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PE20160933A1 - Antagonista selectivos de nr2b - Google Patents

Antagonista selectivos de nr2b

Info

Publication number
PE20160933A1
PE20160933A1 PE2016001107A PE2016001107A PE20160933A1 PE 20160933 A1 PE20160933 A1 PE 20160933A1 PE 2016001107 A PE2016001107 A PE 2016001107A PE 2016001107 A PE2016001107 A PE 2016001107A PE 20160933 A1 PE20160933 A1 PE 20160933A1
Authority
PE
Peru
Prior art keywords
compounds
selective antagonist
nr2b selective
phenyl
nr2b
Prior art date
Application number
PE2016001107A
Other languages
English (en)
Inventor
Imadul Islam
Dalton King
John E Macor
Jayakumar Sankara Warrier
Srinivasan Thangathirupathy
Iii Lorin A Thompson
Jianliang Shi
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PE20160933A1 publication Critical patent/PE20160933A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La descripcion se refiere generalmente a compuestos de la formula I, donde: Ar1 es entre otros fenilo; Ar2 es entre otros fenilo; X es enlace o alquileno C1-C3; n es 1 o 2; el anillo A es entre otros azetidinilo. Incluyendo sus sales, asi como composiciones y metodos de uso de los compuestos. Los compuestos son ligandos del receptor NR2B y pueden ser utiles para el tratamiento de diversos trastornos del sistema nervioso central
PE2016001107A 2014-01-09 2015-01-06 Antagonista selectivos de nr2b PE20160933A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201461925363P 2014-01-09 2014-01-09

Publications (1)

Publication Number Publication Date
PE20160933A1 true PE20160933A1 (es) 2016-09-10

Family

ID=52463126

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2016001107A PE20160933A1 (es) 2014-01-09 2015-01-06 Antagonista selectivos de nr2b

Country Status (28)

Country Link
US (10) US9221796B2 (es)
EP (1) EP3092224B1 (es)
JP (1) JP6543259B2 (es)
KR (1) KR102311518B1 (es)
CN (1) CN106061961B (es)
AR (1) AR099071A1 (es)
AU (1) AU2015205001A1 (es)
CA (1) CA2936293A1 (es)
CL (1) CL2016001763A1 (es)
DK (1) DK3092224T3 (es)
EA (1) EA201691413A1 (es)
ES (1) ES2693250T3 (es)
HR (1) HRP20181585T1 (es)
HU (1) HUE041986T2 (es)
IL (1) IL246599A0 (es)
LT (1) LT3092224T (es)
MX (1) MX2016008898A (es)
PE (1) PE20160933A1 (es)
PL (1) PL3092224T3 (es)
PT (1) PT3092224T (es)
RS (1) RS57830B1 (es)
SG (1) SG11201605618WA (es)
SI (1) SI3092224T1 (es)
SM (1) SMT201800619T1 (es)
TR (1) TR201815579T4 (es)
TW (1) TWI640515B (es)
UY (1) UY35947A (es)
WO (1) WO2015105772A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9221796B2 (en) * 2014-01-09 2015-12-29 Bristol-Myers Squibb Company Selective NR2B antagonists
JP6876625B2 (ja) * 2015-06-01 2021-05-26 リューゲン ホールディングス （ケイマン） リミテッド Ｎｒ２ｂｎｍｄａレセプターアンタゴニストとしての３，３−ジフルオロピペリジンカルバメート複素環式化合物
EA201890946A1 (ru) * 2015-10-14 2018-09-28 Бристол-Маерс Сквибб Компани Селективные антагонисты nr2b
CA3001894A1 (en) 2015-10-14 2017-04-20 Bristol-Myers Squibb Company Selective nr2b antagonists
US11000526B2 (en) 2016-11-22 2021-05-11 Rugen Holdings (Cayman) Limited Treatment of autism spectrum disorders, obsessive-compulsive disorder and anxiety disorders
CN108203404A (zh) * 2018-03-02 2018-06-26 上海博邦医药科技有限公司 (r)-3-苯基哌啶或/和(s)-3-苯基哌啶以及尼拉帕尼的手性中间体的合成方法
US10781172B2 (en) 2018-06-21 2020-09-22 Northwestern University Catalysts and methods for enantioselective conjugate additions of amines to unsaturated electrophiles
WO2024197289A1 (en) * 2023-03-22 2024-09-26 Gilgamesh Pharmaceuticals, Inc. Negative allosteric modulators of glun2b receptors and methods of making and using the same
WO2025113519A1 (zh) * 2023-11-28 2025-06-05 成都地奥制药集团有限公司 内酰胺环类化合物及其用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2744448B1 (fr) 1996-02-02 1998-04-24 Pf Medicament Nouvelles piperidines derivees d'aryl piperazine, ainsi que leur procede de preparation, les compositions pharmaceutiques et leur utilisation comme medicaments
WO2000063173A1 (en) 1999-04-14 2000-10-26 F. Hoffmann-La Roche Ag Process for the preparation of substituted piperidines
US6476041B1 (en) 1999-10-29 2002-11-05 Merck & Co., Inc. 1,4 substituted piperidinyl NMDA/NR2B antagonists
KR20020093950A (ko) * 2000-04-26 2002-12-16 워너-램버트 캄파니 아형 선택적인 ｎｍｄａ 수용체 길항제로서의시클로헥실아민 유도체
WO2003035641A1 (en) 2001-10-22 2003-05-01 Shionogi & Co., Ltd. Novel carbamoylpyrrolidone derivative
MXPA05013151A (es) 2003-06-04 2006-03-17 Merck & Co Inc 3-fluoro-piperidinas como antagonistas de n-metil-d-aspartato/nr2b.
JP2007508288A (ja) 2003-10-08 2007-04-05 ファイザー株式会社 縮合ラクタム化合物
US7935706B2 (en) 2006-02-23 2011-05-03 Shionogi & Co., Ltd. Nitrogen-containing heterocycle derivatives substituted with cyclic group
CN101815518B (zh) * 2007-06-29 2013-01-09 埃莫里大学 用于神经保护的nmda受体拮抗剂
US9221796B2 (en) * 2014-01-09 2015-12-29 Bristol-Myers Squibb Company Selective NR2B antagonists

Also Published As

Publication number Publication date
US20210121453A1 (en) 2021-04-29
US20180000807A1 (en) 2018-01-04
CN106061961A (zh) 2016-10-26
LT3092224T (lt) 2018-10-25
US20200163949A1 (en) 2020-05-28
JP2017502063A (ja) 2017-01-19
US9221796B2 (en) 2015-12-29
US20180250283A1 (en) 2018-09-06
SI3092224T1 (sl) 2018-11-30
CA2936293A1 (en) 2015-07-16
US20190117638A1 (en) 2019-04-25
US20180110766A1 (en) 2018-04-26
AU2015205001A1 (en) 2016-08-18
WO2015105772A1 (en) 2015-07-16
MX2016008898A (es) 2016-10-04
JP6543259B2 (ja) 2019-07-10
SG11201605618WA (en) 2016-08-30
TR201815579T4 (tr) 2018-11-21
EP3092224A1 (en) 2016-11-16
IL246599A0 (en) 2016-08-31
PT3092224T (pt) 2018-11-14
RS57830B1 (sr) 2018-12-31
US20160081995A1 (en) 2016-03-24
TWI640515B (zh) 2018-11-11
UY35947A (es) 2015-07-31
AR099071A1 (es) 2016-06-29
CN106061961B (zh) 2018-12-18
US20150191452A1 (en) 2015-07-09
TW201613884A (en) 2016-04-16
KR20160105885A (ko) 2016-09-07
ES2693250T3 (es) 2018-12-10
HUE041986T2 (hu) 2019-06-28
KR102311518B1 (ko) 2021-10-08
US20190314358A1 (en) 2019-10-17
US20170258777A1 (en) 2017-09-14
PL3092224T3 (pl) 2019-05-31
CL2016001763A1 (es) 2017-02-10
HRP20181585T1 (hr) 2018-12-14
EA201691413A1 (ru) 2016-10-31
DK3092224T3 (en) 2018-11-26
SMT201800619T1 (it) 2019-01-11
EP3092224B1 (en) 2018-08-22

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