PE20170503A1 - Proteinas de fusion de interleucina 2/receptor de interleucina-2 alfa y metodos de uso - Google Patents
Proteinas de fusion de interleucina 2/receptor de interleucina-2 alfa y metodos de usoInfo
- Publication number
- PE20170503A1 PE20170503A1 PE2017000128A PE2017000128A PE20170503A1 PE 20170503 A1 PE20170503 A1 PE 20170503A1 PE 2017000128 A PE2017000128 A PE 2017000128A PE 2017000128 A PE2017000128 A PE 2017000128A PE 20170503 A1 PE20170503 A1 PE 20170503A1
- Authority
- PE
- Peru
- Prior art keywords
- interleukin
- polypeptide
- alpha receptor
- methods
- fusion proteins
- Prior art date
Links
- 102000000588 Interleukin-2 Human genes 0.000 title abstract 6
- 108010002350 Interleukin-2 Proteins 0.000 title abstract 6
- 102000037865 fusion proteins Human genes 0.000 title abstract 3
- 108020001507 fusion proteins Proteins 0.000 title abstract 3
- 229920001184 polypeptide Polymers 0.000 abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 239000012634 fragment Substances 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 108040006849 interleukin-2 receptor activity proteins Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Cell Biology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Virology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
Abstract
Se refiere a una proteina de fusion que comprende: (a) un primer polipeptido que comprende interleucina-2 (IL-2) o una variante funcional o fragmento de la misma; y (b) un segundo polipeptido, fusionado dentro del marco de lectura al primer polipeptido, el segundo polipeptido comprende un dominio extracelular de receptor de interleucina 2 alfa (IL-2R?) o una variante funcional o fragmento del mismo; en donde la proteina de fusion tiene actividad IL-2. Dichas proteinas modulan la respuesta inmune siendo utiles en el tratamiento de cancer y VIH/AID
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462033726P | 2014-08-06 | 2014-08-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20170503A1 true PE20170503A1 (es) | 2017-05-11 |
Family
ID=53836871
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2017000128A PE20170503A1 (es) | 2014-08-06 | 2015-08-05 | Proteinas de fusion de interleucina 2/receptor de interleucina-2 alfa y metodos de uso |
Country Status (32)
| Country | Link |
|---|---|
| US (3) | US12084483B2 (es) |
| EP (2) | EP4438621A3 (es) |
| JP (3) | JP6723982B2 (es) |
| KR (1) | KR102653758B1 (es) |
| CN (2) | CN107074967B (es) |
| AU (3) | AU2015301071C1 (es) |
| BR (1) | BR112017001940A2 (es) |
| CA (1) | CA2957273C (es) |
| CL (1) | CL2017000284A1 (es) |
| CO (1) | CO2017002166A2 (es) |
| DK (1) | DK3177307T3 (es) |
| EA (2) | EA202091342A3 (es) |
| ES (1) | ES2986097T3 (es) |
| FI (1) | FI3177307T3 (es) |
| HR (1) | HRP20241258T1 (es) |
| HU (1) | HUE068478T2 (es) |
| IL (2) | IL250007B (es) |
| LT (1) | LT3177307T (es) |
| MA (2) | MA40094B1 (es) |
| MX (1) | MX388977B (es) |
| MY (1) | MY180831A (es) |
| PE (1) | PE20170503A1 (es) |
| PH (1) | PH12017500042A1 (es) |
| PT (1) | PT3177307T (es) |
| RS (1) | RS65930B1 (es) |
| SA (1) | SA517380842B1 (es) |
| SG (2) | SG10201913695PA (es) |
| SI (1) | SI3177307T1 (es) |
| SM (1) | SMT202400414T1 (es) |
| TN (1) | TN2017000020A1 (es) |
| WO (1) | WO2016022671A1 (es) |
| ZA (1) | ZA201700245B (es) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140044675A1 (en) | 2012-08-10 | 2014-02-13 | Roche Glycart Ag | Interleukin-2 fusion proteins and uses thereof |
| NZ719654A (en) | 2014-02-06 | 2020-06-26 | Hoffmann La Roche | Interleukin-2 fusion proteins and uses thereof |
| MA40094B1 (fr) * | 2014-08-06 | 2022-05-31 | Univ Miami | Protéines de fusion de l'interleukine-2/récepteur alpha de l'interleukine-2 et procédés d'utilisation |
| US12202856B2 (en) | 2016-05-19 | 2025-01-21 | The General Hospital Corporation | Tethered interleukin-2 to its receptor IL-2RBETA, a platform to enhance natural killer and regulatory T cell activity |
| JP2019534710A (ja) | 2016-09-28 | 2019-12-05 | ゾーマ （ユーエス） リミテッド ライアビリティ カンパニー | インターロイキン２に結合する抗体およびその使用 |
| US10961310B2 (en) | 2017-03-15 | 2021-03-30 | Pandion Operations, Inc. | Targeted immunotolerance |
| SG11201909949XA (en) | 2017-05-24 | 2019-11-28 | Pandion Therapeutics Inc | Targeted immunotolerance |
| EP3746103A4 (en) * | 2017-12-06 | 2022-03-30 | The Board of Trustees of the Leland Stanford Junior University | PROTEINS ENGINEERED TO INCREASE A CELL'S SENSITIVITY TO IL-2 |
| USRE50550E1 (en) | 2017-12-06 | 2025-08-26 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| US10174092B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
| US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| WO2019183389A1 (en) * | 2018-03-23 | 2019-09-26 | Kite Pharma, Inc. | Chimeric transmembrane proteins and uses thereof |
| MX2020009975A (es) * | 2018-03-28 | 2020-10-12 | Bristol Myers Squibb Co | Proteinas de fusion interleucina-2/receptor alfa de interleucina-2 y metodos de uso. |
| MX2021011258A (es) * | 2019-03-18 | 2021-12-10 | Biontech Cell & Gene Therapies Gmbh | Variantes de interleucina-2 (il2) y receptor de interleucina-2 (il2r) para la activacion especifica de celulas efectoras inmunitarias. |
| CN111944036B (zh) | 2019-05-14 | 2024-09-06 | 上海盖浦生物科技有限公司 | 一种增殖免疫细胞的突变体蛋白 |
| WO2020236875A1 (en) | 2019-05-20 | 2020-11-26 | Pandion Therapeutics, Inc. | Madcam targeted immunotolerance |
| CN113874390A (zh) * | 2019-05-24 | 2021-12-31 | 普罗维瓦疗法香港有限公司 | Il-2组合物及其使用方法 |
| US11246906B2 (en) * | 2019-06-11 | 2022-02-15 | Alkermes Pharma Ireland Limited | Compositions and methods for subcutaneous administration of cancer immunotherapy |
| WO2021011353A1 (en) * | 2019-07-12 | 2021-01-21 | Proviva Therapeutics (Hong Kong) Limited | Il-2 compositions and methods of use thereof |
| CN114466657B (zh) * | 2019-07-25 | 2024-11-15 | 芝加哥大学 | 包括蛋白酶激活治疗剂的组合物和方法 |
| US20220378933A1 (en) * | 2019-09-19 | 2022-12-01 | Proviva Therapeutics (Hong Kong) Limited | Il-2 compositions and methods of use thereof |
| MX2022004577A (es) * | 2019-10-18 | 2022-05-10 | Alkermes Pharma Ireland Ltd | Agentes inmunomoduladores il-2 en combinacion con inhibidores de puntos de control inmune. |
| MX2022007754A (es) | 2019-12-20 | 2022-07-19 | Regeneron Pharma | Nuevos agonistas de il2 y metodos de uso de estos. |
| US11981715B2 (en) | 2020-02-21 | 2024-05-14 | Pandion Operations, Inc. | Tissue targeted immunotolerance with a CD39 effector |
| CN115996946A (zh) | 2020-04-30 | 2023-04-21 | 免疫靶向有限公司 | 可活化il2组合物和使用方法 |
| CN116194480A (zh) * | 2020-08-13 | 2023-05-30 | 百时美施贵宝公司 | 将il-2重定向到目的靶细胞的方法 |
| TW202317623A (zh) | 2021-06-14 | 2023-05-01 | 美商再生元醫藥公司 | 基於il2之治療劑及其使用方法 |
| KR20240149421A (ko) * | 2022-02-11 | 2024-10-14 | 뮤럴 온콜로지, 인코포레이티드 | 암 면역요법을 위한 조성물 및 방법 |
| WO2023159135A2 (en) * | 2022-02-16 | 2023-08-24 | University Of Miami | Il-2 and tl1a fusion proteins and methods of use thereof |
| CN114875069B (zh) * | 2022-04-22 | 2023-09-15 | 四川大学 | 基因工程修饰的il2细胞因子的重组载体、宿主细胞及其用途 |
| AU2024224039A1 (en) * | 2023-02-22 | 2025-06-26 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Anti-il2ra antibodies and uses thereof |
| WO2025207491A1 (en) * | 2024-03-25 | 2025-10-02 | Mural Oncology, Inc. | Compositions and methods for cancer immunotherapy |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ201918A (en) | 1981-09-18 | 1987-04-30 | Genentech Inc | N-terminal methionyl analogues of bovine growth hormone |
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US4873192A (en) | 1987-02-17 | 1989-10-10 | The United States Of America As Represented By The Department Of Health And Human Services | Process for site specific mutagenesis without phenotypic selection |
| FR2619719B1 (fr) | 1987-09-01 | 1991-05-10 | Sanofi Sa | Procede d'obtention d'interleukine-2 a partir de cellules eucaryotes, vecteurs necessaires a sa mise en oeuvre et lignees cellulaires hautement productrices |
| US5250296A (en) * | 1990-11-29 | 1993-10-05 | Takeda Chemical Industries, Ltd. | Immunostimulant agent containing interleukin-2 and 5'-deoxy-5-fluorouridine |
| US5837458A (en) | 1994-02-17 | 1998-11-17 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
| US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| AU704829B2 (en) | 1994-12-28 | 1999-05-06 | University Of Kentucky | Murine anti-idiotype antibody 3H1 |
| US6967092B1 (en) * | 1996-10-25 | 2005-11-22 | Mc Kearn John P | Multi-functional chimeric hematopoietic receptor agonists |
| DE19701141C1 (de) * | 1997-01-16 | 1998-04-09 | Hoechst Ag | Genkonstrukte für durch Proteasen aktivierbare Wirksubstanzen |
| DZ2788A1 (fr) | 1998-05-15 | 2003-12-01 | Bayer Ag | Agonistes et antagonistes selectifs à IL-2. |
| JPWO2003029475A1 (ja) | 2001-09-28 | 2005-01-20 | 株式会社ディナベック研究所 | エピトープ結合β２ｍをコードする哺乳動物細胞感染性ウイルスベクターおよびその利用 |
| CA2557677A1 (en) | 2004-03-05 | 2005-10-06 | Chiron Corporation | In vitro test system for predicting patient tolerability of therapeutic agents |
| EP3263581B2 (en) | 2005-05-17 | 2025-07-09 | University of Connecticut | Compositions and methods for immunomodulation in an organism |
| CN101255197B (zh) | 2008-03-28 | 2012-01-25 | 浙江海正药业股份有限公司 | 血清白蛋白与白介素1受体拮抗剂的融合蛋白及应用 |
| GB0815216D0 (en) * | 2008-08-21 | 2008-09-24 | Asterion Ltd | Interleukin |
| EP2553101A4 (en) * | 2010-04-02 | 2013-09-04 | Univ Rochester | PROTEASE-ACTIVATED CYTOKINES |
| WO2012088383A2 (en) | 2010-12-23 | 2012-06-28 | Genentech, Inc. | PILR alpha INTERACTIONS AND METHODS OF MODIFYING SAME |
| CA2869674A1 (en) | 2012-06-08 | 2013-12-12 | Alkermes, Inc. | Fusion polypeptides comprising an active protein linked to a mucin-domain polypeptide |
| US20140044675A1 (en) * | 2012-08-10 | 2014-02-13 | Roche Glycart Ag | Interleukin-2 fusion proteins and uses thereof |
| WO2014100913A1 (en) | 2012-12-24 | 2014-07-03 | Beijing Anxinhuaide Biotech. Co., Ltd | Improving the half life of a therapeutic polypeptide by fusing with a trimeric scaffold protein via a spacer |
| MA40094B1 (fr) | 2014-08-06 | 2022-05-31 | Univ Miami | Protéines de fusion de l'interleukine-2/récepteur alpha de l'interleukine-2 et procédés d'utilisation |
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2015
- 2015-08-04 MA MA40094A patent/MA40094B1/fr unknown
- 2015-08-05 MX MX2017001062A patent/MX388977B/es unknown
- 2015-08-05 SG SG10201913695PA patent/SG10201913695PA/en unknown
- 2015-08-05 SI SI201532026T patent/SI3177307T1/sl unknown
- 2015-08-05 EP EP24181690.9A patent/EP4438621A3/en active Pending
- 2015-08-05 HR HRP20241258TT patent/HRP20241258T1/hr unknown
- 2015-08-05 PT PT157505603T patent/PT3177307T/pt unknown
- 2015-08-05 MY MYPI2017700387A patent/MY180831A/en unknown
- 2015-08-05 BR BR112017001940A patent/BR112017001940A2/pt active Search and Examination
- 2015-08-05 CN CN201580042330.XA patent/CN107074967B/zh active Active
- 2015-08-05 EA EA202091342A patent/EA202091342A3/ru unknown
- 2015-08-05 CN CN202110539190.4A patent/CN113912737A/zh active Pending
- 2015-08-05 PE PE2017000128A patent/PE20170503A1/es unknown
- 2015-08-05 WO PCT/US2015/043792 patent/WO2016022671A1/en not_active Ceased
- 2015-08-05 SG SG11201700706WA patent/SG11201700706WA/en unknown
- 2015-08-05 DK DK15750560.3T patent/DK3177307T3/da active
- 2015-08-05 MA MA40721A patent/MA40721B1/fr unknown
- 2015-08-05 KR KR1020177005686A patent/KR102653758B1/ko active Active
- 2015-08-05 JP JP2017506395A patent/JP6723982B2/ja active Active
- 2015-08-05 AU AU2015301071A patent/AU2015301071C1/en active Active
- 2015-08-05 ES ES15750560T patent/ES2986097T3/es active Active
- 2015-08-05 EA EA201790063A patent/EA035956B1/ru not_active IP Right Cessation
- 2015-08-05 SM SM20240414T patent/SMT202400414T1/it unknown
- 2015-08-05 TN TN2017000020A patent/TN2017000020A1/en unknown
- 2015-08-05 RS RS20240999A patent/RS65930B1/sr unknown
- 2015-08-05 US US15/501,392 patent/US12084483B2/en active Active
- 2015-08-05 FI FIEP15750560.3T patent/FI3177307T3/fi active
- 2015-08-05 HU HUE15750560A patent/HUE068478T2/hu unknown
- 2015-08-05 LT LTEPPCT/US2015/043792T patent/LT3177307T/lt unknown
- 2015-08-05 CA CA2957273A patent/CA2957273C/en active Active
- 2015-08-05 EP EP15750560.3A patent/EP3177307B1/en active Active
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2017
- 2017-01-06 PH PH12017500042A patent/PH12017500042A1/en unknown
- 2017-01-09 IL IL250007A patent/IL250007B/en active IP Right Grant
- 2017-01-11 ZA ZA2017/00245A patent/ZA201700245B/en unknown
- 2017-02-03 CL CL2017000284A patent/CL2017000284A1/es unknown
- 2017-02-05 SA SA517380842A patent/SA517380842B1/ar unknown
- 2017-03-03 CO CONC2017/0002166A patent/CO2017002166A2/es unknown
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2020
- 2020-05-22 AU AU2020203352A patent/AU2020203352B2/en active Active
- 2020-06-24 JP JP2020108721A patent/JP7272663B2/ja active Active
- 2020-07-09 IL IL275944A patent/IL275944B/en unknown
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2022
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2023
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2025
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