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PE20141197A1 - INHIBIDORES DE mTOR CINASA PARA INDICADORES DE ONCOLOGIA Y ENFERMEDADES ASOCIADAS CON LA TRAYECTORIA mTOR/PI3K/AKT - Google Patents

INHIBIDORES DE mTOR CINASA PARA INDICADORES DE ONCOLOGIA Y ENFERMEDADES ASOCIADAS CON LA TRAYECTORIA mTOR/PI3K/AKT

Info

Publication number
PE20141197A1
PE20141197A1 PE2014000555A PE2014000555A PE20141197A1 PE 20141197 A1 PE20141197 A1 PE 20141197A1 PE 2014000555 A PE2014000555 A PE 2014000555A PE 2014000555 A PE2014000555 A PE 2014000555A PE 20141197 A1 PE20141197 A1 PE 20141197A1
Authority
PE
Peru
Prior art keywords
mtor
pirazin
kinase inhibitors
methyl
pi3k
Prior art date
Application number
PE2014000555A
Other languages
English (en)
Inventor
Jan Elsner
Roy L Harris
Branden Lee
Deborah Mortensen
Garrick Packard
Patrick Papa
Rama K Narla
Kimberly Fultz
Loui Madakamutil
Jason Parnes
Jingjing Zhao
Weiming Xu
Sophie Perrin-Ninkovic
Lida Tehrani
Graziella Shevlin
John Sapienza
Sabita Sankar
Jennifer Riggs
Original Assignee
Signal Pharm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41490345&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20141197(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Signal Pharm Llc filed Critical Signal Pharm Llc
Publication of PE20141197A1 publication Critical patent/PE20141197A1/es

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE 3,4-DIHIDROPIRAZINO[2,3-b]PIRAZIN-2(1H)-ONA TALES COMO 6-(1H-PIRROLO[2,3-b]PIRIDIN-3-IL)-4-(2-(TETRAHIDRO-2H-PIRAN-4-IL)ETIL)-3,4-DIHIDROPIRAZINO[2,3-b]PIRAZIN-2(1H)-ONA; 6-(4-METIL-6-(1H-1,2,4-TRIAZOL-3-IL)PIRIDIN-3-IL)-4-((TETRAHIDRO-2H-PIRAN-4-IL)METIL)-3,4-DIHIDROPIRAZINO[2,3-b]PIRAZIN-2(1H)-ONA; 6-(5-FLUORO-2-METIL-4-(1H-1,2,4-TRIAZOL-3-IL)FENIL)-4-((TRANS-4-METOXICICLOHEXIL)METIL)-3,4-DIHIDROPIRAZINO[2,3-b]PIRAZIN-2(1H)-ONA; 6-(6-(1H-1,2,4-TRIAZOL-3-IL)PIRIDIN-3-IL)-4-((TRANS-4-METOXICICLOHEXIL)METIL)-3,4-DIHIDROPIRAZINO[2,3-b]PIRAZIN-2(1H)-ONA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE CINASA SIENDO UTILES EN EL TRATAMIENTO DEL CANCER, TRANSTORNOS INFLAMATORIOS, INMUNOLOGICOS
PE2014000555A 2008-10-27 2009-10-27 INHIBIDORES DE mTOR CINASA PARA INDICADORES DE ONCOLOGIA Y ENFERMEDADES ASOCIADAS CON LA TRAYECTORIA mTOR/PI3K/AKT PE20141197A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10862708P 2008-10-27 2008-10-27

Publications (1)

Publication Number Publication Date
PE20141197A1 true PE20141197A1 (es) 2014-09-22

Family

ID=41490345

Family Applications (3)

Application Number Title Priority Date Filing Date
PE2011000936A PE20110575A1 (es) 2008-10-27 2009-10-27 INHIBIDORES DE mTOR CINASA PARA INDICADORES DE ONCOLOGIA Y ENFERMEDADES ASOCIADAS CON LA TRAYECTORIA mTOR/PI3K/AKT
PE2012002515A PE20130457A1 (es) 2008-10-27 2009-10-27 INHIBIDORES DE mTOR CINASA PARA INDICADORES DE ONCOLOGIA Y ENFERMEDADES ASOCIADAS CON LA TRAYECTORIA mTOR/PI3K/AKT
PE2014000555A PE20141197A1 (es) 2008-10-27 2009-10-27 INHIBIDORES DE mTOR CINASA PARA INDICADORES DE ONCOLOGIA Y ENFERMEDADES ASOCIADAS CON LA TRAYECTORIA mTOR/PI3K/AKT

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PE2011000936A PE20110575A1 (es) 2008-10-27 2009-10-27 INHIBIDORES DE mTOR CINASA PARA INDICADORES DE ONCOLOGIA Y ENFERMEDADES ASOCIADAS CON LA TRAYECTORIA mTOR/PI3K/AKT
PE2012002515A PE20130457A1 (es) 2008-10-27 2009-10-27 INHIBIDORES DE mTOR CINASA PARA INDICADORES DE ONCOLOGIA Y ENFERMEDADES ASOCIADAS CON LA TRAYECTORIA mTOR/PI3K/AKT

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US (10) US8110578B2 (es)
EP (5) EP2358718B1 (es)
JP (3) JP5689420B2 (es)
KR (2) KR101815604B1 (es)
CN (3) CN104744475B (es)
AR (2) AR073995A1 (es)
AU (1) AU2009320137C1 (es)
BR (1) BRPI0920254A2 (es)
CA (1) CA2740975C (es)
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PE (3) PE20110575A1 (es)
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SG (3) SG10201402273RA (es)
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Families Citing this family (126)

* Cited by examiner, † Cited by third party
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US9273077B2 (en) 2008-05-21 2016-03-01 Ariad Pharmaceuticals, Inc. Phosphorus derivatives as kinase inhibitors
EA029131B1 (ru) 2008-05-21 2018-02-28 Ариад Фармасьютикалз, Инк. Фосфорсодержащие производные в качестве ингибиторов киназы
US8110578B2 (en) * 2008-10-27 2012-02-07 Signal Pharmaceuticals, Llc Pyrazino[2,3-b]pyrazine mTOR kinase inhibitors for oncology indications and diseases associated with the mTOR/PI3K/Akt pathway
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