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PE20151007A1 - Derivados de aril-sultamo como moduladores de rorc - Google Patents

Derivados de aril-sultamo como moduladores de rorc

Info

Publication number
PE20151007A1
PE20151007A1 PE2015000022A PE2015000022A PE20151007A1 PE 20151007 A1 PE20151007 A1 PE 20151007A1 PE 2015000022 A PE2015000022 A PE 2015000022A PE 2015000022 A PE2015000022 A PE 2015000022A PE 20151007 A1 PE20151007 A1 PE 20151007A1
Authority
PE
Peru
Prior art keywords
phenyl
fluoro
ethanone
piperazin
thiazinan
Prior art date
Application number
PE2015000022A
Other languages
English (en)
Inventor
Van Niel Monique Bodil
Benjamin Fauber
Simon Gaines
Alberto Gobbi
Olivier Rene
David Vesey
Stuart Ward
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20151007A1 publication Critical patent/PE20151007A1/es

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    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D515/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La invencion esta compuestos de la formula I: que modulan la funcion del receptor de organo RORc, o las sales farmaceuticamente aceptables de los mismos, en la que m, n, p, q, r, A, W, X1, X2, X3, X4, Y, Z, R1, R2, R3, R4, R5, R6, R7, R8, R9,R10, R11 y R12 tienen los significados aqui definidos. Se describen tambien metodos de obtencion de los compuestos y de uso de los mismos para el tratamiento de enfermedades inflamatorias, por ejemplo la artritis. Son compuestos preferidos 1-(4-(4-((1,1-dioxido-6-fenil-1,2-tiazinan-2-il)metil)-3-fluorfenil) piperazin-1-il) etanona ; 2-(2-fluor-4-((1-(metilsulfonil) piperidin-4-il) oxi) bencil)-6-fenil-1, 2-tiazinano 1,1-dioxido; 1-{4-[4-(1,1-dioxo-6-fenil-[1,2]tiazinan-2-ilmetil)-3-fluor-fenil]-piperazin-1-il} -etanona; 1-(4-{ 3-fluor-4-[6-(4-fluor-fenil)-1,1 dioxo-[1, 2] tiazinan-2-ilmetil]-fenil}-piperazin-1-il)-etanona; 1-{4-[4-(1,1-dioxo-5-fenil-isotiazolidin-2-ilmetil)-3-fluor-feni]-piperazin-1-il} -etanona; entre otros
PE2015000022A 2012-07-11 2013-07-11 Derivados de aril-sultamo como moduladores de rorc PE20151007A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261670519P 2012-07-11 2012-07-11
US201361788430P 2013-03-15 2013-03-15
US201361837461P 2013-06-20 2013-06-20

Publications (1)

Publication Number Publication Date
PE20151007A1 true PE20151007A1 (es) 2015-06-29

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Family Applications (1)

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PE2015000022A PE20151007A1 (es) 2012-07-11 2013-07-11 Derivados de aril-sultamo como moduladores de rorc

Country Status (21)

Country Link
US (1) US9115101B2 (es)
EP (1) EP2872504B1 (es)
JP (1) JP6262228B2 (es)
KR (1) KR20150029739A (es)
CN (2) CN104470917B (es)
AR (1) AR092348A1 (es)
AU (1) AU2013288756A1 (es)
BR (1) BR112015000581A2 (es)
CA (1) CA2876449A1 (es)
CL (1) CL2014003572A1 (es)
CO (1) CO7141456A2 (es)
CR (1) CR20140548A (es)
ES (1) ES2612165T3 (es)
HK (1) HK1244781A1 (es)
IL (1) IL236293A0 (es)
MX (1) MX2015000325A (es)
PE (1) PE20151007A1 (es)
PH (1) PH12014502788B1 (es)
SG (1) SG11201408534VA (es)
TW (1) TW201408652A (es)
WO (1) WO2014009447A1 (es)

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