剤
US20220056044A1 (en) * 2018-12-14 2022-02-24 Jiangsu Hengrui Medicine Co., Ltd. Tricyclic compounds as sting agonists, and preparation methods and medicinal uses thereof
WO2020132582A1 (en) * 2018-12-21 2020-06-25 Nimbus Titan, Inc. Sting agonists and uses thereof
WO2020132566A1 (en) * 2018-12-21 2020-06-25 Nimbus Titan, Inc. Sting pyrazole agonists and uses thereof
WO2020146237A1 (en) * 2019-01-07 2020-07-16 Incyte Corporation Heteroaryl amide compounds as sting activators
CN111471056B (zh) * 2019-01-23 2021-07-02 成都先导药物开发股份有限公司 一种大环类免疫调节剂
CN111499617B (zh) * 2019-01-31 2021-08-06 成都先导药物开发股份有限公司 一种免疫调节剂
WO2020165600A1 (en) 2019-02-14 2020-08-20 Bicycletx Limited Bicyclic peptide ligand sting conjugates and uses thereof
KR102808642B1 (ko) 2019-03-07 2025-05-14 인스티튜트 오브 오가닉 케미스트리 앤드 바이오케미스트리 에이에스 씨알 브이.브이.아이. 3'3'-사이클릭 다이뉴클레오티드 및 이의 프로드럭
KR102707808B1 (ko) 2019-03-07 2024-09-19 인스티튜트 오브 오가닉 케미스트리 앤드 바이오케미스트리 에이에스 씨알 브이.브이.아이. 2'3'-사이클릭 다이뉴클레오티드 및 이의 프로드럭
US11766447B2 (en) 2019-03-07 2023-09-26 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 3′3′-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator
SG11202109587TA (en) 2019-03-21 2021-10-28 Codiak Biosciences Inc Extracellular vesicle conjugates and uses thereof
WO2020191361A2 (en) 2019-03-21 2020-09-24 Codiak Biosciences, Inc. Extracellular vesicles for vaccine delivery
KR20210146370A (ko) 2019-03-28 2021-12-03 루핀 리미티드 Sting 효능제로서의 매크로사이클릭 화합물
TW202104214A (zh) 2019-04-05 2021-02-01 英商葛蘭素史密斯克藍智慧財產發展有限公司 化合物
WO2021000770A1 (zh) * 2019-07-02 2021-01-07 凯复制药有限公司 可增强免疫活性的杂环化合物、其制备方法及其在医药上的应用
WO2021003445A1 (en) 2019-07-03 2021-01-07 Codiak Biosciences, Inc. Extracellular vesicles targeting t cells and uses thereof
US11339159B2 (en) 2019-07-17 2022-05-24 Pfizer Inc. Toll-like receptor agonists
GB201910305D0 (en) 2019-07-18 2019-09-04 Ctxt Pty Ltd Compounds
GB201910304D0 (en) 2019-07-18 2019-09-04 Ctxt Pty Ltd Compounds
DK4004002T3 (da) * 2019-07-22 2024-09-30 Lupin Ltd Makrocykliske forbindelser som sting-agonister samt fremgangsmåder og anvendelser dermed
CN112279835B (zh) * 2019-07-24 2022-07-22 中国医学科学院药物研究所 芳环或芳杂环并咪唑类化合物，其制备方法及制药用途
US12435104B2 (en) 2019-07-25 2025-10-07 Beigene, Ltd. Cyclic dinucleotides as sting agonists
JP7474319B2 (ja) * 2019-07-25 2024-04-24 シャンハイ ジェミンケア ファーマシューティカル カンパニー，リミティド ヘテロ環式アミド化合物及びその製造方法並びに使用
CN114585623A (zh) * 2019-08-02 2022-06-03 梅尔莎纳医疗公司 双[N-((5-氨基甲酰基)-1H-苯并[d]咪唑-2-基)吡唑-5-甲酰胺]衍生物和相关化合物作为STING（干扰素基因刺激物）激动剂用于治疗癌症
CN112521394A (zh) * 2019-09-19 2021-03-19 中国药科大学 杂环酰胺类化合物、其可药用的盐及其制备方法和用途
CN112521371B (zh) * 2019-09-19 2022-11-25 中国药科大学 杂环酰胺类化合物、其可药用的盐及其制备方法和用途
WO2021062060A1 (en) 2019-09-25 2021-04-01 Codiak Biosciences, Inc. Sting agonist comprising exosomes combined with il-12 displaying exosomes for treating a tumour
CN114727947A (zh) 2019-09-25 2022-07-08 科迪亚克生物科学公司 细胞外囊泡组合物
EP4034276A1 (en) 2019-09-25 2022-08-03 Codiak BioSciences, Inc. Methods of producing extracellular vesicles
WO2021062058A1 (en) 2019-09-25 2021-04-01 Codiak Biosciences, Inc. Sting agonist comprising exosomes for treating neuroimmunological disorders
WO2021068866A1 (en) * 2019-10-10 2021-04-15 Beigene, Ltd. Heterocyclic compounds as sting modulators
WO2021083383A1 (zh) * 2019-11-02 2021-05-06 上海凌达生物医药有限公司 一类含氮稠环类sting调节剂类化合物、制备方法和用途
CN112940004B (zh) * 2019-12-11 2022-07-12 中国科学院上海药物研究所 一种杂环化合物及其用途
CA3164751A1 (en) * 2019-12-18 2021-06-24 Benjamin Joseph MORROW Compounds
CN113087668B (zh) * 2019-12-23 2022-11-04 中国科学院上海药物研究所 一类苯并咪唑二聚体、其制备方法及用途
CN113248475B (zh) * 2020-02-11 2023-03-17 中国科学院上海药物研究所 一类杂环取代的苯并咪唑二聚体或其药学上可接受的盐、组合物及其用途
IL296124A (en) 2020-03-06 2022-11-01 Daiichi Sankyo Co Ltd Antibody-drug conjugate including novel cyclic dinucleotide derivative
EP4117717A1 (en) 2020-03-13 2023-01-18 Codiak BioSciences, Inc. Extracellular vesicles for treating neurological disorders
WO2021189047A2 (en) 2020-03-20 2021-09-23 Codiak Biosciences, Inc. Extracellular vesicles for therapy
CA3174297A1 (en) 2020-04-02 2021-10-07 Jeremy R. Duvall Antibody drug conjugates comprising sting agonists
US20230141284A1 (en) 2020-04-10 2023-05-11 Ono Pharmaceutical Co., Ltd. Cancer therapeutic method
WO2021237100A1 (en) 2020-05-21 2021-11-25 Codiak Biosciences, Inc. Methods of targeting extracellular vesicles to lung
EP4208260A1 (en) * 2020-09-02 2023-07-12 The Scripps Research Institute Agonists of stimulator of interferon genes sting
AU2021338014A1 (en) 2020-09-02 2023-03-09 Daiichi Sankyo Company, Limited Novel endo-β-N-acetylglucosaminidase
EP4216993A2 (en) 2020-09-23 2023-08-02 Codiak BioSciences, Inc. Methods of producing extracellular vesicles
WO2022066883A1 (en) 2020-09-23 2022-03-31 Codiak Biosciences, Inc. Extracellular vesicles comprising kras antigens and uses thereof
PE20231947A1 (es) 2020-11-09 2023-12-05 Takeda Pharmaceuticals Co Conjugados de anticuerpo y farmaco
AU2022208054A1 (en) * 2021-01-15 2023-07-27 Seagen Inc. Immunomodulatory antibody-drug conjugates
CN112920172B (zh) * 2021-02-01 2022-03-22 厦门大学 一种干扰素刺激蛋白靶向化合物、其放射性标记物、及它们的制备方法与应用
WO2022177307A1 (ko) * 2021-02-17 2022-08-25 한국화학연구원 벤즈이미다졸 유도체를 유효 성분으로 포함하는 인터페론 유전자 자극제 조성물
KR102881036B1 (ko) 2021-02-17 2025-11-05 한국화학연구원 벤즈이미다졸 유도체를 유효 성분으로 포함하는 인터페론 유전자 자극제 조성물
EP4326769A1 (en) 2021-04-20 2024-02-28 Institut Curie Compositions and methods for use in immunotherapy
US20240285755A1 (en) 2021-05-24 2024-08-29 Glaxosmithkline Biologicals Sa Adjuvants
WO2022246597A1 (en) * 2021-05-24 2022-12-01 Forever Millets Limited Imidazopyridine derivatives as sting agonists
IL309278A (en) * 2021-06-25 2024-02-01 Bolt Biotherapeutics Inc Bis-benzimidazole STING agonist conjugates and uses thereof
WO2023020994A1 (en) 2021-08-16 2023-02-23 Glaxosmithkline Biologicals Sa Novel methods
WO2023020992A1 (en) 2021-08-16 2023-02-23 Glaxosmithkline Biologicals Sa Novel methods
WO2023020993A1 (en) 2021-08-16 2023-02-23 Glaxosmithkline Biologicals Sa Novel methods
CN115724838A (zh) * 2021-08-26 2023-03-03 成都先导药物开发股份有限公司 一种适合作为抗体偶联药物效应分子的sting激动剂
WO2023056468A1 (en) 2021-09-30 2023-04-06 Codiak Biosciences, Inc. Extracellular vesicle comprising cholesterol tagged sting-agonist
EP4169513A1 (en) 2021-10-19 2023-04-26 GlaxoSmithKline Biologicals S.A. Adjuvant composition comprising sting agonists
CA3242000A1 (en) * 2022-01-11 2023-07-20 Jeongbeob Seo Fused heteroaryl hydroxamates as sting agonists
MX2024009404A (es) * 2022-02-02 2024-08-14 Hoffmann La Roche Macrociclos de imidazol para el tratamiento de enfermedades autoinmunitarias.
EP4482529A1 (en) 2022-02-22 2025-01-01 Araris Biotech AG Peptide linkers comprising two or more payloads
AU2023229142A1 (en) 2022-03-02 2024-10-03 Daiichi Sankyo Company, Limited METHOD FOR PRODUCING Fc-CONTAINING MOLECULE
WO2024003773A1 (en) 2022-07-01 2024-01-04 Pfizer Inc. 2,7-naphthyridine compounds as mastl inhibitors
CR20240556A (es) 2022-07-05 2025-01-29 Pfizer Compuestos de pirido[4,3-d]pirimidina
TW202417056A (zh) 2022-08-29 2024-05-01 日商第一三共股份有限公司 包含變異Fc區域的抗體藥物結合物
CN120712250A (zh) * 2022-10-03 2025-09-26 托马斯杰斐逊大学 基于吡咯烷和咪唑烷的DNA聚合酶θ抑制剂及其用途
WO2024074977A1 (en) 2022-10-04 2024-04-11 Pfizer Inc. Substituted 1 h-pyrazolo-pyridine and-pyrimidine compounds
WO2024084364A1 (en) 2022-10-18 2024-04-25 Pfizer Inc. Compounds for the treatment of cancer
WO2024105563A1 (en) 2022-11-16 2024-05-23 Pfizer Inc. Substituted bicyclic pyridone derivatives
WO2024137619A1 (en) 2022-12-20 2024-06-27 Bolt Biotherapeutics, Inc. Anti-claudin, bis-benzimid azole sting agonist immunoconjugates, and uses thereof
WO2024182414A1 (en) 2023-02-27 2024-09-06 Biontech Us Inc. Sting agonists containing hydrazide, hydrazine, and hydroxamic acid functional groups
WO2024180103A1 (en) 2023-02-27 2024-09-06 BioNTech SE Sting agonists containing benzylic alcohol and benzylic amine functional groups
WO2024186626A1 (en) 2023-03-03 2024-09-12 Bolt Biotherapeutics, Inc. Aza-bicyclic sting agonist immunoconjugates, and uses thereof
AU2024253142A1 (en) 2023-04-05 2025-10-16 Pfizer Inc. Pyrido[4,3-d]pyrimidine compounds
WO2024213979A1 (en) 2023-04-10 2024-10-17 Pfizer Inc. Pyrido[4,3-d]pyrimidine compounds
WO2025012195A1 (en) * 2023-07-10 2025-01-16 F. Hoffmann-La Roche Ag Bicyclic macrocycles for the treatment of autoimmune disease
WO2025029832A2 (en) * 2023-07-31 2025-02-06 Sutro Biopharma, Inc. Sting agonist compounds and conjugates
KR20250040871A (ko) * 2023-09-15 2025-03-25 삼진제약주식회사 Sting(인터페론 유전자 자극인자) 활성화제로서의 헤테로 고리 유도체 및 이를 포함하는 약학적 조성물
EP4534147A1 (en) 2023-10-05 2025-04-09 Sulis Therapeutics ApS Sting antagonist compounds
WO2025094035A1 (en) 2023-11-01 2025-05-08 Pfizer Inc. Toll-like receptor agonists and conjugates thereof

Family Cites Families (105)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5681835A (en) 1994-04-25 1997-10-28 Glaxo Wellcome Inc. Non-steroidal ligands for the estrogen receptor
US6113918A (en) 1997-05-08 2000-09-05 Ribi Immunochem Research, Inc. Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors
GB9716557D0 (en) 1997-08-06 1997-10-08 Glaxo Group Ltd Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity
US6312700B1 (en) 1998-02-24 2001-11-06 Andrew D. Weinberg Method for enhancing an antigen specific immune response with OX-40L
GB9824310D0 (en) * 1998-11-05 1998-12-30 Univ London Activators of soluble guanylate cyclase
EP1065213A3 (en) 1999-07-02 2003-11-05 Japan Tobacco Inc. HCV polymerase suitable for crystal structure analysis and method for using the enzyme
US7605238B2 (en) 1999-08-24 2009-10-20 Medarex, Inc. Human CTLA-4 antibodies and their uses
CA2381770C (en) 1999-08-24 2007-08-07 Medarex, Inc. Human ctla-4 antibodies and their uses
JP3871503B2 (ja) 1999-08-30 2007-01-24 日本たばこ産業株式会社 免疫性疾患治療剤
JP4210454B2 (ja) 2001-03-27 2009-01-21 日本たばこ産業株式会社 炎症性腸疾患治療剤
CA2363274A1 (en) 1999-12-27 2001-07-05 Japan Tobacco Inc. Fused-ring compounds and use thereof as drugs for hepatitis c
ATE395923T1 (de) 2000-05-19 2008-06-15 Corixa Corp Prophylaktische und therapeutische behandlung von infektiösen, autoimmunen und allergischen krankheiten mit verbindungen, die auf monosacchariden basieren
US6448281B1 (en) 2000-07-06 2002-09-10 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
US7129219B2 (en) 2000-08-04 2006-10-31 Corixa Corporation Immunoeffector compounds
US6310224B1 (en) 2001-01-19 2001-10-30 Arco Chemical Technology, L.P. Epoxidation catalyst and process
EP1539188B1 (en) 2001-01-22 2015-01-07 Merck Sharp & Dohme Corp. Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
JP4212278B2 (ja) 2001-03-01 2009-01-21 日本たばこ産業株式会社 移植片拒絶反応抑制剤
NZ528270A (en) 2001-03-19 2005-10-28 Ono Pharmaceutical Co Drugs containing triazaspiro[5.5]undecane derivatives as the active ingredient
AR035543A1 (es) 2001-06-26 2004-06-16 Japan Tobacco Inc Agente terapeutico para la hepatitis c que comprende un compuesto de anillo condensado, compuesto de anillo condensado, composicion farmaceutica que lo comprende, compuestos de benzimidazol, tiazol y bifenilo utiles como intermediarios para producir dichos compuestos, uso del compuesto de anillo con
US6841566B2 (en) 2001-07-20 2005-01-11 Boehringer Ingelheim, Ltd. Viral polymerase inhibitors
US6911434B2 (en) 2002-02-04 2005-06-28 Corixa Corporation Prophylactic and therapeutic treatment of infectious and other diseases with immunoeffector compounds
US6525028B1 (en) 2002-02-04 2003-02-25 Corixa Corporation Immunoeffector compounds
IL164376A0 (en) 2002-04-03 2005-12-18 Applied Research Systems Ox4or binding agents, their preparation and pharmaceutical compositions containing them
CA2481502A1 (en) 2002-04-04 2003-10-16 Achillion Pharmaceuticals, Inc. Hcv antiviral and cytotoxicity drug screening assay
DOP2003000641A (es) 2002-05-10 2003-11-15 Pfizer Inhibidores de las arn polimerasa dependiente de arn del virus de las hepatitis c y composiciones y tratamiento que los usan
DE60317677T2 (de) 2002-06-13 2008-10-30 Crucell Holland B.V. Ox40 (=cd134) rezeptor agonisten und therapeutische verwendung
US7595048B2 (en) 2002-07-03 2009-09-29 Ono Pharmaceutical Co., Ltd. Method for treatment of cancer by inhibiting the immunosuppressive signal induced by PD-1
AU2003276172A1 (en) 2002-10-24 2004-05-13 Glaxo Group Limited 1-acyl-pyrrolidine derivatives for the treatment of viral infections
CN1731993A (zh) 2002-11-01 2006-02-08 维洛药品公司 苯并呋喃化合物、组合物以及治疗和预防丙型肝炎病毒感染及相关疾病的方法
AU2003296992A1 (en) 2002-12-13 2004-07-09 Smithkline Beecham Corporation Pyrrolidine and azetidine compounds as ccr5 antagonists
ATE410426T1 (de) 2002-12-13 2008-10-15 Smithkline Beecham Corp Heterocyclische verbindungen alsccr5-antagonisten
JP2006511554A (ja) 2002-12-13 2006-04-06 スミスクライン ビーチャム コーポレーション Ｃｃｒ５アンタゴニストとしてのピペリジン誘導体
US7589207B2 (en) 2002-12-13 2009-09-15 Smithkline Beecham Corporation Cyclohexyl compounds as CCR5 antagonists
AU2003300952A1 (en) 2002-12-13 2004-07-09 Smithkline Beecham Corporation Indane compounds as ccr5 antagonists
WO2004055010A2 (en) 2002-12-13 2004-07-01 Smithkline Beecham Corporation Cyclopropyl compounds as ccr5 antagonists
ATE514713T1 (de) 2002-12-23 2011-07-15 Wyeth Llc Antikörper gegen pd-1 und ihre verwendung
US7960522B2 (en) 2003-01-06 2011-06-14 Corixa Corporation Certain aminoalkyl glucosaminide phosphate compounds and their use
US7098231B2 (en) 2003-01-22 2006-08-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7223785B2 (en) 2003-01-22 2007-05-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
WO2004072286A1 (ja) 2003-01-23 2004-08-26 Ono Pharmaceutical Co., Ltd. ヒトｐｄ−１に対し特異性を有する物質
US7148226B2 (en) 2003-02-21 2006-12-12 Agouron Pharmaceuticals, Inc. Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same
CN1829709A (zh) 2003-08-01 2006-09-06 健亚生物科技公司 对抗黄病毒的双环咪唑衍生物
WO2005014543A1 (ja) 2003-08-06 2005-02-17 Japan Tobacco Inc. 縮合環化合物及びそのｈｃｖポリメラーゼ阻害剤としての利用
WO2005070420A1 (en) 2004-01-14 2005-08-04 Boehringer Ingelheim Pharmaceuticals, Inc. 1h-benzimidazol-2-yl-benzamide derivatives and related compounds as itk inhibitors (interleukin-2-inducible t cell kinase) for the treatment of inflammation, immunological and allergic disorders
CA2553433A1 (en) 2004-01-23 2005-08-11 Amgen Inc. Quinoline quinazoline pyridine and pyrimidine compounds and their use in the treatment of inflammation angiogenesis and cancer
EA201301284A1 (ru) 2004-02-20 2014-03-31 Бёрингер Ингельхайм Интернациональ Гмбх Способ получения соединений, являющихся ингибиторами вирусной полимеразы и способ получения фармацевтических композиций, а также промежуточные соединения
JP4887284B2 (ja) 2004-03-15 2012-02-29 デイビッド・ケイ・アール・カラオリス 癌細胞の増殖を阻害するための、または癌細胞のアポトーシスを増大させるための方法
KR20070011501A (ko) 2004-04-28 2007-01-24 애로우 쎄라퓨틱스 리미티드 항바이러스제로서 유용한 모르폴리닐아닐리노퀴나졸린유도체
TW200600492A (en) 2004-05-18 2006-01-01 Achillion Pharmaceuticals Inc Substituted aryl acylthioureas and related compounds; inhibitors of viral replication
US7153848B2 (en) 2004-08-09 2006-12-26 Bristol-Myers Squibb Company Inhibitors of HCV replication
WO2006018725A1 (en) 2004-08-18 2006-02-23 Pfizer Inc. Inhibitors of hepatitis c virus rna-dependent rna polymerase, and compositions and treatments using the same
GB0423673D0 (en) 2004-10-25 2004-11-24 Glaxo Group Ltd Compounds
US20070060589A1 (en) * 2004-12-21 2007-03-15 Purandare Ashok V Inhibitors of protein arginine methyl transferases
KR20070116682A (ko) 2005-05-04 2007-12-10 에프. 호프만-라 로슈 아게 헤테로사이클릭 항바이러스성 화합물
AP2358A (en) 2005-05-09 2012-01-30 Achillion Pharmaceuticals Inc Thiazole compounds and methods of use.
NZ563193A (en) 2005-05-09 2010-05-28 Ono Pharmaceutical Co Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics
ES2401482T3 (es) 2005-05-10 2013-04-22 Incyte Corporation Moduladores de la indolamina 2,3-dioxigenasa y métodos de uso de los mismos
CA2612241C (en) 2005-07-01 2018-11-06 Medarex, Inc. Human monoclonal antibodies to programmed death ligand 1 (pd-l1)
EP1782826A1 (en) 2005-11-08 2007-05-09 GBF Gesellschaft für Biotechnologische Forschung mbH PQS and c-diGMP and its conjugates as adjuvants and their uses in pharmaceutical compositions
US8017612B2 (en) 2006-04-18 2011-09-13 Japan Tobacco Inc. Piperazine compound and use thereof as a HCV polymerase inhibitor
US8329159B2 (en) 2006-08-11 2012-12-11 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
CA2685465C (en) 2007-05-07 2020-02-25 Medimmune, Llc Anti-icos antibodies and their use in treatment of oncology, transplantation and autoimmune disease
PT2170959E (pt) 2007-06-18 2014-01-07 Merck Sharp & Dohme Anticorpos para o receptor humano de morte programada pd-1
RU2010129045A (ru) 2007-12-14 2012-01-20 Бристоль-Мейерз Сквибб Компани (US) Связывающие молекулы к рецептору ох40 человека
AU2009208947B2 (en) 2008-02-01 2014-02-06 Takeda Pharmaceutical Company Limited Oxim derivatives as HSP90 inhibitors
US8168757B2 (en) 2008-03-12 2012-05-01 Merck Sharp & Dohme Corp. PD-1 binding proteins
CA2724430A1 (en) * 2008-05-19 2009-11-26 Schering Corporation Heterocyclic compounds as factor ixa inhibitors
EP2324055A2 (en) 2008-08-25 2011-05-25 Amplimmune, Inc. Pd-1 antagonists and methods of use thereof
WO2010036959A2 (en) 2008-09-26 2010-04-01 Dana-Farber Cancer Institute Human anti-pd-1, pd-l1, and pd-l2 antibodies and uses therefor
US20110293605A1 (en) 2008-11-12 2011-12-01 Hasige Sathish Antibody formulation
SMT202400136T1 (it) 2008-12-09 2024-05-14 Hoffmann La Roche Anticorpi anti-pd-l1 e loro uso per potenziare la funzione dei linfociti t
US9150554B2 (en) 2009-03-27 2015-10-06 Presidio Pharmaceuticals, Inc. Fused ring inhibitors of hepatitis C
WO2011066342A2 (en) 2009-11-24 2011-06-03 Amplimmune, Inc. Simultaneous inhibition of pd-l1/pd-l2
EP3279215B1 (en) 2009-11-24 2020-02-12 MedImmune Limited Targeted binding agents against b7-h1
US8362020B2 (en) 2009-12-30 2013-01-29 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
WO2011091446A1 (en) 2010-01-22 2011-07-28 Glaxosmithkline Llc Chemical compounds
UY33288A (es) * 2010-03-25 2011-10-31 Glaxosmithkline Llc Derivados de indolina inhibidores de la proteina quinasa r del reticulo endoplasmatico
BR112012024380A2 (pt) * 2010-03-25 2015-09-15 Glaxosmithkline Llc compostos químicos
US20110280877A1 (en) 2010-05-11 2011-11-17 Koji Tamada Inhibition of B7-H1/CD80 interaction and uses thereof
EA201690998A1 (ru) * 2010-05-17 2017-01-30 Инкозен Терапьютикс Пвт. Лтд. НОВЫЕ СОЕДИНЕНИЯ 3,5-ДИЗАМЕЩЕННОГО-3H-ИМИДАЗО[4,5-b]ПИРИДИНА И 3,5-ДИЗАМЕЩЕННОГО-3H-[1,2,3]ТРИАЗОЛО[4,5-b]ПИРИДИНА КАК МОДУЛЯТОРЫ ПРОТЕИНКИНАЗ
CN101898945B (zh) 2010-07-27 2013-05-08 大连理工大学 盐析萃取发酵液中丙酮和丁醇的方法
EA029793B1 (ru) 2010-08-23 2018-05-31 Борд Оф Риджентс, Дзе Юниверсити Оф Техас Систем Антитела к ох40 и способы их применения
EP2651926A4 (en) * 2010-12-15 2014-07-09 Abbvie Inc ANTI-VIRAL COMPOUNDS
CA3050674C (en) 2011-03-31 2021-10-12 Julien FAGET Antibodies directed against icos and uses thereof
AU2012290121B2 (en) 2011-08-01 2015-11-26 Genentech, Inc. Methods of treating cancer using PD-1 axis binding antagonists and MEK inhibitors
AU2012299421B2 (en) 2011-08-23 2016-02-04 Board Of Regents, The University Of Texas System Anti-OX40 antibodies and methods of using the same
EP2844756A4 (en) 2012-04-30 2016-02-24 Glen N Barber MODULATION OF IMMUNE REACTIONS
CN113967253A (zh) 2012-05-15 2022-01-25 百时美施贵宝公司 通过破坏pd-1/pd-l1信号传输的免疫治疗
SG10201610251PA (en) 2012-06-08 2017-01-27 Aduro Biotech Compositions and methods for cancer immunotherapy
WO2014001464A1 (en) * 2012-06-27 2014-01-03 4Sc Discovery Gmbh Bifluorodioxalane-amino-benzimidazole kinase inhibitors for the treatment of cancer, autoimmuneinflammation and cns disorders
WO2014033327A1 (en) 2012-09-03 2014-03-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Antibodies directed against icos for treating graft-versus-host disease
CA3139031A1 (en) 2012-10-04 2014-04-10 Dana-Farber Cancer Institute, Inc. Human monoclonal anti-pd-l1 antibodies and methods of use
EA201590396A1 (ru) 2012-12-13 2015-12-30 Адуро Биотек, Инк. Композиция, содержащая циклические пуриновые динуклеотиды с определенной стереохимией, и способ ее получения и применения
US9549944B2 (en) 2013-05-18 2017-01-24 Aduro Biotech, Inc. Compositions and methods for inhibiting “stimulator of interferon gene”—dependent signalling
US9724408B2 (en) 2013-05-18 2017-08-08 Aduro Biotech, Inc. Compositions and methods for activating stimulator of interferon gene-dependent signalling
JP2016538344A (ja) 2013-11-19 2016-12-08 ザ・ユニバーシティ・オブ・シカゴＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃｈｉｃａｇｏ 癌処置としてのｓｔｉｎｇアゴニストの使用
CN106460057A (zh) 2014-06-02 2017-02-22 贝斯4创新公司 核苷酸多态性检测方法
EA029856B9 (ru) * 2014-06-04 2018-08-31 Глаксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед Циклические динуклеотиды в качестве модуляторов стимулятора генов интерферона (sting)
BR112017000497B1 (pt) 2014-07-11 2023-12-26 Ventana Medical Systems, Inc Anticorpo isolado, célula hospedeira procariótica, imunoconjugado e método de detecção da presença ou do nível de expressão de pd-l1
MA41414A (fr) 2015-01-28 2017-12-05 Centre Nat Rech Scient Protéines de liaison agonistes d' icos
KR20170129902A (ko) 2015-03-23 2017-11-27 조운스 테라퓨틱스, 인크. Icos에 대한 항체
PE20180688A1 (es) 2015-08-13 2018-04-23 Merck Sharp & Dohme Compuestos di-nucleotidos ciclicos como agonistas de sting
WO2017093933A1 (en) 2015-12-03 2017-06-08 Glaxosmithkline Intellectual Property Development Limited Cyclic purine dinucleotides as modulators of sting
PE20181884A1 (es) 2016-04-07 2018-12-07 Glaxosmithkline Ip Dev Ltd Amidas heterociclicas utiles como moduladores de proteinas
ES2781474T3 (es) 2016-04-07 2020-09-02 Glaxosmithkline Ip Dev Ltd Amidas heterocíclicas útiles como moduladores de proteínas

Also Published As

Publication number Publication date
SG10201900629VA (en) 2019-02-27
IL261482A (en) 2018-10-31
IL261482B (en) 2021-09-30
CL2018002850A1 (es) 2018-12-14
NZ745957A (en) 2020-07-31
KR20180132806A (ko) 2018-12-12
EP3440076A1 (en) 2019-02-13
US10189820B2 (en) 2019-01-29
MY189100A (en) 2022-01-25
AU2018229497B2 (en) 2019-06-27
CR20200045A (es) 2020-03-11
CL2018003290A1 (es) 2019-02-01
PE20181919A1 (es) 2018-12-11
CN113549110B (zh) 2024-08-16
CO2018010727A2 (es) 2018-10-22
HUE058932T2 (hu) 2022-09-28
JP7119158B2 (ja) 2022-08-16
SMT202200339T1 (it) 2022-09-14
CN109608443A (zh) 2019-04-12
IL295649B1 (en) 2025-08-01
MX2020009947A (es) 2021-10-26
US20210139473A1 (en) 2021-05-13
MX2020009948A (es) 2021-10-26
KR20180124149A (ko) 2018-11-20
PH12018502151A1 (en) 2019-07-08
TW201738235A (zh) 2017-11-01
IL295649A (en) 2022-10-01
CR20200044A (es) 2020-03-11
US20230071675A1 (en) 2023-03-09
BR122018070838A2 (pt) 2019-09-10
AU2018229497C1 (en) 2020-09-03
TWI868471B (zh) 2025-01-01
AU2020200692C1 (en) 2021-03-04
US20180105514A1 (en) 2018-04-19
LT3440076T (lt) 2022-09-26
AU2020200692A1 (en) 2020-02-20
IL285702A (en) 2021-09-30
MX2018012333A (es) 2019-03-07
CN109071514B (zh) 2021-07-06
CN109608443B (zh) 2021-09-07
KR102527784B1 (ko) 2023-04-28
EP4032885A1 (en) 2022-07-27
BR122018070836A2 (pt) 2019-09-10
AU2018229498C1 (en) 2020-09-03
US11365190B2 (en) 2022-06-21
IL285702B (en) 2022-09-01
AU2018229497A1 (en) 2018-10-04
PE20181920A1 (es) 2018-12-11
AU2017247798B2 (en) 2019-10-31
DK3440076T3 (da) 2022-07-11
MX379169B (es) 2025-03-10
PH12018502202A1 (en) 2020-06-22
MX387353B (es) 2025-03-18
ES2921855T3 (es) 2022-09-01
RS63462B1 (sr) 2022-08-31
AU2017247798C1 (en) 2020-08-27
JP7466596B2 (ja) 2024-04-12
PH12018502151B1 (en) 2022-01-12
JP6746712B2 (ja) 2020-08-26
TWI777014B (zh) 2022-09-11
JP2021105013A (ja) 2021-07-26
CL2018003291A1 (es) 2019-02-01
SG11201808621TA (en) 2018-10-30
US10981901B1 (en) 2021-04-20
JP2019510796A (ja) 2019-04-18
JOP20170083B1 (ar) 2022-03-14
JP2022166060A (ja) 2022-11-01
IL261657B (en) 2021-09-30
SI3440076T1 (sl) 2022-09-30
NZ750114A (en) 2025-05-30
BR112018070655A2 (pt) 2019-02-05
AU2017247798A1 (en) 2018-09-27
TW201920161A (zh) 2019-06-01
JP6861307B2 (ja) 2021-04-21
AU2018229498A1 (en) 2018-10-04
UA123407C2 (uk) 2021-03-31
CA3019630A1 (en) 2017-10-12
US11970480B2 (en) 2024-04-30
PL3440076T3 (pl) 2022-09-05
HRP20220936T1 (hr) 2022-10-28
BR122018070838A8 (pt) 2022-07-19
SG10201900628RA (en) 2019-02-27
PH12018502179A1 (en) 2020-06-15
BR122018070836A8 (pt) 2022-07-19
TWI776806B (zh) 2022-09-11
CN109071514A (zh) 2018-12-21
EP3440076B1 (en) 2022-06-01
AU2020200692B2 (en) 2020-08-27
CN113549110A (zh) 2021-10-26
DOP2020000019A (es) 2020-03-15
DOP2018000217A (es) 2018-10-31
KR102527786B1 (ko) 2023-04-28
AU2018229498B2 (en) 2019-06-27
TW202246285A (zh) 2022-12-01
IL261657A (en) 2018-10-31
MX387354B (es) 2025-03-18
JP2020100646A (ja) 2020-07-02
PT3440076T (pt) 2022-07-29
UY37195A (es) 2017-10-31
DOP2020000018A (es) 2020-03-15
WO2017175147A1 (en) 2017-10-12

Similar Documents

Publication Publication Date Title
PE20181884A1 (es) Amidas heterociclicas utiles como moduladores de proteinas
EA201991197A1 (ru) БЕНЗИМИДАЗОЛЬНЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ c-Kit
CA3254669A1 (en) Targeted integration of nucleic acids
MX387984B (es) Inhibidor del egfr y preparación y aplicación del mismo.
MX2021014286A (es) Proteinas multiespecificas.
JOP20190194A1 (ar) مركبات نيوكليوتيدات ثنائية حلقية لعلاج السرطان
MX382927B (es) Compuestos de benzolactama como inhibidores de la proteína cinasa.
EA202090516A3 (ru) Бициклические гетероциклы в качестве ингибиторов fgfr
EA201792205A1 (ru) Гетероциклические соединения как ингибиторы lsd1
CL2015003731A1 (es) Inhibidores de bromodominios
CO2017004784A2 (es) Isómeros de ácido-1-[(3-cloro-2-fluoro-fenil)metil]-4-[[3-fluoro-6-[(5-metil-1h-pirazol-3-il)amino]-2-piridil]metil]-2-metil-piperidin-4-carboxílico como inhibidores de la cinasa aurora a
EA201890731A1 (ru) Модуляторы корового белка гепатита b
CA2936543C (en) Immunomodulatory agents
MX375524B (es) Anticuerpos anti-axl.
CY1119361T1 (el) 3,4-διυδροισοκινολιν-2(1h)-υλικες ενωσεις
MX381487B (es) Ciertos inhibidores de la proteina quinasa.
EP3558237C0 (en) SYSTEM FOR TARGETED APPLICATION OF TOPICAL AGENTS TO AN ISOLATED BODY PART
MX383880B (es) Inhibidores de ectonucleotidasa y metodos de uso de los mismos.
MX372964B (es) Derivados de fenil quinolinona como inhibidores de isocitrato deshidrogenasa mutante (mt-idh)
EA201691997A1 (ru) Производные 2,4-тиазолинидона в лечении расстройств центральной нервной системы
MX395032B (es) Ciertos inhibidores de la proteína quinasa.
PH12016502347A1 (en) 1 -(cyclopent-2-en-1 -yl)-3-(2-hydroxy-3-(arylsulfonyl)phenyl)urea derivatives as cxcr2 inhibitors
EA201791530A1 (ru) НОВЫЕ N-АЦИЛАРИЛСУЛЬФОНАМИДНЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ АМИНОАЦИЛ-тРНК СИНТЕТАЗЫ
EA201892714A1 (ru) Имидазолиновые соединения в качестве ингибиторов эластазы нейтрофилов человека
MX2016016491A (es) Derivados de o-alquil-bencilidenguanidina y uso terapeutico para el tratamiento de trastornos asociados con acumulacion de proteinas mal plegadas.