AR080841A1 - Derivados de isoxazolina sustituida; composiciones veterinarias que los comprenden y su uso en el tratamiento de parasitos en animales - Google Patents
Derivados de isoxazolina sustituida; composiciones veterinarias que los comprenden y su uso en el tratamiento de parasitos en animalesInfo
- Publication number
- AR080841A1 AR080841A1 ARP110101163A ARP110101163A AR080841A1 AR 080841 A1 AR080841 A1 AR 080841A1 AR P110101163 A ARP110101163 A AR P110101163A AR P110101163 A ARP110101163 A AR P110101163A AR 080841 A1 AR080841 A1 AR 080841A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- haloalkyl
- cyano
- cycloalkyl
- animals
- Prior art date
Links
- WEQPBCSPRXFQQS-UHFFFAOYSA-N 4,5-dihydro-1,2-oxazole Chemical compound C1CC=NO1 WEQPBCSPRXFQQS-UHFFFAOYSA-N 0.000 title abstract 2
- 241001465754 Metazoa Species 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 244000045947 parasite Species 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 5
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 abstract 4
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 230000000590 parasiticidal effect Effects 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 229910003827 NRaRb Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- -1 cyano, hydroxyl Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000002297 parasiticide Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Derivado de isooxazolina o una sal aceptable desde el punto de vista veterinario del mismo, con actividad parasiticida, composiciones del mismo, y su uso como un parasiticida en animales o pájaros. Reivindicacion 1: Un compuesto de formula (1) o una sal aceptable desde el punto de vista veterinario del mismo, en la que cada uno de R1a, R1b y R1c se selecciona independientemente entre halogeno, ciano, alquilo C1-8, haloalquilo C1-6 y haloalcoxi C1-6, y cada R1 puede ser idéntico o diferente entre sí; R2 es hidrogeno, halo, ciano, alquilo C1-6, haloalquilo C1-6 o alcoxi C1-6, haloalcoxi C1-6, cicloalquilo C3-6, en la que n es un numero entero 1, 2 o 3, y cuando n es 2 o 3, cada R2 puede ser idéntico o diferente entre sí; R3 se selecciona entre alquilo C1-8, alquil C0-3-cicloalquilo C3-6, alquil C1-6-OR4 o alquil C1-6C(O)NRaRb, en la que el alquilo C1-8 y el alquil C0-3-cicloalquilo C3-6 están opcionalmente sustituidos con al menos un sustituyente seleccionado entre halo, ciano, hidroxilo y S(O)pR4; R4 es alquilo C1-6 o haloalquilo C1-6; Ra es hidrogeno o alquilo C1-6; Rb es hidrogeno, alquilo C1-6, haloalquilo C1-6, alquil C0-4-cicloalquilo C3-6 o alquil C1-3Het, en el que Het es un anillo monocíclico aromático de 5 o 6 miembros que contienen al menos un heteroátomo seleccionado entre N, O o S, y el Het puede estar opcionalmente sustituido con al menos un sustituyente seleccionado entre halo, ciano, alquilo C1-6 y haloalquilo C1-6 y p es el numero entero 0, 1 o 2.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32214410P | 2010-04-08 | 2010-04-08 | |
| US201161431107P | 2011-01-10 | 2011-01-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR080841A1 true AR080841A1 (es) | 2012-05-09 |
Family
ID=44169107
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP110101163A AR080841A1 (es) | 2010-04-08 | 2011-04-07 | Derivados de isoxazolina sustituida; composiciones veterinarias que los comprenden y su uso en el tratamiento de parasitos en animales |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20110251247A1 (es) |
| EP (1) | EP2556060A1 (es) |
| JP (1) | JP2013523805A (es) |
| CN (1) | CN102933563A (es) |
| AR (1) | AR080841A1 (es) |
| AU (1) | AU2011236510A1 (es) |
| CA (1) | CA2794428A1 (es) |
| CL (1) | CL2012002770A1 (es) |
| MX (1) | MX2012011549A (es) |
| WO (1) | WO2011124998A1 (es) |
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|---|---|---|---|---|
| CA3013000C (en) | 2008-12-19 | 2022-12-13 | Vertex Pharmaceuticals Incorporated | Pyrazine derivatives useful as inhibitors of atr kinase |
| TWI487486B (zh) | 2009-12-01 | 2015-06-11 | Syngenta Participations Ag | 以異唑啉衍生物為主之殺蟲化合物 |
| EP2569289A1 (en) | 2010-05-12 | 2013-03-20 | Vertex Pharmaceuticals Incorporated | Pyrazines useful as inhibitors of atr kinase |
| NZ603478A (en) | 2010-05-12 | 2014-09-26 | Vertex Pharma | 2 -aminopyridine derivatives useful as inhibitors of atr kinase |
| EP2569286B1 (en) | 2010-05-12 | 2014-08-20 | Vertex Pharmaceuticals Inc. | Compounds useful as inhibitors of atr kinase |
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| US20140171475A1 (en) * | 2011-05-31 | 2014-06-19 | Sumitomo Chemical Company, Limited | Animal ectoparasite-controlling agent |
| US9309250B2 (en) | 2011-06-22 | 2016-04-12 | Vertex Pharmaceuticals Incorporated | Substituted pyrrolo[2,3-b]pyrazines as ATR kinase inhibitors |
| WO2012178124A1 (en) | 2011-06-22 | 2012-12-27 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
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| CN103957917A (zh) | 2011-09-30 | 2014-07-30 | 沃泰克斯药物股份有限公司 | 用atr抑制剂治疗胰腺癌和非小细胞肺癌 |
| KR20140084112A (ko) | 2011-09-30 | 2014-07-04 | 버텍스 파마슈티칼스 인코포레이티드 | Ａｔｒ 키나제의 억제제로서 유용한 화합물 |
| US8853217B2 (en) | 2011-09-30 | 2014-10-07 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| EP3878851A1 (en) | 2011-09-30 | 2021-09-15 | Vertex Pharmaceuticals Incorporated | Process for making compounds useful as inhibitors of atr kinase |
| EP2751088B1 (en) | 2011-09-30 | 2016-04-13 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| WO2013071094A1 (en) | 2011-11-09 | 2013-05-16 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| WO2013071088A1 (en) | 2011-11-09 | 2013-05-16 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| EP2776419B1 (en) | 2011-11-09 | 2016-05-11 | Vertex Pharmaceuticals Incorporated | Pyrazine compounds useful as inhibitors of atr kinase |
| WO2013071090A1 (en) | 2011-11-09 | 2013-05-16 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| EP2776420A1 (en) | 2011-11-09 | 2014-09-17 | Vertex Pharmaceuticals Incorporated | Pyrazine compounds useful as inhibitors of atr kinase |
| ES2720201T3 (es) | 2012-02-06 | 2019-07-18 | Merial Inc | Composiciones parasiticidas orales veterinarias que comprenden agentes activos de acción sistémica y usos de las mismas |
| JO3626B1 (ar) | 2012-02-23 | 2020-08-27 | Merial Inc | تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها |
| US20150057321A1 (en) | 2012-04-04 | 2015-02-26 | Intervet Inc. | Soft chewable pharmaceutical products |
| HK1205028A1 (en) | 2012-04-05 | 2015-12-11 | 沃泰克斯药物股份有限公司 | Compounds useful as inhibitors of atr kinase and combination therapies thereof |
| MX336431B (es) | 2012-05-09 | 2016-01-18 | Zoetis Services Llc | Derivados de azetidina como agentes antiparasitarios. |
| EP2904406B1 (en) | 2012-10-04 | 2018-03-21 | Vertex Pharmaceuticals Incorporated | Method for measuring atr inhibition mediated increases in dna damage |
| WO2014062604A1 (en) | 2012-10-16 | 2014-04-24 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| US9532946B2 (en) | 2012-11-20 | 2017-01-03 | Intervet Inc. | Manufacturing of semi-plastic pharmaceutical dosage units |
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| EP2970286A1 (en) | 2013-03-15 | 2016-01-20 | Vertex Pharmaceuticals Inc. | Fused pyrazolopyrimidine derivatives useful as inhibitors of atr kinase |
| SG11201603430XA (en) | 2013-11-01 | 2016-05-30 | Merial Ltd | Antiparasitic and pesticidal isoxazoline compounds |
| HRP20192183T1 (hr) | 2013-12-06 | 2020-02-21 | Vertex Pharmaceuticals Inc. | Spoj 2-amino-6-fluoro-n-[5-fluoro-piridin-3-il]pirazolo[1,5-a]pirimidin-3-karboksamida koristan kao inhibitor atr kinase, njegova priprava, različiti kruti oblici te njegovi radioaktivno označeni derivati |
| AU2015247463B2 (en) | 2014-04-17 | 2018-03-29 | Basf, Se | Use of malononitrile compounds for protecting animals from parasites |
| EP3152212B9 (en) | 2014-06-05 | 2020-05-27 | Vertex Pharmaceuticals Inc. | Radiolabelled derivatives of a 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]- pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, the preparation of said compound and different solid forms thereof |
| EP3157566B1 (en) | 2014-06-17 | 2019-05-01 | Vertex Pharmaceuticals Incorporated | Method for treating cancer using a combination of chk1 and atr inhibitors |
| UY36570A (es) | 2015-02-26 | 2016-10-31 | Merial Inc | Formulaciones inyectables de acción prolongada que comprenden un agente activo isoxazolina, métodos y usos de las mismas |
| SG10202103403SA (en) | 2015-05-20 | 2021-05-28 | Boehringer Ingelheim Animal Health Usa Inc | Anthelmintic depsipeptide compounds |
| WO2016207234A1 (en) | 2015-06-23 | 2016-12-29 | Intervet International B.V. | Isoxazoline solution containing vitamin e for use with sanitized drinking water |
| HK1258570A1 (zh) | 2015-09-30 | 2019-11-15 | Vertex Pharmaceuticals Inc. | 使用dna损伤剂及atr抑制剂的组合治疗癌症的方法 |
| JP6961586B2 (ja) | 2015-11-11 | 2021-11-05 | ジーランド ファーマ エイ／エス | α４β７インテグリンを標的とする環状ペプチド |
| WO2018071535A1 (en) | 2016-10-14 | 2018-04-19 | Merial, Inc. | Pesticidal and parasiticidal vinyl isoxazoline compounds |
| US11111273B2 (en) | 2016-11-11 | 2021-09-07 | Zealand Pharma A/S | Cyclic peptides multimers targeting alpha-4-beta-7 integrin |
| US11382949B2 (en) | 2016-11-16 | 2022-07-12 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic depsipeptide compounds |
| JP7274425B2 (ja) | 2017-05-10 | 2023-05-16 | ジーランド ファーマ アクティーゼルスカブ | α４β７インテグリンを標的とするホモデチック環状ペプチド |
| WO2019036407A1 (en) | 2017-08-14 | 2019-02-21 | Merial, Inc. | PYRAZOLE-ISOXAZOLINE COMPOUNDS WITH PESTICIDE AND PARASITICIDE ACTIVITY |
| PH12020550555B1 (en) | 2017-11-07 | 2024-03-06 | Intervet Int Bv | Injectable isoxazoline pharmaceutical compositions and uses thereof |
| AR113997A1 (es) | 2017-12-21 | 2020-07-08 | Intervet Int Bv | Composiciones antiparasitarias para unción dorsal continua |
| IL279977B2 (en) | 2018-07-09 | 2024-06-01 | Boehringer Ingelheim Animal Health Usa Inc | Heterocyclic anthelmintic compounds |
| US11773066B2 (en) | 2018-11-20 | 2023-10-03 | Boehringer Ingelheim Animal Health USA Inc. | Indazolylcyanoethylamino compound, compositions of same, method of making, and methods of using thereof |
| US11560388B2 (en) | 2019-03-19 | 2023-01-24 | Boehringer Ingelheim Vetmedica Gmbh | Anthelmintic aza-benzothiophene and aza-benzofuran compounds |
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| MX2022007309A (es) | 2019-12-16 | 2022-07-12 | Intervet Int Bv | Composicion para control de piojos en aves de corral. |
| AU2020409532A1 (en) | 2019-12-16 | 2022-05-12 | Intervet International B.V. | Composition for lice control |
| WO2021122515A1 (en) | 2019-12-16 | 2021-06-24 | Intervet International B.V. | Parasite control in ruminants |
| DK4153133T3 (da) | 2020-05-20 | 2024-02-05 | Intervet Int Bv | Injicerbare farmaceutiske sammensætninger og anvendelser deraf |
| CA3183100A1 (en) | 2020-05-29 | 2021-12-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Anthelmintic heterocyclic compounds |
| US20240116854A1 (en) | 2021-01-27 | 2024-04-11 | Intervet Inc. | Cyclopropylamide compounds against parasites in fish |
| CA3209562A1 (en) | 2021-01-27 | 2022-08-04 | Intervet International B.V. | Cyclopropylamide compounds against parasites in fish |
| IL304983A (en) | 2021-02-11 | 2023-10-01 | Basf Se | Isoxazoline histories are transmuted |
| EP4043444A1 (en) | 2021-02-11 | 2022-08-17 | Basf Se | Substituted isoxazoline derivatives |
| WO2022258797A1 (en) | 2021-06-11 | 2022-12-15 | Intervet International B.V. | Tick control methods |
| BR112023027372A2 (pt) | 2021-06-25 | 2024-03-12 | Intervet Int Bv | Composições veterinárias palatáveis |
| JP2025507585A (ja) | 2022-02-17 | 2025-03-21 | ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー | 流体製品メーラーを提供する方法及びシステム |
| AU2023332216A1 (en) | 2022-09-02 | 2025-02-20 | Intervet International B.V. | Treatment of fasciolosis |
| NO20240925A1 (en) | 2023-09-15 | 2025-03-17 | Evah Atlantic Inc | Dihydroisoxazole compound for use in reducing ectoparasite infestations on fish |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW524667B (en) | 1996-12-05 | 2003-03-21 | Pfizer | Parasiticidal pyrazoles |
| WO2002081428A1 (en) | 2001-03-30 | 2002-10-17 | Eisai Co., Ltd. | Benzene compound and salt thereof |
| JP4451849B2 (ja) | 2003-11-28 | 2010-04-14 | 日本曹達株式会社 | アリール複素環誘導体および農園芸用殺菌剤および殺虫剤 |
| GB0329314D0 (en) | 2003-12-18 | 2004-01-21 | Pfizer Ltd | Substituted arylpyrazoles |
| CN102558082B (zh) | 2004-03-05 | 2015-09-30 | 日产化学工业株式会社 | 异噁唑啉取代苯甲酰胺化合物的制备中间体 |
| DE102004030753A1 (de) * | 2004-06-25 | 2006-01-19 | Bayer Cropscience Ag | 3'-Alkoxy spirocyclische Tetram- und Tretronsäuren |
| AU2006285613B2 (en) | 2005-09-02 | 2011-11-17 | Nissan Chemical Corporation | Isoxazoline-substituted benzamide compound and harmful organism-controlling agent |
| DE602007006288D1 (de) | 2006-03-10 | 2010-06-17 | Nissan Chemical Ind Ltd | Substituierte isoxazolin-verbindung und schädlingsbekämpfungsmittel |
| JP2008239611A (ja) | 2007-02-27 | 2008-10-09 | Nissan Chem Ind Ltd | イソキサゾリン置換ベンズアミド化合物及び有害生物防除剤 |
| JP2008260691A (ja) * | 2007-04-10 | 2008-10-30 | Bayer Cropscience Ag | 殺虫性アリールイソオキサゾリン誘導体 |
| BRPI0810196A2 (pt) | 2007-04-10 | 2011-12-06 | Bayer Cropscience Ag | inseticidas de derivados de aril isoxazolina |
| AU2009294050B2 (en) * | 2008-09-18 | 2011-11-17 | Nippon Soda Co., Ltd. | Nitrogen-containing heterocyclic compound and pest control agent |
-
2011
- 2011-03-17 JP JP2013503195A patent/JP2013523805A/ja not_active Withdrawn
- 2011-03-17 CN CN2011800176874A patent/CN102933563A/zh active Pending
- 2011-03-17 EP EP11715039A patent/EP2556060A1/en not_active Withdrawn
- 2011-03-17 AU AU2011236510A patent/AU2011236510A1/en not_active Abandoned
- 2011-03-17 MX MX2012011549A patent/MX2012011549A/es not_active Application Discontinuation
- 2011-03-17 CA CA2794428A patent/CA2794428A1/en not_active Abandoned
- 2011-03-17 WO PCT/IB2011/051129 patent/WO2011124998A1/en not_active Ceased
- 2011-04-06 US US13/080,721 patent/US20110251247A1/en not_active Abandoned
- 2011-04-07 AR ARP110101163A patent/AR080841A1/es not_active Application Discontinuation
-
2012
- 2012-10-02 CL CL2012002770A patent/CL2012002770A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2794428A1 (en) | 2011-10-13 |
| CL2012002770A1 (es) | 2013-03-01 |
| MX2012011549A (es) | 2013-01-29 |
| CN102933563A (zh) | 2013-02-13 |
| AU2011236510A1 (en) | 2012-10-11 |
| WO2011124998A1 (en) | 2011-10-13 |
| US20110251247A1 (en) | 2011-10-13 |
| EP2556060A1 (en) | 2013-02-13 |
| JP2013523805A (ja) | 2013-06-17 |
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