PE20141706A1 - Anticuerpos de union a trombina y usos del mismo - Google Patents
Anticuerpos de union a trombina y usos del mismoInfo
- Publication number
- PE20141706A1 PE20141706A1 PE2014000953A PE2014000953A PE20141706A1 PE 20141706 A1 PE20141706 A1 PE 20141706A1 PE 2014000953 A PE2014000953 A PE 2014000953A PE 2014000953 A PE2014000953 A PE 2014000953A PE 20141706 A1 PE20141706 A1 PE 20141706A1
- Authority
- PE
- Peru
- Prior art keywords
- seq
- trombina
- union
- antibodies
- same
- Prior art date
Links
- 150000001413 amino acids Chemical class 0.000 abstract 4
- 208000005189 Embolism Diseases 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A UNA MOLECULA DE ANTICUERPO AISLADA QUE SE UNE ESPECIFICAMENTE A LA REGION DE EXOSITIO 1 DE LA TROMBINA INHIBIENDO SU ACTIVIDAD, LA CUAL COMPRENDE: A) UN LCDR1, LCDR2 Y LCDR3 QUE TIENE LA SECUENCIA DE AMINOACIDOS DE SEQ ID N�: 7, 8 Y 9 RESPECTIVAMENTE; B) UN HCDR1, HCDR2 Y HCDR3 QUE TIENE LA SECUENCIA DE AMINOACIDOS DE SEQ ID N�: 3, 4 Y 5 RESPECTIVAMENTE; C) UN DOMINIO VH QUE TIENE LA SECUENCIA DE AMINOACIDOS DE SEQ ID N�: 2; Y D) UN DOMINIO VL QUE TIENE LA SECUENCIA DE AMINOACIDOS DE SEQ ID N�: 6. TAMBIEN SE REFIERE A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA UTIL EN EL TRATAMIENTO DE TROMBOSIS, EMBOLISMO
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1121513.4A GB201121513D0 (en) | 2011-12-14 | 2011-12-14 | Thrombin-binding antibody molecules and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20141706A1 true PE20141706A1 (es) | 2014-11-13 |
Family
ID=45560465
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2014000953A PE20141706A1 (es) | 2011-12-14 | 2012-12-14 | Anticuerpos de union a trombina y usos del mismo |
| PE2018002007A PE20190171A1 (es) | 2011-12-14 | 2012-12-14 | Anticuerpos de union a trombina y usos del mismo |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2018002007A PE20190171A1 (es) | 2011-12-14 | 2012-12-14 | Anticuerpos de union a trombina y usos del mismo |
Country Status (34)
| Country | Link |
|---|---|
| US (5) | US9518129B2 (es) |
| EP (2) | EP3275903A1 (es) |
| JP (2) | JP6216954B2 (es) |
| KR (1) | KR102114506B1 (es) |
| CN (2) | CN107936119B (es) |
| AU (2) | AU2012351858B2 (es) |
| BR (1) | BR112014014605A2 (es) |
| CA (1) | CA2856656C (es) |
| CO (1) | CO7101192A2 (es) |
| CY (1) | CY1119599T1 (es) |
| DK (1) | DK2791177T3 (es) |
| ES (1) | ES2642718T3 (es) |
| GB (1) | GB201121513D0 (es) |
| HK (1) | HK1246326A1 (es) |
| HR (1) | HRP20171775T1 (es) |
| HU (1) | HUE034793T2 (es) |
| IL (1) | IL232797B (es) |
| LT (1) | LT2791177T (es) |
| ME (1) | ME02901B (es) |
| MX (2) | MX376876B (es) |
| MY (1) | MY170980A (es) |
| NO (1) | NO2791177T3 (es) |
| PE (2) | PE20141706A1 (es) |
| PH (1) | PH12014501169A1 (es) |
| PL (1) | PL2791177T3 (es) |
| PT (1) | PT2791177T (es) |
| RS (1) | RS56510B1 (es) |
| RU (2) | RU2642276C2 (es) |
| SG (1) | SG11201402560WA (es) |
| SI (1) | SI2791177T1 (es) |
| SM (1) | SMT201700580T1 (es) |
| UA (1) | UA116531C2 (es) |
| WO (1) | WO2013088164A1 (es) |
| ZA (1) | ZA201403836B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201121513D0 (en) | 2011-12-14 | 2012-01-25 | Cambridge Entpr Ltd | Thrombin-binding antibody molecules and uses thereof |
| US9518128B2 (en) * | 2011-12-14 | 2016-12-13 | Janssen Pharmaceuticals, Inc. | Thrombin-binding antibody molecules |
| GB201310949D0 (en) * | 2013-06-19 | 2013-07-31 | Cambridge Entpr Ltd | Binding Motif |
| GB201310948D0 (en) * | 2013-06-19 | 2013-07-31 | Cambridge Entpr Ltd | Screening methods |
| MX2018009264A (es) * | 2016-02-05 | 2018-08-28 | Jiangsu Hengrui Medicine Co | Anticuerpo de trombina, fragmento de antigeno y sus usos farmaceuticos. |
| CN107043423B (zh) * | 2016-02-05 | 2021-02-26 | 江苏恒瑞医药股份有限公司 | 凝血酶抗体、其抗原结合片段及医药用途 |
| WO2018081534A1 (en) * | 2016-10-28 | 2018-05-03 | President And Fellows Of Harvard College | Assay for exo-site binding molecules |
| WO2019030706A1 (en) | 2017-08-10 | 2019-02-14 | Janssen Pharmaceutica Nv | ANTI-THROMBIN ANTIBODY MOLECULES AND METHODS OF USE IN ORTHOPEDIC SURGERY |
| WO2019035055A1 (en) | 2017-08-16 | 2019-02-21 | Janssen Pharmaceutica Nv | ANTI-THROMBIN ANTIBODY MOLECULES AND METHODS OF USE WITH PLATELET ANTI-AGGREGATE AGENTS |
| WO2020003077A1 (en) * | 2018-06-25 | 2020-01-02 | Janssen Pharmaceutica Nv | Anti-thrombin antibody molecules for use in patients at risk for gastrointestinal (gi) bleeding |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0417193B1 (en) * | 1988-05-27 | 1993-08-04 | Centocor, Inc. | Freeze-dried formulation for antibody products |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5240913A (en) | 1989-08-18 | 1993-08-31 | Biogen, Inc. | Inhibitors of thrombin |
| US5196404B1 (en) | 1989-08-18 | 1996-09-10 | Biogen Inc | Inhibitors of thrombin |
| CA2082643A1 (en) | 1990-05-10 | 1991-11-11 | Jan H. Nuijens | Inhibitors of factor xii activation and applications thereof |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US5443827A (en) * | 1993-05-03 | 1995-08-22 | President And Fellows Of Harvard College | Fibrin-targeted inhibitors of thrombin |
| CA2180140A1 (en) * | 1993-12-27 | 1995-07-06 | Jeffrey I. Weitz | Methods and compositions for inhibiting thrombogenesis |
| GB9613718D0 (en) | 1996-06-29 | 1996-08-28 | Thrombosis Res Inst | Thrombin inhibitors |
| US5985833A (en) | 1996-09-17 | 1999-11-16 | Wisconsin Alumni Research Foundation | Thrombin inhibitor |
| WO2001000667A2 (en) | 1999-06-29 | 2001-01-04 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-thrombin peptide from anopheles albimanus salivary gland |
| CA2378473A1 (en) * | 1999-07-23 | 2001-02-01 | The Regents Of The University Of California | Modulation of platelet activation |
| CN100339132C (zh) * | 2000-05-15 | 2007-09-26 | 史密丝克莱恩比彻姆公司 | 抗血栓剂 |
| WO2002017711A2 (en) | 2000-08-31 | 2002-03-07 | Cor Therapeutics, Inc. | Therapeutics and diagnostics based on a novel signal transduction system in platelets |
| CA2453202C (en) * | 2001-07-06 | 2012-10-16 | Oregon Health & Science University | Peptides which modulate blood coagulation and methods of use thereof |
| TWI338009B (en) * | 2001-10-29 | 2011-03-01 | Genentech Inc | Antibodies for inhibiting blood coagulation and methods of use thereof |
| MEP0208A (xx) | 2005-08-26 | 2010-02-10 | Archemix Corp | Aptameri koji vezuje trombin sa visokim afininitetom |
| JP2009530312A (ja) | 2006-03-15 | 2009-08-27 | エモリー ユニヴァーシティ | トロンビン阻害剤の抗凝固効果を阻害するためのトロンビン変異体の使用 |
| GB0711779D0 (en) | 2007-06-18 | 2007-07-25 | Univ Singapore | Thrombin inhibitor |
| PL2297207T3 (pl) | 2008-06-19 | 2019-03-29 | Prothix Bv | Zastosowanie przeciwciał przeciw czynnikowi XI do zapobiegania lub leczenia tworzenia skrzepliny |
| US20110275701A1 (en) | 2008-09-18 | 2011-11-10 | Archemix Corp. | Anti-thrombin aptamer formulations and methods for use |
| LT2734552T (lt) | 2011-07-22 | 2025-01-10 | Csl Behring Gmbh | Inhibitoriniai monokloniniai antikūnai prieš xii/xiia faktorių ir jų panaudojimas |
| US9518128B2 (en) | 2011-12-14 | 2016-12-13 | Janssen Pharmaceuticals, Inc. | Thrombin-binding antibody molecules |
| GB201121513D0 (en) * | 2011-12-14 | 2012-01-25 | Cambridge Entpr Ltd | Thrombin-binding antibody molecules and uses thereof |
-
2011
- 2011-12-14 GB GBGB1121513.4A patent/GB201121513D0/en not_active Ceased
-
2012
- 2012-12-14 UA UAA201406892A patent/UA116531C2/uk unknown
- 2012-12-14 CN CN201711384542.3A patent/CN107936119B/zh not_active Expired - Fee Related
- 2012-12-14 AU AU2012351858A patent/AU2012351858B2/en not_active Ceased
- 2012-12-14 PT PT128066412T patent/PT2791177T/pt unknown
- 2012-12-14 JP JP2014546649A patent/JP6216954B2/ja not_active Expired - Fee Related
- 2012-12-14 RS RS20171073A patent/RS56510B1/sr unknown
- 2012-12-14 RU RU2014124985A patent/RU2642276C2/ru active
- 2012-12-14 MX MX2018000197A patent/MX376876B/es unknown
- 2012-12-14 RU RU2017144629A patent/RU2017144629A/ru unknown
- 2012-12-14 LT LTEP12806641.2T patent/LT2791177T/lt unknown
- 2012-12-14 NO NO12806641A patent/NO2791177T3/no unknown
- 2012-12-14 MY MYPI2014001764A patent/MY170980A/en unknown
- 2012-12-14 SG SG11201402560WA patent/SG11201402560WA/en unknown
- 2012-12-14 HU HUE12806641A patent/HUE034793T2/en unknown
- 2012-12-14 HR HRP20171775TT patent/HRP20171775T1/hr unknown
- 2012-12-14 PL PL12806641T patent/PL2791177T3/pl unknown
- 2012-12-14 SI SI201231145T patent/SI2791177T1/en unknown
- 2012-12-14 DK DK12806641.2T patent/DK2791177T3/en active
- 2012-12-14 EP EP17177235.3A patent/EP3275903A1/en not_active Withdrawn
- 2012-12-14 KR KR1020147019168A patent/KR102114506B1/ko not_active Expired - Fee Related
- 2012-12-14 BR BR112014014605A patent/BR112014014605A2/pt not_active Application Discontinuation
- 2012-12-14 EP EP12806641.2A patent/EP2791177B1/en active Active
- 2012-12-14 PE PE2014000953A patent/PE20141706A1/es active IP Right Grant
- 2012-12-14 CN CN201280061294.8A patent/CN104053673B/zh not_active Expired - Fee Related
- 2012-12-14 US US14/363,514 patent/US9518129B2/en not_active Expired - Fee Related
- 2012-12-14 CA CA2856656A patent/CA2856656C/en active Active
- 2012-12-14 WO PCT/GB2012/053140 patent/WO2013088164A1/en not_active Ceased
- 2012-12-14 MX MX2014007170A patent/MX353281B/es active IP Right Grant
- 2012-12-14 SM SM20170580T patent/SMT201700580T1/it unknown
- 2012-12-14 ES ES12806641.2T patent/ES2642718T3/es active Active
- 2012-12-14 ME MEP-2017-243A patent/ME02901B/me unknown
- 2012-12-14 PE PE2018002007A patent/PE20190171A1/es unknown
-
2014
- 2014-05-26 IL IL232797A patent/IL232797B/en active IP Right Grant
- 2014-05-26 PH PH12014501169A patent/PH12014501169A1/en unknown
- 2014-05-26 ZA ZA2014/03836A patent/ZA201403836B/en unknown
- 2014-07-11 CO CO14150372A patent/CO7101192A2/es unknown
-
2016
- 2016-11-10 US US15/348,250 patent/US9988463B2/en active Active
-
2017
- 2017-08-30 JP JP2017165700A patent/JP6705785B2/ja not_active Expired - Fee Related
- 2017-11-14 CY CY20171101189T patent/CY1119599T1/el unknown
- 2017-12-01 AU AU2017268655A patent/AU2017268655B2/en not_active Ceased
-
2018
- 2018-05-08 HK HK18105913.3A patent/HK1246326A1/en unknown
- 2018-05-10 US US15/976,512 patent/US10287363B2/en not_active Expired - Fee Related
-
2019
- 2019-03-25 US US16/363,396 patent/US20190276558A1/en not_active Abandoned
-
2021
- 2021-06-10 US US17/344,577 patent/US20210371543A1/en not_active Abandoned
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |